NO173548C - Analogifremgangsmaate for fremstilling av terapeutisk aktive glykokonjugater av forsforamidsennep eller ifosfamidsennep - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive glykokonjugater av forsforamidsennep eller ifosfamidsennep

Info

Publication number: NO173548C
Authority: NO; Norway
Prior art keywords: mustard; sugar; ifosfamide; preforamide; preparation
Prior art date: 1988-10-20

Application number

NO902717A

Other languages

English (en)

Norwegian (no)

Other versions

NO902717D0 (no

NO902717L (no

NO173548B (no

Inventor

Manfred Wiessler

Michael Dickes

Original Assignee

Deutsches Krebsforsch

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-20

Filing date

1990-06-19

Publication date

1993-12-29

1990-06-19 Application filed by Deutsches Krebsforsch filed Critical Deutsches Krebsforsch

1990-06-19 Publication of NO902717D0 publication Critical patent/NO902717D0/no

1990-08-20 Publication of NO902717L publication Critical patent/NO902717L/no

1993-09-20 Publication of NO173548B publication Critical patent/NO173548B/no

1993-12-29 Publication of NO173548C publication Critical patent/NO173548C/no

Links

BKCJZNIZRWYHBN-UHFFFAOYSA-N Isophosphamide mustard Chemical compound ClCCNP(=O)(O)NCCCl BKCJZNIZRWYHBN-UHFFFAOYSA-N 0.000 title abstract 2
241000219198 Brassica Species 0.000 title 1
235000003351 Brassica cretica Nutrition 0.000 title 1
235000003343 Brassica rupestris Nutrition 0.000 title 1
QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 title 1
235000010460 mustard Nutrition 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001268 conjugating effect Effects 0.000 abstract 1
150000004676 glycans Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
RJXQSIKBGKVNRT-UHFFFAOYSA-N phosphoramide mustard Chemical group ClCCN(P(O)(=O)N)CCCl RJXQSIKBGKVNRT-UHFFFAOYSA-N 0.000 abstract 1
150000008039 phosphoramides Chemical class 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
150000003018 phosphorus compounds Chemical class 0.000 abstract 1
229920001282 polysaccharide Polymers 0.000 abstract 1
239000005017 polysaccharide Substances 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Cephalosporin Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

NO902717A 1988-10-20 1990-06-19 Analogifremgangsmaate for fremstilling av terapeutisk aktive glykokonjugater av forsforamidsennep eller ifosfamidsennep NO173548C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3835772A DE3835772A1 (de)	1988-10-20	1988-10-20	Tumorhemmende saccharid-konjugate
PCT/EP1989/001251 WO1990004597A1 (fr)	1988-10-20	1989-10-19	Conjugues de saccharide employes comme inhibiteurs tumoraux

Publications (4)

Publication Number	Publication Date
NO902717D0 NO902717D0 (no)	1990-06-19
NO902717L NO902717L (no)	1990-08-20
NO173548B NO173548B (no)	1993-09-20
NO173548C true NO173548C (no)	1993-12-29

Family

ID=6365559

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO902717A NO173548C (no)	1988-10-20	1990-06-19	Analogifremgangsmaate for fremstilling av terapeutisk aktive glykokonjugater av forsforamidsennep eller ifosfamidsennep

Country Status (16)

