NO161975C - Fremgangsmaate for fremstilling av n-etoksykarbonyl-14-bhydroksynorkodeinon. - Google Patents

Fremgangsmaate for fremstilling av n-etoksykarbonyl-14-bhydroksynorkodeinon.

Info

Publication number: NO161975C
Authority: NO; Norway
Prior art keywords: ethoxycarbonyl; norcodeinone; contacting; sub; basic
Prior art date: 1984-03-27

Application number

NO851217A

Other languages

English (en)

Norwegian (no)

Other versions

NO161975B (no

NO851217L (no

Inventor

Frank Kavka

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-03-27

Filing date

1985-03-26

Publication date

1989-10-18

1985-03-26 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

1985-09-30 Publication of NO851217L publication Critical patent/NO851217L/no

1989-07-10 Publication of NO161975B publication Critical patent/NO161975B/no

1989-10-18 Publication of NO161975C publication Critical patent/NO161975C/no

Links

238000000034 method Methods 0.000 title abstract 3
XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 title 1
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 abstract 3
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 2
NFDFQCUYFHCNBW-SCGPFSFSSA-N dienestrol Chemical compound C=1C=C(O)C=CC=1\C(=C/C)\C(=C\C)\C1=CC=C(O)C=C1 NFDFQCUYFHCNBW-SCGPFSFSSA-N 0.000 abstract 2
HLMSIZPQBSYUNL-IPOQPSJVSA-N Noroxymorphone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4 HLMSIZPQBSYUNL-IPOQPSJVSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229960004126 codeine Drugs 0.000 abstract 1
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
150000004965 peroxy acids Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
Noodles (AREA)
Thermistors And Varistors (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO851217A 1984-03-27 1985-03-26 Fremgangsmaate for fremstilling av n-etoksykarbonyl-14-bhydroksynorkodeinon. NO161975C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/593,752 US4639520A (en)	1984-03-27	1984-03-27	Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone

Publications (3)

Publication Number	Publication Date
NO851217L NO851217L (no)	1985-09-30
NO161975B NO161975B (no)	1989-07-10
NO161975C true NO161975C (no)	1989-10-18

Family

ID=24376012

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO851217A NO161975C (no)	1984-03-27	1985-03-26	Fremgangsmaate for fremstilling av n-etoksykarbonyl-14-bhydroksynorkodeinon.

Country Status (9)

Country	Link
US (1)	US4639520A (de)
EP (1)	EP0159823B1 (de)
JP (1)	JPH0651702B2 (de)
AT (1)	ATE45358T1 (de)
DE (1)	DE3572172D1 (de)
ES (2)	ES8607306A1 (de)
FR (1)	FR2566777B1 (de)
IT (1)	IT1184058B (de)
NO (1)	NO161975C (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4795813A (en) *	1981-08-17	1989-01-03	The Florida Board Of Regents On Behalf Of The Florida State University	Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5112975A (en) *	1984-03-27	1992-05-12	Mallinckrodt Specialty Chemicals Company	Preparation of noroxymorphone from morphine
US5668285A (en) *	1986-10-31	1997-09-16	The United States Of America As Represented By The Department Of Health And Human Services	Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
DE69033035T2 (de) *	1989-10-16	1999-08-05	The United States of America, represented by the Secretary, U.S. Department of Commerce, Washington, D.C.	Totale synthese von northebain-, normorphin-, noroxymorphon-enantiomeren und -derivaten via n-nor-zwischenverbindungen
US5869669A (en) *	1996-07-26	1999-02-09	Penick Corporation	Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
TWI365880B (en) *	2004-03-30	2012-06-11	Euro Celtique Sa	Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
DE602006019246D1 (de) *	2005-06-16	2011-02-10	Mallinckrodt Inc	Synthetische route zu 14-hydroxylopiaten über 1-halogenthebain oder analoga
PL2125824T5 (pl) *	2007-03-23	2024-11-04	SpecGx LLC	Ulepszony sposób wytwarzania oksymorfonu z oripawiny
WO2008130553A1 (en) *	2007-04-16	2008-10-30	Mallinckrodt Inc.	Novel opiate reduction utilizing catalytic hydrogen transfer reaction
EP2896614B1 (de) *	2008-05-27	2017-07-12	Mallinckrodt LLC	Verfahren und Verbindungen zur Herstellung von Normorphinanen
CA2936749C (en)	2010-06-11	2019-07-09	Rhodes Technologies	Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
TWI471289B (zh)	2010-06-11	2015-02-01	Rhodes Technologies	使三級胺進行ｎ－脫烷反應之方法
DE102012108266A1 (de)	2012-09-05	2014-03-06	Aesculap Ag	Chirurgisches, Drehmoment übertragendes Instrument einschließlich zugehöriges Werkzeug

