NO172987C - Analogifremgangsmaate for fremstilling av terapeutisk aktive benzopyranon-beta-d-tioxylosider - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive benzopyranon-beta-d-tioxylosider

Info

Publication number: NO172987C
Authority: NO; Norway
Prior art keywords: group; beta; atom; thioxylosides; benzopyranon
Prior art date: 1989-09-22

Application number

NO904088A

Other languages

English (en)

Norwegian (no)

Other versions

NO904088L (no

NO172987B (no

NO904088D0 (no

Inventor

Soth Samreth

Veronique Barberousse

Patrice Renaut

Francois Bellamy

Jean Millet

Original Assignee

Fournier Ind & Sante

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-22

Filing date

1990-09-19

Publication date

1993-10-06

1989-09-22 Priority claimed from FR8912452A external-priority patent/FR2652353B1/fr

1990-03-16 Priority claimed from FR9003401A external-priority patent/FR2659659B1/fr

1990-09-19 Application filed by Fournier Ind & Sante filed Critical Fournier Ind & Sante

1990-09-19 Publication of NO904088D0 publication Critical patent/NO904088D0/no

1991-03-25 Publication of NO904088L publication Critical patent/NO904088L/no

1993-06-28 Publication of NO172987B publication Critical patent/NO172987B/no

1993-10-06 Publication of NO172987C publication Critical patent/NO172987C/no

Links

230000001225 therapeutic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000004430 oxygen atom Chemical group O* 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
OPRFTHPXVIXGNH-UHFFFAOYSA-N 1,2,3,4-tetrahydroxanthen-9-one Chemical group O1C2=CC=CC=C2C(=O)C2=C1CCCC2 OPRFTHPXVIXGNH-UHFFFAOYSA-N 0.000 abstract 1
KPURGZHUDCFENA-UHFFFAOYSA-N 7,8,9,10-tetrahydrobenzo[c]chromen-6-one Chemical group C1CCCC2=C1C(C=CC=C1)=C1OC2=O KPURGZHUDCFENA-UHFFFAOYSA-N 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
229960004676 antithrombotic agent Drugs 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/07—Benzo[b]pyran-4-ones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/075—Benzo[b]pyran-2-ones

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Pyrane Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Cultivation Of Plants (AREA)
Cephalosporin Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Plural Heterocyclic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Dental Preparations (AREA)
Compositions Of Macromolecular Compounds (AREA)

NO904088A 1989-09-22 1990-09-19 Analogifremgangsmaate for fremstilling av terapeutisk aktive benzopyranon-beta-d-tioxylosider NO172987C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8912452A FR2652353B1 (fr)	1989-09-22	1989-09-22	Nouveaux benzopyran-2-one-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.
FR9003401A FR2659659B1 (fr)	1990-03-16	1990-03-16	Nouveaux benzopyran-4-one-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.

Publications (4)

Publication Number	Publication Date
NO904088D0 NO904088D0 (no)	1990-09-19
NO904088L NO904088L (no)	1991-03-25
NO172987B NO172987B (no)	1993-06-28
NO172987C true NO172987C (no)	1993-10-06

Family

ID=26227568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO904088A NO172987C (no)	1989-09-22	1990-09-19	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzopyranon-beta-d-tioxylosider

Country Status (24)

