NO173506C - Fremgangsmaate ved fremtilling av disvovelanaloger av ll-E33288-antitumormidler - Google Patents

Fremgangsmaate ved fremtilling av disvovelanaloger av ll-E33288-antitumormidler

Info

Publication number
NO173506C
NO173506C NO884834A NO884834A NO173506C NO 173506 C NO173506 C NO 173506C NO 884834 A NO884834 A NO 884834A NO 884834 A NO884834 A NO 884834A NO 173506 C NO173506 C NO 173506C
Authority
NO
Norway
Prior art keywords
disulfur
analogs
preparing
procedure
tumor agents
Prior art date
Application number
NO884834A
Other languages
English (en)
Norwegian (no)
Other versions
NO884834D0 (no
NO173506B (no
NO884834L (no
Inventor
William James Mcgahren
Martin Leon Sassiver
George A Ellestad
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of NO884834D0 publication Critical patent/NO884834D0/no
Publication of NO884834L publication Critical patent/NO884834L/no
Publication of NO173506B publication Critical patent/NO173506B/no
Publication of NO173506C publication Critical patent/NO173506C/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO884834A 1987-10-30 1988-10-28 Fremgangsmaate ved fremtilling av disvovelanaloger av ll-E33288-antitumormidler NO173506C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11494087A 1987-10-30 1987-10-30

Publications (4)

Publication Number Publication Date
NO884834D0 NO884834D0 (no) 1988-10-28
NO884834L NO884834L (no) 1989-05-02
NO173506B NO173506B (no) 1993-09-13
NO173506C true NO173506C (no) 1993-12-22

Family

ID=22358378

Family Applications (2)

Application Number Title Priority Date Filing Date
NO884834A NO173506C (no) 1987-10-30 1988-10-28 Fremgangsmaate ved fremtilling av disvovelanaloger av ll-E33288-antitumormidler
NO884833A NO176480C (no) 1987-10-30 1988-10-28 Analogifremgangsmåte ved fremstilling av målrettede former av metyltritio-anti-tumormidler

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO884833A NO176480C (no) 1987-10-30 1988-10-28 Analogifremgangsmåte ved fremstilling av målrettede former av metyltritio-anti-tumormidler

Country Status (20)

Country Link
EP (2) EP0313873B1 (da)
JP (2) JP2720933B2 (da)
KR (2) KR970011385B1 (da)
AR (1) AR246083A1 (da)
AT (2) ATE112172T1 (da)
AU (2) AU612714B2 (da)
BR (1) BR1100939A (da)
CA (1) CA1321582C (da)
DE (2) DE3851682T2 (da)
DK (2) DK174739B1 (da)
ES (2) ES2061586T3 (da)
FI (2) FI95204C (da)
HK (2) HK131897A (da)
IE (2) IE65053B1 (da)
IL (2) IL87946A (da)
NO (2) NO173506C (da)
NZ (2) NZ226727A (da)
PT (2) PT88882B (da)
PY (1) PY0101654A (da)
ZA (2) ZA888127B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5606040A (en) * 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
IL93733A (en) * 1989-04-14 1996-01-19 American Cyanamid Co Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group and targeted forms thereof
GB9007384D0 (en) * 1990-04-02 1990-05-30 Duncan Ruth Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
US5714586A (en) * 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
ATE481487T1 (de) 1998-11-27 2010-10-15 Ucb Sa Zusammensetzungen und verfahren zur erhöhung der knochenmineralisierung
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
CA2529623A1 (en) 2003-06-16 2005-02-17 Celltech R & D, Inc. Antibodies specific for sclerostin and methods for increasing bone mineralization
WO2008028050A2 (en) * 2006-08-30 2008-03-06 Wisconsin Alumni Research Foundation Reversible natural product glycosyltransferase-catalyzed reactions, compounds and related methods
KR100979928B1 (ko) * 2008-07-16 2010-09-03 한주학 수직축형 부력풍차
CN108047287B (zh) * 2013-11-04 2021-04-27 辉瑞大药厂 用于合成加利车霉素衍生物的中间体和方法
WO2018138591A1 (en) * 2017-01-24 2018-08-02 Pfizer Inc. Calicheamicin derivatives and antibody drug conjugates thereof
CA3129501A1 (en) * 2019-02-15 2020-08-20 University Of Southern California Lym-1 and lym-2 antibody compositions and improved car constructs
JP7750853B2 (ja) * 2020-10-22 2025-10-07 富士フイルム株式会社 皮膚感作性測定試薬、化合物、及び皮膚感作性の測定方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430943A1 (fr) * 1978-07-13 1980-02-08 Toyo Jozo Kk Nouveaux derives disulfures
EP0040506B1 (en) * 1980-05-21 1986-08-20 Teijin Limited Reactive polymer and process for the preparation thereof
US4530835A (en) * 1983-07-08 1985-07-23 Warner-Lambert Company CL-1577 Antibiotic compounds and their production
CA1314245C (en) * 1984-05-23 1993-03-09 Franz Jansen Process for the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, which are useful as immunotoxin potentiators
IL76878A (en) * 1984-11-16 1991-12-15 American Cyanamid Co Antitumor antibiotic ll-33288alpha-br complex and process for its preparation
EP0330874A3 (en) * 1988-02-29 1989-10-18 American Cyanamid Company Antibacterial and antitumor agents LL-E33288 epsilon-I and LL-E33288-epsilonBr, with processes and intermediates for producing said agents
EP0342341A3 (en) * 1988-05-17 1991-07-24 American Cyanamid Company Process for producing antitumor antibiotic ll-e33288gamma2

