NO167661C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 3,3-disubstituerte indoliner. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 3,3-disubstituerte indoliner.

Info

Publication number: NO167661C
Authority: NO; Norway
Prior art keywords: alkyl; indolines; pyridyl; chem; independently
Prior art date: 1986-04-10

Application number

NO871492A

Other languages

English (en)

Norwegian (no)

Other versions

NO871492D0 (no

NO167661B (no

NO871492L (no

Inventor

Melvyn John Myers

Victor Johannes Nickolson

Original Assignee

Du Pont Merck Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-10

Filing date

1987-04-09

Publication date

1991-11-27

1987-04-09 Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma

1987-04-09 Publication of NO871492D0 publication Critical patent/NO871492D0/no

1987-10-12 Publication of NO871492L publication Critical patent/NO871492L/no

1991-08-19 Publication of NO167661B publication Critical patent/NO167661B/no

1991-11-27 Publication of NO167661C publication Critical patent/NO167661C/no

Links

150000002476 indolines Chemical class 0.000 title abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
-1 3,3-disubstituted indolines Chemical class 0.000 abstract 1
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000001149 cognitive effect Effects 0.000 abstract 1
230000007812 deficiency Effects 0.000 abstract 1
230000006735 deficit Effects 0.000 abstract 1
230000003340 mental effect Effects 0.000 abstract 1
230000036651 mood Effects 0.000 abstract 1
230000007658 neurological function Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

NO871492A 1986-04-10 1987-04-09 Analogifremgangsmaate for fremstilling av terapeutisk aktive 3,3-disubstituerte indoliner. NO167661C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US85001586A	1986-04-10	1986-04-10
US06/944,953 US4760083A (en)	1986-04-10	1987-01-05	3,3-disubstituted indolines

Publications (4)

Publication Number	Publication Date
NO871492D0 NO871492D0 (no)	1987-04-09
NO871492L NO871492L (no)	1987-10-12
NO167661B NO167661B (no)	1991-08-19
NO167661C true NO167661C (no)	1991-11-27

Family

ID=27126891

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO871492A NO167661C (no)	1986-04-10	1987-04-09	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3,3-disubstituerte indoliner.

Country Status (18)

