PT95237A - Processo de preparacao de 4-hidroxi-tetrahidropirano-2-onas e dos respectivos derivados de acidos dihidroxi-carboxilicos, sais e esteres, bem como de composicoes farmaceuticas que os contem e de compostos intermediarios - Google Patents

Processo de preparacao de 4-hidroxi-tetrahidropirano-2-onas e dos respectivos derivados de acidos dihidroxi-carboxilicos, sais e esteres, bem como de composicoes farmaceuticas que os contem e de compostos intermediarios

Info

Publication number: PT95237A
Authority: PT; Portugal
Prior art keywords: preparation; carboxylic acids; esters; salts; tetrahydropyrane
Prior art date: 1989-09-08

Application number

PT95237A

Other languages

English (en)

Other versions

PT95237B (pt

Inventor

Heiner Jendralla

Guenther Wess

Kurt Kebeler

Gerhard Beck

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-08

Filing date

1990-09-07

Publication date

1991-05-22

1990-09-07 Application filed by Hoechst Ag filed Critical Hoechst Ag

1991-05-22 Publication of PT95237A publication Critical patent/PT95237A/pt

1997-06-30 Publication of PT95237B publication Critical patent/PT95237B/pt

Links

150000001875 compounds Chemical class 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
MMCOUVMKNAHQOY-UHFFFAOYSA-N carbonoperoxoic acid Chemical class OOC(O)=O MMCOUVMKNAHQOY-UHFFFAOYSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/12—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
- C07C1/20—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as heteroatoms
- C07C1/24—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as heteroatoms by elimination of water
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/10—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
- C07C46/04—Preparation of quinones by oxidation giving rise to quinoid structures of unsubstituted ring carbon atoms in six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/24—Quinones containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Pyrane Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT95237A 1989-09-08 1990-09-07 Processo de preparacao de 4-hidroxi-tetrahidropirano-2-onas e dos respectivos derivados de acidos dihidroxi-carboxilicos, sais e esteres, bem como de composicoes farmaceuticas que os contem e de compostos intermediarios PT95237B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3929913A DE3929913A1 (de)	1989-09-08	1989-09-08	4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte

Publications (2)

Publication Number	Publication Date
PT95237A true PT95237A (pt)	1991-05-22
PT95237B PT95237B (pt)	1997-06-30

Family

ID=6388931

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT95237A PT95237B (pt)	1989-09-08	1990-09-07	Processo de preparacao de 4-hidroxi-tetrahidropirano-2-onas e dos respectivos derivados de acidos dihidroxi-carboxilicos, sais e esteres, bem como de composicoes farmaceuticas que os contem e de compostos intermediarios

Country Status (19)

Country	Link
US (1)	US5294724A (pt)
EP (1)	EP0418648B1 (pt)
JP (1)	JP3053417B2 (pt)
KR (1)	KR0162081B1 (pt)
AT (1)	ATE116979T1 (pt)
AU (1)	AU629977B2 (pt)
CA (1)	CA2024849C (pt)
DE (2)	DE3929913A1 (pt)
DK (1)	DK0418648T3 (pt)
ES (1)	ES2067609T3 (pt)
FI (1)	FI108642B (pt)
GR (1)	GR3015360T3 (pt)
HU (1)	HU212103B (pt)
IE (1)	IE66106B1 (pt)
IL (1)	IL95599A (pt)
NO (1)	NO175002C (pt)
NZ (1)	NZ235194A (pt)
PT (1)	PT95237B (pt)
ZA (1)	ZA907134B (pt)

