NO171505C - Fremgangsmaate for syntese av amikacin - Google Patents

Fremgangsmaate for syntese av amikacin

Info

Publication number: NO171505C
Authority: NO; Norway
Prior art keywords: synthesis; amikacin; procedure; derivative; economicity
Prior art date: 1987-11-27

Application number

NO885270A

Other languages

English (en)

Norwegian (no)

Other versions

NO885270L (no

NO885270D0 (no

NO171505B (no

Inventor

Alberto Mangia

Original Assignee

Pierrel Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-27

Filing date

1988-11-25

Publication date

1993-03-24

1988-11-25 Application filed by Pierrel Spa filed Critical Pierrel Spa

1988-11-25 Publication of NO885270D0 publication Critical patent/NO885270D0/no

1989-05-29 Publication of NO885270L publication Critical patent/NO885270L/no

1992-12-14 Publication of NO171505B publication Critical patent/NO171505B/no

1993-03-24 Publication of NO171505C publication Critical patent/NO171505C/no

Links

230000015572 biosynthetic process Effects 0.000 title abstract 3
238000003786 synthesis reaction Methods 0.000 title abstract 3
229960004821 amikacin Drugs 0.000 title abstract 2
LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
IVUOMFWNDGNLBJ-VKHMYHEASA-N (2s)-4-amino-2-hydroxybutanoic acid Chemical class NCC[C@H](O)C(O)=O IVUOMFWNDGNLBJ-VKHMYHEASA-N 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
239000007810 chemical reaction solvent Substances 0.000 abstract 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical class O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Insulating Materials (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polymerisation Methods In General (AREA)
Quinoline Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Financial Or Insurance-Related Operations Such As Payment And Settlement (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)

NO885270A 1987-11-27 1988-11-25 Fremgangsmaate for syntese av amikacin NO171505C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8722783A IT1225484B (it)	1987-11-27	1987-11-27	Procedimento di sintesi dell'amikacina

Publications (4)

Publication Number	Publication Date
NO885270D0 NO885270D0 (no)	1988-11-25
NO885270L NO885270L (no)	1989-05-29
NO171505B NO171505B (no)	1992-12-14
NO171505C true NO171505C (no)	1993-03-24

Family

ID=11200418

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO885270A NO171505C (no)	1987-11-27	1988-11-25	Fremgangsmaate for syntese av amikacin

Country Status (23)

