NO172168C - Fremgangsmaate for fremstilling av faste nifedipinpreparater med hoey biotilgjengelighet og med forlenget virkning - Google Patents

Fremgangsmaate for fremstilling av faste nifedipinpreparater med hoey biotilgjengelighet og med forlenget virkning

Info

Publication number: NO172168C
Authority: NO; Norway
Prior art keywords: polyethylene glycol; active substance; solution; micronized; bios
Prior art date: 1985-10-15

Application number

NO864060A

Other languages

English (en)

Norwegian (no)

Other versions

NO864060D0 (no

NO172168B (no

NO864060L (no

Inventor

Massimo Calanchi

Piergiorgio Rossi

Original Assignee

Eurand Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-15

Filing date

1986-10-13

Publication date

1993-06-16

1986-10-13 Application filed by Eurand Int filed Critical Eurand Int

1986-10-13 Publication of NO864060D0 publication Critical patent/NO864060D0/no

1987-04-21 Publication of NO864060L publication Critical patent/NO864060L/no

1993-03-08 Publication of NO172168B publication Critical patent/NO172168B/no

1993-06-16 Publication of NO172168C publication Critical patent/NO172168C/no

Links

HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 title abstract 3
229960001597 nifedipine Drugs 0.000 title abstract 3
239000007787 solid Substances 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 2
239000002202 Polyethylene glycol Substances 0.000 abstract 4
239000013543 active substance Substances 0.000 abstract 4
239000000203 mixture Substances 0.000 abstract 4
229920001223 polyethylene glycol Polymers 0.000 abstract 4
239000000546 pharmaceutical excipient Substances 0.000 abstract 3
239000010419 fine particle Substances 0.000 abstract 2
238000009472 formulation Methods 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
238000001704 evaporation Methods 0.000 abstract 1
235000011389 fruit/vegetable juice Nutrition 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
238000002156 mixing Methods 0.000 abstract 1
239000002244 precipitate Substances 0.000 abstract 1
238000000935 solvent evaporation Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Hydrogenated Pyridines (AREA)
Heat Treatment Of Sheet Steel (AREA)
Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)

NO864060A 1985-10-15 1986-10-13 Fremgangsmaate for fremstilling av faste nifedipinpreparater med hoey biotilgjengelighet og med forlenget virkning NO172168C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT22494/85A IT1187751B (it)	1985-10-15	1985-10-15	Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute

Publications (4)

Publication Number	Publication Date
NO864060D0 NO864060D0 (no)	1986-10-13
NO864060L NO864060L (no)	1987-04-21
NO172168B NO172168B (no)	1993-03-08
NO172168C true NO172168C (no)	1993-06-16

Family

ID=11197023

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO864060A NO172168C (no)	1985-10-15	1986-10-13	Fremgangsmaate for fremstilling av faste nifedipinpreparater med hoey biotilgjengelighet og med forlenget virkning

Country Status (18)

Country	Link
US (1)	US4880623A (fr)
EP (1)	EP0220760B1 (fr)
JP (1)	JPH0811731B2 (fr)
KR (1)	KR940006320B1 (fr)
AT (1)	ATE66367T1 (fr)
AU (1)	AU590622B2 (fr)
CA (1)	CA1280976C (fr)
DE (1)	DE3680989D1 (fr)
DK (1)	DK168691B1 (fr)
ES (1)	ES2040209T3 (fr)
FI (1)	FI87424C (fr)
GR (1)	GR3003150T3 (fr)
HK (1)	HK12595A (fr)
IT (1)	IT1187751B (fr)
NO (1)	NO172168C (fr)
NZ (1)	NZ217841A (fr)
PT (1)	PT83522B (fr)
ZA (1)	ZA867767B (fr)

