ATE50572T1 - 3,3-disubstituierte indoline. - Google Patents

3,3-disubstituierte indoline.

Info

Publication number
ATE50572T1
ATE50572T1 AT87105190T AT87105190T ATE50572T1 AT E50572 T1 ATE50572 T1 AT E50572T1 AT 87105190 T AT87105190 T AT 87105190T AT 87105190 T AT87105190 T AT 87105190T AT E50572 T1 ATE50572 T1 AT E50572T1
Authority
AT
Austria
Prior art keywords
alkyl
pyridyl
chem
independently
halo
Prior art date
Application number
AT87105190T
Other languages
English (en)
Inventor
Melvyn John Myers
Victor Johannes Nickolson
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Application granted granted Critical
Publication of ATE50572T1 publication Critical patent/ATE50572T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
AT87105190T 1986-04-10 1987-04-08 3,3-disubstituierte indoline. ATE50572T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85001586A 1986-04-10 1986-04-10
US06/944,953 US4760083A (en) 1986-04-10 1987-01-05 3,3-disubstituted indolines
EP87105190A EP0241006B1 (de) 1986-04-10 1987-04-08 3,3-Disubstituierte Indoline

Publications (1)

Publication Number Publication Date
ATE50572T1 true ATE50572T1 (de) 1990-03-15

Family

ID=27126891

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87105190T ATE50572T1 (de) 1986-04-10 1987-04-08 3,3-disubstituierte indoline.

Country Status (18)

Country Link
US (1) US4760083A (de)
EP (1) EP0241006B1 (de)
JP (1) JPH068293B2 (de)
KR (1) KR960007528B1 (de)
AT (1) ATE50572T1 (de)
AU (1) AU599370B2 (de)
CA (1) CA1301151C (de)
DE (1) DE3761768D1 (de)
DK (1) DK170164B1 (de)
ES (1) ES2054627T3 (de)
FI (1) FI89482C (de)
GR (1) GR3000359T3 (de)
HU (1) HU196792B (de)
IE (1) IE59680B1 (de)
MX (1) MX173308B (de)
NO (1) NO167661C (de)
NZ (1) NZ219928A (de)
PT (1) PT84651B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173489A (en) * 1986-04-10 1992-12-22 The Dupont Merck Pharmaceutical Co. α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US5300642A (en) * 1986-04-10 1994-04-05 The Du Pont Merck Pharmaceutical Company α, α-disubstituted aromatics and heteroaromatics as cognition enhancers
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4806651A (en) * 1987-10-07 1989-02-21 E. I. Du Pont De Nemours And Company Process for preparing 3,3-disubstituted indolines
US4965066A (en) * 1989-06-06 1990-10-23 E. I. Du Pont De Nemours And Company Intranasal administration of 3,3-disubstituted indolines
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5260452A (en) * 1989-11-03 1993-11-09 Hoechst-Roussel Pharmaceuticals Inc. 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
US5087628A (en) * 1990-01-12 1992-02-11 Du Pont Merck Pharmaceutical Company 4,4'-[9H-fluoren-9-ylidenebis (methylene)]bispyrimidine for treating neurological disorders
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
US5278045A (en) * 1990-02-28 1994-01-11 Du Pont Merck Pharmaceutical Company Method and compositions to screen compounds for enhancement of the cholinergic, dopaminergic and serotonergic function
US5171745A (en) * 1990-07-13 1992-12-15 Du Pont Merck Pharmaceutical Company Method of treating neurological dysfunction using neutrotransmitter enhancers
US5698559A (en) * 1992-01-16 1997-12-16 The Dupont Merck Pharmaceutical Company Disubstituted polycyclic systems as cognition enhancers
DE69218795T2 (de) * 1992-01-16 1997-07-10 Du Pont Merck Pharma Verbindungen,die neurotransmitter freisetzen,um die lernfähigkeit zu erhöhen
RU2051151C1 (ru) * 1992-01-16 1995-12-27 Дзе Дюпон Мерк Фармасьютикал Компани Азотсодержащие гетероциклические производные флуорена
JPH07507772A (ja) * 1992-04-16 1995-08-31 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー 認識欠損治療用の置換された窒素含有スピロ化合物
US5278162A (en) * 1992-09-18 1994-01-11 The Du Pont Merck Pharmaceutical Company 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man
US5296478A (en) * 1992-10-07 1994-03-22 The Dupont Merck Pharmaceutical Co. 1-substituted oxindoles as cognition enhancers
CA2146000A1 (en) * 1992-10-13 1994-04-28 Richard Alan Earl 3,3-disubstituted tri-and tetracyclic indolin-2-ones useful for the treatment of cognitive disorders
TW281669B (de) * 1993-02-17 1996-07-21 Chugai Pharmaceutical Co Ltd
RU2152944C1 (ru) * 1993-04-08 2000-07-20 Дзе Дюпон Мерк Фармасьютикал Компани Полициклические соединения, их производные, фармацевтические препараты как усилители и метод лечения нарушения мыслительной деятельности
US5594001A (en) * 1993-04-08 1997-01-14 The Dupont Merck Pharmaceutical Company Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders
US5308851A (en) * 1993-06-03 1994-05-03 The Du Pont Merck Pharmaceutical Company Bispyridyl-containing heterocycles useful for treating cognitive disorders
FR2708606B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
DE69533284T2 (de) * 1994-04-29 2005-07-21 Pfizer Inc. Neue cyclische und acyclische amide zur erhöhung der neurotransmitter ausschüttung
US5948781A (en) * 1997-05-27 1999-09-07 Pfizer Inc Adamantyl substituted oxindoles as pharmaceutical agents
US6262081B1 (en) 1998-07-10 2001-07-17 Dupont Pharmaceuticals Company Composition for and method of treating neurological disorders
CA2387719C (en) 1999-07-30 2010-04-27 Zenyaku Kogyo Kabushiki Kaisha Azaindolizinone derivatives and cognitive enhancers comprising the same as effective components
FR2804115B1 (fr) * 2000-01-25 2002-03-08 Sanofi Synthelabo Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
JP2008544743A (ja) 2005-05-10 2008-12-11 インターミューン インコーポレイテッド ストレス活性化蛋白質キナーゼ系をモジュレートするためのピリドン誘導体
MX2010012848A (es) 2008-06-03 2011-03-01 Intermune Inc Compuestos y metodos para tratar trastornos inflamatorios y fibroticos.
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
JP6525437B2 (ja) 2014-04-02 2019-06-05 インターミューン， インコーポレイテッド 抗線維性ピリジノン
CN108658834B (zh) * 2017-03-31 2021-03-23 烟台药物研究所 一种吲哚酮衍生物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1154976A (en) * 1967-02-21 1969-06-11 Pfizer Ltd N-Phenyl Indoline Derivatives
US3725403A (en) * 1970-10-20 1973-04-03 Squibb & Sons Inc Benzothiazine derivatives
ES426436A1 (es) * 1974-05-18 1976-07-01 Andreu Sa Dr Procedimiento para la obtencion de derivados de la 3,3-bis (4-hidroxifenil)-2-indolinona.
US4273860A (en) * 1977-12-28 1981-06-16 Eastman Kodak Company Inhibition of image formation utilizing cobalt(III) complexes
CU21107A3 (es) * 1978-02-10 1988-02-01 Hoffmann La Roche Pyrrolidines derivatives
JPS55129284A (en) * 1979-03-27 1980-10-06 Shionogi & Co Ltd 3-(1-imipazolyl)indolin-2-one
US4372960A (en) * 1980-12-12 1983-02-08 Warner-Lambert Company Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators
US4476307A (en) * 1982-09-20 1984-10-09 Pfizer Inc. Heteroylidene indolone compounds
US4452990A (en) * 1982-11-15 1984-06-05 Warner-Lambert Company 1-Aroyl-5-oxo-2-pyrrolidinepropanoic acids and related esters
US4434169A (en) * 1983-01-03 1984-02-28 Warner-Lambert Company Pharmaceutical compositions and methods