Country	Link
US (1)	US5763587A (cs)
EP (1)	EP0317970B1 (cs)
JP (1)	JPH0637512B2 (cs)
AT (1)	ATE125544T1 (cs)
AU (1)	AU608665B2 (cs)
BG (1)	BG49048A3 (cs)
CA (1)	CA1324375C (cs)
CS (1)	CS277017B6 (cs)
DD (1)	DD283564A5 (cs)
DE (1)	DE3854225T2 (cs)
DK (1)	DK170050B1 (cs)
ES (1)	ES2074431T3 (cs)
FI (1)	FI90243C (cs)
HU (1)	HU201771B (cs)
IT (1)	IT1225484B (cs)
NO (1)	NO171505C (cs)
NZ (1)	NZ227113A (cs)
PH (1)	PH25818A (cs)
PL (1)	PL161416B1 (cs)
RO (1)	RO102339B1 (cs)
RU (1)	RU1776262C (cs)
YU (1)	YU47063B (cs)
ZA (1)	ZA888855B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW465235B (en)	1998-09-17	2001-11-21	United Video Properties Inc	Electronic program guide with digital storage
US7794713B2 (en)	2004-04-07	2010-09-14	Lpath, Inc.	Compositions and methods for the treatment and prevention of hyperproliferative diseases
AU2006297289B2 (en)	2005-09-29	2013-03-21	Novartis Ag	Antibiotic formulations, unit doses, kits, and methods
AU2006320374B2 (en)	2005-12-02	2012-08-30	Isis Pharmaceuticals, Inc.	Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
US7862812B2 (en)	2006-05-31	2011-01-04	Lpath, Inc.	Methods for decreasing immune response and treating immune conditions
CA2684957A1 (en) *	2007-04-10	2008-10-16	Achaogen Inc.	Antibacterial 1,4,5-substituted aminoglycoside analogs
WO2010030704A2 (en)	2008-09-10	2010-03-18	Achaogen, Inc.	Antibacterial aminoglycoside analogs
WO2010030690A1 (en)	2008-09-10	2010-03-18	Isis Pharmaceuticals, Inc.	Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
US8791245B2 (en) *	2008-10-03	2014-07-29	Glycan Bioscience LLC	Anionic conjugates of glycosylated bacterial metabolite
WO2010042850A1 (en)	2008-10-09	2010-04-15	Achaogen, Inc.	Antibacterial aminoglycoside analogs
WO2010042851A1 (en)	2008-10-09	2010-04-15	Achaogen, Inc.	Antibacterial aminoglycoside analogs
CA2777107A1 (en)	2009-10-09	2011-04-14	Achaogen, Inc.	Antibacterial aminoglycoside analogs
CN103282370A (zh)	2010-11-17	2013-09-04	尔察祯有限公司	抗菌氨基糖苷类类似物
CN103113429B (zh) *	2013-03-05	2015-02-18	齐鲁天和惠世制药有限公司	一种由阿米卡星制备硫酸阿米卡星的方法
CN105440090B (zh) *	2014-08-27	2018-03-09	北大医药重庆大新药业股份有限公司	一种阿米卡星的合成方法
CN111233952A (zh) *	2020-04-02	2020-06-05	管炫棣	一种阿卡米星的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI60217C (fi) *	1973-11-14	1981-12-10	Bristol Myers Co	Foerfarande foer framstaellning av 1-(l-(-)-ny-amino-alfa-hydroxibutyryl)kanamycin a
JPS51127045A (en) *	1975-04-24	1976-11-05	Microbial Chem Res Found	A process for preparing 3'- deoxykanamycin a derivatives.
GB1530201A (en) *	1976-04-14	1978-10-25	Pfizer Ltd	Process for the preparation of aminoglycoside antibiotics and intermediates therefor
US4136254A (en) *	1976-06-17	1979-01-23	Schering Corporation	Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
IE54288B1 (en) *	1982-03-05	1989-08-16	Fujisawa Pharmaceutical Co	New 1,4-diaminocyclitol derivatives, processes for their preparation and pharmaceutical compositions containing them
JPS6041692A (ja) *	1983-08-15	1985-03-05	Microbial Chem Res Found	２′，３′−ジデオキシカナマイシンａ誘導体
IT1200774B (it) *	1985-10-10	1989-01-27	Pierrel Spa	Procedimento di sentisi dell'amikacina