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GB9025251D0 (en) *	1990-11-20	1991-01-02	Solomon Montague C	Nifedipine dosage forms
US5145859A (en) *	1991-03-20	1992-09-08	Case Western Reserve University	Methods of treating interstitial cystitis and urethral syndrome
US5271944A (en) *	1991-04-05	1993-12-21	Biofor, Ltd.	Pharmacologically enhanced formulations
US5302397A (en) *	1991-11-19	1994-04-12	Amsden Brian G	Polymer-based drug delivery system
EP0557244B1 (fr) *	1992-02-17	1996-03-13	Siegfried Pharma AG	Applications de l'efficacité à longue spectre
IL104192A (en) *	1992-02-17	1998-01-04	Siegfried Ag Pharma	Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient
WO1994005262A1 (fr) *	1992-09-10	1994-03-17	F.H. Faulding & Co. Limited	Composition sous forme de matrice a liberation prolongee
US5455046A (en) *	1993-09-09	1995-10-03	Edward Mendell Co., Inc.	Sustained release heterodisperse hydrogel systems for insoluble drugs
US6726930B1 (en) *	1993-09-09	2004-04-27	Penwest Pharmaceuticals Co.	Sustained release heterodisperse hydrogel systems for insoluble drugs
US5773025A (en) *	1993-09-09	1998-06-30	Edward Mendell Co., Inc.	Sustained release heterodisperse hydrogel systems--amorphous drugs
US5543099A (en) *	1994-09-29	1996-08-06	Hallmark Pharmaceutical, Inc.	Process to manufacture micronized nifedipine granules for sustained release medicaments
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IL123505A (en)	1996-07-08	2004-12-15	Penwest Pharmaceuticals Compan	Sustained release matrix for high-dose insoluble drugs
IT1284604B1 (it) *	1996-09-27	1998-05-21	Roberto Valducci	Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva
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US5837379A (en) *	1997-01-31	1998-11-17	Andrx Pharmaceuticals, Inc.	Once daily pharmaceutical tablet having a unitary core
US6056977A (en)	1997-10-15	2000-05-02	Edward Mendell Co., Inc.	Once-a-day controlled release sulfonylurea formulation
US6485748B1 (en)	1997-12-12	2002-11-26	Andrx Pharmaceuticals, Inc.	Once daily pharmaceutical tablet having a unitary core
US8236352B2 (en)	1998-10-01	2012-08-07	Alkermes Pharma Ireland Limited	Glipizide compositions
US8293277B2 (en)	1998-10-01	2012-10-23	Alkermes Pharma Ireland Limited	Controlled-release nanoparticulate compositions
US7521068B2 (en)	1998-11-12	2009-04-21	Elan Pharma International Ltd.	Dry powder aerosols of nanoparticulate drugs
ES2304980T3 (es) *	1999-09-30	2008-11-01	Penwest Pharmaceuticals Co.	Sistemas de matriz de liberacion sostenida para farmacos altamente solubles.
GEP20053427B (en)	1999-12-23	2005-01-25	Pfizer Prod Inc	Pharmaceutical Compositions Providing Enhanced Drug Concentrations
IL134701A0 (en) *	2000-02-23	2001-04-30	J P M E D Ltd	Homogeneous solid matrix containing vegetable proteins
US7198795B2 (en)	2000-09-21	2007-04-03	Elan Pharma International Ltd.	In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions
AU2002309172A1 (en) *	2001-06-22	2003-01-08	Pfizer Products Inc.	Pharmaceutical compositions containing polymer and drug assemblies
EP1269994A3 (fr) *	2001-06-22	2003-02-12	Pfizer Products Inc.	Compositions Pharmaceutiques comprenant un médicament et un polymère permettant d'améliorer la concentration du médicament
DE10142417A1 (de) *	2001-08-31	2003-03-20	Molecular And Clinical Drug Re	Arzneimittel
DE10142416A1 (de) *	2001-08-31	2003-03-20	Molecular And Clinical Drug Re	Verfahren zur Herstellung von Lösungen
WO2003033462A2 (fr) *	2001-10-15	2003-04-24	The Regents Of The University Of Michigan	Systemes et procedes de fabrication de polymorphes cristallins
GB0205253D0 (en) *	2002-03-06	2002-04-17	Univ Gent	Immediate release pharmaceutical granule compositions and a continuous process for making them
US20040048931A1 (en) *	2002-07-12	2004-03-11	Craig Heacock	Modafinil pharmaceutical compositions
RU2219927C1 (ru) *	2002-11-21	2003-12-27	Азад Зияд Оглы Абышев	Анкардин-retard - средство пролонгированного антикальциевого действия
US7244865B2 (en) *	2003-02-24	2007-07-17	Mallinckrodt Inc.	Process for preparing benzhydrylthioacetamide
EP1511470A2 (fr) *	2003-03-26	2005-03-09	Teva Pharmaceutical Industries Ltd.	Procede de preparation d'un principe actif pharmaceutique a aire de surface specifique elevee
US20040253308A1 (en) *	2003-04-29	2004-12-16	Barr Laboratories, Inc.	Surface-treated modafinil particles
RU2255728C1 (ru) *	2004-03-04	2005-07-10	Азад Зияд Оглы Абышев	Средство пролонгированного антикальциевого действия в виде 0,1% раствора для внутривенного введения
EP2562168B1 (fr) *	2006-02-28	2014-04-16	Dart Neuroscience (Cayman) Ltd	Pipérazines thérapeutiques en tant qu'inhibiteurs de PDE4
US20080181966A1 (en) *	2006-10-18	2008-07-31	Cephalon, Inc.	Modafinil pharmaceutical compositions
JP2010524919A (ja) *	2007-04-23	2010-07-22	サン、ファーマスーティカル、インダストリーズ、リミテッド	医薬組成物
RU2629843C1 (ru) *	2016-05-24	2017-09-04	федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет)	Способ получения мази нифедипина (варианты)

