NO169960C - Analogifremgangsmaate for fremstilling av terapeutisk aktive, substituerte 1h-imidazoler og deres ikke-toksiske, farmasoeytisk akseptable syreaddisjonssalter - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive, substituerte 1h-imidazoler og deres ikke-toksiske, farmasoeytisk akseptable syreaddisjonssalter

Info

Publication number: NO169960C
Authority: NO; Norway
Prior art keywords: imidazoles; preparation; substituted; pharmasoeytic; toxic
Prior art date: 1986-11-04

Application number

NO874572A

Other languages

English (en)

Norwegian (no)

Other versions

NO874572L (no

NO169960B (no

NO874572D0 (no

Inventor

Eric Cossement

Jean-Pierre Geerts

Jean Gobert

Philippe Michel

Original Assignee

Ucb Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-04

Filing date

1987-11-03

Publication date

1992-08-26

1987-11-03 Application filed by Ucb Sa filed Critical Ucb Sa

1987-11-03 Publication of NO874572D0 publication Critical patent/NO874572D0/no

1988-05-05 Publication of NO874572L publication Critical patent/NO874572L/no

1992-05-18 Publication of NO169960B publication Critical patent/NO169960B/no

1992-08-26 Publication of NO169960C publication Critical patent/NO169960C/no

Links

150000003839 salts Chemical class 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
231100000252 nontoxic Toxicity 0.000 title 1
230000003000 nontoxic effect Effects 0.000 title 1
RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 7
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
-1 imidazole compound Chemical class 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000002253 anti-ischaemic effect Effects 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Epoxy Resins (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO874572A 1986-11-04 1987-11-03 Analogifremgangsmaate for fremstilling av terapeutisk aktive, substituerte 1h-imidazoler og deres ikke-toksiske, farmasoeytisk akseptable syreaddisjonssalter NO169960C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB868626287A GB8626287D0 (en)	1986-11-04	1986-11-04	Substituted 1h-imidazoles

Publications (4)

Publication Number	Publication Date
NO874572D0 NO874572D0 (no)	1987-11-03
NO874572L NO874572L (no)	1988-05-05
NO169960B NO169960B (no)	1992-05-18
NO169960C true NO169960C (no)	1992-08-26

Family

ID=10606751

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO874572A NO169960C (no)	1986-11-04	1987-11-03	Analogifremgangsmaate for fremstilling av terapeutisk aktive, substituerte 1h-imidazoler og deres ikke-toksiske, farmasoeytisk akseptable syreaddisjonssalter

Country Status (24)