Country	Link
US (1)	US5169838A (de)
EP (1)	EP0421829B1 (de)
JP (1)	JPH07103147B2 (de)
KR (1)	KR0142670B1 (de)
CN (1)	CN1027268C (de)
AT (1)	ATE113956T1 (de)
AU (2)	AU631456B2 (de)
CA (1)	CA2024476C (de)
DE (1)	DE69014064T2 (de)
DK (1)	DK0421829T3 (de)
ES (1)	ES2066165T3 (de)
FI (1)	FI100183B (de)
GR (1)	GR3014966T3 (de)
HR (1)	HRP920811B1 (de)
HU (1)	HU207867B (de)
IE (1)	IE65092B1 (de)
IL (1)	IL95582A (de)
NO (1)	NO172987C (de)
NZ (1)	NZ245783A (de)
PT (1)	PT95369B (de)
RU (1)	RU1838323C (de)
SK (1)	SK280827B6 (de)
UA (1)	UA13476A (de)
YU (1)	YU47867B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2801055B1 (fr) *	1999-11-17	2002-02-08	Fournier Ind & Sante	Derives de beta-d-5-thioxylose, procede de preparation et utilisation en therapeutique
FR2824559B1 (fr)	2001-05-11	2004-02-13	Fournier Lab Sa	Nouveaux derives 5-thio-beta-xylopyronasides, procede de preparation, compositions pharmaceutiques les contenant et leur utilisation en therapeutique
FR2846966A1 (fr) *	2002-11-07	2004-05-14	Fournier Lab Sa	Derive du 4-methyl-2-oxo-2h-1-benzopyran-7-yl 5-thio-beta-d- xylopyranoside, son procede de preparation et composition pharmaceutique le contenant
CA2527769A1 (en) *	2003-06-11	2004-12-16	Merck Frosst Canada Ltd.	7- (1, 3-thiazol-2-yl)thio!-coumarin derivatives and their use as leukotriene biosynthesis inhibitors
FR2860234B1 (fr)	2003-09-25	2005-12-23	Fournier Lab Sa	Nouveaux derives 666 du thioxylose
PE20061010A1 (es) *	2005-02-18	2006-11-11	Glaxo Group Ltd	Composiciones farmaceuticas que contienen 4-metil-2-oxo-2h-1-benzopiran-7-il-5-tio-beta-d-xilopiranosido
FR2903698B1 (fr)	2006-07-13	2009-01-30	Fournier S A Sa Lab	Nouveaux derives de 5-thioxylopyranose.
FR2906248B1 (fr)	2006-09-27	2008-12-26	Fournier S A Sa Lab	Nouveaux derives de 5-thioxylopyranose
FR2906247B1 (fr)	2006-09-27	2008-12-26	Fournier S A Sa Lab	Nouveaux derives de 5-thioxylopyranose
US20090075914A1 (en) *	2007-09-13	2009-03-19	Protia, Llc	Deuterium-enriched odiparcil
CN101397315B (zh) *	2007-09-24	2013-08-07	中国医学科学院药物研究所	香豆素苷类化合物、其制法和其药物组合物与用途
FR3011468B1 (fr) *	2013-10-04	2015-12-04	Inventiva	Utilisation de l'odiparcil dans le traitement d'une mucopolysaccharidose
US10092540B2 (en)	2013-10-04	2018-10-09	Inventiva	Method of treatment of a mucopolysaccharidosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2034306A1 (de) *	1970-07-10	1972-01-20	Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof	2 (3,4 Dimethyl-cumarin 7 yl) oxy alkylcarbonsaure Derivate und Verfahren zu ihrer Herstellung
FR2492830A1 (fr) *	1980-10-29	1982-04-30	Sori Soc Rech Ind	Nouveaux composes appartenant a la famille des benzoyl- et a-hydroxybenzyl-phenyl-osides, leur procede de preparation et leur application en therapeutique
JPS6013788A (ja) *	1983-07-05	1985-01-24	Yamanouchi Pharmaceut Co Ltd	新規なクマリン誘導体
FR2549476B1 (fr) *	1983-07-20	1986-04-25	Rech Ind	Benzyl-phenyl-osides, procede de preparation et utilisation en therapeutique
US4681954A (en) *	1985-10-07	1987-07-21	Pennwalt Corporation	7,8,9,10-tetrahydro-6-oxo-6H-dibenzo(b,d)pyranyloxy-propanes
FR2614893B1 (fr) *	1987-05-04	1989-12-22	Fournier Innovation Synergie	Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique

1990
- 1990-08-31 CA CA002024476A patent/CA2024476C/en not_active Expired - Fee Related
- 1990-08-31 DK DK90402403.1T patent/DK0421829T3/da active
- 1990-08-31 ES ES90402403T patent/ES2066165T3/es not_active Expired - Lifetime
- 1990-08-31 AT AT90402403T patent/ATE113956T1/de not_active IP Right Cessation
- 1990-08-31 EP EP90402403A patent/EP0421829B1/de not_active Expired - Lifetime
- 1990-08-31 DE DE69014064T patent/DE69014064T2/de not_active Expired - Fee Related
- 1990-09-04 IL IL9558290A patent/IL95582A/en not_active IP Right Cessation
- 1990-09-10 US US07/579,702 patent/US5169838A/en not_active Expired - Lifetime
- 1990-09-17 AU AU62531/90A patent/AU631456B2/en not_active Ceased
- 1990-09-19 NO NO904088A patent/NO172987C/no unknown
- 1990-09-19 FI FI904614A patent/FI100183B/fi not_active IP Right Cessation
- 1990-09-20 YU YU178790A patent/YU47867B/sh unknown
- 1990-09-20 PT PT95369A patent/PT95369B/pt not_active IP Right Cessation
- 1990-09-21 RU SU904831306A patent/RU1838323C/ru active
- 1990-09-21 UA UA4831306A patent/UA13476A/uk unknown
- 1990-09-21 NZ NZ245783A patent/NZ245783A/xx unknown
- 1990-09-21 HU HU906005A patent/HU207867B/hu not_active IP Right Cessation
- 1990-09-21 KR KR1019900014981A patent/KR0142670B1/ko not_active Expired - Fee Related
- 1990-09-21 JP JP2253983A patent/JPH07103147B2/ja not_active Expired - Fee Related
- 1990-09-21 IE IE341490A patent/IE65092B1/en not_active IP Right Cessation
- 1990-09-21 CN CN90107856A patent/CN1027268C/zh not_active Expired - Fee Related
- 1990-09-24 SK SK4638-90A patent/SK280827B6/sk unknown
1992
- 1992-09-28 AU AU25397/92A patent/AU642829B2/en not_active Ceased
- 1992-10-02 HR HRP-1787/90A patent/HRP920811B1/xx not_active IP Right Cessation
1995
- 1995-02-07 GR GR950400222T patent/GR3014966T3/el unknown

