NO175002C - Analogifremgangsmåte for fremstilling av 4-hydroksytetrahydropyran-2-on og de tilsvarende dihydroksykarboksylsyrederivater, salter og estere - Google Patents

Analogifremgangsmåte for fremstilling av 4-hydroksytetrahydropyran-2-on og de tilsvarende dihydroksykarboksylsyrederivater, salter og estere

Info

Publication number: NO175002C
Authority: NO; Norway
Prior art keywords: preparation; esters; salts; hydroxytetrahydropyran; acid derivatives
Prior art date: 1989-09-08

Application number

NO903911A

Other languages

English (en)

Other versions

NO903911D0 (no

NO175002B (no

NO903911L (no

Inventor

Heiner Jendralla

Gunther Wess

Kurt Kesseler

Gerhard Beck

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-08

Filing date

1990-09-07

Publication date

1994-08-17

1990-09-07 Application filed by Hoechst Ag filed Critical Hoechst Ag

1990-09-07 Publication of NO903911D0 publication Critical patent/NO903911D0/no

1991-03-11 Publication of NO903911L publication Critical patent/NO903911L/no

1994-05-09 Publication of NO175002B publication Critical patent/NO175002B/no

1994-08-17 Publication of NO175002C publication Critical patent/NO175002C/no

Links

MMCOUVMKNAHQOY-UHFFFAOYSA-N carbonoperoxoic acid Chemical class OOC(O)=O MMCOUVMKNAHQOY-UHFFFAOYSA-N 0.000 title abstract 2
150000002148 esters Chemical class 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2
WMHRYMDGHQIARA-UHFFFAOYSA-N 4-hydroxyoxan-2-one Chemical compound OC1CCOC(=O)C1 WMHRYMDGHQIARA-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/12—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
- C07C1/20—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as heteroatoms
- C07C1/24—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as heteroatoms by elimination of water
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/10—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
- C07C46/04—Preparation of quinones by oxidation giving rise to quinoid structures of unsubstituted ring carbon atoms in six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/24—Quinones containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Pyrane Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO903911A 1989-09-08 1990-09-07 Analogifremgangsmåte for fremstilling av 4-hydroksytetrahydropyran-2-on og de tilsvarende dihydroksykarboksylsyrederivater, salter og estere NO175002C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3929913A DE3929913A1 (de)	1989-09-08	1989-09-08	4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte

Publications (4)

Publication Number	Publication Date
NO903911D0 NO903911D0 (no)	1990-09-07
NO903911L NO903911L (no)	1991-03-11
NO175002B NO175002B (no)	1994-05-09
NO175002C true NO175002C (no)	1994-08-17

Family

ID=6388931

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO903911A NO175002C (no)	1989-09-08	1990-09-07	Analogifremgangsmåte for fremstilling av 4-hydroksytetrahydropyran-2-on og de tilsvarende dihydroksykarboksylsyrederivater, salter og estere

Country Status (19)

