NO168353C - Analogifremgangsmaate for fremstilling av terapeutisk aktive n-(2'-aminofenyl)-benzamidderivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive n-(2'-aminofenyl)-benzamidderivater

Info

Publication number: NO168353C
Authority: NO; Norway
Prior art keywords: aminophenyl; preparation; therapeutic active; benzamide derivatives; analogy procedure
Prior art date: 1986-04-22

Application number

NO871640A

Other languages

English (en)

Norwegian (no)

Other versions

NO168353B (no

NO871640L (no

NO871640D0 (no

Inventor

Ute Weiershausen

Gerhard Satzinger

Karl-Otto Vollmer

Wolfgang Herrmann

Original Assignee

Goedecke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-22

Filing date

1987-04-21

Publication date

1992-02-12

1986-04-22 Priority claimed from DE19863613571 external-priority patent/DE3613571A1/de

1986-07-26 Priority claimed from DE19863625359 external-priority patent/DE3625359A1/de

1987-04-21 Application filed by Goedecke Ag filed Critical Goedecke Ag

1987-04-21 Publication of NO871640D0 publication Critical patent/NO871640D0/no

1987-10-23 Publication of NO871640L publication Critical patent/NO871640L/no

1991-11-04 Publication of NO168353B publication Critical patent/NO168353B/no

1992-02-12 Publication of NO168353C publication Critical patent/NO168353C/no

Links

RFDVMOUXHKTCDO-UHFFFAOYSA-N n-(2-aminophenyl)benzamide Chemical class NC1=CC=CC=C1NC(=O)C1=CC=CC=C1 RFDVMOUXHKTCDO-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Oncology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO871640A 1986-04-22 1987-04-21 Analogifremgangsmaate for fremstilling av terapeutisk aktive n-(2'-aminofenyl)-benzamidderivater NO168353C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19863613571 DE3613571A1 (de)	1986-04-22	1986-04-22	N-(2'-aminophenyl)-benzamid-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung neoplastischer erkrankungen
DE19863625359 DE3625359A1 (de)	1986-07-26	1986-07-26	N-(2'-aminophenyl)-benzamid-derivat, verfahren zu dessen herstellung und dessen verwendung bei der bekaempfung neoplastischer erkrankungen

Publications (4)

Publication Number	Publication Date
NO871640D0 NO871640D0 (no)	1987-04-21
NO871640L NO871640L (no)	1987-10-23
NO168353B NO168353B (no)	1991-11-04
NO168353C true NO168353C (no)	1992-02-12

Family

ID=25843119

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO871640A NO168353C (no)	1986-04-22	1987-04-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive n-(2'-aminofenyl)-benzamidderivater

Country Status (19)

