NO172240C - Analogifremgangsmaate for fremstilling av terapeutisk aktive nye 2'-halometylidenderivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive nye 2'-halometylidenderivater

Info

Publication number: NO172240C
Authority: NO; Norway
Prior art keywords: halomethylendend; derivatives; preparation; therapeutically active; active new
Prior art date: 1988-11-15

Application number

NO894539A

Other languages

English (en)

Norwegian (no)

Other versions

NO894539L (no

NO172240B (no

NO894539D0 (no

Inventor

James Ray Mccarthy

Michael Louis Edwards

Donald Paul Matthews

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-15

Filing date

1989-11-14

Publication date

1993-06-23

1989-11-14 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-11-14 Publication of NO894539D0 publication Critical patent/NO894539D0/no

1990-05-16 Publication of NO894539L publication Critical patent/NO894539L/no

1993-03-15 Publication of NO172240B publication Critical patent/NO172240B/no

1993-06-23 Publication of NO172240C publication Critical patent/NO172240C/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

NO894539A 1988-11-15 1989-11-14 Analogifremgangsmaate for fremstilling av terapeutisk aktive nye 2'-halometylidenderivater NO172240C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US27147988A	1988-11-15	1988-11-15

Publications (4)

Publication Number	Publication Date
NO894539D0 NO894539D0 (no)	1989-11-14
NO894539L NO894539L (no)	1990-05-16
NO172240B NO172240B (no)	1993-03-15
NO172240C true NO172240C (no)	1993-06-23

Family

ID=23035764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO894539A NO172240C (no)	1988-11-15	1989-11-14	Analogifremgangsmaate for fremstilling av terapeutisk aktive nye 2'-halometylidenderivater

Country Status (19)

Country	Link
EP (1)	EP0372268B1 (de)
JP (1)	JP2802947B2 (de)
KR (1)	KR0144865B1 (de)
CN (1)	CN1022248C (de)
AR (1)	AR247891A1 (de)
AT (1)	ATE105297T1 (de)
AU (1)	AU621160B2 (de)
CA (1)	CA2002648C (de)
DE (1)	DE68915128T2 (de)
DK (1)	DK171844B1 (de)
ES (1)	ES2056180T3 (de)
FI (1)	FI92588C (de)
HU (3)	HU205134B (de)
IE (1)	IE63563B1 (de)
IL (1)	IL92293A (de)
NO (1)	NO172240C (de)
NZ (1)	NZ231365A (de)
PT (1)	PT92309B (de)
ZA (1)	ZA898567B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458772B1 (en)	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
KR910008800B1 (ko) *	1987-03-19	1991-10-21	야마사 쇼오유 가부시끼가이샤	2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도
NZ234534A (en) *	1989-07-17	1994-12-22	Univ Birmingham	Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor
US5521163A (en) *	1990-07-13	1996-05-28	University Of Birmingham	Antiviral pyrimidine nucleosides and methods for using same
FR2668153B1 (fr) *	1990-10-22	1995-03-31	Pasteur Merieux Serums Vacc	Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
WO1993022327A1 (fr) *	1992-04-23	1993-11-11	Yoshitomi Pharmaceutical Industries, Ltd.	Compose de 2'-methylidenenucleoside et utilisation pharmaceutique de ce compose
US5589587A (en) *	1992-05-12	1996-12-31	Merrell Pharmaceuticals Inc.	Process for the preparation of ribonucleotide reductase inhibitors
CA2133961C (en) *	1992-05-12	1998-03-31	James R. Mccarthy	A process for the preparation of ribonucleotide reductase inhibitors
CA2150671C (en) *	1992-12-03	2000-12-26	Sai P. Sunkara	Compositions containing acyclovir-like compounds and 2'-vinyl substituted nucleoside analogs for the treatment of viral infections
JPH09511227A (ja) *	1994-01-07	1997-11-11	メレルファーマスーティカルズインコーポレイテッド	（ｅ）−２’−デオキシ−２’−（フルオロメチレン）シチジンの一水和物
US5627053A (en) *	1994-03-29	1997-05-06	Ribozyme Pharmaceuticals, Inc.	2'deoxy-2'-alkylnucleotide containing nucleic acid
AU2768295A (en) *	1994-07-11	1996-02-09	Hoechst Marion Roussel, Inc.	Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
US5811408A (en) *	1994-07-12	1998-09-22	Yamasa Corporation	2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
JP2005536440A (ja) *	2001-09-28	2005-12-02	イデニクス（ケイマン）リミテツド	４’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物
KR20040094692A (ko) *	2002-02-14	2004-11-10	파마셋, 리미티드	변형된 불소화 뉴클레오사이드 유사체
KR20040036417A (ko) *	2002-10-25	2004-04-30	정낙신	항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
CN100389119C (zh) *	2004-10-27	2008-05-21	北京东华康明生物科技有限公司	（反式）-2-脱氧-2-（氟亚甲基）-4-r酰胞苷化合物及其制备方法
UA117095C2 (uk)	2011-12-22	2018-06-25	Аліос Біофарма, Інк.	Нуклеозидна сполука або її фармацевтично прийнятна сіль
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
CA2891125A1 (en) *	2012-11-19	2014-05-22	Merck Sharp & Dohme Corp.	2 -alkynyl substituted nucleoside derivatives for treating viral diseases
WO2018092107A1 (en) *	2016-11-21	2018-05-24	Munisekhar Medasani	Novel anti-viral and anti-cancer molecule