Country	Link
US (1)	US5294724A (no)
EP (1)	EP0418648B1 (no)
JP (1)	JP3053417B2 (no)
KR (1)	KR0162081B1 (no)
AT (1)	ATE116979T1 (no)
AU (1)	AU629977B2 (no)
CA (1)	CA2024849C (no)
DE (2)	DE3929913A1 (no)
DK (1)	DK0418648T3 (no)
ES (1)	ES2067609T3 (no)
FI (1)	FI108642B (no)
GR (1)	GR3015360T3 (no)
HU (1)	HU212103B (no)
IE (1)	IE66106B1 (no)
IL (1)	IL95599A (no)
NO (1)	NO175002C (no)
NZ (1)	NZ235194A (no)
PT (1)	PT95237B (no)
ZA (1)	ZA907134B (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL90249A (en) *	1988-05-13	1994-01-25	Hoechst Ag	Hydroxytethrahydropyran-2-ones, the corresponding dihydroxycarboxylic acid derivatives and salts, process of preparation and pharmaceutical compositions containing them
US5248793A (en) *	1990-10-17	1993-09-28	Warner-Lambert Company	Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5103024A (en) *	1990-10-17	1992-04-07	Warner-Lambert Company	Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
DE4312034A1 (de) *	1993-04-13	1994-10-20	Hesch Rolf Dieter Prof Dr Med	Neuartige Androgene und Anabolika
IL129871A (en) *	1994-05-06	2003-11-23	Pharmacia & Upjohn Inc	Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
IL113567A0 (en) *	1994-05-06	1995-08-31	Upjohn Co	Compounds useful to treat retroviral infections
US5925672A (en)	1996-12-06	1999-07-20	Neurosciences Research Foundation, Inc.	Methods of treating mental diseases, inflammation and pain
US6670398B2 (en) *	1997-05-14	2003-12-30	Atherogenics, Inc.	Compounds and methods for treating transplant rejection
EP1464639B1 (en) *	1997-05-14	2007-03-07	Atherogenics, Inc.	Succinic acid ester of probucol for the inhibition of the expression of VCAM-1
US6852878B2 (en) *	1998-05-14	2005-02-08	Atherogenics, Inc.	Thioketals and thioethers for inhibiting the expression of VCAM-1
EA200800375A1 (ru)	1997-05-14	2008-06-30	Атеродженикс, Инк.	Соединения и способы ингибирования экспрессии vcam-1
KR20010020611A (ko)	1997-07-01	2001-03-15	아테로제닉스, 인코포레이티드	항산화제에 의한 과증식질병 치료의 향상
US6083497A (en)	1997-11-05	2000-07-04	Geltex Pharmaceuticals, Inc.	Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
EP1083894A1 (en)	1998-06-08	2001-03-21	Advanced Medicine, Inc.	MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE
WO2001070757A2 (en) *	2000-03-21	2001-09-27	Atherogenics, Inc.	Thioketals and thioethers for inhibiting the expression of vcam-1
AU5340101A (en)	2000-04-11	2001-10-23	Atherogenics Inc	Compounds and methods to increase plasma hdl cholesterol levels and improve hdl functionality
NL1015744C2 (nl) *	2000-07-19	2002-01-22	Dsm Nv	Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
WO2002087556A2 (en) *	2001-04-11	2002-11-07	Atherogenics, Inc.	Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
BRPI0406738A (pt)	2003-01-13	2005-12-20	Atherogenics Inc	Processo de preparação de ésteres e éteres de probucol e derivados desse
US20050113445A1 (en) *	2003-02-20	2005-05-26	Daniele Piomelli	Methods of treating mental diseases, inflammation and pain
US7294737B2 (en)	2004-04-20	2007-11-13	Atherogenics, Inc.	Process of preparing esters and ethers of probucol and derivatives thereof
US20060194981A1 (en) *	2005-02-26	2006-08-31	Jass Paul A	Process for preparation of probucol derivatives
JP2010522762A (ja)	2007-03-26	2010-07-08	サルトリア・フアーマシユーテイカルズ・エル・エル・シー	糖尿病の治療のための方法及びプロブコール誘導体の組成物
US20080280985A1 (en) *	2007-03-27	2008-11-13	Scott Robert A D	Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
EP3698797A1 (en)	2017-10-16	2020-08-26	Tsinghua University	Mevalonic acid pathway inhibitor and pharmaceutical composition thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4077805A (en)	1974-10-25	1978-03-07	Shirow Asakawa	Light-sensitive composition containing antioxidant
DE3674521D1 (de) *	1985-08-29	1990-10-31	Hoechst Ag	6-phenoxymethyl-4-hydroxytetrahydropyran-2-one, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte.
DE3632893A1 (de) *	1986-09-27	1988-04-07	Hoechst Ag	4-(r)-hydroxy-6(s)-arylthiomethyl-tetrahydropyran-2-one, deren entsprechende sulfoxide und sulfone, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
US4789682A (en) *	1987-03-17	1988-12-06	Merck & Co., Inc.	Antihypercholesterolemic compounds
DE3722809A1 (de) *	1987-07-10	1989-01-19	Hoechst Ag	3-desmethyl-4-fluor-mevalonsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen, ihre verwendung und zwischenprodukte
IT1217402B (it) *	1988-04-12	1990-03-22	Donegani Guido Ist	Procedimento per la preparazione di difenoli monoesteri sostituiti con gruppi arilici e prodotti cosi' ottenuti
DE3819999A1 (de) *	1988-06-11	1989-12-21	Hoechst Ag	Neue 6-phenoxymethyl-4-hydroxytetrahydropyran-2-one und 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2 -one, sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zur herstellung dieser verbindung, ihre verwendung als arzneimittel, pharmazeutische praeparate und neue phenole sowie thiophenole
IL90249A (en) *	1988-05-13	1994-01-25	Hoechst Ag	Hydroxytethrahydropyran-2-ones, the corresponding dihydroxycarboxylic acid derivatives and salts, process of preparation and pharmaceutical compositions containing them
US5093363A (en) *	1989-08-22	1992-03-03	Shionogi & Co., Ltd.	2,4,6-substituted phenol derivatives

