PH26551A - (Aryl or heteroaromatic methyl)-2,2'-bi-hi-imidazoles and their use as anti-hypertensive agents - Google Patents

(Aryl or heteroaromatic methyl)-2,2'-bi-hi-imidazoles and their use as anti-hypertensive agents Download PDF

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Publication number
PH26551A
PH26551A PH37306A PH37306A PH26551A PH 26551 A PH26551 A PH 26551A PH 37306 A PH37306 A PH 37306A PH 37306 A PH37306 A PH 37306A PH 26551 A PH26551 A PH 26551A
Authority
PH
Philippines
Prior art keywords
compound
imidazole
substituted
phenyl
chloro
Prior art date
Application number
PH37306A
Other languages
English (en)
Inventor
Donald P Matthews
James R Mccarthy
Jeffrey P Whitten
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Priority to PH39550A priority Critical patent/PH26027A/en
Priority to PH39549A priority patent/PH26028A/en
Publication of PH26551A publication Critical patent/PH26551A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
PH37306A 1987-07-28 1988-07-28 (Aryl or heteroaromatic methyl)-2,2'-bi-hi-imidazoles and their use as anti-hypertensive agents PH26551A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PH39550A PH26027A (en) 1987-07-28 1989-11-17 A process for preparing (aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles
PH39549A PH26028A (en) 1987-07-28 1989-11-17 A process for preparing (aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/078,352 US4839375A (en) 1987-07-28 1987-07-28 (Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their use as anti-hypertensive agents

Publications (1)

Publication Number Publication Date
PH26551A true PH26551A (en) 1992-08-19

Family

ID=22143494

Family Applications (1)

Application Number Title Priority Date Filing Date
PH37306A PH26551A (en) 1987-07-28 1988-07-28 (Aryl or heteroaromatic methyl)-2,2'-bi-hi-imidazoles and their use as anti-hypertensive agents

Country Status (19)

Country Link
US (1) US4839375A (de)
EP (1) EP0301456B1 (de)
JP (1) JP2750578B2 (de)
KR (1) KR970011301B1 (de)
CN (1) CN1016173B (de)
AT (1) ATE101151T1 (de)
AU (1) AU605609B2 (de)
CA (1) CA1338786C (de)
DE (1) DE3887585T2 (de)
DK (1) DK420588A (de)
ES (1) ES2063008T3 (de)
FI (1) FI883499A7 (de)
HU (1) HU202861B (de)
IL (1) IL87217A (de)
NO (1) NO169841C (de)
NZ (1) NZ225561A (de)
PH (1) PH26551A (de)
PT (1) PT88121B (de)
ZA (1) ZA885360B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0949314B1 (de) * 1998-03-20 2006-06-14 China Petrochemical Corporation Hydroentschwefelung von Kohlenwasserstoffölen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283661C (en) * 1984-06-20 1991-04-30 Franz Jansen Imidazolides, process for their preparation and application as intermediates for the synthesis of cytotoxic conjugates
CA1286301C (en) * 1985-11-25 1991-07-16 Donald P. Matthews 2,2'-bi-1h-imidazoles
IL82401A0 (en) * 1986-05-06 1987-11-30 Merrell Dow Pharma Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IL87217A0 (en) 1988-12-30
PT88121B (pt) 1995-03-01
JP2750578B2 (ja) 1998-05-13
CA1338786C (en) 1996-12-10
DK420588D0 (da) 1988-07-27
DE3887585T2 (de) 1994-05-26
FI883499A0 (fi) 1988-07-25
US4839375A (en) 1989-06-13
EP0301456B1 (de) 1994-02-02
NZ225561A (en) 1990-12-21
EP0301456A2 (de) 1989-02-01
FI883499L (fi) 1989-01-29
KR890002112A (ko) 1989-04-08
PT88121A (pt) 1989-07-31
KR970011301B1 (ko) 1997-07-09
ATE101151T1 (de) 1994-02-15
JPS6440465A (en) 1989-02-10
AU1976588A (en) 1989-02-02
ZA885360B (en) 1989-03-29
NO169841B (no) 1992-05-04
HUT53900A (en) 1990-12-28
CN1034718A (zh) 1989-08-16
AU605609B2 (en) 1991-01-17
CN1016173B (zh) 1992-04-08
ES2063008T3 (es) 1995-01-01
DK420588A (da) 1989-01-29
EP0301456A3 (en) 1990-12-05
HU202861B (en) 1991-04-29
DE3887585D1 (de) 1994-03-17
NO169841C (no) 1992-08-12
IL87217A (en) 1992-07-15
FI883499A7 (fi) 1989-01-29
NO883322D0 (no) 1988-07-27
NO883322L (no) 1989-01-30

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