NO167731C - Fremgangsmaate for fremstilling av 4-(3,4-diklorfenyl)-4-fenylbutansyre, og mellomprodukter til bruk ved fremgangsmaaten. - Google Patents

Fremgangsmaate for fremstilling av 4-(3,4-diklorfenyl)-4-fenylbutansyre, og mellomprodukter til bruk ved fremgangsmaaten.

Info

Publication number: NO167731C
Authority: NO; Norway
Prior art keywords: dichlorophenyl; dihydro; acid; procedure; furanone
Prior art date: 1987-06-11

Application number

NO882566A

Other languages

English (en)

Norwegian (no)

Other versions

NO882566L (no

NO882566D0 (no

NO167731B (no

Inventor

George Joseph Quallich

Michael Trevelyan Williams

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-11

Filing date

1988-06-10

Publication date

1992-03-04

1988-06-10 Application filed by Pfizer filed Critical Pfizer

1988-06-10 Publication of NO882566D0 publication Critical patent/NO882566D0/no

1988-12-12 Publication of NO882566L publication Critical patent/NO882566L/no

1991-01-09 Priority to NO910095A priority Critical patent/NO170077C/no

1991-08-26 Publication of NO167731B publication Critical patent/NO167731B/no

1992-03-04 Publication of NO167731C publication Critical patent/NO167731C/no

Links

238000000034 method Methods 0.000 title abstract 4
ZBLZQVJTLMFDCG-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-4-phenylbutanoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(CCC(=O)O)C1=CC=CC=C1 ZBLZQVJTLMFDCG-UHFFFAOYSA-N 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title 1
TXURVWVBXWPFRO-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid Chemical compound OC(=O)CCC(O)C1=CC=C(Cl)C(Cl)=C1 TXURVWVBXWPFRO-UHFFFAOYSA-N 0.000 abstract 3
HSAZYDYRKKZYSQ-UHFFFAOYSA-N 5-(3,4-dichlorophenyl)oxolan-2-one Chemical compound C1=C(Cl)C(Cl)=CC=C1C1OC(=O)CC1 HSAZYDYRKKZYSQ-UHFFFAOYSA-N 0.000 abstract 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
JGMBHJNMQVKDMW-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-3,4-dihydro-2h-naphthalen-1-one Chemical compound C1=C(Cl)C(Cl)=CC=C1C1C2=CC=CC=C2C(=O)CC1 JGMBHJNMQVKDMW-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
DPCXOOJTAKKWIC-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)C1=CC=C(Cl)C(Cl)=C1 DPCXOOJTAKKWIC-UHFFFAOYSA-N 0.000 abstract 1
238000005727 Friedel-Crafts reaction Methods 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
YEJRWHAVMIAJKC-UHFFFAOYSA-N gamma-butyrolactone Natural products O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 abstract 1
-1 gamma-butyrolactone compound Chemical class 0.000 abstract 1
150000001261 hydroxy acids Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 abstract 1
229960002073 sertraline Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/15—Saturated compounds containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Furan Compounds (AREA)
Catalysts (AREA)
Medicinal Preparation (AREA)

NO882566A 1987-06-11 1988-06-10 Fremgangsmaate for fremstilling av 4-(3,4-diklorfenyl)-4-fenylbutansyre, og mellomprodukter til bruk ved fremgangsmaaten. NO167731C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO910095A NO170077C (no)	1987-06-11	1991-01-09	Fremgangsmaate for fremstilling av 4-(3,4-diklorfenyl)-3,4-dihydro-1(2h)-naftalenon

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/060,577 US4777288A (en)	1987-06-11	1987-06-11	Process for preparing a 4,4-diphenylbutanoic acid derivative

Publications (4)

Publication Number	Publication Date
NO882566D0 NO882566D0 (no)	1988-06-10
NO882566L NO882566L (no)	1988-12-12
NO167731B NO167731B (no)	1991-08-26
NO167731C true NO167731C (no)	1992-03-04

Family

ID=22030394

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO882566A NO167731C (no)	1987-06-11	1988-06-10	Fremgangsmaate for fremstilling av 4-(3,4-diklorfenyl)-4-fenylbutansyre, og mellomprodukter til bruk ved fremgangsmaaten.

