NO172577C - Fremgangsmaate og mellomprodukter ved fremstilling av substituerte indolinonderivater - Google Patents

Fremgangsmaate og mellomprodukter ved fremstilling av substituerte indolinonderivater

Info

Publication number: NO172577C
Authority: NO; Norway
Prior art keywords: indolino; substitution; derivatives; substituted; procedure
Prior art date: 1987-06-19

Application number

NO882588A

Other languages

English (en)

Norwegian (no)

Other versions

NO882588L (no

NO882588D0 (no

NO172577B (no

Inventor

Joseph M Fortunak

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-19

Filing date

1988-06-13

Publication date

1993-08-11

1988-06-13 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1988-06-13 Publication of NO882588D0 publication Critical patent/NO882588D0/no

1988-12-20 Publication of NO882588L publication Critical patent/NO882588L/no

1993-05-03 Publication of NO172577B publication Critical patent/NO172577B/no

1993-08-11 Publication of NO172577C publication Critical patent/NO172577C/no

Links

238000000034 method Methods 0.000 title abstract 2
239000013067 intermediate product Substances 0.000 title 1
238000006467 substitution reaction Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 abstract 2
229910021578 Iron(III) chloride Inorganic materials 0.000 abstract 1
-1 acetyl halide Chemical class 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000002829 reductive effect Effects 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
- C07C205/09—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/85—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Polyesters Or Polycarbonates (AREA)
Heat Sensitive Colour Forming Recording (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Glass Compositions (AREA)
Iron Core Of Rotating Electric Machines (AREA)

NO882588A 1987-06-19 1988-06-13 Fremgangsmaate og mellomprodukter ved fremstilling av substituerte indolinonderivater NO172577C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878714371A GB8714371D0 (en)	1987-06-19	1987-06-19	Process

Publications (4)

Publication Number	Publication Date
NO882588D0 NO882588D0 (no)	1988-06-13
NO882588L NO882588L (no)	1988-12-20
NO172577B NO172577B (no)	1993-05-03
NO172577C true NO172577C (no)	1993-08-11

Family

ID=10619198

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO882588A NO172577C (no)	1987-06-19	1988-06-13	Fremgangsmaate og mellomprodukter ved fremstilling av substituerte indolinonderivater

Country Status (24)

Country	Link
US (1)	US4997954A (fr)
EP (1)	EP0300614B1 (fr)
JP (1)	JPH07596B2 (fr)
KR (1)	KR0143088B1 (fr)
CN (1)	CN1019296B (fr)
AT (1)	ATE93521T1 (fr)
AU (1)	AU600582B2 (fr)
CA (1)	CA1326035C (fr)
CY (1)	CY1951A (fr)
DE (1)	DE3883456T2 (fr)
DK (1)	DK169965B1 (fr)
EG (1)	EG18412A (fr)
ES (1)	ES2058285T3 (fr)
FI (1)	FI89264C (fr)
GB (1)	GB8714371D0 (fr)
HU (4)	HU205339B (fr)
IE (1)	IE62830B1 (fr)
IL (1)	IL86736A (fr)
MY (1)	MY103583A (fr)
NO (1)	NO172577C (fr)
NZ (1)	NZ225072A (fr)
PH (1)	PH24608A (fr)
PT (1)	PT87770B (fr)
ZA (1)	ZA884334B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9008605D0 (en) *	1990-04-17	1990-06-13	Smith Kline French Lab	Process
MX9304801A (es) *	1992-08-06	1997-06-28	Warner Lambert Co	2-toindoles (selenoidoles) disulfuros (seleniduros) relacinados, los cuales inhiben a las proteinas tirosina cinasas y los cuales tienen propiedades anti-tumorales.
US5278162A (en) *	1992-09-18	1994-01-11	The Du Pont Merck Pharmaceutical Company	3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man
GB9300309D0 (en) *	1993-01-08	1993-03-03	Smithkline Beecham Plc	Process
US6218421B1 (en) *	1999-07-01	2001-04-17	Smithkline Beecham P.L.C.	Method of promoting smoking cessation
AR030557A1 (es)	2000-04-14	2003-08-27	Jagotec Ag	Una tableta en multicapa de liberacion controlada y metodo de tratamiento
AU2002222642A1 (en) *	2000-12-14	2002-06-24	Nissan Chemical Industries Ltd.	Method for producing indole derivative
WO2005074387A2 (fr) *	2003-12-30	2005-08-18	Sun Pharmaceutical Industries Limited	Nouvelles formes cristallines d'hydrochlorure de 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone
US7378439B2 (en) *	2004-01-20	2008-05-27	Usv, Ltd.	Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride
WO2005105741A1 (fr) *	2004-02-11	2005-11-10	Sun Pharmaceutical Industries Limited	Hydrochlorure de 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone sensiblement pur
WO2005080333A1 (fr) *	2004-02-19	2005-09-01	Torrent Pharmaceuticals Ltd	Processus de purification de ropinirole
EP1568689A1 (fr) *	2004-02-19	2005-08-31	Helm AG	Procédé de préparation du dérivé 2-oxoindole, Ropinirole
EP1756072A2 (fr)	2004-04-27	2007-02-28	Wyeth	Purification de modulateurs de recepteur de progesterone
ZA200809282B (en)	2006-03-29	2009-12-30	Alembic Ltd	A process for the purification of ropinirole hydrochloride
US20070254941A1 (en) *	2006-04-21	2007-11-01	Glenmark Pharmaceuticals Limited	Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation
CN100457732C (zh) *	2006-05-25	2009-02-04	药源药物化学（上海）有限公司	罗匹尼罗的制备方法
WO2010023693A2 (fr) *	2008-09-01	2010-03-04	Lupin Limited	Nouvelles compositions de ropinirole à libération contrôlée
US9238025B2 (en)	2009-05-21	2016-01-19	Hisamitsu Pharmaceutical Co., Inc.	Transdermal preparation comprising a ropinirole derivative
CN110621660B (zh)	2017-06-16	2022-06-28	浙江华海立诚药业有限公司	盐酸罗匹尼罗的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4588740A (en) *	1982-12-07	1986-05-13	Smithkline Beckman Corporation	Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones
US4452808A (en) *	1982-12-07	1984-06-05	Smithkline Beckman Corporation	4-Aminoalkyl-2(3H)-indolones
US4761485A (en) *	1987-03-11	1988-08-02	Pfizer Inc.	Synthetic method for indol-2(3H)-ones