Country	Link
US (1)	US5137918A (fr)
EP (1)	EP0242851B1 (fr)
JP (1)	JPH0825977B2 (fr)
CN (1)	CN1012498B (fr)
AT (1)	AT388913B (fr)
CA (1)	CA1334760C (fr)
CS (1)	CS262448B2 (fr)
DE (1)	DE3763191D1 (fr)
DK (1)	DK170771B1 (fr)
ES (1)	ES2095824T3 (fr)
FI (1)	FI87766C (fr)
GR (1)	GR3000562T3 (fr)
HU (1)	HU197295B (fr)
IE (1)	IE60332B1 (fr)
IL (1)	IL82265A (fr)
NO (1)	NO168353C (fr)
NZ (1)	NZ219974A (fr)
PH (1)	PH23928A (fr)
PT (1)	PT84737B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5602277A (en) *	1995-03-30	1997-02-11	Biocryst Pharmaceuticals, Inc.	Substituted benzene derivatives useful as neuraminidase inhibitors
AU6878198A (en) *	1997-04-24	1998-11-13	Warner-Lambert Company	Use of acetyldinaline for the manufacture of a medicament for the treatment of renal cell carcinoma
ATE225655T1 (de) *	1998-09-25	2002-10-15	Warner Lambert Co	Chemotherapie des krebses mit acetyldinalin in verbindung mit gemcitabin, capecitabin oder cisplatin
JP2003513912A (ja) *	1999-11-10	2003-04-15	ワーナー−ランバート・カンパニー	組合せ化学療法
CZ20022216A3 (cs) *	2001-07-02	2003-05-14	Warner-Lambert Company	Kombinační chemoterapie
AR034897A1 (es)	2001-08-07	2004-03-24	Hoffmann La Roche	Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos
CN101851173A (zh) *	2001-09-14	2010-10-06	梅特希尔基因公司	组蛋白脱乙酰化酶抑制剂
US7868204B2 (en) *	2001-09-14	2011-01-11	Methylgene Inc.	Inhibitors of histone deacetylase
US6897220B2 (en) *	2001-09-14	2005-05-24	Methylgene, Inc.	Inhibitors of histone deacetylase
GB0202873D0 (en) *	2002-02-07	2002-03-27	Novartis Ag	Organic compounds
TW200426138A (en) *	2002-12-10	2004-12-01	Hoffmann La Roche	Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives, their manufacture and use as pharmaceutical agents
TW200424174A (en)	2003-02-06	2004-11-16	Hoffmann La Roche	New TP diamide
US7208491B2 (en)	2003-02-07	2007-04-24	Hoffmann-La Roche Inc.	N-monoacylated o-phenylenediamines
TW200424187A (en)	2003-04-04	2004-11-16	Hoffmann La Roche	New oxime derivatives and their use as pharmaceutically active agents
WO2005030705A1 (fr) *	2003-09-24	2005-04-07	Methylgene, Inc.	Inhibiteurs d'histone deacetylase
DK1696898T3 (en)	2003-12-02	2016-02-22	Univ Ohio State Res Found	ZN2 + -CHELATING DESIGN-BASED SHORT-CHAIN FAT ACIDS AS AN UNKNOWN CLASS OF HISTONDEACETYLASE INHIBITORS
US7253204B2 (en) *	2004-03-26	2007-08-07	Methylgene Inc.	Inhibitors of histone deacetylase
CN101466670B (zh) *	2006-04-07	2013-04-17	梅特希尔基因公司	组蛋白脱乙酰酶抑制剂
WO2007136858A2 (fr)	2006-05-19	2007-11-29	H. Lee Moffitt Cancer Center & Research Institute	Petites molécules inhibitrices de stat3 ayant une activité antitumorale
WO2009076234A2 (fr) *	2007-12-07	2009-06-18	University Of Maryland, Baltimore	Procédés de synthèse d'inhibiteurs de l'histone désacétylase (hdaci)
WO2010036404A2 (fr) *	2008-05-09	2010-04-01	University Of Maryland, Baltimore	Nouveaux rétinamides inhibiteurs du métabolisme de l'acide rétinoïque
US8173621B2 (en)	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
AU2009329872B2 (en)	2008-12-23	2016-07-07	Gilead Pharmasset Llc	Synthesis of purine nucleosides
NZ593649A (en)	2008-12-23	2013-11-29	Gilead Pharmasset Llc	Nucleoside analogs
PA8855601A1 (es)	2008-12-23	2010-07-27		Forformidatos de nucleósidos
SG184324A1 (en)	2010-03-31	2012-11-29	Gilead Pharmasset Llc	Nucleoside phosphoramidates
CA2834548C (fr)	2011-04-28	2021-06-01	The Broad Institute, Inc.	Inhibiteurs de l'histone desacetylase
US8691875B2 (en)	2011-07-01	2014-04-08	Broad Institute, Inc.	Solid forms of tacedinaline
EP2877444B1 (fr)	2012-07-27	2020-09-02	The Broad Institute, Inc.	Inhibiteurs d'histone-désacétylases
US9914717B2 (en)	2012-12-20	2018-03-13	The Broad Institute, Inc.	Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
US9636298B2 (en)	2014-01-17	2017-05-02	Methylgene Inc.	Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs
CN104058983B (zh) *	2014-07-02	2016-01-13	郑攀锋	一种医药原料酰胺类化合物的合成方法
EP3737362B1 (fr)	2018-01-12	2025-10-15	Kdac Therapeutics, Inc.	Combinaison d'un inhibiteur sélectif de désacétylase d'histone 3 (hdac3) et d'un agent d'immunothérapie pour le traitement du cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1493783A1 (de) *	1965-07-12	1969-01-30	Goedecke Ag	Verfahren zur Herstellung von 2-Amino-4'-(diaethylamino)-2'-methyl-benzanilid
DE1643264A1 (de) *	1967-12-20	1971-06-09	Basf Ag	Verfahren zur Herstellung von Aminoaniliden
US4004029A (en) *	1974-05-13	1977-01-18	The Upjohn Company	Compositions and method for treating epilepsy and convulsions
DE3305755A1 (de) *	1983-02-19	1984-08-23	Gödecke AG, 1000 Berlin	N-phenyl-benzamid-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von erkranungen des immunsystems
CH653670A5 (de) *	1983-03-03	1986-01-15	Hoffmann La Roche	Benzamid-derivate.
US4642379A (en) *	1985-08-30	1987-02-10	Eli Lilly And Company	Intermediates for anticonvulsant agents

