NO178065C - Analogifremgangsmåte ved fremstilling av terapeutisk aktive nye vitamin D-analoger, samt mellomprodukt - Google Patents

Analogifremgangsmåte ved fremstilling av terapeutisk aktive nye vitamin D-analoger, samt mellomprodukt

Info

Publication number: NO178065C
Authority: NO; Norway
Prior art keywords: formula; well; compounds; analogues; therapeutically active
Prior art date: 1989-02-23

Application number

NO912902A

Other languages

English (en)

Norwegian (no)

Other versions

NO178065B (no

NO912902L (no

NO912902D0 (no

Inventor

Martin John Calverley

Kai Hansen

Lise Binderup

Original Assignee

Leo Pharm Prod Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-23

Filing date

1991-07-25

Publication date

1996-01-17

1991-07-25 Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd

1991-07-25 Publication of NO912902L publication Critical patent/NO912902L/no

1991-07-25 Publication of NO912902D0 publication Critical patent/NO912902D0/no

1995-10-09 Publication of NO178065B publication Critical patent/NO178065B/no

1996-01-17 Publication of NO178065C publication Critical patent/NO178065C/no

Links

229930003316 Vitamin D Natural products 0.000 title 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title 1
235000019166 vitamin D Nutrition 0.000 title 1
239000011710 vitamin D Substances 0.000 title 1
150000003710 vitamin D derivatives Chemical class 0.000 title 1
229940046008 vitamin d Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000024245 cell differentiation Effects 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
210000000987 immune system Anatomy 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO912902A 1989-02-23 1991-07-25 Analogifremgangsmåte ved fremstilling av terapeutisk aktive nye vitamin D-analoger, samt mellomprodukt NO178065C (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB898904154A GB8904154D0 (en)	1989-02-23	1989-02-23	Chemical compounds
PCT/DK1990/000036 WO1990009991A1 (en)	1989-02-23	1990-02-13	Novel vitamin d analogues
SG131794A SG131794G (en)	1989-02-23	1994-09-12	Novel vitamin D analogues

Publications (4)

Publication Number	Publication Date
NO912902L NO912902L (no)	1991-07-25
NO912902D0 NO912902D0 (no)	1991-07-25
NO178065B NO178065B (no)	1995-10-09
NO178065C true NO178065C (no)	1996-01-17

Family

ID=26295003

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO912902A NO178065C (no)	1989-02-23	1991-07-25	Analogifremgangsmåte ved fremstilling av terapeutisk aktive nye vitamin D-analoger, samt mellomprodukt

Country Status (22)