1987
- 1987-06-19 GB GB878714371A patent/GB8714371D0/en active Pending
1988
- 1988-06-13 PH PH37063A patent/PH24608A/en unknown
- 1988-06-13 CA CA000569292A patent/CA1326035C/fr not_active Expired - Lifetime
- 1988-06-13 NO NO882588A patent/NO172577C/no not_active IP Right Cessation
- 1988-06-14 IL IL86736A patent/IL86736A/xx not_active IP Right Cessation
- 1988-06-15 US US07/207,351 patent/US4997954A/en not_active Expired - Lifetime
- 1988-06-16 AT AT88305510T patent/ATE93521T1/de not_active IP Right Cessation
- 1988-06-16 EP EP88305510A patent/EP0300614B1/fr not_active Expired - Lifetime
- 1988-06-16 ES ES88305510T patent/ES2058285T3/es not_active Expired - Lifetime
- 1988-06-16 CN CN88103732A patent/CN1019296B/zh not_active Expired
- 1988-06-16 DE DE88305510T patent/DE3883456T2/de not_active Expired - Lifetime
- 1988-06-17 ZA ZA884334A patent/ZA884334B/xx unknown
- 1988-06-17 HU HU911599A patent/HU205339B/hu not_active IP Right Cessation
- 1988-06-17 HU HU906948A patent/HUT55360A/hu unknown
- 1988-06-17 IE IE183788A patent/IE62830B1/en not_active IP Right Cessation
- 1988-06-17 HU HU883123A patent/HU202200B/hu unknown
- 1988-06-17 AU AU18119/88A patent/AU600582B2/en not_active Expired
- 1988-06-17 DK DK334788A patent/DK169965B1/da not_active IP Right Cessation
- 1988-06-17 MY MYPI88000674A patent/MY103583A/en unknown
- 1988-06-17 FI FI882919A patent/FI89264C/fi active IP Right Grant
- 1988-06-17 KR KR1019880007283A patent/KR0143088B1/ko not_active Expired - Lifetime
- 1988-06-17 PT PT87770A patent/PT87770B/pt not_active IP Right Cessation
- 1988-06-17 JP JP63151067A patent/JPH07596B2/ja not_active Expired - Lifetime
- 1988-06-17 HU HU893988A patent/HU203723B/hu not_active IP Right Cessation
- 1988-06-17 NZ NZ225072A patent/NZ225072A/xx unknown
- 1988-06-19 EG EG342/88A patent/EG18412A/xx active
1997
- 1997-05-16 CY CY195197A patent/CY1951A/xx unknown

