NO177186C - Fremgangsmåte ved fremstilling av enantiomert rene polysubstituerte 1,4-dihydropyridiner - Google Patents

Fremgangsmåte ved fremstilling av enantiomert rene polysubstituerte 1,4-dihydropyridiner

Info

Publication number: NO177186C
Authority: NO; Norway
Prior art keywords: dihydropyridines; enantiomerically pure; polysubstituted; preparation; racemic
Prior art date: 1989-02-17

Application number

NO913188A

Other languages

English (en)

Norwegian (no)

Other versions

NO177186B (no

NO913188D0 (no

NO913188L (no

Inventor

Carmelo A Gandolfi

Marco Frigerio

Carlo Riva

Andrea Zaliani

Giorgio Long

Roberto Di Domenico

Original Assignee

Boehringer Mannheim Italia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-17

Filing date

1991-08-15

Publication date

1995-08-02

1991-08-15 Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia

1991-08-15 Publication of NO913188D0 publication Critical patent/NO913188D0/no

1991-08-15 Publication of NO913188L publication Critical patent/NO913188L/no

1995-04-24 Publication of NO177186B publication Critical patent/NO177186B/no

1995-08-02 Publication of NO177186C publication Critical patent/NO177186C/no

Links

YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 2
239000002253 acid Substances 0.000 abstract 2
150000007513 acids Chemical class 0.000 abstract 2
238000007796 conventional method Methods 0.000 abstract 1
150000002541 isothioureas Chemical class 0.000 abstract 1
-1 isothioureido groups Chemical group 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical class NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 1
230000009466 transformation Effects 0.000 abstract 1
238000000844 transformation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Treatments Of Macromolecular Shaped Articles (AREA)

NO913188A 1989-02-17 1991-08-15 Fremgangsmåte ved fremstilling av enantiomert rene polysubstituerte 1,4-dihydropyridiner NO177186C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT8919477A IT1230752B (it)	1989-02-17	1989-02-17	Processo per la preparazione di 1,4 diidropiridine polisostituite in forma enantiomericamente pura.
PCT/EP1990/000243 WO1990009376A1 (en)	1989-02-17	1990-02-15	A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines

Publications (4)

Publication Number	Publication Date
NO913188D0 NO913188D0 (no)	1991-08-15
NO913188L NO913188L (no)	1991-08-15
NO177186B NO177186B (no)	1995-04-24
NO177186C true NO177186C (no)	1995-08-02

Family

ID=11158352

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO913188A NO177186C (no)	1989-02-17	1991-08-15	Fremgangsmåte ved fremstilling av enantiomert rene polysubstituerte 1,4-dihydropyridiner

Country Status (17)

Country	Link
US (1)	US5245039A (de)
EP (2)	EP0458823B1 (de)
JP (1)	JPH04505610A (de)
KR (1)	KR0155557B1 (de)
AT (1)	ATE95813T1 (de)
AU (1)	AU630928B2 (de)
CA (1)	CA2047741A1 (de)
DE (1)	DE69003936T2 (de)
DK (1)	DK0458823T3 (de)
ES (1)	ES2060144T3 (de)
FI (1)	FI95371C (de)
HU (1)	HUT62270A (de)
IE (1)	IE66498B1 (de)
IT (1)	IT1230752B (de)
NO (1)	NO177186C (de)
RU (1)	RU2069658C1 (de)
WO (1)	WO1990009376A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5571827A (en) *	1990-03-13	1996-11-05	Sepracor Inc.	Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine
CA2125149A1 (en) *	1991-12-02	1993-06-10	James W. Young	Methods and compositions for treating hypertension, angina, and other disorders using optically pure s(-) felodipine
US5834496A (en) *	1991-12-02	1998-11-10	Sepracor, Inc.	Methods for treating hypertension using optically pure S(-) felodipine
ES2055655B1 (es) *	1992-09-22	1995-03-01	Elmuquimica Farm Sl	Procedimiento de obtencion de 2,6-dimetil-4-(2-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isobutil-5-metil.
ES2055653B1 (es) *	1992-09-22	1995-03-01	Elmuquimica Farm Sl	Procedimiento de obtencion del 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isopropil-5-(2-metoxi)etil.
ES2055654B1 (es) *	1992-09-22	1995-03-01	Elmuquimica Farm Sl	Procedimiento de obtencion de 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-etil-5-metil.
ES2055652B1 (es) *	1992-09-22	1995-03-01	Elmuquimica Farm Sl	Procedimiento de obtencion de 2,6-dimetil-4-(2,3-diclorofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-etil-5-metil.
GB9405833D0 (en) *	1994-03-24	1994-05-11	Pfizer Ltd	Separation of the enantiomers of amlodipine
FR2719585B1 (fr) *	1994-05-05	1996-08-02	Lafon Labor	Procédé d'obtention de 1,4-dihydropyridines optiquement pures.
US5554621A (en) *	1995-06-07	1996-09-10	Bristol-Myers Squibb Company	Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives
TWI246921B (en) *	2000-04-11	2006-01-11	Sankyo Co	Stabilized pharmaceutical composition with calcium blocker
ITMI20012434A1 (it)	2001-11-20	2003-05-20	Dompe Spa	Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3447169A1 (de) *	1984-12-22	1986-07-03	Bayer Ag, 5090 Leverkusen	Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
WO1987000836A1 (en) *	1985-08-06	1987-02-12	Boehringer Biochemia Robin S.P.A.	Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines
EP0225175A3 (de) *	1985-11-28	1988-12-28	FISONS plc	Dihydropyridin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
US4920225A (en) *	1986-12-22	1990-04-24	Laboratoires Syntex S.A.	Resolution of 1,4-dihydropyridine derivatives
WO1988007525A1 (fr) *	1987-03-27	1988-10-06	Byk Gulden Lomberg Chemische Fabrik Gmbh	Enantiomeres de 1,4-dihydropyridine
AU1541188A (en) *	1987-03-27	1988-11-02	Byk Gulden Lomberg Chemische Fabrik Gmbh	New optically active compounds