Country	Link
US (1)	US4760083A (de)
EP (1)	EP0241006B1 (de)
JP (1)	JPH068293B2 (de)
KR (1)	KR960007528B1 (de)
AT (1)	ATE50572T1 (de)
AU (1)	AU599370B2 (de)
CA (1)	CA1301151C (de)
DE (1)	DE3761768D1 (de)
DK (1)	DK170164B1 (de)
ES (1)	ES2054627T3 (de)
FI (1)	FI89482C (de)
GR (1)	GR3000359T3 (de)
HU (1)	HU196792B (de)
IE (1)	IE59680B1 (de)
MX (1)	MX173308B (de)
NO (1)	NO167661C (de)
NZ (1)	NZ219928A (de)
PT (1)	PT84651B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5300642A (en) *	1986-04-10	1994-04-05	The Du Pont Merck Pharmaceutical Company	α, α-disubstituted aromatics and heteroaromatics as cognition enhancers
US5173489A (en) *	1986-04-10	1992-12-22	The Dupont Merck Pharmaceutical Co.	α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US4791107A (en) *	1986-07-16	1988-12-13	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4806651A (en) *	1987-10-07	1989-02-21	E. I. Du Pont De Nemours And Company	Process for preparing 3,3-disubstituted indolines
US4965066A (en) *	1989-06-06	1990-10-23	E. I. Du Pont De Nemours And Company	Intranasal administration of 3,3-disubstituted indolines
US4914102A (en) *	1989-09-28	1990-04-03	Hoechst Roussel Pharmaceuticals, Inc.	N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5260452A (en) *	1989-11-03	1993-11-09	Hoechst-Roussel Pharmaceuticals Inc.	4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
US5087628A (en) *	1990-01-12	1992-02-11	Du Pont Merck Pharmaceutical Company	4,4'-[9H-fluoren-9-ylidenebis (methylene)]bispyrimidine for treating neurological disorders
GB9002375D0 (en) *	1990-02-02	1990-04-04	Pfizer Ltd	Triazole antifungal agents
US5278045A (en) *	1990-02-28	1994-01-11	Du Pont Merck Pharmaceutical Company	Method and compositions to screen compounds for enhancement of the cholinergic, dopaminergic and serotonergic function
US5171745A (en) *	1990-07-13	1992-12-15	Du Pont Merck Pharmaceutical Company	Method of treating neurological dysfunction using neutrotransmitter enhancers
RU2051151C1 (ru) *	1992-01-16	1995-12-27	Дзе Дюпон Мерк Фармасьютикал Компани	Азотсодержащие гетероциклические производные флуорена
CA2128233A1 (en) *	1992-01-16	1993-07-22	Wendell Wilkie Wilkerson	Novel neurotransmitter releasers useful for cognition enhancement
US5698559A (en) *	1992-01-16	1997-12-16	The Dupont Merck Pharmaceutical Company	Disubstituted polycyclic systems as cognition enhancers
AU4027693A (en) *	1992-04-16	1993-11-18	Du Pont Merck Pharmaceutical Company, The	Substituted nitrogen containing spiro compounds for use in treating cognitive deficits
US5278162A (en) *	1992-09-18	1994-01-11	The Du Pont Merck Pharmaceutical Company	3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man
US5296478A (en) *	1992-10-07	1994-03-22	The Dupont Merck Pharmaceutical Co.	1-substituted oxindoles as cognition enhancers
EP0664810A1 (de) *	1992-10-13	1995-08-02	The Du Pont Merck Pharmaceutical Company	3,3-substituierte tri- und tetracyclische ludolin-2-one zur behandlung von kognitiven störungen
TW281669B (de) *	1993-02-17	1996-07-21	Chugai Pharmaceutical Co Ltd
US5594001A (en) *	1993-04-08	1997-01-14	The Dupont Merck Pharmaceutical Company	Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders
HUT74104A (en) *	1993-04-08	1996-11-28	Du Pont Merck Pharma	Novel polycyclic derivatives and pharmaceutical compositions containing them
US5308851A (en) *	1993-06-03	1994-05-03	The Du Pont Merck Pharmaceutical Company	Bispyridyl-containing heterocycles useful for treating cognitive disorders
FR2708606B1 (fr) *	1993-07-30	1995-10-27	Sanofi Sa	Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
CA2188427C (en) *	1994-04-29	2000-06-27	Robert A. Volkmann	Neurotransmitter release enhancers
US5948781A (en) *	1997-05-27	1999-09-07	Pfizer Inc	Adamantyl substituted oxindoles as pharmaceutical agents
US6262081B1 (en) *	1998-07-10	2001-07-17	Dupont Pharmaceuticals Company	Composition for and method of treating neurological disorders
DE60006145T2 (de)	1999-07-30	2004-06-09	Zenyaku Kogyo K.K.	Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten
FR2804115B1 (fr) *	2000-01-25	2002-03-08	Sanofi Synthelabo	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
ES2600460T3 (es)	2005-05-10	2017-02-09	Intermune, Inc.	Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
CN102099036B (zh)	2008-06-03	2015-05-27	英特芒尼公司	用于治疗炎性疾患和纤维化疾患的化合物和方法
AR092742A1 (es)	2012-10-02	2015-04-29	Intermune Inc	Piridinonas antifibroticas
MX382781B (es)	2014-04-02	2025-03-13	Intermune Inc	Piridinonas anti-fibroticas.
CN108658834B (zh) *	2017-03-31	2021-03-23	烟台药物研究所	一种吲哚酮衍生物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1154976A (en) *	1967-02-21	1969-06-11	Pfizer Ltd	N-Phenyl Indoline Derivatives
US3725403A (en) *	1970-10-20	1973-04-03	Squibb & Sons Inc	Benzothiazine derivatives
ES426436A1 (es) *	1974-05-18	1976-07-01	Andreu Sa Dr	Procedimiento para la obtencion de derivados de la 3,3-bis (4-hidroxifenil)-2-indolinona.
US4273860A (en) *	1977-12-28	1981-06-16	Eastman Kodak Company	Inhibition of image formation utilizing cobalt(III) complexes
CU21107A3 (es) *	1978-02-10	1988-02-01	Hoffmann La Roche	Pyrrolidines derivatives
JPS55129284A (en) *	1979-03-27	1980-10-06	Shionogi & Co Ltd	3-(1-imipazolyl)indolin-2-one
US4372960A (en) *	1980-12-12	1983-02-08	Warner-Lambert Company	Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators
US4476307A (en) *	1982-09-20	1984-10-09	Pfizer Inc.	Heteroylidene indolone compounds
US4452990A (en) *	1982-11-15	1984-06-05	Warner-Lambert Company	1-Aroyl-5-oxo-2-pyrrolidinepropanoic acids and related esters
US4434169A (en) *	1983-01-03	1984-02-28	Warner-Lambert Company	Pharmaceutical compositions and methods

