NO149813C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 4,5-dicyklisk-2-(substituert thio)-imidazoler og deres tilsvarende sulfoner - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 4,5-dicyklisk-2-(substituert thio)-imidazoler og deres tilsvarende sulfoner

Info

Publication number: NO149813C
Authority: NO; Norway
Prior art keywords: dicyclic; sulphones; imidazoles; preparation; similar
Prior art date: 1977-02-09

Application number

NO780432A

Other languages

English (en)

Norwegian (no)

Other versions

NO149813B (no

NO780432L (no

Inventor

Saul Carl Cherkofsky

Thomas Ray Sharpe

Original Assignee

Du Pont

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-02-09

Filing date

1978-02-08

Publication date

1984-06-27

1978-02-08 Application filed by Du Pont filed Critical Du Pont

1978-08-10 Publication of NO780432L publication Critical patent/NO780432L/no

1984-03-19 Publication of NO149813B publication Critical patent/NO149813B/no

1984-06-27 Publication of NO149813C publication Critical patent/NO149813C/no

Links

SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical class C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO780432A 1977-02-09 1978-02-08 Analogifremgangsmaate for fremstilling av terapeutisk aktive 4,5-dicyklisk-2-(substituert thio)-imidazoler og deres tilsvarende sulfoner NO149813C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US76721977A	1977-02-09	1977-02-09
US05/865,831 US4182769A (en)	1977-02-09	1978-01-05	Anti-inflammatory 1-substituted-4,5-diaryl-2-(substituted-thio) imidazoles and their corresponding sulfoxides and sulfones

Publications (3)

Publication Number	Publication Date
NO780432L NO780432L (no)	1978-08-10
NO149813B NO149813B (no)	1984-03-19
NO149813C true NO149813C (no)	1984-06-27

Family

ID=27117878

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO780432A NO149813C (no)	1977-02-09	1978-02-08	Analogifremgangsmaate for fremstilling av terapeutisk aktive 4,5-dicyklisk-2-(substituert thio)-imidazoler og deres tilsvarende sulfoner

Country Status (27)

Country	Link
US (1)	US4182769A (fr)
JP (1)	JPS53130665A (fr)
AR (1)	AR221590A1 (fr)
AT (1)	AT363076B (fr)
AU (1)	AU524360B2 (fr)
CA (1)	CA1107286A (fr)
CH (1)	CH643834A5 (fr)
DE (1)	DE2805166A1 (fr)
DK (1)	DK16878A (fr)
ES (1)	ES466793A1 (fr)
FI (1)	FI68619C (fr)
FR (1)	FR2380264A1 (fr)
GB (1)	GB1587373A (fr)
GR (1)	GR64157B (fr)
HU (1)	HU181868B (fr)
IE (1)	IE46454B1 (fr)
IL (1)	IL53996A (fr)
IT (1)	IT1092439B (fr)
LU (1)	LU79028A1 (fr)
MX (1)	MX5934E (fr)
NL (1)	NL7801454A (fr)
NO (1)	NO149813C (fr)
NZ (1)	NZ186411A (fr)
PT (1)	PT67625B (fr)
SE (1)	SE7801466L (fr)
SU (1)	SU867301A3 (fr)
YU (1)	YU28978A (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2823197A1 (de) *	1978-05-24	1979-11-29	Schering Ag	Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
EP0008072B1 (fr) *	1978-08-10	1984-02-22	Ciba-Geigy Ag	Amides substituées de l'acide anthranilique, procédé pour leur préparation et compositions pharmaceutiques les contenant et leur préparation
US4308277A (en) *	1978-08-10	1981-12-29	Ciba-Geigy Corporation	2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same
US4199592A (en) *	1978-08-29	1980-04-22	E. I. Du Pont De Nemours And Company	Antiinflammatory 4,5-diaryl-2-nitroimidazoles
DK337779A (da) *	1978-10-02	1980-04-03	Du Pont	Fremgangsmaade til fremstilling af antiinflammatoriske 2-substituerede 1h-phenantro (9,10)-imidazoler
DE2856909A1 (de) *	1978-12-28	1980-07-17	Schering Ag	Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
IT1110282B (it) *	1979-02-19	1985-12-23	Acraf	Tio-indazoli basici
DE3025484A1 (de) *	1980-07-03	1982-02-04	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4438117A (en)	1980-09-03	1984-03-20	E. I. Du Pont De Nemours And Company	2-Substituted thio-4,5-diarylpyrimidines
US4355041A (en) *	1982-01-04	1982-10-19	E. I. Du Pont De Nemours And Company	4,5-Bis-(4-fluorophenyl)-1-(4-nitrobenzyl)-2-[((1,1,2,2-tetrafluoroethyl)sulfonyl]-1H-imidazole, composition and use
US4503065A (en) *	1982-08-03	1985-03-05	E. I. Du Pont De Nemours And Company	Antiinflammatory 4,5-diaryl 1-2-halo imidazoles
ZA826501B (en) *	1982-09-06	1984-04-25	Du Pont	Anti-hypertensive imidazole derivative
DE3504678A1 (de) *	1985-02-12	1986-08-14	A. Nattermann & Cie GmbH, 5000 Köln	Neue imidazolyl-oxyalkansaeuren und -thioalkansaeuren, ihre derivate und verfahren zu ihrer herstellung
DE3508665A1 (de) *	1985-03-12	1986-09-18	Hoechst Ag, 6230 Frankfurt	Heterocyclische sulfide und ihre anwendung als immunmodulatoren
US4686231A (en) *	1985-12-12	1987-08-11	Smithkline Beckman Corporation	Inhibition of 5-lipoxygenase products
US4780470A (en) *	1986-08-19	1988-10-25	Smithkline Beckman Corporation	Inhibition of interleukin-1 by monocytes and/or macrophages
US5300519A (en) *	1988-07-06	1994-04-05	The University Of Sheffield	Immunosuppressive agents
US5030644A (en) *	1989-07-31	1991-07-09	Merck & Co., Inc.	Imidazole compounds and their use as transglutaminase inhibitors
US5098707A (en) *	1989-07-31	1992-03-24	Merck & Co., Inc.	Imidazole compounds and their use as transglutaminase inhibitors
JPH03145473A (ja) *	1989-10-27	1991-06-20	Hisamitsu Pharmaceut Co Inc	新規なイミダゾール酢酸誘導体
GB9005966D0 (en) *	1990-03-16	1990-05-09	May & Baker Ltd	New compositions of matter
DE4010797A1 (de) *	1990-04-04	1991-10-10	Hoechst Ag	Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
AU8757098A (en) *	1997-06-30	1999-02-10	Ortho-Mcneil Pharmaceutical, Inc.	2-substituted imidazoles useful in the treatment of inflammatory diseases
FR2823747B1 (fr) *	2001-04-24	2003-05-23	Oreal	Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires
US10392381B2 (en)	2014-07-18	2019-08-27	Ohio University	Prevention and treatment of non-alcoholic fatty liver disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE688585A (fr) *	1965-10-21	1967-04-20
US3707475A (en) *	1970-11-16	1972-12-26	Pfizer	Antiinflammatory imidazoles
US3929807A (en) *	1971-05-10	1975-12-30	Ciba Geigy Corp	2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
JPS5343958B2 (fr) *	1972-07-29	1978-11-24