Also Published As

Publication number	Publication date
HU202200B (en)	1991-02-28
IE62830B1 (en)	1995-03-08
IL86736A (en)	1992-03-29
DK334788D0 (da)	1988-06-17
KR890000421A (ko)	1989-03-14
HUT55360A (en)	1991-05-28
DK169965B1 (da)	1995-04-18
HU911599D0 (en)	1991-11-28
EP0300614A1 (fr)	1989-01-25
AU1811988A (en)	1988-12-22
PH24608A (en)	1990-08-17
CY1951A (en)	1997-05-16
ZA884334B (en)	1990-04-25
ES2058285T3 (es)	1994-11-01
FI89264C (fi)	1993-09-10
AU600582B2 (en)	1990-08-16
HUT48583A (en)	1989-06-28
GB8714371D0 (en)	1987-07-22
CA1326035C (fr)	1994-01-11
IE881837L (en)	1988-12-19
NZ225072A (en)	1990-05-28
NO882588L (no)	1988-12-20
PT87770A (pt)	1989-05-31
CN1019296B (zh)	1992-12-02
FI882919A0 (fi)	1988-06-17
DK334788A (da)	1988-12-20
EG18412A (en)	1992-12-30
HK1003226A1 (en)	1998-10-16
NO882588D0 (no)	1988-06-13
NO172577B (no)	1993-05-03
KR0143088B1 (ko)	1998-07-15
DE3883456D1 (de)	1993-09-30
HU205339B (en)	1992-04-28
FI882919L (fi)	1988-12-20
DE3883456T2 (de)	1994-03-17
JPH07596B2 (ja)	1995-01-11
EP0300614B1 (fr)	1993-08-25
FI89264B (fi)	1993-05-31
HU203723B (en)	1991-09-30
US4997954A (en)	1991-03-05
ATE93521T1 (de)	1993-09-15
MY103583A (en)	1993-08-28
PT87770B (pt)	1992-10-30
HUT52043A (en)	1990-06-28
CN1030076A (zh)	1989-01-04
JPS6419065A (en)	1989-01-23

Legal Events

Date	Code	Title	Description
2008-06-23	MK1K	Patent expired

Publication	Publication Date	Title
NO172577C (no)	1993-08-11	Fremgangsmaate og mellomprodukter ved fremstilling av substituerte indolinonderivater
HUT57722A (en)	1991-12-30	Process for producing azaspiran derivatives and pharmaceutical compositions comprising such compounds
ATE21105T1 (de)	1986-08-15	7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
FI101376B1 (fi)	1998-06-15	Menetelmä 3-bentsyyliamino-2-fenyylipiperidiinijohdannaisten valmistamiseksi
YU86988A (en)	1989-10-31	Process for obtaining new beta-d-phenyl-thioxylozides
SE9000871D0 (sv)	1990-03-12	Derivatives of thieno-triazolo-diazepine, a preparation process of the same and therapeutic compositions containing them
CA1273957C (fr)	1990-09-11
NO973842L (no)	1997-08-21	Aminotetralonderivater og fremgangsmåter for fremstilling derav
HUT58270A (en)	1992-02-28	Process for producing amine derivatives and pharmaceutical compositions containing them
YU3099A (sh)	2001-12-26	Novi derivati eritromicina, postupak za njihovo dobijanje i njihova primena
GR79558B (fr)	1984-10-30
HUT45260A (en)	1988-06-28	Proces for producing new pename-and azetidinone derivatives
NO932231L (no)	1993-12-20	Fremgangsmaate for fremstilling av pyrrolidinylacetamidderivater
HUT34478A (en)	1985-03-28	Process for producing hexahydro-pyrrolo/2.1-a/isoquinoline derivatives and pharmaceutical compositions containing them
ZA924888B (en)	1993-04-28	Process for the synthesis of enantiomers of 3-aminochroman compounds
HUT34316A (en)	1985-03-28	Process for producing heterocyclic hydroximidates and thiohydroximidates and their carbamate-ester derivatives
FI944967L (fi)	1994-10-21	Menetelmiä proteolyyttisen entsyymin inhibiittoreina käyttökelpoisten sakkariinijohdannaisten ja niiden välituotteiden valmistamiseksi
HUT41776A (en)	1987-05-28	Process for producing ergolinyl- thiourea derivatives