Country	Link
EP (1)	EP0460032B1 (pt)
JP (1)	JP2807083B2 (pt)
KR (1)	KR0163194B1 (pt)
AT (1)	ATE104957T1 (pt)
AU (1)	AU627001B2 (pt)
CA (1)	CA2044280C (pt)
DE (1)	DE69008517T2 (pt)
DK (1)	DK0460032T3 (pt)
ES (1)	ES2055905T3 (pt)
FI (1)	FI92929C (pt)
GB (1)	GB8904154D0 (pt)
HK (1)	HK128894A (pt)
HU (1)	HU211025B (pt)
IE (1)	IE63123B1 (pt)
LT (1)	LT3983B (pt)
LV (1)	LV10428B (pt)
NO (1)	NO178065C (pt)
PT (1)	PT93232B (pt)
RO (1)	RO109939B1 (pt)
RU (1)	RU2037484C1 (pt)
SG (1)	SG131794G (pt)
WO (1)	WO1990009991A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8904153D0 (en) *	1989-02-23	1989-04-05	Leo Pharm Prod Ltd	Chemical compounds
DE4011682A1 (de) *	1990-04-06	1991-10-10	Schering Ag	24-oxa-derivate in der vitamin d-reihe
GB9015774D0 (en) *	1990-07-18	1990-09-05	Leo Pharm Prod Ltd	Novel treatment
US5486509A (en) *	1991-06-28	1996-01-23	University Of Miami	Method of preventing and treating chemotherapy-induced alopecia
AU666563B2 (en) *	1992-08-07	1996-02-15	Wisconsin Alumni Research Foundation	Preparation of 19-nor-vitamin D compounds
GB9220272D0 (en) *	1992-09-25	1992-11-11	Leo Pharm Prod Ltd	Chemical compounds
GB9220439D0 (en) *	1992-09-28	1992-11-11	Leo Pharm Prod Ltd	Chemical compounds
US5449668A (en) *	1993-06-04	1995-09-12	Duphar International Research B.V.	Vitamin D compounds and method of preparing these compounds
US6392071B1 (en)	1997-03-17	2002-05-21	Wisconsin Alumni: Research Foundation	26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US6316642B1 (en)	1997-03-17	2001-11-13	Wisconsin Alumni Research Foundation	26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
US5945410A (en)	1997-03-17	1999-08-31	Wisconsin Alumni Research Foundation	2-alkyl-19-nor-vitamin D compounds
US6306844B1 (en)	1997-03-17	2001-10-23	Wisconsin Alumni Research Foundation	Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
US5939406A (en)	1997-07-21	1999-08-17	Wisconsin Alumni Research Foundation	18-substituted-19-nor-vitamin D compounds
US6359152B2 (en)	1997-07-21	2002-03-19	Wisconsin Alumni Research Foundation	18-substituted-19-nor-vitamin D compounds
JP4046363B2 (ja) *	1998-03-04	2008-02-13	帝人株式会社	活性型ビタミンｄ３乳剤性ローション剤
US5962707A (en) *	1998-08-18	1999-10-05	Wisconsin Alumni Research Foundation	19-nor-vitamin D3 compounds with calcemic activity
PT3146969T (pt) *	1999-04-23	2018-10-18	Leo Pharma As	Composição farmacêutica para aplicação dérmica para uso no tratamento da psoríase compreendendo vitamina d e um corticosteroide
EP1275643A4 (en) *	2000-04-19	2009-06-03	Chugai Pharmaceutical Co Ltd	VITAMIN D DERIVATIVES
US20030018017A1 (en) *	2001-01-25	2003-01-23	Deluca Hector F.	Method of treatment of type I diabetes
WO2004076468A1 (ja) *	2003-02-25	2004-09-10	Kobe Tennenbutsu Kagaku Kabushiki Kaisha	ビタミンｄ誘導体を合成するための新規な中間体
BRPI0409194A (pt)	2003-04-10	2006-04-11	Wisconsin Alumni Res Found	compostos, composição farmacêutica e método de tratamento de doença metabólica do osso, da psorìase, da leucemia, cáncer do cólon, cáncer da mama, cáncer da pele ou cáncer da próstata, de doença auto-imune, de doença inflamatória do intestino e de aumento da resistência do osso
US6894037B2 (en)	2003-07-03	2005-05-17	Wisconsin Alumni Research Foundation	2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses
US7713951B2 (en)	2004-04-09	2010-05-11	Wisconsin Alumni Research Foundation	2-alkylidene-18,19-dinor-vitamin D compounds
CA2586679A1 (en)	2004-11-12	2006-05-18	Bioxell Spa	Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
EP2010483A2 (en)	2006-04-05	2009-01-07	Wisconsin Alumni Research Foundation	1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and use thereof
US8377913B2 (en) *	2007-11-20	2013-02-19	Abbvie Inc.	Vitamin D receptor activators and methods of making
JP5563324B2 (ja) *	2010-02-03	2014-07-30	フォーモサ・ラボラトリーズ・インコーポレーテッド	マキサカルシトール中間体およびその製造方法
JP2014514274A (ja)	2011-03-09	2014-06-19	テバファーマシューティカルインダストリーズリミティド	マキサカルシトールの多形およびマキサカルシトールの調製方法
CN102796134B (zh) *	2012-08-31	2015-07-01	甘肃皓天化学科技有限公司	一种马沙骨化醇中间体的制备方法
CN103910666A (zh) *	2014-04-15	2014-07-09	湖南华腾制药有限公司	一种制备马沙骨化醇的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0078704B1 (en)	1981-11-02	1987-04-29	Research Institute For Medicine And Chemistry Inc.	Intermediates in the synthesis of vitamin d derivatives
DE3577552D1 (de) *	1984-11-27	1990-06-13	Chugai Pharmaceutical Co Ltd	Vitamin d-derivate und verfahren zu deren herstellung.
JPH07100685B2 (ja)	1985-08-02	1995-11-01	レオ・ファ−マシュ−ティカル・プロダクツ・リミテッド・エイ／エス（レ−ベンス・ケミスケ・ファブリック・プロデュクチオンスアクチ−セルスカブ）	新規ビタミンｄ類似体
KR0144358B1 (ko)	1988-04-21	1998-07-15	피. 라이달 크리스텐슨	비타민 d 동족체
GB8904153D0 (en) *	1989-02-23	1989-04-05	Leo Pharm Prod Ltd	Chemical compounds