1978
- 1978-01-05 US US05/865,831 patent/US4182769A/en not_active Expired - Lifetime
- 1978-01-13 DK DK16878A patent/DK16878A/da not_active Application Discontinuation
- 1978-02-06 PT PT67625A patent/PT67625B/pt unknown
- 1978-02-07 CA CA296,605A patent/CA1107286A/fr not_active Expired
- 1978-02-07 IT IT20079/78A patent/IT1092439B/it active
- 1978-02-08 LU LU79028A patent/LU79028A1/fr unknown
- 1978-02-08 IL IL53996A patent/IL53996A/xx unknown
- 1978-02-08 IE IE280/78A patent/IE46454B1/en unknown
- 1978-02-08 SE SE7801466A patent/SE7801466L/xx unknown
- 1978-02-08 AT AT0087078A patent/AT363076B/de not_active IP Right Cessation
- 1978-02-08 SU SU782574555A patent/SU867301A3/ru active
- 1978-02-08 NO NO780432A patent/NO149813C/no unknown
- 1978-02-08 YU YU00289/78A patent/YU28978A/xx unknown
- 1978-02-08 ES ES466793A patent/ES466793A1/es not_active Expired
- 1978-02-08 DE DE19782805166 patent/DE2805166A1/de not_active Withdrawn
- 1978-02-08 FR FR7803517A patent/FR2380264A1/fr not_active Withdrawn
- 1978-02-08 MX MX786830U patent/MX5934E/es unknown
- 1978-02-08 NL NL7801454A patent/NL7801454A/xx not_active Application Discontinuation
- 1978-02-08 AU AU33097/78A patent/AU524360B2/en not_active Expired
- 1978-02-08 GB GB5097/78A patent/GB1587373A/en not_active Expired
- 1978-02-08 NZ NZ186411A patent/NZ186411A/xx unknown
- 1978-02-09 HU HU78DU280A patent/HU181868B/hu unknown
- 1978-02-09 AR AR271047A patent/AR221590A1/es active
- 1978-02-09 FI FI780429A patent/FI68619C/fi not_active IP Right Cessation
- 1978-02-09 CH CH147578A patent/CH643834A5/de not_active IP Right Cessation
- 1978-02-09 GR GR55397A patent/GR64157B/el unknown
- 1978-02-09 JP JP1304778A patent/JPS53130665A/ja active Pending

Also Published As

Publication number	Publication date
AU3309778A (en)	1979-08-16
AR221590A1 (es)	1981-02-27
NO149813B (no)	1984-03-19
GB1587373A (en)	1981-04-01
ES466793A1 (es)	1979-08-01
DK16878A (da)	1978-08-10
IL53996A (en)	1982-04-30
PT67625B (en)	1979-07-17
FI68619C (fi)	1985-10-10
AU524360B2 (en)	1982-09-16
JPS53130665A (en)	1978-11-14
ATA87078A (de)	1980-12-15
MX5934E (es)	1984-08-30
YU28978A (en)	1983-01-21
SE7801466L (sv)	1978-08-10
CH643834A5 (de)	1984-06-29
FI780429A7 (fi)	1978-08-10
SU867301A3 (ru)	1981-09-23
IE780280L (en)	1978-08-09
HU181868B (en)	1983-11-28
IT1092439B (it)	1985-07-12
FR2380264A1 (fr)	1978-09-08
AT363076B (de)	1981-07-10
PT67625A (en)	1978-03-01
IE46454B1 (en)	1983-06-15
IL53996A0 (en)	1978-04-30
US4182769A (en)	1980-01-08
DE2805166A1 (de)	1978-08-10
NL7801454A (nl)	1978-08-11
NZ186411A (en)	1981-03-16
NO780432L (no)	1978-08-10
GR64157B (en)	1980-02-05
LU79028A1 (fr)	1979-05-25
CA1107286A (fr)	1981-08-18
IT7820079A0 (it)	1978-02-07
FI68619B (fi)	1985-06-28

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