1989
- 1989-02-17 IT IT8919477A patent/IT1230752B/it active
1990
- 1990-02-15 RU SU905001680A patent/RU2069658C1/ru active
- 1990-02-15 ES ES90903015T patent/ES2060144T3/es not_active Expired - Lifetime
- 1990-02-15 WO PCT/EP1990/000243 patent/WO1990009376A1/en not_active Ceased
- 1990-02-15 CA CA002047741A patent/CA2047741A1/en not_active Abandoned
- 1990-02-15 KR KR1019900702275A patent/KR0155557B1/ko not_active Expired - Fee Related
- 1990-02-15 DK DK90903015.7T patent/DK0458823T3/da active
- 1990-02-15 EP EP90903015A patent/EP0458823B1/de not_active Expired - Lifetime
- 1990-02-15 JP JP2503175A patent/JPH04505610A/ja active Pending
- 1990-02-15 HU HU901962A patent/HUT62270A/hu unknown
- 1990-02-15 AT AT90903015T patent/ATE95813T1/de not_active IP Right Cessation
- 1990-02-15 EP EP90102951A patent/EP0383320A1/de not_active Withdrawn
- 1990-02-15 AU AU50904/90A patent/AU630928B2/en not_active Ceased
- 1990-02-15 US US07/743,415 patent/US5245039A/en not_active Expired - Fee Related
- 1990-02-15 DE DE90903015T patent/DE69003936T2/de not_active Expired - Fee Related
- 1990-02-16 IE IE58490A patent/IE66498B1/en not_active IP Right Cessation
1991
- 1991-08-15 FI FI913861A patent/FI95371C/fi not_active IP Right Cessation
- 1991-08-15 NO NO913188A patent/NO177186C/no unknown

Also Published As

Publication number	Publication date
CA2047741A1 (en)	1990-08-18
ATE95813T1 (de)	1993-10-15
FI913861A0 (fi)	1991-08-15
EP0458823A1 (de)	1991-12-04
IT1230752B (it)	1991-10-29
KR910700234A (ko)	1991-03-14
JPH04505610A (ja)	1992-10-01
IT8919477A0 (it)	1989-02-17
AU5090490A (en)	1990-09-05
WO1990009376A1 (en)	1990-08-23
EP0458823B1 (de)	1993-10-13
RU2069658C1 (ru)	1996-11-27
DK0458823T3 (da)	1994-02-21
FI95371C (fi)	1996-01-25
DE69003936D1 (de)	1993-11-18
IE900584L (en)	1990-08-17
EP0383320A1 (de)	1990-08-22
DE69003936T2 (de)	1994-03-31
KR0155557B1 (ko)	1998-11-16
NO177186B (no)	1995-04-24
US5245039A (en)	1993-09-14
NO913188D0 (no)	1991-08-15
ES2060144T3 (es)	1994-11-16
AU630928B2 (en)	1992-11-12
HUT62270A (en)	1993-04-28
FI95371B (fi)	1995-10-13
NO913188L (no)	1991-08-15
IE66498B1 (en)	1996-01-10

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