1987
- 1987-04-14 NZ NZ219974A patent/NZ219974A/xx unknown
- 1987-04-15 DK DK198487A patent/DK170771B1/da not_active IP Right Cessation
- 1987-04-16 CA CA000534920A patent/CA1334760C/fr not_active Expired - Fee Related
- 1987-04-16 CS CS872736A patent/CS262448B2/cs not_active IP Right Cessation
- 1987-04-20 PH PH35157A patent/PH23928A/en unknown
- 1987-04-21 NO NO871640A patent/NO168353C/no unknown
- 1987-04-21 FI FI871733A patent/FI87766C/fi not_active IP Right Cessation
- 1987-04-21 HU HU871729A patent/HU197295B/hu not_active IP Right Cessation
- 1987-04-21 DE DE8787105846T patent/DE3763191D1/de not_active Expired - Fee Related
- 1987-04-21 JP JP62096357A patent/JPH0825977B2/ja not_active Expired - Fee Related
- 1987-04-21 EP EP87105846A patent/EP0242851B1/fr not_active Expired - Lifetime
- 1987-04-21 IL IL82265A patent/IL82265A/xx not_active IP Right Cessation
- 1987-04-21 ES ES87105846T patent/ES2095824T3/es not_active Expired - Lifetime
- 1987-04-22 IE IE104687A patent/IE60332B1/en not_active IP Right Cessation
- 1987-04-22 CN CN87103096A patent/CN1012498B/zh not_active Expired
- 1987-04-22 PT PT84737A patent/PT84737B/pt unknown
- 1987-10-08 AT AT0265187A patent/AT388913B/de not_active IP Right Cessation
1990
- 1990-06-14 GR GR90400340T patent/GR3000562T3/el unknown
- 1990-10-09 US US07/594,592 patent/US5137918A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PH23928A (en)	1990-01-23
IL82265A0 (en)	1987-10-30
IE871046L (en)	1987-10-22
IE60332B1 (en)	1994-06-29
HUT43808A (en)	1987-12-28
FI87766B (fi)	1992-11-13
NO168353B (no)	1991-11-04
DE3763191D1 (de)	1990-07-19
FI871733A0 (fi)	1987-04-21
PT84737B (pt)	1989-12-29
GR3000562T3 (en)	1991-07-31
NO871640L (no)	1987-10-23
EP0242851A1 (fr)	1987-10-28
AT388913B (de)	1989-09-25
NO871640D0 (no)	1987-04-21
DK170771B1 (da)	1996-01-15
CN87103096A (zh)	1987-11-18
JPH0825977B2 (ja)	1996-03-13
CS273687A2 (en)	1988-07-15
DK198487A (da)	1987-10-23
JPS63115852A (ja)	1988-05-20
DK198487D0 (da)	1987-04-15
NZ219974A (en)	1989-08-29
CA1334760C (fr)	1995-03-14
FI87766C (fi)	1993-02-25
CS262448B2 (en)	1989-03-14
HU197295B (en)	1989-03-28
CN1012498B (zh)	1991-05-01
ATA265187A (de)	1989-02-15
ES2095824T3 (es)	1997-03-01
FI871733L (fi)	1987-10-23
US5137918A (en)	1992-08-11
EP0242851B1 (fr)	1990-06-13
PT84737A (en)	1987-05-01
IL82265A (en)	1991-01-31

Publication	Publication Date	Title
NO168353C (no)	1992-02-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive n-(2'-aminofenyl)-benzamidderivater
NO168770C (no)	1992-04-01	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater
NO172801C (no)	1993-09-08	Analogifremgangsmaate for fremstilling av terapeutisk aktive kinuklidin-derivater
NO170629C (no)	1992-11-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive dikloranilin-derivater
NO914667L (no)	1992-05-29	Fremgangsmaate for fremstilling av terapeutisk aktive arylderivater
NO168174C (no)	1992-01-22	Analogifremgangsmaate for fremstilling av terapeutisk aktive triazolforbindelser
NO168422C (no)	1992-02-19	Analogifremgangsmaate ved fremstilling av terapeutisk aktive n-substituerte benzamider
NO851695L (no)	1985-10-31	Fremgangsmaate for fremstilling av terapeutisk aktive 2-(n-substituert-guanidino)-4-heteroaryl-tiazol-derivater
NO171269C (no)	1993-02-17	Analogifremgangsmaate for fremstilling av terapeutisk aktive propenonoksimetere og mellomprodukter
NO167026C (no)	1991-09-25	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater
NO172240C (no)	1993-06-23	Analogifremgangsmaate for fremstilling av terapeutisk aktive nye 2'-halometylidenderivater
NO171909C (no)	1993-05-19	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,4-dihydropyridinderivater
NO168355C (no)	1992-02-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater
NO171412C (no)	1993-03-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksatiolan- eller 1,3-ditiolanderivater
NO170482C (no)	1992-10-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive karboksamid-derivater
NO168299C (no)	1992-02-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive alkansulfonanilid-derivater
NO172539C (no)	1993-08-04	Analogifremgangsmaate for fremstilling av terapeutisk aktive indolpiperidin-forbindelser
NO171857C (no)	1993-05-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2'-halomethyliden-adenosin-derivater
NO168644C (no)	1992-03-18	Fremgangsmaate for fremstilling av terapeutisk aktive n-(pyrrol-1-yl)pyridinaminer
NO173185C (no)	1993-11-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinoxalinforbindelser
NO173061C (no)	1993-10-20	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-benzotiazoliner
NO169069C (no)	1992-05-06	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-alkoksy-2-aminopropylaminderivater
NO172802C (no)	1993-09-08	Analogifremgangsmaate for fremstilling av terapeutisk aktive tienopyraner
NO914071D0 (no)	1991-10-17	Fremgangsmaate for fremstilling av terapeutisk aktive forbindelser
NO831995L (no)	1983-12-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive n-(2-metoksyetyl)-noroksymorfon