Country Status (29)

Country	Link
US (1)	US4777288A (cs)
EP (1)	EP0295050B1 (cs)
JP (1)	JPH0627098B2 (cs)
KR (1)	KR910000780B1 (cs)
CN (2)	CN1025328C (cs)
AT (1)	ATE62657T1 (cs)
AU (1)	AU586953B2 (cs)
CA (1)	CA1285574C (cs)
CS (1)	CS272238B2 (cs)
DD (2)	DD279013A5 (cs)
DE (1)	DE3862434D1 (cs)
DK (1)	DK175280B1 (cs)
EG (1)	EG18404A (cs)
ES (1)	ES2022621B3 (cs)
FI (1)	FI90657C (cs)
GR (1)	GR3001908T3 (cs)
HU (2)	HU198670B (cs)
IE (1)	IE61072B1 (cs)
IL (1)	IL86629A0 (cs)
MX (1)	MX172786B (cs)
MY (2)	MY103570A (cs)
NO (1)	NO167731C (cs)
NZ (1)	NZ224984A (cs)
PH (1)	PH25099A (cs)
PL (2)	PL153028B1 (cs)
PT (1)	PT87691B (cs)
RU (2)	RU1799377C (cs)
YU (2)	YU47120B (cs)
ZA (1)	ZA884161B (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE145198T1 (de) *	1991-12-13	1996-11-15	Pfizer	Verfahren zur herstellung eines keton enantiomers
US5196607A (en) *	1992-02-14	1993-03-23	Pfizer Inc.	Process for preparing ketone enantiomer
US5466880A (en) *	1992-09-15	1995-11-14	Pfizer Inc.	Process for preparing ketone enantiomer
DE69406553T2 (de) *	1993-11-30	1998-02-26	Pfizer Inc., New York, N.Y.	Verfahren zur herstellung von chiralen tetralonen
US6410794B1 (en)	1994-12-16	2002-06-25	Uop Llc	Process for preparation of pharmaceutically desired chiral tetralone from tetralones
HUP0002296A3 (en)	1997-07-01	2001-11-28	Pfizer	Sertraline salts and sustained-release dosage forms of sertraline
WO1999046233A1 (en) *	1998-03-09	1999-09-16	Sumika Fine Chemicals Co., Ltd.	Benzyl alcohol derivatives
IL132500A0 (en)	1998-10-29	2001-03-19	Pfizer Prod Inc	Stereoselective microbial reduction of a racemic tetralone
IN187170B (cs)	2000-01-04	2002-02-23	Sun Pharmaceutical Ind Ltd
FR2817256B1 (fr) *	2000-11-27	2005-07-15	Univ Pasteur	Derives de l'acides 4-hydroxybutanoique et de son homologue superieur comme ligands des recepteurs du gamma- hydroxybutyrate (ghb), compositions pharmaceutiques les contenant et utilisations pharmaceutiques
CN100413856C (zh) *	2006-09-06	2008-08-27	大连来克精化有限公司	一种威士忌内酯的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3412146A (en) *	1965-08-13	1968-11-19	Geigy Chem Corp	Process for preparation of diphenyl alkanoic acids
DE2112715A1 (de) *	1971-03-17	1972-10-05	Thomae Gmbh Dr K	Neue 4-(4-Biphenylyl)-4-hydroxybuttersaeuren,ihre Salze,Ester und Lactone
US4556676A (en) *	1979-11-01	1985-12-03	Pfizer Inc.	Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4536518A (en) *	1979-11-01	1985-08-20	Pfizer Inc.	Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
FR2504127B1 (fr) *	1981-04-17	1985-07-19	Roussel Uclaf	Nouveaux derives d'acides phenyl aliphatique carboxyliques, procede pour leur preparation et leur application comme medicaments
FR2521857B1 (fr) *	1982-02-23	1985-10-31	Solvay	Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee
US4543428A (en) *	1983-03-11	1985-09-24	Oregon Graduate Center For Study & Research	Production of a hexahydronaphthalenone compound
DE3615157A1 (de) *	1986-05-05	1987-11-12	Schwabe Willmar Gmbh & Co	5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe
US4855500A (en) *	1988-05-04	1989-08-08	Pfizer Inc.	Process for preparing a ketimine