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IL90249A (en) *	1988-05-13	1994-01-25	Hoechst Ag	Hydroxytethrahydropyran-2-ones, the corresponding dihydroxycarboxylic acid derivatives and salts, process of preparation and pharmaceutical compositions containing them
US5103024A (en) *	1990-10-17	1992-04-07	Warner-Lambert Company	Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5248793A (en) *	1990-10-17	1993-09-28	Warner-Lambert Company	Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
DE4312034A1 (de) *	1993-04-13	1994-10-20	Hesch Rolf Dieter Prof Dr Med	Neuartige Androgene und Anabolika
IL113567A0 (en) *	1994-05-06	1995-08-31	Upjohn Co	Compounds useful to treat retroviral infections
IL129871A (en) *	1994-05-06	2003-11-23	Pharmacia & Upjohn Inc	Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
US5925672A (en) *	1996-12-06	1999-07-20	Neurosciences Research Foundation, Inc.	Methods of treating mental diseases, inflammation and pain
US6670398B2 (en)	1997-05-14	2003-12-30	Atherogenics, Inc.	Compounds and methods for treating transplant rejection
EP1468989A3 (en) *	1997-05-14	2008-12-03	Atherogenics, Inc.	Compounds and methods for the inhibition of the expression of VCAM-1
US6852878B2 (en)	1998-05-14	2005-02-08	Atherogenics, Inc.	Thioketals and thioethers for inhibiting the expression of VCAM-1
CN1275596C (zh) *	1997-05-14	2006-09-20	阿特罗吉尼克斯公司	普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用
WO1999001118A2 (en)	1997-07-01	1999-01-14	Atherogenics, Inc.	Antioxidant enhancement of therapy for hyperproliferative conditions
US6083497A (en)	1997-11-05	2000-07-04	Geltex Pharmaceuticals, Inc.	Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
WO1999063994A1 (en)	1998-06-08	1999-12-16	Advanced Medicine, Inc.	MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE
CA2403823A1 (en) *	2000-03-21	2001-09-27	Atherogenics, Inc.	Thioketals and thioethers for inhibiting the expression of vcam-1
US6881860B2 (en)	2000-04-11	2005-04-19	Atherogenics, Inc.	Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
NL1015744C2 (nl) *	2000-07-19	2002-01-22	Dsm Nv	Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
US20030064967A1 (en) *	2001-04-11	2003-04-03	Jayraz Luchoomun	Methods to increase plasma HDL cholesterol levels and improve HDL functionality with probucol monoesters
CN101391972A (zh)	2003-01-13	2009-03-25	阿特罗吉尼克斯公司	制备普罗布考及其衍生物的酯和醚的方法
US20050113445A1 (en) *	2003-02-20	2005-05-26	Daniele Piomelli	Methods of treating mental diseases, inflammation and pain
US20070260087A1 (en)	2004-04-20	2007-11-08	Atherogenics, Inc.	Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof
US20060194981A1 (en) *	2005-02-26	2006-08-31	Jass Paul A	Process for preparation of probucol derivatives
EP2139320A4 (en)	2007-03-26	2010-09-08	Salutria Pharmaceuticals Llc	METHODS AND COMPOSITIONS OF PROBUCOL DERIVATIVES FOR THE TREATMENT OF DIABETES
WO2008118946A1 (en) *	2007-03-27	2008-10-02	Atherogenics, Inc.	Methods and compositions using certain phenolic derivatives for the treatment of diabetes
KR20200066690A (ko)	2017-10-16	2020-06-10	칭화대학교	메발로네이트 경로 억제제 및 이의 약제학적 조성물

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US4077805A (en)	1974-10-25	1978-03-07	Shirow Asakawa	Light-sensitive composition containing antioxidant
EP0216127B1 (de) *	1985-08-29	1990-09-26	Hoechst Aktiengesellschaft	6-Phenoxymethyl-4-hydroxytetrahydropyran-2-one, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, pharmazeutische Präparate und Zwischenprodukte
DE3632893A1 (de) *	1986-09-27	1988-04-07	Hoechst Ag	4-(r)-hydroxy-6(s)-arylthiomethyl-tetrahydropyran-2-one, deren entsprechende sulfoxide und sulfone, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
US4789682A (en) *	1987-03-17	1988-12-06	Merck & Co., Inc.	Antihypercholesterolemic compounds
DE3722809A1 (de) *	1987-07-10	1989-01-19	Hoechst Ag	3-desmethyl-4-fluor-mevalonsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen, ihre verwendung und zwischenprodukte
IT1217402B (it) *	1988-04-12	1990-03-22	Donegani Guido Ist	Procedimento per la preparazione di difenoli monoesteri sostituiti con gruppi arilici e prodotti cosi' ottenuti
IL90249A (en) *	1988-05-13	1994-01-25	Hoechst Ag	Hydroxytethrahydropyran-2-ones, the corresponding dihydroxycarboxylic acid derivatives and salts, process of preparation and pharmaceutical compositions containing them
DE3819999A1 (de) *	1988-06-11	1989-12-21	Hoechst Ag	Neue 6-phenoxymethyl-4-hydroxytetrahydropyran-2-one und 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2 -one, sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zur herstellung dieser verbindung, ihre verwendung als arzneimittel, pharmazeutische praeparate und neue phenole sowie thiophenole
US5093363A (en) *	1989-08-22	1992-03-03	Shionogi & Co., Ltd.	2,4,6-substituted phenol derivatives

1989
- 1989-09-08 DE DE3929913A patent/DE3929913A1/de not_active Withdrawn
1990
- 1990-09-05 ES ES90117043T patent/ES2067609T3/es not_active Expired - Lifetime
- 1990-09-05 AT AT90117043T patent/ATE116979T1/de not_active IP Right Cessation
- 1990-09-05 DK DK90117043.1T patent/DK0418648T3/da active
- 1990-09-05 EP EP90117043A patent/EP0418648B1/de not_active Expired - Lifetime
- 1990-09-05 DE DE59008238T patent/DE59008238D1/de not_active Expired - Lifetime
- 1990-09-06 IL IL9559990A patent/IL95599A/en active IP Right Grant
- 1990-09-06 US US07/578,240 patent/US5294724A/en not_active Expired - Lifetime
- 1990-09-06 FI FI904395A patent/FI108642B/fi active IP Right Grant
- 1990-09-06 NZ NZ235194A patent/NZ235194A/en unknown
- 1990-09-07 CA CA002024849A patent/CA2024849C/en not_active Expired - Lifetime
- 1990-09-07 ZA ZA907134A patent/ZA907134B/xx unknown
- 1990-09-07 IE IE326290A patent/IE66106B1/en not_active IP Right Cessation
- 1990-09-07 AU AU62277/90A patent/AU629977B2/en not_active Expired
- 1990-09-07 HU HU905827A patent/HU212103B/hu unknown
- 1990-09-07 KR KR1019900014100A patent/KR0162081B1/ko not_active Expired - Lifetime
- 1990-09-07 NO NO903911A patent/NO175002C/no not_active IP Right Cessation
- 1990-09-07 JP JP2235998A patent/JP3053417B2/ja not_active Expired - Lifetime
- 1990-09-07 PT PT95237A patent/PT95237B/pt not_active IP Right Cessation
1995
- 1995-03-10 GR GR950400518T patent/GR3015360T3/el unknown