1989
- 1989-09-08 DE DE3929913A patent/DE3929913A1/de not_active Withdrawn
1990
- 1990-09-05 ES ES90117043T patent/ES2067609T3/es not_active Expired - Lifetime
- 1990-09-05 EP EP90117043A patent/EP0418648B1/de not_active Expired - Lifetime
- 1990-09-05 DE DE59008238T patent/DE59008238D1/de not_active Expired - Lifetime
- 1990-09-05 AT AT90117043T patent/ATE116979T1/de not_active IP Right Cessation
- 1990-09-05 DK DK90117043.1T patent/DK0418648T3/da active
- 1990-09-06 IL IL9559990A patent/IL95599A/en active IP Right Grant
- 1990-09-06 FI FI904395A patent/FI108642B/fi active IP Right Grant
- 1990-09-06 NZ NZ235194A patent/NZ235194A/en unknown
- 1990-09-06 US US07/578,240 patent/US5294724A/en not_active Expired - Lifetime
- 1990-09-07 JP JP2235998A patent/JP3053417B2/ja not_active Expired - Lifetime
- 1990-09-07 PT PT95237A patent/PT95237B/pt not_active IP Right Cessation
- 1990-09-07 ZA ZA907134A patent/ZA907134B/xx unknown
- 1990-09-07 CA CA002024849A patent/CA2024849C/en not_active Expired - Lifetime
- 1990-09-07 IE IE326290A patent/IE66106B1/en not_active IP Right Cessation
- 1990-09-07 NO NO903911A patent/NO175002C/no not_active IP Right Cessation
- 1990-09-07 AU AU62277/90A patent/AU629977B2/en not_active Expired
- 1990-09-07 KR KR1019900014100A patent/KR0162081B1/ko not_active Expired - Lifetime
- 1990-09-07 HU HU905827A patent/HU212103B/hu unknown
1995
- 1995-03-10 GR GR950400518T patent/GR3015360T3/el unknown

Also Published As

Publication number	Publication date
PT95237A (pt)	1991-05-22
IL95599A0 (en)	1991-06-30
FI904395A0 (fi)	1990-09-06
ZA907134B (en)	1991-06-26
JP3053417B2 (ja)	2000-06-19
HU212103B (en)	1996-02-28
AU629977B2 (en)	1992-10-15
EP0418648A1 (de)	1991-03-27
NZ235194A (en)	1992-06-25
HU905827D0 (en)	1991-03-28
FI108642B (fi)	2002-02-28
EP0418648B1 (de)	1995-01-11
NO903911D0 (no)	1990-09-07
NO175002B (no)	1994-05-09
NO903911L (no)	1991-03-11
AU6227790A (en)	1991-03-14
IE66106B1 (en)	1995-12-13
GR3015360T3 (en)	1995-06-30
KR910006263A (ko)	1991-04-29
IL95599A (en)	1999-07-14
DE3929913A1 (de)	1991-04-04
KR0162081B1 (ko)	1998-12-01
CA2024849A1 (en)	1991-03-09
CA2024849C (en)	2002-01-01
IE903262A1 (en)	1991-03-13
HUT56085A (en)	1991-07-29
US5294724A (en)	1994-03-15
DK0418648T3 (da)	1995-06-12
ES2067609T3 (es)	1995-04-01
PT95237B (pt)	1997-06-30
DE59008238D1 (de)	1995-02-23
JPH0399075A (ja)	1991-04-24
ATE116979T1 (de)	1995-01-15

Legal Events

Date	Code	Title	Description
2010-10-18	MK1K	Patent expired

Publication	Publication Date	Title
AU629977B2 (en)	1992-10-15	4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, process for their preparation, their use as pharmaceuticals, and pharmaceutical preparations and precursors
GR3018825T3 (en)	1996-04-30	3-Demethyl-4-fluoro-mevalonic-acid derivatives, process for their preparation, pharmaceutical preparations based on those compounds, their use and intermediates
NO177004C (no)	1995-07-05	Analogifremgangsmåte for fremstilling av 7-substituerte derivater av 3,5-dihydroksyhept-6-ynsyre
JPS6438086A (en)	1989-02-08	Mevalonic acid derivative and manufacture
NO175637C (no)	1994-11-09	Analogifremgangsmåte for fremstilling av terapeutisk aktive 6-fluor-3,5-dihydroksykarboksylsyrer og derivater derav
AU532982B2 (en)	1983-10-20	Piperidine derivatives of 4,5-dialkyl-3-hydroxy-pyrrole-2- carboxylic acid esters
ATE90095T1 (de)	1993-06-15	Optisch aktive produkte von 20,21dinoreburnamenin-derivaten,verfahren zur herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammenstellungen.
ATE4808T1 (de)	1983-10-15	Piperidinderivate von 3-hydroxy-thiophen-2carbons[ureestern,ihre herstellung und diese enthaltende pharmazeutische zubereitungen.
EP0244833A3 (en)	1989-10-18	4(r)-substituted 6(s)-phenoxymethyl-, 6(s)-beta-phenylethyl- and 6(s)-beta-styryl-tetrahydropyran-2-ones, a highly stereoselective process for their preparation, pharmaceutical preparation based on these compounds and their use