NO170806C - Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinoxalinforbindelser - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinoxalinforbindelser

Info

Publication number: NO170806C
Authority: NO; Norway
Prior art keywords: compounds; imidazokinoxal; preparation; therapeutic active; analogy procedure
Prior art date: 1988-06-14

Application number

NO892456A

Other languages

English (en)

Norwegian (no)

Other versions

NO892456D0 (no

NO892456L (no

NO170806B (no

Inventor

Holger Claus Hansen

Frank Waetjen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-14

Filing date

1989-06-13

Publication date

1992-12-09

1989-06-13 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1989-06-13 Publication of NO892456D0 publication Critical patent/NO892456D0/no

1989-12-15 Publication of NO892456L publication Critical patent/NO892456L/no

1992-08-31 Publication of NO170806B publication Critical patent/NO170806B/no

1992-12-09 Publication of NO170806C publication Critical patent/NO170806C/no

Links

150000001875 compounds Chemical class 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
YELMWJNXDALKFE-UHFFFAOYSA-N 3h-imidazo[4,5-f]quinoxaline Chemical class N1=CC=NC2=C(NC=N3)C3=CC=C21 YELMWJNXDALKFE-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
229940125681 anticonvulsant agent Drugs 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
229940005530 anxiolytics Drugs 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
230000003920 cognitive function Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
239000003326 hypnotic agent Substances 0.000 abstract 1
230000000147 hypnotic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)

NO892456A 1988-06-14 1989-06-13 Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinoxalinforbindelser NO170806C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK322088A DK161148C (da)	1988-06-14	1988-06-14	Imidazoquinoxalinforbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeprater indeholdende forbindelserne

Publications (4)

Publication Number	Publication Date
NO892456D0 NO892456D0 (no)	1989-06-13
NO892456L NO892456L (no)	1989-12-15
NO170806B NO170806B (no)	1992-08-31
NO170806C true NO170806C (no)	1992-12-09

Family

ID=8120424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO892456A NO170806C (no)	1988-06-14	1989-06-13	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinoxalinforbindelser

Country Status (18)

Country	Link
US (1)	US5034530A (da)
EP (1)	EP0347094B1 (da)
JP (1)	JPH0236184A (da)
KR (1)	KR910000665A (da)
AT (1)	ATE111100T1 (da)
AU (1)	AU618366B2 (da)
CA (1)	CA1327798C (da)
DE (1)	DE68918003T2 (da)
DK (1)	DK161148C (da)
ES (1)	ES2060769T3 (da)
FI (1)	FI92204C (da)
IE (1)	IE69963B1 (da)
IL (1)	IL90543A0 (da)
NO (1)	NO170806C (da)
NZ (1)	NZ229499A (da)
PH (1)	PH26337A (da)
PT (1)	PT90865B (da)
ZA (1)	ZA894430B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK160876C (da) *	1987-12-08	1991-10-14	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar
DK151890D0 (da) *	1990-06-22	1990-06-22	Ferrosan As	Heterocykliske forbindelser deres fremstilling og brug
US5276028A (en) *	1990-06-22	1994-01-04	Nordisk A/S	Imidazoquinoxaline compounds
US5371080A (en) *	1990-06-22	1994-12-06	Novo Nordisk A/S	Imidazoquinazoline compounds and their use
US5153196A (en) *	1991-06-05	1992-10-06	Eli Lilly And Company	Excitatory amino acid receptor antagonists and methods for the use thereof
EP0590022A1 (en) *	1991-06-14	1994-04-06	PHARMACIA & UPJOHN COMPANY	IMIDAZO 1,5-a]QUINOXALINES
IL112099A (en) *	1993-12-23	1999-07-14	Ortho Pharma Corp	N-oxides of 4-arylpiperazines and 4-arylpiperidines and pharmaceutical compositions containing them
US6635626B1 (en)	1997-08-25	2003-10-21	Bristol-Myers Squibb Co.	Imidazoquinoxaline protein tyrosine kinase inhibitors
US6235740B1 (en)	1997-08-25	2001-05-22	Bristol-Myers Squibb Co.	Imidazoquinoxaline protein tyrosine kinase inhibitors
DE69940808D1 (de) *	1998-03-04	2009-06-10	Bristol Myers Squibb Co	Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren
US20040180898A1 (en) *	2003-03-03	2004-09-16	Bang-Chi Chen	Processes for preparing imidazoquinoxalinones, heterocyclic-substituted imidazopyrazinones, imidazoquinoxalines and heterocyclic-substituted imidazopyrazines
EP2227472A1 (en) *	2007-11-30	2010-09-15	Elbion Gmbh	Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10
EP2225248A1 (en)	2007-11-30	2010-09-08	Wyeth LLC	Aryl and heteroaryl fused imidazo[1,5-a]pyrazines as inhibitors of phosphodiesterase 10
TW201111383A (en) *	2009-05-29	2011-04-01	Wyeth Llc	Substituted imidazo[1,5-a]quinoxalines as inhibitors of phosphodiesterase 10

