NO177748B - Fremgangsmåte for å redusere en karbonylinneholdende acridin - Google Patents
Fremgangsmåte for å redusere en karbonylinneholdende acridin Download PDFInfo
- Publication number
- NO177748B NO177748B NO911255A NO911255A NO177748B NO 177748 B NO177748 B NO 177748B NO 911255 A NO911255 A NO 911255A NO 911255 A NO911255 A NO 911255A NO 177748 B NO177748 B NO 177748B
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- solvent
- formula
- alkali metal
- platinum
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Chemically Coating (AREA)
- Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Manufacturing Of Electric Cables (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Chemical Treatment Of Metals (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Electroplating Methods And Accessories (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Carbon And Carbon Compounds (AREA)
- Manufacturing Of Printed Wiring (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Claims (9)
1.
Fremgangsmåte for redusering av et karbonylinneholdende acridinderivat med formel I til en forbindelse med formel:
der n er 1, 2 eller 3 og X er hydrogen, halogen eller trifluormetyl; R^ er hydrogen, laverealkyl, dilaverealkyl-aminolaverealkyl, fenyllaverealkyl, difenyllaverealkyl, thienyllaverealkyl, oksygen-brobundet fenyllaverealkyl, oksygen-brobundet difenyllaverealkyl, karakterisert ved at den omfatter reaksjon av nevnte karbonylinneholdende acridin med en edelmetallkatalysator under hydrogentrykk i nærvær av en alkalimetallbase i et passende oppløsningsmiddel fortrinnsvis et laverealkanol-oppløsningsmiddel som har 2 til 8 karbonatomer valgt fra gruppen etanol, 1-propanol, 2-propanol og 1-butanol, og ved en forhøyet temperatur fortrinnsvis 40-100°C.
2.
Fremgangsmåte ifølge krav 1, karakterisert ved at edelmetallkatalysatoren er platina, platinaoksid eller et platinasalt.
3.
Fremgangsmåte ifølge krav 1, karakterisert ved at alkalimetallbasen blir valgt fra 1itiumhydroksid og dens hydrater, natriumhydroksid og lavere alkoksider._av natrium eller litium.
4.
Fremgangsmåte ifølge krav 3, karakterisert ved at alkalimetallbasen er natriumhydroksid eller litiumhydroksidmonohydrat.
5.
Fremgangsmåte ifølge krav 1, karakterisert ved at oppløsningsmidlet er 1-butanol.
6.
Fremgangsmåte ifølge krav 1, karakterisert ved at 2 til 1056 v/v vann blir tilsatt oppløsningsmidlet.
7.
Fremgangsmåte ifølge krav 1, karakterisert ved at temperaturen er 60-80"C.
8.
Fremgangsmåte ifølge krav 1, karakterisert ved at katalysatoren er platina, alkalimetallbasen er litiumhydroksid og oppløsningsmidlet er 1-butanol.
9.
Fremgangsmåte ifølge krav 1, karakterisert ved at forbindelsen med formel Ia
der R1=H, X=Hogn=2,
eller et farmasøytisk aksepterbart syreaddisjonssalt derav reduseres til en forbindelse med formel Ila
eller et farmasøytisk aksepterbart syreaddisjonssalt derav.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/500,967 US5053513A (en) | 1990-03-29 | 1990-03-29 | Method of reducing a carbonyl containing acridine |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO911255D0 NO911255D0 (no) | 1991-03-27 |
| NO911255L NO911255L (no) | 1991-09-30 |
| NO177748B true NO177748B (no) | 1995-08-07 |
| NO177748C NO177748C (no) | 1995-11-15 |
Family
ID=23991612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO911255A NO177748C (no) | 1990-03-29 | 1991-03-27 | Fremgangsmåte for å redusere en karbonylinneholdende acridin |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5053513A (no) |
| EP (1) | EP0449172B1 (no) |
| JP (1) | JPH07113017B2 (no) |
| KR (1) | KR0178275B1 (no) |
| CN (1) | CN1032649C (no) |
| AT (1) | ATE138913T1 (no) |
| AU (1) | AU640759B2 (no) |
| BR (1) | BR9101252A (no) |
| CA (1) | CA2039318A1 (no) |
| CS (1) | CS83591A2 (no) |
| DE (1) | DE69119961T2 (no) |
| DK (1) | DK0449172T3 (no) |
| ES (1) | ES2099717T3 (no) |
| FI (1) | FI98366C (no) |
| GR (1) | GR3020518T3 (no) |
| HU (1) | HUT57732A (no) |
| IE (1) | IE76463B1 (no) |
| IL (1) | IL97697A (no) |
| NO (1) | NO177748C (no) |
| NZ (1) | NZ237603A (no) |
| PL (1) | PL165759B1 (no) |
