NO169841C - Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive (arylfenyl- eller thienylmethyl)-2,2'-bi-1h-imidazoler - Google Patents

Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive (arylfenyl- eller thienylmethyl)-2,2'-bi-1h-imidazoler

Info

Publication number
NO169841C
NO169841C NO883322A NO883322A NO169841C NO 169841 C NO169841 C NO 169841C NO 883322 A NO883322 A NO 883322A NO 883322 A NO883322 A NO 883322A NO 169841 C NO169841 C NO 169841C
Authority
NO
Norway
Prior art keywords
arylphenyl
thienylmethyl
imidazoles
preparation
new
Prior art date
Application number
NO883322A
Other languages
English (en)
Norwegian (no)
Other versions
NO169841B (no
NO883322D0 (no
NO883322L (no
Inventor
Donald P Matthews
James R Mccarthy
Jeffrey P Whitten
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO883322D0 publication Critical patent/NO883322D0/no
Publication of NO883322L publication Critical patent/NO883322L/no
Publication of NO169841B publication Critical patent/NO169841B/no
Publication of NO169841C publication Critical patent/NO169841C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
NO883322A 1987-07-28 1988-07-27 Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive (arylfenyl- eller thienylmethyl)-2,2'-bi-1h-imidazoler NO169841C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/078,352 US4839375A (en) 1987-07-28 1987-07-28 (Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their use as anti-hypertensive agents

Publications (4)

Publication Number Publication Date
NO883322D0 NO883322D0 (no) 1988-07-27
NO883322L NO883322L (no) 1989-01-30
NO169841B NO169841B (no) 1992-05-04
NO169841C true NO169841C (no) 1992-08-12

Family

ID=22143494

Family Applications (1)

Application Number Title Priority Date Filing Date
NO883322A NO169841C (no) 1987-07-28 1988-07-27 Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive (arylfenyl- eller thienylmethyl)-2,2'-bi-1h-imidazoler

Country Status (19)

Country Link
US (1) US4839375A (de)
EP (1) EP0301456B1 (de)
JP (1) JP2750578B2 (de)
KR (1) KR970011301B1 (de)
CN (1) CN1016173B (de)
AT (1) ATE101151T1 (de)
AU (1) AU605609B2 (de)
CA (1) CA1338786C (de)
DE (1) DE3887585T2 (de)
DK (1) DK420588A (de)
ES (1) ES2063008T3 (de)
FI (1) FI883499A7 (de)
HU (1) HU202861B (de)
IL (1) IL87217A (de)
NO (1) NO169841C (de)
NZ (1) NZ225561A (de)
PH (1) PH26551A (de)
PT (1) PT88121B (de)
ZA (1) ZA885360B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0949314B1 (de) * 1998-03-20 2006-06-14 China Petrochemical Corporation Hydroentschwefelung von Kohlenwasserstoffölen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283661C (en) * 1984-06-20 1991-04-30 Franz Jansen Imidazolides, process for their preparation and application as intermediates for the synthesis of cytotoxic conjugates
CA1286301C (en) * 1985-11-25 1991-07-16 Donald P. Matthews 2,2'-bi-1h-imidazoles
IL82401A0 (en) * 1986-05-06 1987-11-30 Merrell Dow Pharma Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IL87217A0 (en) 1988-12-30
PT88121B (pt) 1995-03-01
JP2750578B2 (ja) 1998-05-13
CA1338786C (en) 1996-12-10
DK420588D0 (da) 1988-07-27
DE3887585T2 (de) 1994-05-26
FI883499A0 (fi) 1988-07-25
US4839375A (en) 1989-06-13
EP0301456B1 (de) 1994-02-02
NZ225561A (en) 1990-12-21
EP0301456A2 (de) 1989-02-01
FI883499L (fi) 1989-01-29
KR890002112A (ko) 1989-04-08
PT88121A (pt) 1989-07-31
KR970011301B1 (ko) 1997-07-09
ATE101151T1 (de) 1994-02-15
JPS6440465A (en) 1989-02-10
AU1976588A (en) 1989-02-02
ZA885360B (en) 1989-03-29
NO169841B (no) 1992-05-04
HUT53900A (en) 1990-12-28
CN1034718A (zh) 1989-08-16
AU605609B2 (en) 1991-01-17
CN1016173B (zh) 1992-04-08
ES2063008T3 (es) 1995-01-01
DK420588A (da) 1989-01-29
EP0301456A3 (en) 1990-12-05
HU202861B (en) 1991-04-29
DE3887585D1 (de) 1994-03-17
IL87217A (en) 1992-07-15
FI883499A7 (fi) 1989-01-29
NO883322D0 (no) 1988-07-27
PH26551A (en) 1992-08-19
NO883322L (no) 1989-01-30

Similar Documents

Publication Publication Date Title
RU94023250A (ru) 2,3-дигидро-1,4-бензодиоксин-5-ил-пиперазиновые производные, обладающие 5-нт1а-антагонистической активностью, способы их получения, фармкомпозиция на их основе, получение ее и способ лечения расстройств нервной системы
NO178969C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte kinazolinoner
FI905280A0 (fi) Menetelmä valmistaa terapeuttisesti aktiivista bentsopyridopiperidiini-, piperidylideeni- ja -piperatsiiniyhdistettä
ATE226574T1 (de) 4,6-diarylpyrimidin-derivate und deren salze
HUP9802447A2 (hu) Piperazinszármazékok, eljárás előállításukra és 5-HT1A antagonistaként történő alkalmazásuk
DE69131359D1 (de) Kondensierte Thiazolverbindungen, ihre Darstellung und ihre Anwendung
KR890001957A (ko) N-아미노부틸-n-페닐아릴아미드 유도체, 그의 제법 및 치료에의 응용
NO176603C (no) Analogifremgangsmåte for fremstilling av nye, terapeutisk aktive 8-substituert-2-aminotetraliner
NO173444C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive 4-(4'- fluorfenyl-)-tienopyridin-derivater
NO902099D0 (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive arylsulfonamider.
NO881835D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive bicykliske forbindelser.
FI901761A0 (fi) Menetelmä lääkeaineina käyttökelpoisten pyridiinijohdannaisten valmistamiseksi
DE3586649D1 (de) Verwendung von spergualinderivaten zur herstellung von arzneimitteln mit immunodepressiver wirkung.
NO176097C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte cykloheksener
JPS6016933B2 (ja) 2,6−ジメチル−3,5−ジメトキシカルボニル−4−(0−ジフルオロメトキシフエニル)−1,4−ジヒドロピリジン
NO173991C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive 1,2,5-ditiazocin-derivater
FR2804958B1 (fr) Derives de xanthine, leur procede de preparation et les intermediaires de ce procede, leur application comme medicament et les compositions pharmaceutiques les renfermant
NO883322D0 (no) Fremgangsmaate for fremstilling av nye (aryl eller heteroaromatisk methyl)-2,2'-bi-lh-imidazoler.
ES500810A0 (es) Procedimiento de preparacion de aminoalcoxipirazoles
NO894698L (no) Kondenserte heterocykliske derivater av 1,2,3,4-tetrahydroakridiner samt fremgangsmaate for fremstilling derav.
MX15697A (es) Derivados heterotetraciclicos de lactama y procesopara su preparacion
KR890012990A (ko) 삼치환된 아민 이들의 제법 및 이들을 함유하는 제약조성물
FR2623501B1 (fr) Nouveaux derives substitues de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant
NO914567L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridylderivater
ITMI920082A1 (it) Derivati solforati di acidi biliari