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4440929A (en) *	1981-07-16	1984-04-03	Usv Pharmaceutical Corporation	Imidazoquinoxaline compounds
DK476885D0 (da) *	1985-10-17	1985-10-17	Ferrosan As	Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
ES2019583B3 (es) *	1985-10-19	1991-07-01	Beecham Group Plc	Composicion para el tratamiento de infecciones.
DK155524C (da) *	1987-03-18	1989-09-11	Ferrosan As	Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse

1988
- 1988-06-14 DK DK322088A patent/DK161148C/da not_active IP Right Cessation
1989
- 1989-06-06 IL IL90543A patent/IL90543A0/xx not_active IP Right Cessation
- 1989-06-07 EP EP89305728A patent/EP0347094B1/en not_active Expired - Lifetime
- 1989-06-07 DE DE68918003T patent/DE68918003T2/de not_active Expired - Fee Related
- 1989-06-07 AT AT89305728T patent/ATE111100T1/de not_active IP Right Cessation
- 1989-06-07 ES ES89305728T patent/ES2060769T3/es not_active Expired - Lifetime
- 1989-06-08 PH PH38760A patent/PH26337A/en unknown
- 1989-06-08 US US07/363,585 patent/US5034530A/en not_active Expired - Fee Related
- 1989-06-12 NZ NZ229499A patent/NZ229499A/xx unknown
- 1989-06-12 ZA ZA894430A patent/ZA894430B/xx unknown
- 1989-06-13 IE IE189289A patent/IE69963B1/en not_active IP Right Cessation
- 1989-06-13 CA CA000602682A patent/CA1327798C/en not_active Expired - Fee Related
- 1989-06-13 NO NO892456A patent/NO170806C/no unknown
- 1989-06-13 JP JP1148537A patent/JPH0236184A/ja active Pending
- 1989-06-13 AU AU36244/89A patent/AU618366B2/en not_active Ceased
- 1989-06-14 FI FI892908A patent/FI92204C/fi not_active IP Right Cessation
- 1989-06-14 KR KR1019890008164A patent/KR910000665A/ko not_active Ceased
- 1989-06-14 PT PT90865A patent/PT90865B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH0236184A (ja)	1990-02-06
AU3624489A (en)	1989-12-21
KR910000665A (ko)	1991-01-30
FI92204B (fi)	1994-06-30
PT90865A (pt)	1989-12-29
NO892456D0 (no)	1989-06-13
CA1327798C (en)	1994-03-15
PH26337A (en)	1992-04-29
FI892908L (fi)	1989-12-15
ZA894430B (en)	1990-02-28
DK161148C (da)	1991-11-18
FI92204C (fi)	1994-10-10
AU618366B2 (en)	1991-12-19
FI892908A0 (fi)	1989-06-14
DK322088A (da)	1990-03-27
DE68918003D1 (de)	1994-10-13
IE891892L (en)	1989-12-14
DE68918003T2 (de)	1995-01-05
US5034530A (en)	1991-07-23
DK161148B (da)	1991-06-03
IE69963B1 (en)	1996-10-16
EP0347094A1 (en)	1989-12-20
NO892456L (no)	1989-12-15
IL90543A0 (en)	1990-01-18
NZ229499A (en)	1991-04-26
ES2060769T3 (es)	1994-12-01
PT90865B (pt)	1994-11-30
DK322088D0 (da)	1988-06-14
EP0347094B1 (en)	1994-09-07
NO170806B (no)	1992-08-31
ATE111100T1 (de)	1994-09-15

Publication	Publication Date	Title
NO892456D0 (no)	1989-06-13	Fremgangsmaate for fremstilling av imidazokinoxalinforbindelser.
NO169540C (no)	1992-07-08	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinoxalinforbindelser
NO165840C (no)	1991-04-17	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazo-quinazolinforbindelser.
FI914007A0 (fi)	1991-08-23	4-substituerade dihydropyrido (4,3-d) pyrimidiner som smaertslindrande och lokala inflammationshaemmande medel vid vaord av hudsjukdomar.
NO168646C (no)	1992-03-18	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolthienopyrimidiner
NO180634C (no)	1997-05-21	Analogifremgangsmåte for fremstilling av terapeutisk aktive imidazoquinoksalinforbindelser