Also Published As

Publication number	Publication date
EP0418648A1 (de)	1991-03-27
KR910006263A (ko)	1991-04-29
NO175002C (no)	1994-08-17
NO903911L (no)	1991-03-11
DE59008238D1 (de)	1995-02-23
NO175002B (no)	1994-05-09
IL95599A0 (en)	1991-06-30
DK0418648T3 (da)	1995-06-12
HU212103B (en)	1996-02-28
AU629977B2 (en)	1992-10-15
HUT56085A (en)	1991-07-29
IL95599A (en)	1999-07-14
EP0418648B1 (de)	1995-01-11
IE903262A1 (en)	1991-03-13
ATE116979T1 (de)	1995-01-15
NZ235194A (en)	1992-06-25
CA2024849C (en)	2002-01-01
JPH0399075A (ja)	1991-04-24
CA2024849A1 (en)	1991-03-09
JP3053417B2 (ja)	2000-06-19
HU905827D0 (en)	1991-03-28
ES2067609T3 (es)	1995-04-01
FI904395A0 (fi)	1990-09-06
DE3929913A1 (de)	1991-04-04
IE66106B1 (en)	1995-12-13
KR0162081B1 (ko)	1998-12-01
AU6227790A (en)	1991-03-14
NO903911D0 (no)	1990-09-07
US5294724A (en)	1994-03-15
ZA907134B (en)	1991-06-26
FI108642B (fi)	2002-02-28
PT95237B (pt)	1997-06-30
GR3015360T3 (en)	1995-06-30

Legal Events

Date

Code

Title

Description

1991-05-22

BB1A

Laying open of patent application

Effective date: 19901228

1997-06-30

FG3A

Patent granted, date of granting

Effective date: 19970310

2012-03-19

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20120312

Publication	Publication Date	Title
PT95237A (pt)	1991-05-22	Processo de preparacao de 4-hidroxi-tetrahidropirano-2-onas e dos respectivos derivados de acidos dihidroxi-carboxilicos, sais e esteres, bem como de composicoes farmaceuticas que os contem e de compostos intermediarios
FI894477A0 (fi)	1989-09-21	Menetelmä terapeuttisesti aktiivisten 7-substituoitujen 3,5-dihydroksihept-6-yynihappojen ja niiden johdannaisten valmistamiseksi ja välituotteina käyttökelpoiset yhdisteet
NZ225344A (en)	1990-08-28	3-demethylmevalonic acid derivatives and lactones and pharmaceutical compositions; intermediates for the preparation thereof
ES2077199T3 (es)	1995-11-16	Nuevas piperacinas 1,4-disustituidas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
PT82987B (pt)	1988-07-01	Processo para a preparacao de novos de derivados de acidos carboxilicos bem como de composicoes farmaceuticas que os contem
PT90362A (pt)	1989-11-10	Metodo para o tratamento de doencas muco-epiteliais e da pele em mamiferos que utiliza acidos 4-quinolinocarboxilicos e seus derivados e processo para a preparacao de composicoes farmaceuticas que contem os mesmos compostos
PT87930A (pt)	1989-06-30	Processo para a preparacao de derivados de acido 3-desmetil-4-fluor-mevalonico e de composicoes farmaceuticas que os contem
PT91362A (pt)	1990-03-08	Processo para a preparacao de novos acidos 6-fluor-3,5-di-hidroxi-carboxilicos e seus derivados, e de composicoes farmaceuticas que os contem e de produtos intermediarios
ATE6640T1 (de)	1984-03-15	N-benzoyl-alpha-anilinoalkylcarboxylsaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate.
ATE82850T1 (de)	1992-12-15	Verwendung von 2-pyrimidinyl-1-piperazinderivaten.
ATE2746T1 (de)	1983-03-15	Piperidinderivate von 4,5-dialkyl-3-hydroxypyrrol-2-carbons[ureestern, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.
ATE90095T1 (de)	1993-06-15	Optisch aktive produkte von 20,21dinoreburnamenin-derivaten,verfahren zur herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammenstellungen.
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