NO171857C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 2'-halomethyliden-adenosin-derivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 2'-halomethyliden-adenosin-derivater

Info

Publication number
NO171857C
NO171857C NO893826A NO893826A NO171857C NO 171857 C NO171857 C NO 171857C NO 893826 A NO893826 A NO 893826A NO 893826 A NO893826 A NO 893826A NO 171857 C NO171857 C NO 171857C
Authority
NO
Norway
Prior art keywords
halomethylideen
preparation
therapeutic active
adenosine derivatives
analogy procedure
Prior art date
Application number
NO893826A
Other languages
English (en)
Norwegian (no)
Other versions
NO171857B (no
NO893826L (no
NO893826D0 (no
Inventor
James R Mccarthy
Michael L Edwards
David M Stemerick
Esa T Jarvi
Nellikunja J Prakash
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO893826D0 publication Critical patent/NO893826D0/no
Publication of NO893826L publication Critical patent/NO893826L/no
Publication of NO171857B publication Critical patent/NO171857B/no
Publication of NO171857C publication Critical patent/NO171857C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO893826A 1988-09-27 1989-09-26 Analogifremgangsmaate for fremstilling av terapeutisk aktive 2'-halomethyliden-adenosin-derivater NO171857C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24991188A 1988-09-27 1988-09-27
US38939189A 1989-08-03 1989-08-03

Publications (4)

Publication Number Publication Date
NO893826D0 NO893826D0 (no) 1989-09-26
NO893826L NO893826L (no) 1990-03-28
NO171857B NO171857B (no) 1993-02-01
NO171857C true NO171857C (no) 1993-05-12

Family

ID=26940460

Family Applications (1)

Application Number Title Priority Date Filing Date
NO893826A NO171857C (no) 1988-09-27 1989-09-26 Analogifremgangsmaate for fremstilling av terapeutisk aktive 2'-halomethyliden-adenosin-derivater

Country Status (18)

Country Link
EP (1) EP0365849B1 (da)
JP (1) JP2968002B2 (da)
KR (1) KR0146333B1 (da)
CN (1) CN1046334A (da)
AR (1) AR248283A1 (da)
AT (1) ATE111477T1 (da)
AU (1) AU621664B2 (da)
CA (1) CA1336903C (da)
DE (1) DE68918215T2 (da)
DK (1) DK171237B1 (da)
ES (1) ES2063796T3 (da)
FI (1) FI94763C (da)
HU (1) HU204843B (da)
IE (1) IE63561B1 (da)
IL (1) IL91773A (da)
NO (1) NO171857C (da)
NZ (1) NZ230766A (da)
PT (1) PT91803B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
US5340816A (en) * 1990-10-18 1994-08-23 E. R. Squibb & Sons, Inc. Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
CA2133961C (en) * 1992-05-12 1998-03-31 James R. Mccarthy A process for the preparation of ribonucleotide reductase inhibitors
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
US5811408A (en) * 1994-07-12 1998-09-22 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
WO2000074686A1 (en) * 1999-06-09 2000-12-14 Anticancer, Inc. Modulators of methylation for control of bacterial virulence
US6579857B1 (en) 1999-06-11 2003-06-17 Evanston Northwestern Healthcare Research Institute Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
KR20040094692A (ko) * 2002-02-14 2004-11-10 파마셋, 리미티드 변형된 불소화 뉴클레오사이드 유사체
UA117095C2 (uk) 2011-12-22 2018-06-25 Аліос Біофарма, Інк. Нуклеозидна сполука або її фармацевтично прийнятна сіль
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84414A0 (en) * 1986-11-14 1988-04-29 Ciba Geigy Ag N9-cyclopentyl-substituted adenine derivatives
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도
NZ225906A (en) * 1987-08-26 1990-10-26 Merrell Dow Pharma Aristeromycin/adenosine derivatives and pharmaceutical compositions
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives

Also Published As

Publication number Publication date
FI894546A7 (fi) 1990-03-28
FI894546A0 (fi) 1989-09-26
KR900004736A (ko) 1990-04-12
IE63561B1 (en) 1995-05-17
PT91803A (pt) 1990-03-30
EP0365849B1 (en) 1994-09-14
IL91773A0 (en) 1990-06-10
NZ230766A (en) 1992-07-28
IL91773A (en) 1994-02-27
KR0146333B1 (ko) 1998-08-01
NO171857B (no) 1993-02-01
HUT50844A (en) 1990-03-28
CN1046334A (zh) 1990-10-24
EP0365849A3 (en) 1990-12-27
JP2968002B2 (ja) 1999-10-25
IE893080L (en) 1990-03-27
FI94763B (fi) 1995-07-14
DK171237B1 (da) 1996-08-05
DK473289A (da) 1990-03-28
CA1336903C (en) 1995-09-05
DK473289D0 (da) 1989-09-26
AU4176089A (en) 1990-04-05
NO893826L (no) 1990-03-28
NO893826D0 (no) 1989-09-26
DE68918215T2 (de) 1995-02-02
FI94763C (fi) 1995-10-25
DE68918215D1 (de) 1994-10-20
HU204843B (en) 1992-02-28
PT91803B (pt) 1995-05-31
AU621664B2 (en) 1992-03-19
EP0365849A2 (en) 1990-05-02
AR248283A1 (es) 1995-07-12
ES2063796T3 (es) 1995-01-16
ATE111477T1 (de) 1994-09-15
JPH02160769A (ja) 1990-06-20

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