Also Published As

Publication number Publication date
NO884833D0 (no) 1988-10-28
DK602488A (da) 1989-05-01
PT88881B (pt) 1993-01-29
DK602488D0 (da) 1988-10-28
ATE104309T1 (de) 1994-04-15
FI95204B (fi) 1995-09-29
JPH0296599A (ja) 1990-04-09
AU618763B2 (en) 1992-01-09
FI884984A7 (fi) 1989-05-01
EP0313874A2 (en) 1989-05-03
NZ226726A (en) 1991-08-27
NO884834D0 (no) 1988-10-28
DE3889063T2 (de) 1994-12-01
FI884984A0 (fi) 1988-10-28
DE3851682D1 (de) 1994-11-03
JPH01193282A (ja) 1989-08-03
PT88882B (pt) 1993-01-29
ZA888123B (en) 1989-07-26
HK131997A (en) 1997-10-03
FI91262C (fi) 1994-06-10
IE883261L (en) 1989-04-30
NO176480C (no) 1995-04-12
KR0133130B1 (ko) 1998-04-17
JP2820256B2 (ja) 1998-11-05
IE883262L (en) 1989-04-30
IE65989B1 (en) 1995-11-29
DE3889063D1 (de) 1994-05-19
FI95204C (fi) 1996-01-10
NZ226727A (en) 1991-12-23
NO176480B (no) 1995-01-02
IL87947A (en) 1995-05-26
FI884983A0 (fi) 1988-10-28
NO884833L (no) 1989-05-02
ATE112172T1 (de) 1994-10-15
FI884983L (fi) 1989-05-01
FI91262B (fi) 1994-02-28
ZA888127B (en) 1989-07-26
EP0313874A3 (en) 1990-05-09
NO173506B (no) 1993-09-13
DK602588D0 (da) 1988-10-28
EP0313874B1 (en) 1994-04-13
IL87946A0 (en) 1989-03-31
DK602588A (da) 1989-05-01
EP0313873A1 (en) 1989-05-03
IL87946A (en) 1995-06-29
AU2448988A (en) 1989-05-04
AU2449488A (en) 1989-05-04
HK131897A (en) 1997-10-03
EP0313873B1 (en) 1994-09-28
KR970011385B1 (ko) 1997-07-10
NO884834L (no) 1989-05-02
DK174739B1 (da) 2003-10-13
IE65053B1 (en) 1995-10-04
ES2061586T3 (es) 1994-12-16
KR890006245A (ko) 1989-06-12
AR246083A1 (es) 1994-03-30
IL87947A0 (en) 1989-03-31
PY0101654A (es) 2002-08-01
KR890006244A (ko) 1989-06-12
CA1321582C (en) 1993-08-24
BR1100939A (pt) 1999-08-31
DE3851682T2 (de) 1995-05-04
AU612714B2 (en) 1991-07-18
JP2720933B2 (ja) 1998-03-04
ES2059464T3 (es) 1994-11-16

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Legal Events

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MK1K Patent expired