Country	Link
US (1)	US4814343A (de)
EP (1)	EP0269599B1 (de)
JP (1)	JP2632877B2 (de)
KR (1)	KR910003116B1 (de)
AT (1)	ATE98640T1 (de)
AU (1)	AU592733B2 (de)
CA (1)	CA1301174C (de)
CY (1)	CY1845A (de)
DE (1)	DE3788507T2 (de)
DK (1)	DK166584B1 (de)
ES (1)	ES2060608T3 (de)
FI (1)	FI91858C (de)
GB (1)	GB8626287D0 (de)
HK (1)	HK78895A (de)
HU (1)	HU206684B (de)
IE (1)	IE61901B1 (de)
IL (1)	IL84322A (de)
MY (1)	MY102578A (de)
NO (1)	NO169960C (de)
NZ (1)	NZ222382A (de)
PL (3)	PL155119B1 (de)
PT (1)	PT86040B (de)
SU (4)	SU1662349A3 (de)
ZA (1)	ZA878170B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5116984A (en) *	1988-04-07	1992-05-26	Glaxo Group Limited	Imidazole derivatives
GB8810067D0 (en) *	1988-04-28	1988-06-02	Ucb Sa	Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides
JPH04252867A (ja) *	1991-01-25	1992-09-08	Nissan Motor Co Ltd	内燃機関の燃料供給装置
GB9310965D0 (en) *	1993-05-27	1993-07-14	Ucb Sa	2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides
NZ276883A (en) *	1993-11-15	1998-08-26	Schering Corp	1h-imidazol-4-yl)alkyl]benzene derivatives
GB9425211D0 (en) *	1994-12-14	1995-02-15	Ucb Sa	Substituted 1H-imidazoles
GB9521680D0 (en) *	1995-10-23	1996-01-03	Orion Yhtymo Oy	New use of imidazole derivatives
WO2008088936A1 (en) *	2007-01-12	2008-07-24	Allergan, Inc.	Quinolynylmethylimidizoles as therapeutic agents
WO2008088937A1 (en) *	2007-01-12	2008-07-24	Allergan, Inc.	Quinolynylmethylimidizoles as therapeutic agents
US8013169B2 (en) *	2007-01-12	2011-09-06	Allergan, Inc	Naphthylmethylimidizoles as therapeutic agents
RU2373934C1 (ru) *	2008-03-19	2009-11-27	Общество С Ограниченной Ответственностью "Фарминтерпрайсез"	Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств
CN121511240A (zh) *	2023-06-19	2026-02-10	江苏恩华药业股份有限公司	一种取代咪唑衍生物、中间体、制备方法及其应用
CN120865095B (zh) *	2025-07-04	2026-05-05	武穴宏源药业有限公司	一种咪唑环合液的提纯方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US29761A (en) *		1860-08-28		Improvements in telegraphic apparatus
US4070472A (en)	1974-02-07	1978-01-24	Smith Kline & French Laboratories Limited	Guanidino, thioureido, isothioureido and nitrovinylamino derivatives of pyridine
AU518569B2 (en) *	1979-08-07	1981-10-08	Farmos-Yhtyma Oy	4-benzyl- and 4-benzoyl imidazole derivatives
GB2092569B (en) *	1981-02-05	1984-09-19	Farmos Oy	Substituted imidazole derivatives and their preparation and use
GB2101114B (en) *	1981-07-10	1985-05-22	Farmos Group Ltd	Substituted imidazole derivatives and their preparation and use
DE4224020A1 (de) *	1992-07-22	1994-01-27	Deutsche Aerospace	Verfahren zur Auslösung der Zündung eines Gefechtskopfes und Anordnung zum Durchführen des Verfahrens

1986
- 1986-11-04 GB GB868626287A patent/GB8626287D0/en active Pending
1987
- 1987-10-14 CA CA000549258A patent/CA1301174C/en not_active Expired - Lifetime
- 1987-10-30 IL IL84322A patent/IL84322A/xx not_active IP Right Cessation
- 1987-10-30 AT AT87870149T patent/ATE98640T1/de not_active IP Right Cessation
- 1987-10-30 ZA ZA878170A patent/ZA878170B/xx unknown
- 1987-10-30 ES ES87870149T patent/ES2060608T3/es not_active Expired - Lifetime
- 1987-10-30 EP EP87870149A patent/EP0269599B1/de not_active Expired - Lifetime
- 1987-10-30 FI FI874789A patent/FI91858C/fi not_active IP Right Cessation
- 1987-10-30 PT PT86040A patent/PT86040B/pt not_active IP Right Cessation
- 1987-10-30 NZ NZ222382A patent/NZ222382A/en unknown
- 1987-10-30 DE DE3788507T patent/DE3788507T2/de not_active Expired - Fee Related
- 1987-10-31 KR KR1019870012264A patent/KR910003116B1/ko not_active Expired
- 1987-11-02 DK DK572987A patent/DK166584B1/da active
- 1987-11-02 US US07/116,325 patent/US4814343A/en not_active Expired - Lifetime
- 1987-11-02 AU AU80593/87A patent/AU592733B2/en not_active Ceased
- 1987-11-02 MY MYPI87003010A patent/MY102578A/en unknown
- 1987-11-02 PL PL1987268558A patent/PL155119B1/pl unknown
- 1987-11-02 PL PL1987288655A patent/PL156483B1/pl unknown
- 1987-11-02 JP JP62278144A patent/JP2632877B2/ja not_active Expired - Lifetime
- 1987-11-02 PL PL1987288654A patent/PL156482B1/pl unknown
- 1987-11-03 NO NO874572A patent/NO169960C/no not_active IP Right Cessation
- 1987-11-03 IE IE296387A patent/IE61901B1/en not_active IP Right Cessation
- 1987-11-03 SU SU874203647A patent/SU1662349A3/ru active
- 1987-11-04 HU HU874948A patent/HU206684B/hu not_active IP Right Cessation
1988
- 1988-06-30 SU SU884356015A patent/SU1710558A1/ru active
- 1988-12-22 SU SU884613197A patent/SU1628857A3/ru active
- 1988-12-22 SU SU884613108A patent/SU1635899A3/ru active
1995
- 1995-05-18 HK HK78895A patent/HK78895A/xx not_active IP Right Cessation
1996
- 1996-03-08 CY CY184596A patent/CY1845A/xx unknown

