NO161975C - Fremgangsmaate for fremstilling av n-etoksykarbonyl-14-bhydroksynorkodeinon. - Google Patents

Fremgangsmaate for fremstilling av n-etoksykarbonyl-14-bhydroksynorkodeinon.

Info

Publication number: NO161975C
Authority: NO; Norway
Prior art keywords: ethoxycarbonyl; norcodeinone; contacting; sub; basic
Prior art date: 1984-03-27

Application number

NO851217A

Other languages

English (en)

Norwegian (no)

Other versions

NO851217L (no

NO161975B (no

Inventor

Frank Kavka

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-03-27

Filing date

1985-03-26

Publication date

1989-10-18

1985-03-26 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

1985-09-30 Publication of NO851217L publication Critical patent/NO851217L/no

1989-07-10 Publication of NO161975B publication Critical patent/NO161975B/no

1989-10-18 Publication of NO161975C publication Critical patent/NO161975C/no

Links

238000000034 method Methods 0.000 title abstract 3
XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 title 1
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 abstract 3
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 2
NFDFQCUYFHCNBW-SCGPFSFSSA-N dienestrol Chemical compound C=1C=C(O)C=CC=1\C(=C/C)\C(=C\C)\C1=CC=C(O)C=C1 NFDFQCUYFHCNBW-SCGPFSFSSA-N 0.000 abstract 2
HLMSIZPQBSYUNL-IPOQPSJVSA-N Noroxymorphone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4 HLMSIZPQBSYUNL-IPOQPSJVSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229960004126 codeine Drugs 0.000 abstract 1
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
150000004965 peroxy acids Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
Noodles (AREA)
Thermistors And Varistors (AREA)
Medicinal Preparation (AREA)

NO851217A 1984-03-27 1985-03-26 Fremgangsmaate for fremstilling av n-etoksykarbonyl-14-bhydroksynorkodeinon. NO161975C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/593,752 US4639520A (en)	1984-03-27	1984-03-27	Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone

Publications (3)

Publication Number	Publication Date
NO851217L NO851217L (no)	1985-09-30
NO161975B NO161975B (no)	1989-07-10
NO161975C true NO161975C (no)	1989-10-18

Family

ID=24376012

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO851217A NO161975C (no)	1984-03-27	1985-03-26	Fremgangsmaate for fremstilling av n-etoksykarbonyl-14-bhydroksynorkodeinon.

Country Status (9)

Country	Link
US (1)	US4639520A (de)
EP (1)	EP0159823B1 (de)
JP (1)	JPH0651702B2 (de)
AT (1)	ATE45358T1 (de)
DE (1)	DE3572172D1 (de)
ES (2)	ES8607306A1 (de)
FR (1)	FR2566777B1 (de)
IT (1)	IT1184058B (de)
NO (1)	NO161975C (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4795813A (en) *	1981-08-17	1989-01-03	The Florida Board Of Regents On Behalf Of The Florida State University	Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5112975A (en) *	1984-03-27	1992-05-12	Mallinckrodt Specialty Chemicals Company	Preparation of noroxymorphone from morphine
US5668285A (en) *	1986-10-31	1997-09-16	The United States Of America As Represented By The Department Of Health And Human Services	Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
ATE178329T1 (de) *	1989-10-16	1999-04-15	Us Health	Totale synthese von northebain-, normorphin-, noroxymorphon-enantiomeren und -derivaten via n- nor-zwischenverbindungen
US5869669A (en) *	1996-07-26	1999-02-09	Penick Corporation	Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
TWI365880B (en) *	2004-03-30	2012-06-11	Euro Celtique Sa	Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
ES2357216T3 (es) *	2005-06-16	2011-04-20	Mallinckrodt, Inc.	Una ruta de síntesis de 14-hidroxil-opiáceos a través de 1-halo-tebaína o análogos.
WO2008118654A1 (en) *	2007-03-23	2008-10-02	Mallinckrodt Inc.	Improved preparation of oxymorphone from oripavine
WO2008130553A1 (en) *	2007-04-16	2008-10-30	Mallinckrodt Inc.	Novel opiate reduction utilizing catalytic hydrogen transfer reaction
EP2285780B1 (de) *	2008-05-27	2015-08-26	Mallinckrodt LLC	Verfahren und verbindungen zur herstellung von normorphinanen
AU2011263416B2 (en)	2010-06-11	2014-04-10	Rhodes Technologies	Process for N-dealkylation of tertiary amines
CA2802295C (en)	2010-06-11	2016-09-20	Rhodes Technologies	Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
DE102012108266A1 (de)	2012-09-05	2014-03-06	Aesculap Ag	Chirurgisches, Drehmoment übertragendes Instrument einschließlich zugehöriges Werkzeug