| PT (1) | PT97196B (no) |
| RU (1) | RU2069659C1 (no) |
| ZA (1) | ZA912365B (no) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5210087A (en) * | 1991-02-13 | 1993-05-11 | Hoechst-Roussel Pharmaceuticals Inc. | 9-aminotetrahydroacridines and related compounds |
| RU2024509C1 (ru) * | 1991-05-07 | 1994-12-15 | Всероссийский научный центр по безопасности биологически активных веществ | Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность |
| US5247091A (en) * | 1992-07-30 | 1993-09-21 | Hoechst Celanese Corporation | Preparation of enamines in aqueous media |
| ES2059263B1 (es) * | 1992-10-27 | 1995-10-01 | Vita Invest Sa | Procedimiento para la obtencion del (+)-9-amino-1,2,3,4-tetrahidroacridin-1-ol. |
| GB201312228D0 (en) | 2013-07-08 | 2013-08-21 | Ludlow Michael | A lip skin and a method and apparatus for forming a lip skin |
| RU2567388C1 (ru) * | 2014-12-10 | 2015-11-10 | Открытое акционерное общество "Нижегородский химико-фармацевтический завод" | Способ получения 9-бутиламино-3,3-диметил-3,4-дигидроакридин-1(2н)-она гидрохлорида |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0179383B1 (en) * | 1984-10-25 | 1991-05-29 | Hoechst-Roussel Pharmaceuticals Incorporated | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments |
| US4695573A (en) * | 1984-10-25 | 1987-09-22 | Hoechst-Roussel Pharmaceuticals Inc. | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds |
| US4631286A (en) * | 1984-10-25 | 1986-12-23 | Hoechst-Roussel Pharmaceuticals Inc. | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds |
| US4754050A (en) * | 1984-10-25 | 1988-06-28 | Hoechst-Roussel Pharmaceuticals, Inc. | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds |
| US4835275A (en) * | 1984-10-25 | 1989-05-30 | Hoechst-Roussel Pharmaceuticals, Inc. | Method of preparing 9-amino-1,2,3,4,-tetrahydroacridin-1-ones and related compounds |
| US4851536A (en) * | 1987-05-07 | 1989-07-25 | American Home Products Corporation | Cyclohexylquinolines as inhibitors of interleukin 1 |
| US4868177A (en) * | 1988-11-09 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use |
| GB8827704D0 (en) * | 1988-11-28 | 1988-12-29 | Fujisawa Pharmaceutical Co | New acridine derivatives & processes for their production |
| US5155226A (en) * | 1991-02-19 | 1992-10-13 | Hoechst-Roussel Pharmaceuticals Incorporated | Method for the preparation of 9-amino-1,2,3,4-tetrahydroacridine |
-
1990
- 1990-03-29 US US07/500,967 patent/US5053513A/en not_active Expired - Fee Related
-
1991
- 1991-03-25 ES ES91104661T patent/ES2099717T3/es not_active Expired - Lifetime
- 1991-03-25 AT AT91104661T patent/ATE138913T1/de not_active IP Right Cessation
- 1991-03-25 DK DK91104661.3T patent/DK0449172T3/da active
- 1991-03-25 DE DE69119961T patent/DE69119961T2/de not_active Expired - Fee Related
- 1991-03-25 EP EP91104661A patent/EP0449172B1/en not_active Expired - Lifetime
- 1991-03-27 KR KR1019910004757A patent/KR0178275B1/ko not_active Expired - Fee Related
- 1991-03-27 FI FI911513A patent/FI98366C/fi active
- 1991-03-27 CS CS91835A patent/CS83591A2/cs unknown
- 1991-03-27 NO NO911255A patent/NO177748C/no unknown
- 1991-03-27 NZ NZ237603A patent/NZ237603A/en unknown
- 1991-03-27 IL IL9769791A patent/IL97697A/en not_active IP Right Cessation
- 1991-03-28 IE IE107091A patent/IE76463B1/en not_active IP Right Cessation
- 1991-03-28 PT PT97196A patent/PT97196B/pt not_active IP Right Cessation
- 1991-03-28 AU AU73870/91A patent/AU640759B2/en not_active Ceased
- 1991-03-28 PL PL91289656A patent/PL165759B1/pl unknown
- 1991-03-28 RU SU914895044A patent/RU2069659C1/ru active
- 1991-03-28 BR BR919101252A patent/BR9101252A/pt unknown
- 1991-03-28 ZA ZA912365A patent/ZA912365B/xx unknown
- 1991-03-28 JP JP3087252A patent/JPH07113017B2/ja not_active Expired - Lifetime
- 1991-03-28 CA CA002039318A patent/CA2039318A1/en not_active Abandoned
- 1991-03-28 CN CN91101914A patent/CN1032649C/zh not_active Expired - Fee Related
- 1991-03-29 HU HU911055A patent/HUT57732A/hu unknown
-
1996
- 1996-07-11 GR GR960401878T patent/GR3020518T3/el unknown
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