Also Published As

Publication number	Publication date
IL95582A (en)	2001-06-14
FI100183B (fi)	1997-10-15
IL95582A0 (en)	1991-06-30
AU2539792A (en)	1992-11-26
PT95369A (pt)	1991-05-22
JPH03120292A (ja)	1991-05-22
ATE113956T1 (de)	1994-11-15
KR0142670B1 (ko)	1998-07-01
PT95369B (pt)	1997-06-30
EP0421829B1 (de)	1994-11-09
NO904088L (no)	1991-03-25
SK463890A3 (en)	2000-08-14
UA13476A (uk)	1997-04-25
AU642829B2 (en)	1993-10-28
CN1027268C (zh)	1995-01-04
RU1838323C (ru)	1993-08-30
HRP920811B1 (en)	1998-12-31
YU47867B (sh)	1996-02-19
IE65092B1 (en)	1995-10-04
NO172987B (no)	1993-06-28
HU906005D0 (en)	1991-03-28
JPH07103147B2 (ja)	1995-11-08
DK0421829T3 (da)	1995-01-16
AU6253190A (en)	1991-03-28
NZ245783A (en)	1993-07-27
CN1050544A (zh)	1991-04-10
YU178790A (sh)	1992-12-21
DE69014064D1 (de)	1994-12-15
IE903414A1 (en)	1991-04-10
HU207867B (en)	1993-06-28
EP0421829A1 (de)	1991-04-10
FI904614A0 (fi)	1990-09-19
CA2024476A1 (en)	1991-03-23
US5169838A (en)	1992-12-08
DE69014064T2 (de)	1995-05-18
NO904088D0 (no)	1990-09-19
AU631456B2 (en)	1992-11-26
KR910006283A (ko)	1991-04-29
HRP920811A2 (en)	1995-10-31
CA2024476C (en)	1999-10-12
GR3014966T3 (en)	1995-05-31
HUT55794A (en)	1991-06-28
SK280827B6 (sk)	2000-08-14
ES2066165T3 (es)	1995-03-01

Publication	Publication Date	Title
NO172987C (no)	1993-10-06	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzopyranon-beta-d-tioxylosider
ZA897660B (en)	1990-09-26	Biologically active compounds
NO167035C (no)	1991-09-25	Analogifremgangsmaate for fremstilling av terapeutisk aktivt beta-d-fenyltioksylosid
MX9206093A (es)	1993-04-01	Derivado de oxazolidona
UA41329C2 (uk)	2001-09-17	Фармацевтична композиція для лікування порушень серцевого ритму у великих ссавців та людей, похідні 3-фенілсульфоніл-3,7-діазабіцикло[3,3,1]нонану та лікарський засіб для лікування аритмії
IT1230595B (it)	1991-10-28	Perossiacidi immido derivati
WO1989001330A3 (en)	1989-05-05	W-arylsulphonamidoalkanoic acids for treatment of thromboxane mediated diseases
ATE205209T1 (de)	2001-09-15	Chinolincarbonsäurederivate und ihre salze
NO168707C (no)	1992-03-25	Analogifremgangsmaate for fremstilling av terapeutisk aktive heterotetracykliske laktamderivater.
ES2081447T3 (es)	1996-03-16	Sulfonil-fenil-beta-d-tioxilosidos, su procedimiento de preparacion y su empleo en terapeutica.
ATE88176T1 (de)	1993-04-15	2-hydroxy-3-aryloxy-propylaminderivate mit kardiovaskulaerer wirkung.
NO882340D0 (no)	1988-05-27	Fremgangsmaate for fremstilling av terapeutisk aktive tricykliske oxazoloner.
ATE101115T1 (de)	1994-02-15	Salicylate, ihre salze, diese enthaltende pharmazeutische kompositionen und ihr herstellungsverfahren.
ATE95697T1 (de)	1993-10-15	Uricosuretische zusammensetzung.
ES2038702T3 (es)	1993-08-01	Un procedimiento para preparar derivados triazolopirimidina triciclicos.