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2772270A (en) *	1954-10-21	1956-11-27	M J Lewenstein	14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone
DE1938219A1 (de) *	1968-07-26	1970-02-12	Sankyo Co	Verfahren zur Herstellung von 14-Hydroxy-normorphinonderivaten
US4472253A (en) *	1981-08-17	1984-09-18	The Florida Board Of Regents On Behalf Of The Florida State University	Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative

1984
- 1984-03-27 US US06/593,752 patent/US4639520A/en not_active Expired - Lifetime
1985
- 1985-03-26 EP EP85302102A patent/EP0159823B1/de not_active Expired
- 1985-03-26 FR FR858504486A patent/FR2566777B1/fr not_active Expired
- 1985-03-26 AT AT85302102T patent/ATE45358T1/de not_active IP Right Cessation
- 1985-03-26 DE DE8585302102T patent/DE3572172D1/de not_active Expired
- 1985-03-26 IT IT67298/85A patent/IT1184058B/it active
- 1985-03-26 NO NO851217A patent/NO161975C/no not_active IP Right Cessation
- 1985-03-27 ES ES541630A patent/ES8607306A1/es not_active Expired
- 1985-03-27 JP JP60061023A patent/JPH0651702B2/ja not_active Expired - Lifetime
1986
- 1986-01-08 ES ES550731A patent/ES8705447A1/es not_active Expired

Also Published As

Publication number	Publication date
JPS60218392A (ja)	1985-11-01
EP0159823B1 (de)	1989-08-09
IT8567298A1 (it)	1986-09-26
IT8567298A0 (it)	1985-03-26
ES8607306A1 (es)	1986-05-16
JPH0651702B2 (ja)	1994-07-06
EP0159823A1 (de)	1985-10-30
NO851217L (no)	1985-09-30
IT1184058B (it)	1987-10-22
NO161975B (no)	1989-07-10
ATE45358T1 (de)	1989-08-15
DE3572172D1 (en)	1989-09-14
FR2566777B1 (fr)	1989-09-29
ES541630A0 (es)	1986-05-16
FR2566777A1 (fr)	1986-01-03
ES550731A0 (es)	1987-05-01
ES8705447A1 (es)	1987-05-01
US4639520A (en)	1987-01-27

Legal Events

Date	Code	Title	Description
2005-04-18	MK1K	Patent expired

Publication	Publication Date	Title
NO161975C (no)	1989-10-18	Fremgangsmaate for fremstilling av n-etoksykarbonyl-14-bhydroksynorkodeinon.
ES8308826A1 (es)	1983-10-01	Un metodo de preparar quinonas.
ATE126191T1 (de)	1995-08-15	Verfahren zur herstellung p,p'-biphenol.
EP0079785B1 (de)	1987-09-09	Verfahren zur Herstellung von 1-formyl Congeneren aus Indol-dihydroindolen Dimeren
JPS5283315A (en)	1977-07-12	Purification of acetic acid
HUT48593A (en)	1989-06-28	Process for producing asymmetric 1,4-dihydropyridinecarboxylic acid esters
DE59100132D1 (de)	1993-07-01	Verfahren zur herstellung von gemischen cyclischer acroleinglycerinacetale.
JPS5217453A (en)	1977-02-09	Process for preparation of 2,6- naphthalenedicarboxylic acid
JPS5278831A (en)	1977-07-02	Recovery of urea adsorbed on ion-exchange resin
JPS5740432A (en)	1982-03-06	Production of carboxylic acid chloride
ATE67477T1 (de)	1991-10-15	Extraktionsverfahren zur abtrennung einer carbonsaeure aus wasserhaltiger loesung solcher saeure.
JPS5225710A (en)	1977-02-25	Process for preparation of isopropyl acetate
JPS5257111A (en)	1977-05-11	Process for organic carboxylic acid silver
JPS5731629A (en)	1982-02-20	Preparation of bisphenolethane
JPS5795921A (en)	1982-06-15	Preparation of aldehyde
JPS56150082A (en)	1981-11-20	Dibenzo b,e oxepin derivative
JPS53144543A (en)	1978-12-15	Improved method of producing cylcohexane derivative
JPS5217447A (en)	1977-02-09	Process for preparation of trans-4- aminomethylcyclohexane-carboxylic acid ester
JPS52123432A (en)	1977-10-17	Insulating coating
JPS5630987A (en)	1981-03-28	Preparation of 7alpha-methoxycephalosporin
JPS56152821A (en)	1981-11-26	Production of modified aromatic hydrocarbon resin
DE69110374D1 (de)	1995-07-20	Verfahren zur erhöhung des alpha/beta-verhältnisses in einer aspartamkupplungsreaktion.
JPS5562186A (en)	1980-05-10	Preparation of 1,2,3,4-butane tetracarboxylic acid anhidride
JPS5233657A (en)	1977-03-14	Process for preparation of photochromic compounds
JPS56161354A (en)	1981-12-11	Improved preparation of dinitrodiphenyl ether