Also Published As

Publication number	Publication date
FI874789A0 (fi)	1987-10-30
AU592733B2 (en)	1990-01-18
US4814343A (en)	1989-03-21
KR880006205A (ko)	1988-07-22
EP0269599A3 (en)	1990-03-14
ZA878170B (en)	1989-07-26
SU1662349A3 (ru)	1991-07-07
HK78895A (en)	1995-05-26
JPS63132876A (ja)	1988-06-04
SU1635899A3 (ru)	1991-03-15
IL84322A0 (en)	1988-03-31
EP0269599A2 (de)	1988-06-01
NO874572L (no)	1988-05-05
KR910003116B1 (ko)	1991-05-18
EP0269599B1 (de)	1993-12-15
IL84322A (en)	1991-08-16
FI91858C (fi)	1994-08-25
SU1628857A3 (ru)	1991-02-15
PT86040B (pt)	1990-07-31
NO169960B (no)	1992-05-18
HUT56547A (en)	1991-09-30
AU8059387A (en)	1988-05-05
DK572987A (da)	1988-05-05
MY102578A (en)	1992-07-31
PL155119B1 (en)	1991-10-31
NO874572D0 (no)	1987-11-03
ATE98640T1 (de)	1994-01-15
IE61901B1 (en)	1994-11-30
GB8626287D0 (en)	1986-12-03
SU1710558A1 (ru)	1992-02-07
FI874789L (fi)	1988-05-05
CA1301174C (en)	1992-05-19
DE3788507T2 (de)	1994-05-19
PL268558A1 (en)	1988-09-01
NZ222382A (en)	1991-07-26
DK572987D0 (da)	1987-11-02
FI91858B (fi)	1994-05-13
DE3788507D1 (de)	1994-01-27
HU206684B (en)	1992-12-28
ES2060608T3 (es)	1994-12-01
PL156482B1 (pl)	1992-03-31
JP2632877B2 (ja)	1997-07-23
IE872963L (en)	1988-05-04
PT86040A (pt)	1987-11-01
CY1845A (en)	1996-03-08
DK166584B1 (da)	1993-06-14
PL156483B1 (en)	1992-03-31

Legal Events

Date	Code	Title	Description
2002-07-08	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN MAY 2002

Publication	Publication Date	Title
FI874789A0 (fi)	1987-10-30	Menetelmä valmistaa farmakologisesti aktiivisia substituoituja 1H-imidatsoleja
IE811250L (en)	1981-12-06	Imidazole derivatives
EP0322738A3 (de)	1991-05-08	Benzyliden-Malononitril-Derivate zur Hemmung von proliferativen Prozessen in Säugetierzellen
MY101940A (en)	1992-02-15	Chemical compounds
IE780145L (en)	1978-07-27	Meta-sulphonamido-benzamides
DK400781A (da)	1982-03-11	Fremgangsmaade til fremstilling af 2-(1,4-benzodioxan-2-ylalkyl) imidazoler
DE3572808D1 (en)	1989-10-12	4-(nitrophenyl)-tetrahydropyridines, process for their preparation and their application as pharmaceutical compounds
ES8106725A1 (es)	1981-09-16	Procedimiento de preparar derivados 1,2,4-oxadiazolin-5-oni-cos
AU557772B2 (en)	1987-01-08	I-furyl-3,4-dihydroisoquinolines
NO844780L (no)	1985-06-04	Analogifremgangsmaate for fremstilling av terapeutisk aktive indolderivater
ES8500923A1 (es)	1984-11-01	Procedimiento para la preparacion de derivados de acido fenilacetico
ES8105004A1 (es)	1981-06-01	Procedimiento de preparar compuestos pirimidinicos condensa-dos con cabeza de puente de nitrogeno
IE832769L (en)	1984-05-26	Acridanone derivative.
NO165022C (no)	1990-12-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive triazol- og imidazolderivater.