1987
- 1987-01-05 US US06/944,953 patent/US4760083A/en not_active Expired - Lifetime
- 1987-04-02 MX MX005978A patent/MX173308B/es unknown
- 1987-04-07 CA CA000534027A patent/CA1301151C/en not_active Expired - Lifetime
- 1987-04-08 EP EP87105190A patent/EP0241006B1/de not_active Expired - Lifetime
- 1987-04-08 AT AT87105190T patent/ATE50572T1/de not_active IP Right Cessation
- 1987-04-08 DE DE8787105190T patent/DE3761768D1/de not_active Expired - Lifetime
- 1987-04-08 ES ES87105190T patent/ES2054627T3/es not_active Expired - Lifetime
- 1987-04-09 NO NO871492A patent/NO167661C/no not_active IP Right Cessation
- 1987-04-09 JP JP62085893A patent/JPH068293B2/ja not_active Expired - Lifetime
- 1987-04-09 IE IE92187A patent/IE59680B1/en not_active IP Right Cessation
- 1987-04-09 AU AU71334/87A patent/AU599370B2/en not_active Ceased
- 1987-04-09 KR KR1019870003377A patent/KR960007528B1/ko not_active Expired - Fee Related
- 1987-04-09 DK DK182087A patent/DK170164B1/da active IP Right Grant
- 1987-04-09 FI FI871556A patent/FI89482C/fi not_active IP Right Cessation
- 1987-04-09 HU HU871590A patent/HU196792B/hu not_active IP Right Cessation
- 1987-04-09 PT PT84651A patent/PT84651B/pt not_active IP Right Cessation
- 1987-04-09 NZ NZ219928A patent/NZ219928A/xx unknown
1990
- 1990-03-01 GR GR90400061T patent/GR3000359T3/el unknown

Also Published As

Publication number	Publication date
JPH068293B2 (ja)	1994-02-02
DK182087A (da)	1987-10-11
NO871492D0 (no)	1987-04-09
EP0241006A2 (de)	1987-10-14
FI871556A0 (fi)	1987-04-09
KR960007528B1 (ko)	1996-06-05
ATE50572T1 (de)	1990-03-15
IE59680B1 (en)	1994-03-23
DE3761768D1 (de)	1990-04-05
AU7133487A (en)	1987-10-15
FI89482B (fi)	1993-06-30
FI89482C (fi)	1993-10-11
EP0241006A3 (en)	1988-08-10
HUT44028A (en)	1988-01-28
JPS62277381A (ja)	1987-12-02
US4760083A (en)	1988-07-26
ES2054627T3 (es)	1994-08-16
KR870009996A (ko)	1987-11-30
FI871556A7 (fi)	1987-10-11
EP0241006B1 (de)	1990-02-28
MX173308B (es)	1994-02-15
IE870921L (en)	1987-10-10
PT84651A (en)	1987-05-01
DK182087D0 (da)	1987-04-09
AU599370B2 (en)	1990-07-19
DK170164B1 (da)	1995-06-06
GR3000359T3 (en)	1991-06-07
NO167661B (no)	1991-08-19
NZ219928A (en)	1989-08-29
NO871492L (no)	1987-10-12
CA1301151C (en)	1992-05-19
HU196792B (en)	1989-01-30
PT84651B (pt)	1989-12-29

Legal Events

Date	Code	Title	Description
2001-12-10	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN OCTOBER 2001

Publication	Publication Date	Title
NO167661C (no)	1991-11-27	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3,3-disubstituerte indoliner.
DK586588D0 (da)	1988-10-21	Terapeutiske heterocycliske forbindelser
MY101208A (en)	1991-08-17	Phenyl-piperazine anti-arrhythmia agents.
NO178067C (no)	1996-01-17	Analogifremgangsmåte til fremstilling av terapautisk aktive heterocykliske forbindelser
NO900542D0 (no)	1990-02-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzokondenserte n-holdige heterocykliske derivater.
ES2132284T3 (es)	1999-08-16	Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa.
GB1353370A (en)	1974-05-15	Imidazolpyridine derivatives
BG105855A (en)	2002-04-30	2-aminopyridines containing fused ring substituents
NO174712C (no)	1994-06-22	Analogifremgangsmåte for fremstilling av terapeutisk aktive heterocykliske forbindelser
EP0316456A4 (de)	1990-05-14	Ester-substituierte thienotriazoldiazepin-verbindungen und deren verwendung als arzneimittel.
ATE97894T1 (de)	1993-12-15	Pharmakologisch-aktive alkylthiobenzimidazolderivate und verfahren zu deren herstellung.
NO165106C (no)	1990-12-27	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5-aminoalkyl-beta-carbolinderivater.
EA199800720A1 (ru)	1999-02-25	Гетероциклические производные эрголина в качестве лигандов 5-htia рецептора
FI872752A0 (fi)	1987-06-22	Foerfarande foer framstaellning av tert.butyl-ergolinderivat.
DK0560231T3 (da)	1999-03-22	Pyrazolo(3,4-a)acridinderivater som smertestillende midler
UA40569C2 (uk)	2001-08-15	Похідні метилпіперазиназепіну, спосіб їх одержання (варіанти), фармацевтична композиція на їх основі