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR910008800B1 (ko) *	1987-03-19	1991-10-21	야마사 쇼오유 가부시끼가이샤	2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도

1989
- 1989-11-09 CA CA002002648A patent/CA2002648C/en not_active Expired - Lifetime
- 1989-11-09 ZA ZA898567A patent/ZA898567B/xx unknown
- 1989-11-10 AU AU44611/89A patent/AU621160B2/en not_active Ceased
- 1989-11-10 AR AR89315416A patent/AR247891A1/es active
- 1989-11-13 IL IL9229389A patent/IL92293A/en not_active IP Right Cessation
- 1989-11-13 NZ NZ231365A patent/NZ231365A/en unknown
- 1989-11-14 FI FI895417A patent/FI92588C/fi not_active IP Right Cessation
- 1989-11-14 DK DK570089A patent/DK171844B1/da not_active IP Right Cessation
- 1989-11-14 IE IE365189A patent/IE63563B1/en not_active IP Right Cessation
- 1989-11-14 NO NO894539A patent/NO172240C/no not_active IP Right Cessation
- 1989-11-14 HU HU895900A patent/HU205134B/hu not_active IP Right Cessation
- 1989-11-14 PT PT92309A patent/PT92309B/pt not_active IP Right Cessation
- 1989-11-14 KR KR1019890016636A patent/KR0144865B1/ko not_active Expired - Fee Related
- 1989-11-15 CN CN89108557A patent/CN1022248C/zh not_active Expired - Fee Related
- 1989-11-15 DE DE68915128T patent/DE68915128T2/de not_active Expired - Fee Related
- 1989-11-15 JP JP1297225A patent/JP2802947B2/ja not_active Expired - Fee Related
- 1989-11-15 EP EP89121139A patent/EP0372268B1/de not_active Expired - Lifetime
- 1989-11-15 ES ES89121139T patent/ES2056180T3/es not_active Expired - Lifetime
- 1989-11-15 AT AT8989121139T patent/ATE105297T1/de not_active IP Right Cessation
1994
- 1994-11-14 HU HU94P/P00045P patent/HU210343A9/hu unknown
- 1994-11-14 HU HU94P/P00045P patent/HU00045A9/hu unknown

Also Published As

Publication number	Publication date
DE68915128D1 (de)	1994-06-09
FI92588C (fi)	1994-12-12
CN1042715A (zh)	1990-06-06
HU00045A9 (en)	1995-01-30
DK171844B1 (da)	1997-06-30
NO894539L (no)	1990-05-16
HU210343A9 (en)	1995-03-28
DK570089A (da)	1990-05-16
IL92293A (en)	1995-01-24
AR247891A1 (es)	1995-04-28
NO172240B (no)	1993-03-15
NZ231365A (en)	1992-08-26
CA2002648A1 (en)	1990-05-15
IE893651L (en)	1990-05-15
EP0372268A1 (de)	1990-06-13
FI92588B (fi)	1994-08-31
CA2002648C (en)	2000-02-29
DE68915128T2 (de)	1994-08-25
JP2802947B2 (ja)	1998-09-24
PT92309A (pt)	1990-05-31
KR900007833A (ko)	1990-06-02
CN1022248C (zh)	1993-09-29
FI895417A0 (fi)	1989-11-14
NO894539D0 (no)	1989-11-14
DK570089D0 (da)	1989-11-14
IL92293A0 (en)	1990-07-26
HU895900D0 (en)	1990-02-28
HU205134B (en)	1992-03-30
IE63563B1 (en)	1995-05-17
PT92309B (pt)	1996-06-28
ZA898567B (en)	1990-08-29
ATE105297T1 (de)	1994-05-15
JPH02178272A (ja)	1990-07-11
HUT51642A (en)	1990-05-28
EP0372268B1 (de)	1994-05-04
AU4461189A (en)	1990-05-24
AU621160B2 (en)	1992-03-05
ES2056180T3 (es)	1994-10-01
KR0144865B1 (ko)	1998-07-01

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Legal Events

Date	Code	Title	Description
2009-11-23	MK1K	Patent expired