Country	Link
US (1)	US5622936A (fr)
EP (1)	EP0369182B1 (fr)
JP (2)	JP2518739B2 (fr)
AT (1)	ATE120465T1 (fr)
CA (1)	CA2001129C (fr)
DE (2)	DE3835772A1 (fr)
DK (1)	DK170422B1 (fr)
ES (1)	ES2072881T3 (fr)
FI (1)	FI95268C (fr)
GR (1)	GR3015566T3 (fr)
HK (1)	HK157495A (fr)
HU (1)	HU206124B (fr)
IE (1)	IE67529B1 (fr)
NO (1)	NO173548C (fr)
PT (1)	PT92034B (fr)
WO (1)	WO1990004597A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19524515A1 (de)	1995-07-05	1997-01-09	Deutsches Krebsforsch	Saccharid-Konjugate
US20040072889A1 (en) *	1997-04-21	2004-04-15	Pharmacia Corporation	Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
US6506739B1 (en)	2001-05-01	2003-01-14	Telik, Inc.	Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
WO2003079980A2 (fr) *	2002-03-19	2003-10-02	A & D Bioscience, Inc.	Glucuronides, glucosamides et glucosides d'acide carboxylique, de quinolones, penicillines et analogues, et leurs utilisations
US7001888B2 (en) *	2002-03-29	2006-02-21	Threshold Pharmaceuticals, Inc.	Compositions and methods for treating cancer
CN1771334A (zh) *	2003-03-07	2006-05-10	施瑞修德制药公司	用于确定肿瘤对抗肿瘤药剂的治疗的敏感性的方法
ZA200507752B (en) *	2003-03-28	2007-01-31	Threshold Pharmaceuticals Inc	Compositions and methods for treating cancer
WO2004110255A2 (fr) *	2003-06-09	2004-12-23	Gang Zheng	Agents antineoplasiques dont le ciblage s'effectue a l'aide de transporteurs glut
EP1711188B1 (fr)	2004-02-06	2012-06-06	Threshold Pharmaceuticals, Inc.	Therapies anticancereuses
EP1883298A1 (fr) *	2005-05-11	2008-02-06	Threshold Pharmaceuticals, Inc.	Traitement par une association de glufosfamide
CN102746336B (zh)	2005-06-29	2015-08-19	施瑞修德制药公司	氨基磷酸酯烷化剂前体药物
CN100358910C (zh) *	2006-02-14	2008-01-02	海南天源康泽医药科技有限公司	葡膦酰胺结晶及其制备方法与应用
WO2008011588A2 (fr) *	2006-07-20	2008-01-24	Threshold Pharmaceuticals, Inc.	Glycoconjugués d'alkylateurs de phosphoramidate pour le traitement du cancer
EP2114157B1 (fr) *	2006-12-26	2021-05-26	ImmunoGenesis, Inc.	Promédicament d'alkylation de phosphoramidate pour le traitement du cancer
US8765690B2 (en) *	2007-04-05	2014-07-01	Threshold Pharmaceuticals, Inc.	Treatment of cancer with glufosfamide in patients not receiving insulin therapy
US20090118031A1 (en) *	2007-11-01	2009-05-07	Qualizza Gregory K	Shaft Structure with Configurable Bending Profile
CN101481394B (zh) *	2008-01-09	2013-01-30	苏州天人合生物技术有限公司	2,3,4,6-四-o-乙酰基-d-吡喃葡萄糖基-[n, n′-双(2-氯乙基)]-磷酸二酰胺的制备方法
US20110207680A1 (en) *	2008-08-13	2011-08-25	Curd John G	Administration of Glufosfamide For The Treatment of Cancer
CN102115483B (zh) *	2009-12-30	2014-12-17	苏州天人合生物技术有限公司	卤代双去氧糖衍生物及其制备方法与应用
CN103142626B (zh) *	2010-07-21	2014-08-20	苏州天人合生物技术有限公司	三乙酰葡萄烯糖在制备抗肿瘤药物中的应用
CN105002235B (zh) *	2015-07-10	2019-02-22	江苏九旭药业有限公司	一种利用酶制备葡磷酰胺及其类似物的方法
CN105153251B (zh) *	2015-09-29	2018-03-20	浙江合糖科技有限公司	一种单糖甲苷的苄基化方法
AU2024317010A1 (en)	2023-07-28	2026-02-26	Ascentawits Pharmaceuticals, Ltd.	Treatment of p53 gene mutation or defect negative cancer and tumor patients

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE122386C (fr) *
DD122386A1 (fr) *	1975-06-24	1976-10-05
DE3225227A1 (de) *	1982-07-06	1984-01-12	Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen	Derivate des n.n-bis-(2-chlor-aethyl)-phosphorsaeureamids
US5015733A (en) *	1983-12-20	1991-05-14	California Institute Of Technology	Nucleosides possessing blocked aliphatic amino groups
US4849513A (en) *	1983-12-20	1989-07-18	California Institute Of Technology	Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
ZA851062B (en) *	1984-03-01	1985-11-27	Asta Werke Ag Chem Fab	Salts of oxazaphosphorine derivatives and process for their production
US5194428A (en) *	1986-05-23	1993-03-16	Worcester Foundation For Experimental Biology	Inhibition of influenza virus replication by oligonucleotide phosphorothioates
US5055459A (en) *	1986-06-30	1991-10-08	Board Of Regents, The University Of Texas	Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates