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IT629516A (fr) *	1959-04-30
US3988439A (en) *	1973-11-05	1976-10-26	Eli Lilly And Company	Dibenzo[b,d]pyranone dispersions
US3920809A (en) *	1973-11-05	1975-11-18	Lilly Co Eli	Dibenzo(b,d)pyranone dispersions
DE2400819C2 (de) *	1974-01-09	1982-04-22	Bayer Ag, 5090 Leverkusen	Verfahren zur Herstellung fester Zubereitungen von schwerlöslichen Arzneimittelwirkstoffen in feinster Verteilung
US4151273A (en) *	1974-10-31	1979-04-24	The Regents Of The University Of California	Increasing the absorption rate of insoluble drugs
GB1579818A (en) *	1977-06-07	1980-11-26	Yamanouchi Pharma Co Ltd	Nifedipine-containing solid preparation composition
EP0001247A1 (fr) *	1977-09-14	1979-04-04	Kanebo, Ltd.	Composition pharmaceutique contenant de la nifédipine et procédé pour sa préparation.
JPS55129221A (en) *	1979-03-29	1980-10-06	Kaken Pharmaceut Co Ltd	Preparation of oral preparation containing hardly soluble medicine
CA1146866A (fr) *	1979-07-05	1983-05-24	Yamanouchi Pharmaceutical Co. Ltd.	Procede de production d'un compose pharmaceutique a liberation continue sous forme solide
US4311694A (en) *	1979-12-31	1982-01-19	American Cyanamid Company	Amorphous coprecipitates of 4-(monoalkylamino) benzoic acid and derivatives and certain water-soluble materials
DE3033919A1 (de) *	1980-09-09	1982-04-22	Bayer Ag, 5090 Leverkusen	Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung
DE3318649A1 (de) *	1983-05-21	1984-11-22	Bayer Ag, 5090 Leverkusen	Zweiphasenformulierung
NL194389C (nl) *	1984-06-14	2002-03-04	Novartis Ag	Werkwijze voor het bereiden van een vaste dispersie van een farmaceutisch actief middel dat een lage oplosbaarheid in water heeft, in een vaste matrix van een in water oplosbaar polyalkyleenglycol als drager.
IT1178511B (it) *	1984-09-14	1987-09-09	Pharmatec Spa	Procedimento per la preparazione di una forma solida per uso orale a base di nifedipina con rilascio
DE3438830A1 (de) *	1984-10-23	1986-04-30	Rentschler Arzneimittel	Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung

1985
- 1985-10-15 IT IT22494/85A patent/IT1187751B/it active
1986
- 1986-10-02 ES ES198686201704T patent/ES2040209T3/es not_active Expired - Lifetime
- 1986-10-02 DE DE8686201704T patent/DE3680989D1/de not_active Expired - Lifetime
- 1986-10-02 AT AT86201704T patent/ATE66367T1/de not_active IP Right Cessation
- 1986-10-02 EP EP86201704A patent/EP0220760B1/fr not_active Expired - Lifetime
- 1986-10-07 NZ NZ217841A patent/NZ217841A/en unknown
- 1986-10-08 DK DK481186A patent/DK168691B1/da active
- 1986-10-10 PT PT83522A patent/PT83522B/pt not_active IP Right Cessation
- 1986-10-13 AU AU63832/86A patent/AU590622B2/en not_active Ceased
- 1986-10-13 NO NO864060A patent/NO172168C/no unknown
- 1986-10-14 FI FI864151A patent/FI87424C/fi not_active IP Right Cessation
- 1986-10-14 CA CA000520378A patent/CA1280976C/fr not_active Expired - Lifetime
- 1986-10-14 US US06/918,382 patent/US4880623A/en not_active Expired - Fee Related
- 1986-10-14 ZA ZA867767A patent/ZA867767B/xx unknown
- 1986-10-14 JP JP61242180A patent/JPH0811731B2/ja not_active Expired - Lifetime
- 1986-10-15 KR KR1019860008647A patent/KR940006320B1/ko not_active Expired - Fee Related
1991
- 1991-11-19 GR GR91401773T patent/GR3003150T3/el unknown
1995
- 1995-01-26 HK HK12595A patent/HK12595A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA867767B (en)	1987-06-24
GR3003150T3 (en)	1993-02-17
IT1187751B (it)	1987-12-23
DK481186D0 (da)	1986-10-08
US4880623A (en)	1989-11-14
DK168691B1 (da)	1994-05-24
HK12595A (en)	1995-02-03
KR870003779A (ko)	1987-05-04
AU6383286A (en)	1987-04-16
DE3680989D1 (de)	1991-09-26
ES2040209T3 (es)	1993-10-16
KR940006320B1 (ko)	1994-07-16
NO864060D0 (no)	1986-10-13
FI864151A0 (fi)	1986-10-14
NO172168B (no)	1993-03-08
FI87424B (fi)	1992-09-30
EP0220760A3 (en)	1987-09-23
CA1280976C (fr)	1991-03-05
PT83522A (en)	1986-11-01
NO864060L (no)	1987-04-21
ATE66367T1 (de)	1991-09-15
FI864151A7 (fi)	1987-04-16
PT83522B (pt)	1988-11-30
FI87424C (fi)	1993-01-11
NZ217841A (en)	1990-01-29
JPH0811731B2 (ja)	1996-02-07
EP0220760B1 (fr)	1991-08-21
IT8522494A0 (it)	1985-10-15
EP0220760A2 (fr)	1987-05-06
JPS62167727A (ja)	1987-07-24
AU590622B2 (en)	1989-11-09
DK481186A (da)	1987-04-16

Publication	Publication Date	Title
NO864060L (no)	1987-04-21	Fremgangsmaate for fremstilling av faste nifedipinpreparater med hoey biotilgjengelighet og med forlenget virkning.
CA1329543C (fr)	1994-05-17	Formulation a base d'hormone de croissance humaine
JP4615633B2 (ja)	2011-01-19	局所薬剤デリバリのためのゲル調合物
AU685784B2 (en)	1998-01-29	Excipient stabilization of polypeptides treated with organic solvents
CA1069047A (fr)	1980-01-01	Procede de preparation de composes administres par voie orale
DK0503521T3 (da)	1995-11-27	Tørre, farmaceutiske lavdosispræparater
NO863796D0 (no)	1986-09-24	Fremgangsmaate for fremstilling av farmakologiske preparater med forlenget virkningstiden.
Lewis et al.	1965	Alteration of the proteins of the pituitary gland of the rat by estradiol and cortisol
De Smidt et al.	1993	Properties of incorporation, redistribution, and integrity of porphyrin-low-density lipoprotein complexes
CA2171738A1 (fr)	1995-04-06	Busulfan s'administrant par voie parenterale et utilise dans le traitement d'infections malignes
KR101363237B1 (ko)	2014-02-12	증강된 비율의 감마 인터페론 및 알파 인터페론을 포함하는안정화된 제형
CN101229121A (zh)	2008-07-30	喷昔洛韦微乳凝胶制剂及其制备方法
JP2516524B2 (ja)	1996-07-24	持続性製剤
JPH021403A (ja)	1990-01-05	医薬組成物
Shiu et al.	1988	The effect of food on the absorption of controlled-release theophylline in mini-swine
Wisudyaningsih et al.	2022	IAI SPECIAL EDITION: Effect of gelling agent and penetration enhancer on the release rate of ibuprofen-PEG 6000 solid dispersion from gel preparations
Ono et al.	1973	Biochemical studies on the pathogenesis of steroid cataracts, with particular reference to the pituitary-adrenal-liver axis
Kshirsagar et al.	2025	Formulation and Evaluation of Propolis Solid Dispersion Loaded Anti-inflammatory Cream with Molecular Docking and In-Vivo Animal Study
EP3125925A2 (fr)	2017-02-08	Stabilisation de facteur viii sans calcium en tant qu'excipient
Sincholle et al.	1985	Corneal penetration and metabolism of the antiherpetic 5-iodo-2′-deoxycytidine
JPH0193527A (ja)	1989-04-12	医薬組成物
CS234469B1 (cs)	1985-04-16	Dermální přípravek s obsahem kyseliny vitaminu A
JPH02196721A (ja)	1990-08-03	抗癌剤
JPS63170317A (ja)	1988-07-14	ニフエジピン経皮吸収外用製剤