1987
- 1987-06-11 US US07/060,577 patent/US4777288A/en not_active Expired - Lifetime
1988
- 1988-06-06 IL IL86629A patent/IL86629A0/xx not_active IP Right Cessation
- 1988-06-06 MY MYPI88000602A patent/MY103570A/en unknown
- 1988-06-07 EP EP88305179A patent/EP0295050B1/en not_active Expired - Lifetime
- 1988-06-07 DE DE8888305179T patent/DE3862434D1/de not_active Expired - Lifetime
- 1988-06-07 AT AT88305179T patent/ATE62657T1/de not_active IP Right Cessation
- 1988-06-07 ES ES88305179T patent/ES2022621B3/es not_active Expired - Lifetime
- 1988-06-08 JP JP63141429A patent/JPH0627098B2/ja not_active Expired - Fee Related
- 1988-06-08 CS CS883976A patent/CS272238B2/cs not_active IP Right Cessation
- 1988-06-09 PT PT87691A patent/PT87691B/pt not_active IP Right Cessation
- 1988-06-09 PL PL1988272949A patent/PL153028B1/pl unknown
- 1988-06-09 CA CA000569010A patent/CA1285574C/en not_active Expired - Lifetime
- 1988-06-09 EG EG324/88A patent/EG18404A/xx active
- 1988-06-09 PL PL1988278118A patent/PL156829B1/pl unknown
- 1988-06-10 RU SU884355975A patent/RU1799377C/ru active
- 1988-06-10 HU HU883022A patent/HU198670B/hu not_active IP Right Cessation
- 1988-06-10 AU AU17613/88A patent/AU586953B2/en not_active Ceased
- 1988-06-10 YU YU112788A patent/YU47120B/sh unknown
- 1988-06-10 DK DK198803190A patent/DK175280B1/da not_active IP Right Cessation
- 1988-06-10 MX MX011861A patent/MX172786B/es unknown
- 1988-06-10 NZ NZ224984A patent/NZ224984A/en unknown
- 1988-06-10 FI FI882779A patent/FI90657C/fi active IP Right Grant
- 1988-06-10 IE IE176288A patent/IE61072B1/en not_active IP Right Cessation
- 1988-06-10 CN CN88103840A patent/CN1025328C/zh not_active Expired - Fee Related
- 1988-06-10 ZA ZA884161A patent/ZA884161B/xx unknown
- 1988-06-10 NO NO882566A patent/NO167731C/no not_active IP Right Cessation
- 1988-06-10 PH PH37054A patent/PH25099A/en unknown
- 1988-06-10 HU HU883018A patent/HU213617B/hu not_active IP Right Cessation
- 1988-06-10 DD DD88325879A patent/DD279013A5/de not_active IP Right Cessation
- 1988-06-10 KR KR1019880006962A patent/KR910000780B1/ko not_active Expired
- 1988-06-10 DD DD88316663A patent/DD287483A5/de not_active IP Right Cessation
1989
- 1989-03-20 RU SU894613675A patent/RU1839670C/ru active
1991
- 1991-05-03 GR GR91400585T patent/GR3001908T3/el unknown
1992
- 1992-09-21 MY MYPI92001685A patent/MY107026A/en unknown
1993
- 1993-09-22 YU YU60893A patent/YU49242B/sh unknown
- 1993-12-03 CN CN93120776A patent/CN1042129C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HU213617B (en)	1997-08-28
DD287483A5 (de)	1991-02-28
NO882566L (no)	1988-12-12
FI882779A7 (fi)	1988-12-12
MX11861A (es)	1993-03-01
PL153028B1 (en)	1991-02-28
CA1285574C (en)	1991-07-02
US4777288A (en)	1988-10-11
IE61072B1 (en)	1994-09-21
DE3862434D1 (de)	1991-05-23
PL272949A1 (en)	1989-07-10
EP0295050A1 (en)	1988-12-14
EG18404A (en)	1993-02-28
NZ224984A (en)	1990-04-26
JPS649953A (en)	1989-01-13
CS272238B2 (en)	1991-01-15
CN1025328C (zh)	1994-07-06
CN1031837A (zh)	1989-03-22
ATE62657T1 (de)	1991-05-15
CN1100086A (zh)	1995-03-15
ZA884161B (en)	1990-02-28
PT87691B (pt)	1992-09-30
NO882566D0 (no)	1988-06-10
PT87691A (pt)	1988-07-01
CN1042129C (zh)	1999-02-17
MY103570A (en)	1993-08-28
PH25099A (en)	1991-02-19
NO167731B (no)	1991-08-26
MY107026A (en)	1995-08-30
AU586953B2 (en)	1989-07-27
KR890000393A (ko)	1989-03-14
MX172786B (es)	1994-01-13
AU1761388A (en)	1988-12-15
YU112788A (en)	1989-10-31
FI882779A0 (fi)	1988-06-10
YU49242B (sh)	2004-12-31
DK319088A (da)	1988-12-12
DD279013A5 (de)	1990-05-23
FI90657B (fi)	1993-11-30
PL278118A1 (en)	1989-08-21
RU1799377C (ru)	1993-02-28
HUT47070A (en)	1989-01-30
IE881762L (en)	1988-12-11
IL86629A0 (en)	1988-11-30
EP0295050B1 (en)	1991-04-17
PL156829B1 (pl)	1992-04-30
HU198670B (en)	1989-11-28
RU1839670C (ru)	1993-12-30
YU47120B (sh)	1994-12-28
FI90657C (fi)	1994-03-10
ES2022621B3 (es)	1991-12-01
GR3001908T3 (en)	1992-11-23
DK175280B1 (da)	2004-08-09
KR910000780B1 (ko)	1991-02-08
JPH0627098B2 (ja)	1994-04-13
DK319088D0 (da)	1988-06-10
CS397688A2 (en)	1990-03-14
YU60893A (sh)	1997-05-28

Legal Events

Date	Code	Title	Description
2006-01-30	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
Das et al.	2007	A simple and efficient synthesis of gem-dihydroperoxides from ketones using aqueous hydrogen peroxide and catalytic ceric ammonium nitrate
EG18404A (en)	1993-02-28	Process for preparing sertraline intermediates
EP0170955B1 (en)	1992-01-08	Process for the preparation of (+/-)-3a-6,6,9a-tetramethylperhydronaphto[2,1-b]furan
Corey et al.	1975	O, 2-Dilithio derivative of allyl alcohol, a useful synthetic reagent
Rohrmann et al.	1944	The use of chalcones in the synthesis of medicinal intermediates
Astudillo et al.	1993	A very simple oxidation of olefins and ketones with UHP-Maleic anhydride
FI941808A0 (fi)	1994-04-19	Formylointimenetelmä aromaattisten aldehydien valmistamiseksi
Cormier et al.	1988	A synthesis of furans from epoxycarbonyl precursors
Kabalka et al.	1993	Sodium perborate: A convenient reagent for benzylic hydroperoxide rearrangement
Piers et al.	1982	Synthesis of the stemodane carbon skeleton: nonstereoselective photoaddition of allene to a cyclopentenone and a novel rearrangement reaction
JP2979677B2 (ja)	1999-11-15	ケトンの製造法
US4296038A (en)	1981-10-20	Preparation of (-)-dihydrochrysanthemolactone
Hamann et al.	2001	Primary geminal bishydroperoxides by hydroperoxide rearrangement
FI930935L (fi)	1993-03-03	Menetelmä 4-(3,4-dikloorifenyyli)-3,4-dihydro-1(2H)-naftalenonin valmistamiseksi
Osuka et al.	1987	Norrish Type II Photoreaction of 2, 3-Dihydro-2, 3-methano-1, 4-naphthoquinones. A Novel Photorearrangement of α, β-Cyclopropyl Ketone to β, γ-Unsaturated Ketone
Harris	1959	FORMATION AND CONDENSATIONS OF SOME DICARBANIONS PREPARED BY MEANS OF POTASSIUM AMIDE IN LIQUID AMMONIA
NO20000869D0 (no)	2000-02-22	Fremgangsmåte for fremstilling av 1-(cyklopentenyloksy-4- alkoksyfenyl)-4-oksocykloheksankarbonitril
JPS62187455A (ja)	1987-08-15	４−（４−ピリジル）シクロヘキサン−１，３−ジオンおよびその製造法
HU202817B (en)	1991-04-29	Improved process for industrial producing 2,3-dichloro-phenoxy-acetic acid
DE4407464A1 (de)	1995-09-28	Verfahren zur Herstellung von (1R,4S)-4-Hydroxy-1,2,2-trimethyl-cyclopentyl-methylketon sowie Derivaten und Stereoisomeren dieser Verbindung
JPS6054941B2 (ja)	1985-12-03	ｍ‐ベンゾイルヒドロアトロパ酸の製造方法