1988
- 1988-10-20 DE DE3835772A patent/DE3835772A1/de not_active Ceased
1989
- 1989-10-19 AT AT89119408T patent/ATE120465T1/de not_active IP Right Cessation
- 1989-10-19 US US07/499,522 patent/US5622936A/en not_active Expired - Lifetime
- 1989-10-19 HU HU896841A patent/HU206124B/hu unknown
- 1989-10-19 JP JP2500030A patent/JP2518739B2/ja not_active Expired - Lifetime
- 1989-10-19 ES ES89119408T patent/ES2072881T3/es not_active Expired - Lifetime
- 1989-10-19 EP EP89119408A patent/EP0369182B1/fr not_active Expired - Lifetime
- 1989-10-19 DE DE58909141T patent/DE58909141D1/de not_active Expired - Lifetime
- 1989-10-19 PT PT92034A patent/PT92034B/pt not_active IP Right Cessation
- 1989-10-19 WO PCT/EP1989/001251 patent/WO1990004597A1/fr not_active Ceased
- 1989-10-19 IE IE336089A patent/IE67529B1/en not_active IP Right Cessation
- 1989-10-20 CA CA002001129A patent/CA2001129C/fr not_active Expired - Lifetime
1990
- 1990-06-19 DK DK149290A patent/DK170422B1/da not_active IP Right Cessation
- 1990-06-19 NO NO902717A patent/NO173548C/no unknown
- 1990-06-20 FI FI903123A patent/FI95268C/fi active IP Right Grant
1995
- 1995-03-30 GR GR940403849T patent/GR3015566T3/el unknown
- 1995-10-05 HK HK157495A patent/HK157495A/xx not_active IP Right Cessation
- 1995-11-10 JP JP7317538A patent/JP3056408B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HUT54702A (en)	1991-03-28
ES2072881T3 (es)	1995-08-01
WO1990004597A1 (fr)	1990-05-03
DE3835772A1 (de)	1990-04-26
HU206124B (en)	1992-08-28
FI903123A0 (fi)	1990-06-20
NO902717D0 (no)	1990-06-19
ATE120465T1 (de)	1995-04-15
IE67529B1 (en)	1996-04-03
IE893360L (en)	1990-04-20
EP0369182A1 (fr)	1990-05-23
JP3056408B2 (ja)	2000-06-26
DK149290D0 (da)	1990-06-19
GR3015566T3 (en)	1995-06-30
FI95268C (fi)	1996-01-10
DE58909141D1 (de)	1995-05-04
HU896841D0 (en)	1990-12-28
CA2001129A1 (fr)	1990-04-20
HK157495A (en)	1995-10-13
JP2518739B2 (ja)	1996-07-31
DK149290A (da)	1990-08-07
DK170422B1 (da)	1995-08-28
CA2001129C (fr)	2000-06-27
JPH03502934A (ja)	1991-07-04
PT92034B (pt)	1995-05-31
NO902717L (no)	1990-08-20
NO173548B (no)	1993-09-20
US5622936A (en)	1997-04-22
FI95268B (fi)	1995-09-29
PT92034A (pt)	1990-04-30
EP0369182B1 (fr)	1995-03-29
JPH08208680A (ja)	1996-08-13

Publication	Publication Date	Title
NO173548C (no)	1993-12-29	Analogifremgangsmaate for fremstilling av terapeutisk aktive glykokonjugater av forsforamidsennep eller ifosfamidsennep
GB8421849D0 (en)	1984-10-03	Antiviral compounds
KR910000730A (ko)	1991-01-30	N-헤테로아릴-푸린-6-아민, 이의 제조방법 및 약제로서의 이의 용도
MY101132A (en)	1991-07-31	An optically pure pipecoloxylidide hydrochloride and a process for its preparation
DK72686A (da)	1986-08-16	Aminosyrederivat og antikonvulsant praeparat som indeholder derivatet
DE3270925D1 (en)	1986-06-12	Dichloroamino acid derivatives useful as potent germicidal and fungicidal agents
EG15762A (en)	1986-12-30	Substituted hydroxy-malonic acid diamides,a process for their preparation,and their use as pest combating agents
IE780397L (en)	1978-08-24	Guanines.
KR840006183A (ko)	1984-11-22	N-포스포노메틸글리신의 제조방법
SE8204791D0 (sv)	1982-08-20	Process for preparing alkoxy-vincaminic acid esters and alkoxy-apovincaminic acid esters
IL92456A0 (en)	1990-08-31	Preparation of optically active 2-oxoimidazolidine derivatives
EP0218195A3 (fr)	1988-01-07	Bis-(dibenzo[b,d]pyranyloxy)-propanes
RO91474B (ro)	1987-07-01	Compozitie erbicida pe baza de derivati de n-fosofnometilglicina
FR2570380B1 (fr)	1987-09-11	Procede de preparation de o-alcoyle s (alcoyle ramifie en alpha) alcoyl phosphonothioate
ES8201953A1 (es)	1982-01-01	Procedimiento para la preparacion de amidas de aminoalcoho- les y derivados del acido 2-finilpropionico