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2772270A (en) *	1954-10-21	1956-11-27	M J Lewenstein	14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone
DE1938219A1 (de) *	1968-07-26	1970-02-12	Sankyo Co	Verfahren zur Herstellung von 14-Hydroxy-normorphinonderivaten
US4472253A (en) *	1981-08-17	1984-09-18	The Florida Board Of Regents On Behalf Of The Florida State University	Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative

1984
- 1984-03-27 US US06/593,752 patent/US4639520A/en not_active Expired - Lifetime
1985
- 1985-03-26 NO NO851217A patent/NO161975C/no not_active IP Right Cessation
- 1985-03-26 AT AT85302102T patent/ATE45358T1/de not_active IP Right Cessation
- 1985-03-26 FR FR858504486A patent/FR2566777B1/fr not_active Expired
- 1985-03-26 IT IT67298/85A patent/IT1184058B/it active
- 1985-03-26 EP EP85302102A patent/EP0159823B1/de not_active Expired
- 1985-03-26 DE DE8585302102T patent/DE3572172D1/de not_active Expired
- 1985-03-27 ES ES541630A patent/ES8607306A1/es not_active Expired
- 1985-03-27 JP JP60061023A patent/JPH0651702B2/ja not_active Expired - Lifetime
1986
- 1986-01-08 ES ES550731A patent/ES8705447A1/es not_active Expired

Also Published As

Publication number	Publication date
ES550731A0 (es)	1987-05-01
NO161975B (no)	1989-07-10
EP0159823A1 (de)	1985-10-30
IT1184058B (it)	1987-10-22
ES8607306A1 (es)	1986-05-16
FR2566777B1 (fr)	1989-09-29
DE3572172D1 (en)	1989-09-14
JPS60218392A (ja)	1985-11-01
ES8705447A1 (es)	1987-05-01
IT8567298A1 (it)	1986-09-26
FR2566777A1 (fr)	1986-01-03
ES541630A0 (es)	1986-05-16
NO851217L (no)	1985-09-30
JPH0651702B2 (ja)	1994-07-06
ATE45358T1 (de)	1989-08-15
IT8567298A0 (it)	1985-03-26
EP0159823B1 (de)	1989-08-09
US4639520A (en)	1987-01-27

Legal Events

Date	Code	Title	Description
2005-04-18	MK1K	Patent expired

Publication	Publication Date	Title
DE3572172D1 (en)	1989-09-14	Preparation of 14-hydroxy-n-ethoxy-carbonyl-norcodeinone
JPS612707B2 (de)	1986-01-27
ES8308826A1 (es)	1983-10-01	Un metodo de preparar quinonas.
ATE126191T1 (de)	1995-08-15	Verfahren zur herstellung p,p'-biphenol.
EP0079785B1 (de)	1987-09-09	Verfahren zur Herstellung von 1-formyl Congeneren aus Indol-dihydroindolen Dimeren
JPS5469140A (en)	1979-06-02	Coating compound for electrical insulation
ATE144527T1 (de)	1996-11-15	Verfahren zur reinigung von 3-alpha-7-beta- dihydroxycholansäure
HUT48593A (en)	1989-06-28	Process for producing asymmetric 1,4-dihydropyridinecarboxylic acid esters
DE59100132D1 (de)	1993-07-01	Verfahren zur herstellung von gemischen cyclischer acroleinglycerinacetale.
GB1497992A (en)	1978-01-12	Production of carboxy-alkane-phosphonic acids and carboxy-alkyl-phosphinic acids
JPS5217453A (en)	1977-02-09	Process for preparation of 2,6- naphthalenedicarboxylic acid
JPS5278831A (en)	1977-07-02	Recovery of urea adsorbed on ion-exchange resin
ATE67477T1 (de)	1991-10-15	Extraktionsverfahren zur abtrennung einer carbonsaeure aus wasserhaltiger loesung solcher saeure.
JPS5257111A (en)	1977-05-11	Process for organic carboxylic acid silver
JPS5731629A (en)	1982-02-20	Preparation of bisphenolethane
JPS5795921A (en)	1982-06-15	Preparation of aldehyde
JPS53144543A (en)	1978-12-15	Improved method of producing cylcohexane derivative
JPS52123432A (en)	1977-10-17	Insulating coating
JPS5630987A (en)	1981-03-28	Preparation of 7alpha-methoxycephalosporin
JPS56152821A (en)	1981-11-26	Production of modified aromatic hydrocarbon resin
ATE123782T1 (de)	1995-06-15	Verfahren zur erhöhung des alpha/beta- verhältnisses in einer aspartamkupplungsreaktion.
JPS5562186A (en)	1980-05-10	Preparation of 1,2,3,4-butane tetracarboxylic acid anhidride
JPS56161354A (en)	1981-12-11	Improved preparation of dinitrodiphenyl ether
JPS5315311A (en)	1978-02-13	Preparation of aliphatic carboxylic acids
JPS57126432A (en)	1982-08-06	Preparation of oxygen-containing hydrocarbon compound from synthetic gas