1987
- 1987-11-27 IT IT8722783A patent/IT1225484B/it active
1988
- 1988-11-23 AT AT88119460T patent/ATE125544T1/de not_active IP Right Cessation
- 1988-11-23 EP EP88119460A patent/EP0317970B1/en not_active Expired - Lifetime
- 1988-11-23 ES ES88119460T patent/ES2074431T3/es not_active Expired - Lifetime
- 1988-11-23 DE DE3854225T patent/DE3854225T2/de not_active Expired - Fee Related
- 1988-11-25 DK DK661588A patent/DK170050B1/da not_active IP Right Cessation
- 1988-11-25 RU SU884356995A patent/RU1776262C/ru active
- 1988-11-25 CS CS887779A patent/CS277017B6/cs unknown
- 1988-11-25 DD DD88322213A patent/DD283564A5/de not_active IP Right Cessation
- 1988-11-25 NO NO885270A patent/NO171505C/no unknown
- 1988-11-25 HU HU886072A patent/HU201771B/hu not_active IP Right Cessation
- 1988-11-25 PH PH37859A patent/PH25818A/en unknown
- 1988-11-25 FI FI885489A patent/FI90243C/fi not_active IP Right Cessation
- 1988-11-25 ZA ZA888855A patent/ZA888855B/xx unknown
- 1988-11-25 BG BG086218A patent/BG49048A3/xx unknown
- 1988-11-25 CA CA000584227A patent/CA1324375C/en not_active Expired - Fee Related
- 1988-11-26 JP JP63299382A patent/JPH0637512B2/ja not_active Expired - Lifetime
- 1988-11-28 YU YU218888A patent/YU47063B/sh unknown
- 1988-11-28 PL PL1988276047A patent/PL161416B1/pl unknown
- 1988-11-28 NZ NZ227113A patent/NZ227113A/en unknown
- 1988-11-28 RO RO88136098A patent/RO102339B1/ro unknown
- 1988-11-28 AU AU25963/88A patent/AU608665B2/en not_active Ceased
1992
- 1992-02-14 US US07/834,991 patent/US5763587A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2596388A (en)	1989-06-01
CA1324375C (en)	1993-11-16
NO885270L (no)	1989-05-29
FI885489A0 (fi)	1988-11-25
CS777988A3 (en)	1992-06-17
YU47063B (sh)	1994-12-28
DK661588A (da)	1989-05-28
DK661588D0 (da)	1988-11-25
DE3854225T2 (de)	1996-01-04
FI90243C (fi)	1994-01-10
EP0317970A3 (en)	1991-08-28
JPH0637512B2 (ja)	1994-05-18
PL276047A1 (en)	1989-07-10
DK170050B1 (da)	1995-05-08
FI885489L (fi)	1989-05-28
NZ227113A (en)	1991-01-29
NO885270D0 (no)	1988-11-25
AU608665B2 (en)	1991-04-11
IT8722783A0 (it)	1987-11-27
BG49048A3 (en)	1991-07-15
ATE125544T1 (de)	1995-08-15
HU201771B (en)	1990-12-28
NO171505B (no)	1992-12-14
DD283564A5 (de)	1990-10-17
EP0317970A2 (en)	1989-05-31
JPH01186900A (ja)	1989-07-26
ZA888855B (en)	1990-02-28
EP0317970B1 (en)	1995-07-26
IT1225484B (it)	1990-11-14
DE3854225D1 (de)	1995-08-31
ES2074431T3 (es)	1995-09-16
RO102339B1 (ro)	1992-08-01
CS277017B6 (en)	1992-11-18
YU218888A (en)	1989-12-31
FI90243B (fi)	1993-09-30
US5763587A (en)	1998-06-09
PH25818A (en)	1991-11-05
RU1776262C (ru)	1992-11-15
HUT49144A (en)	1989-08-28
PL161416B1 (pl)	1993-06-30

Publication	Publication Date	Title
NO885270L (no)	1989-05-29	Fremgangsmaate for syntese av amikacin.
AU589567B2 (en)	1989-10-19	Novel N-hydroxyl protecting groups and process for the preparation of 3-acylamino-1-hydroxy-2-azetidinones
JPS6466189A (en)	1989-03-13	Production of penicillanic acid derivative
AU3802089A (en)	1990-04-26	Process for the production of o2,2' -anhydro-1-(beta-d- arabinofuranosyl)thymine
DE3268129D1 (en)	1986-02-06	A method for the production of nuclear substituted cinnamoylanthranilic acid derivatives and intermediates thereof
ES8304971A1 (es)	1983-03-16	Un procedimiento para la preparacion de derivados de tiocarbapenem 3-sustituidos.
AU540377B2 (en)	1984-11-15	Preparation of 7-acyl-amino-3-(thio-substituted)methyl- 3-cephem-4-carboxylic acid 1-oxide derivatives
CA1273347C (cs)	1990-08-28
GR3004216T3 (cs)	1993-03-31
JPS55151547A (en)	1980-11-26	Production of guanidinocapronic ester
SG43092A1 (en)	1997-10-17	Process for preparing 5-arylhydantoin
SU1767835A1 (ru)	1996-02-27	Способ получения 1,6-диарил-3,4-дигидрокси-2,4-гексалиен-1,6-дионов
DK33187A (da)	1987-07-24	Bicycliske forbindelser
JPS6438041A (en)	1989-02-08	Production of 2-phenacyl-1,3-indanediones
ES2007387A6 (es)	1989-06-16	Procedimiento para la obtencion de un derivado del acido cromoglicico
JPS54157593A (en)	1979-12-12	Preparation of high-purity 6-acylaminoacylamido penicillanic acid
JPS6445376A (en)	1989-02-17	Production of 1,5-benzothiazepine derivative
JPS56113784A (en)	1981-09-07	2-azaerythrinan derivative
JPS5695158A (en)	1981-08-01	Preparation of n-carbamoyl-p-hydroxyphenylglycine