Also Published As

Publication number Publication date
EP0241006A3 (en) 1988-08-10
PT84651A (en) 1987-05-01
IE870921L (en) 1987-10-10
DK182087A (da) 1987-10-11
DK182087D0 (da) 1987-04-09
AU599370B2 (en) 1990-07-19
NO167661C (no) 1991-11-27
MX173308B (es) 1994-02-15
DK170164B1 (da) 1995-06-06
PT84651B (pt) 1989-12-29
HUT44028A (en) 1988-01-28
CA1301151C (en) 1992-05-19
KR870009996A (ko) 1987-11-30
FI89482B (fi) 1993-06-30
HU196792B (en) 1989-01-30
GR3000359T3 (en) 1991-06-07
NO167661B (no) 1991-08-19
NO871492L (no) 1987-10-12
NZ219928A (en) 1989-08-29
IE59680B1 (en) 1994-03-23
ES2054627T3 (es) 1994-08-16
FI871556A7 (fi) 1987-10-11
US4760083A (en) 1988-07-26
AU7133487A (en) 1987-10-15
DE3761768D1 (de) 1990-04-05
KR960007528B1 (ko) 1996-06-05
FI871556A0 (fi) 1987-04-09
JPS62277381A (ja) 1987-12-02
NO871492D0 (no) 1987-04-09
EP0241006A2 (de) 1987-10-14
FI89482C (fi) 1993-10-11
JPH068293B2 (ja) 1994-02-02
EP0241006B1 (de) 1990-02-28

Similar Documents

Publication Publication Date Title
ATE50572T1 (de) 3,3-disubstituierte indoline.
DE69012512D1 (de) Heterocyclische Oxy-phenoxy-Essigsäurederivate und ihre Verwendung als Herbizide.
ATE127456T1 (de) Pyridazinon derivate und verfahren zur deren herstellung.
ES2132284T3 (es) Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa.
DE3777735D1 (de) Imid-derivate, ihre herstellung und ihre verwendung.
ATE205199T1 (de) Quinolin- oder quinazolinderivate, deren herstellung und verwendung
GB1353370A (en) Imidazolpyridine derivatives
ES8607953A1 (es) Un procedimiento para la preparacion de nuevos derivados de triazina
EP0316456A4 (de) Ester-substituierte thienotriazoldiazepin-verbindungen und deren verwendung als arzneimittel.
DE68911006D1 (de) Pharmakologisch-aktive Alkylthiobenzimidazol-Derivate und Verfahren zu deren Herstellung.
ATE58536T1 (de) 5-aminoalkyl-beta-carbolinderivate, ihre herstellung und verwendung als arzneimittel.
DK322587D0 (da) T-butyl-ergolin-derivativer
ATE160144T1 (de) Pyridazinon derivate, herstellungsverfahren und verwendung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee