NO168300C - Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive imidazoliumsalter - Google Patents

Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive imidazoliumsalter

Info

Publication number
NO168300C
NO168300C NO842835A NO842835A NO168300C NO 168300 C NO168300 C NO 168300C NO 842835 A NO842835 A NO 842835A NO 842835 A NO842835 A NO 842835A NO 168300 C NO168300 C NO 168300C
Authority
NO
Norway
Prior art keywords
imidazoli
salts
preparation
therapeutically active
new therapeutically
Prior art date
Application number
NO842835A
Other languages
English (en)
Norwegian (no)
Other versions
NO168300B (no
NO842835L (no
Inventor
Julius Diamond
Jr William Carl Lumma
Jr Thomas Kenneth Morgan
Ronald Andre Wohl
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO842835L publication Critical patent/NO842835L/no
Publication of NO168300B publication Critical patent/NO168300B/no
Publication of NO168300C publication Critical patent/NO168300C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2635—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving a phosphorus compound, e.g. Wittig synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483—Monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Gas Separation By Absorption (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
NO842835A 1983-07-12 1984-07-11 Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive imidazoliumsalter NO168300C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/513,143 US4581370A (en) 1983-07-12 1983-07-12 Antiarrhythmic imidazoliums

Publications (3)

Publication Number Publication Date
NO842835L NO842835L (no) 1985-01-14
NO168300B NO168300B (no) 1991-10-28
NO168300C true NO168300C (no) 1992-02-05

Family

ID=24042059

Family Applications (1)

Application Number Title Priority Date Filing Date
NO842835A NO168300C (no) 1983-07-12 1984-07-11 Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive imidazoliumsalter

Country Status (15)

Country Link
US (2) US4581370A (fr)
EP (1) EP0131302B1 (fr)
JP (1) JPH08815B2 (fr)
AT (1) ATE72238T1 (fr)
AU (1) AU582538B2 (fr)
CA (1) CA1289563C (fr)
DE (1) DE3485488D1 (fr)
DK (1) DK339184A (fr)
FI (1) FI90232C (fr)
GR (1) GR82282B (fr)
IE (1) IE59337B1 (fr)
IL (1) IL72354A (fr)
NO (1) NO168300C (fr)
NZ (1) NZ208831A (fr)
ZA (1) ZA845410B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0149976A3 (fr) * 1983-12-30 1986-12-10 Ciba-Geigy Ag Imidazoles substitués
US4609670A (en) * 1984-11-13 1986-09-02 Eli Lilly And Company Imidazolium hypoglycemic agents
EP0200947B1 (fr) * 1985-04-26 1990-09-12 F. Hoffmann-La Roche Ag Sels d'imidazolium substitué en position 1,3
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US4937250A (en) * 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
GB8609331D0 (en) * 1986-04-16 1986-05-21 Pfizer Ltd Anti-arrythmia agents
GB8707120D0 (en) * 1987-03-25 1987-04-29 Pfizer Ltd Antiarrhythmic agents
US4918080A (en) * 1987-04-14 1990-04-17 Glaxo Group Limited Imidazollyl containing ketone derivatives
GB8720693D0 (en) * 1987-09-03 1987-10-07 Glaxo Group Ltd Chemical compounds
DK0599968T3 (da) * 1991-08-14 2000-04-17 Procter & Gamble Pharma Oxazolidinonderivater, der er egnede som antiarytmi- og antifibrilleringsmidler
RU2221788C2 (ru) * 1991-08-14 2004-01-20 Проктер энд Гэмбл Фармасьютикалз Оксоциклические соединения мочевины, фармацевтическая композиция, способ лечения
SK279677B6 (sk) * 1991-08-14 1999-02-11 Procter And Gamble Pharmaceuticals Cyklické deriváty močoviny a farmaceutický prostri
US5635521A (en) * 1991-09-23 1997-06-03 Sandoz Ltd. Imidazolylmethyl-pyridines
DE69212844T2 (de) * 1991-12-18 1997-01-09 Schering Corp., Kenilworth, N.J. Imidazolyl oder imidazolylalkyl substituiert mit einem 4- oder 5-gliedrigen stickstoff enthaltenden heterozyklischen ring
GB9127304D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
US5183813A (en) * 1992-02-19 1993-02-02 Sterling Winthrop Inc. Antiarrhythmic agents
US6031109A (en) * 1993-06-22 2000-02-29 Knoll Aktiengesellschaft Phenoxy-, phenylthio-, benzoyl-alkyleneaminoalkylene-imidazole derivatives as therapeutic agents
GB9312893D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
FR2766178B1 (fr) * 1997-07-16 2000-03-17 Oreal Nouvelles bases d'oxydation cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
FR2766179B1 (fr) * 1997-07-16 2000-03-17 Oreal Nouvelles bases d'oxydation cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
FR2782718B1 (fr) * 1998-09-02 2000-11-10 Oreal Nouveaux composes cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
FR2782719B1 (fr) * 1998-09-02 2000-11-10 Oreal Nouvelles orthophenylenediamines cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
JP4620286B2 (ja) * 2001-06-05 2011-01-26 富士フイルム株式会社 電解質組成物、光電変換素子及び光電気化学電池
CN1659131A (zh) 2002-04-08 2005-08-24 葛兰素集团有限公司 2－((2－烷氧基)－苯基)－环戊－1－烯基)芳香碳－以及杂环羧酸及其衍生物
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
JP2008133248A (ja) * 2006-10-24 2008-06-12 Sanyo Chem Ind Ltd イミダゾリウム塩の製造方法
RU2373934C1 (ru) * 2008-03-19 2009-11-27 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2493318A (en) * 1945-07-14 1950-01-03 Lilly Co Eli Imidazolium compounds
FR8357M (fr) * 1966-09-08 1971-02-08
SE7600674L (sv) * 1975-02-05 1976-08-06 Rohm & Haas Fungicider
DE2510525C3 (de) * 1975-03-11 1978-03-30 Th. Goldschmidt Ag, 4300 Essen Quartäre 2-Alkylimidazoliumsalze
AT370095B (de) * 1977-10-19 1983-02-25 Wellcome Found Verfahren zum herstellen von neuen 1-aryl-alkyl-imidazolderivaten und deren salzen
JPS5479278A (en) * 1977-12-05 1979-06-25 Nippon Soda Co Ltd Imidazolium halide
IT1097314B (it) * 1978-07-26 1985-08-31 Recordati Chem Pharm Derivati dell'imidazolo ad attivita' anticonvulsivante
FR2486079A1 (fr) * 1980-07-07 1982-01-08 Rhone Poulenc Agrochimie Sels quaternaires d'alcoyl-1-imidazolium de l'acide phosphoreux ou ses monoesters, procedes pour les preparer et compositions fongicides les contenant
JPS5838261A (ja) * 1981-08-29 1983-03-05 Kissei Pharmaceut Co Ltd 新規な１，３−二置換イミダゾ−ル誘導体及びその製造方法
JPS5855466A (ja) * 1981-09-28 1983-04-01 Kissei Pharmaceut Co Ltd 新規な１，３−二置換イミダゾ−ル誘導体及びその製造方法
DE3319845A1 (de) * 1983-06-01 1984-12-06 Basf Ag, 6700 Ludwigshafen Arylalkylimidazolium- und -triazoliumsalze, verfahren zu ihrer herstellung und ihre verwendung als mikrozide

Also Published As

Publication number Publication date
CA1289563C (fr) 1991-09-24
JPH08815B2 (ja) 1996-01-10
ATE72238T1 (de) 1992-02-15
FI90232C (fi) 1994-01-10
JPS6038366A (ja) 1985-02-27
US4581370A (en) 1986-04-08
EP0131302A3 (en) 1987-06-16
FI842760A0 (fi) 1984-07-10
DK339184D0 (da) 1984-07-10
EP0131302A2 (fr) 1985-01-16
EP0131302B1 (fr) 1992-01-29
FI842760A7 (fi) 1985-01-13
AU3054384A (en) 1985-01-17
US4689341A (en) 1987-08-25
FI90232B (fi) 1993-09-30
NZ208831A (en) 1988-09-29
IE59337B1 (en) 1994-02-09
IL72354A (en) 1988-11-30
GR82282B (fr) 1984-12-13
IL72354A0 (en) 1984-11-30
IE841774L (en) 1985-01-12
AU582538B2 (en) 1989-04-06
DK339184A (da) 1985-01-13
ZA845410B (en) 1985-02-27
NO168300B (no) 1991-10-28
DE3485488D1 (de) 1992-03-12
NO842835L (no) 1985-01-14

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