1989
- 1989-02-23 GB GB898904154A patent/GB8904154D0/en active Pending
1990
- 1990-02-13 ES ES90903793T patent/ES2055905T3/es not_active Expired - Lifetime
- 1990-02-13 CA CA002044280A patent/CA2044280C/en not_active Expired - Fee Related
- 1990-02-13 EP EP90903793A patent/EP0460032B1/en not_active Expired - Lifetime
- 1990-02-13 DE DE69008517T patent/DE69008517T2/de not_active Expired - Fee Related
- 1990-02-13 WO PCT/DK1990/000036 patent/WO1990009991A1/en not_active Ceased
- 1990-02-13 KR KR1019910700655A patent/KR0163194B1/ko not_active Expired - Fee Related
- 1990-02-13 RO RO148060A patent/RO109939B1/ro unknown
- 1990-02-13 JP JP2504126A patent/JP2807083B2/ja not_active Expired - Fee Related
- 1990-02-13 HU HU902300A patent/HU211025B/hu not_active IP Right Cessation
- 1990-02-13 AT AT9090903793T patent/ATE104957T1/de not_active IP Right Cessation
- 1990-02-13 DK DK90903793.9T patent/DK0460032T3/da active
- 1990-02-13 AU AU51983/90A patent/AU627001B2/en not_active Ceased
- 1990-02-22 PT PT93232A patent/PT93232B/pt not_active IP Right Cessation
1991
- 1991-06-19 IE IE42190A patent/IE63123B1/en not_active IP Right Cessation
- 1991-07-25 NO NO912902A patent/NO178065C/no not_active IP Right Cessation
- 1991-08-12 FI FI913812A patent/FI92929C/fi active
- 1991-08-22 RU SU915001741A patent/RU2037484C1/ru not_active IP Right Cessation
1993
- 1993-09-28 LV LVP-93-1106A patent/LV10428B/en unknown
- 1993-12-06 LT LTIP1536A patent/LT3983B/lt not_active IP Right Cessation
1994
- 1994-09-12 SG SG131794A patent/SG131794G/en unknown
- 1994-11-17 HK HK128894A patent/HK128894A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI92929B (fi)	1994-10-14
HUT59664A (en)	1992-06-29
HU211025B (en)	1995-09-28
KR920701145A (ko)	1992-08-11
CA2044280C (en)	1999-12-21
DK0460032T3 (da)	1994-06-06
GB8904154D0 (en)	1989-04-05
LTIP1536A (en)	1995-09-25
KR0163194B1 (ko)	1999-01-15
IE900421L (en)	1990-08-23
AU627001B2 (en)	1992-08-13
WO1990009991A1 (en)	1990-09-07
PT93232A (pt)	1990-08-31
DE69008517T2 (de)	1994-08-18
SG131794G (en)	1995-01-13
NO178065B (no)	1995-10-09
AU5198390A (en)	1990-09-26
DE69008517D1 (de)	1994-06-01
JP2807083B2 (ja)	1998-09-30
RO109939B1 (ro)	1995-07-28
NO912902L (no)	1991-07-25
LV10428A (lv)	1995-02-20
NO912902D0 (no)	1991-07-25
FI92929C (fi)	1995-01-25
IE63123B1 (en)	1995-03-22
HK128894A (en)	1994-11-25
JPH04503669A (ja)	1992-07-02
RU2037484C1 (ru)	1995-06-19
LV10428B (en)	1995-10-20
PT93232B (pt)	1995-12-29
CA2044280A1 (en)	1990-08-24
ES2055905T3 (es)	1994-09-01
EP0460032A1 (en)	1991-12-11
FI913812A0 (fi)	1991-08-12
LT3983B (en)	1996-06-25
ATE104957T1 (de)	1994-05-15
EP0460032B1 (en)	1994-04-27

Legal Events

Date	Code	Title	Description
2003-09-29	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN AUGUST 2003

Publication	Publication Date	Title
NO178065C (no)	1996-01-17	Analogifremgangsmåte ved fremstilling av terapeutisk aktive nye vitamin D-analoger, samt mellomprodukt
FI916151A0 (fi)	1991-12-27	Menetelmä uusien D-vitamiinianalogien valmistamiseksi
CA2078555A1 (en)	1992-02-16	Novel vitamin d analogues
DK0460034T3 (da)	1994-05-30	Nye D-vitaminanaloger
HUT42095A (en)	1987-06-29	Process for producing purine ring or analogue ring-systhems /heteropurine/-containing compounds and pharmaceutical compositions containing them
IE782070L (en)	1979-04-19	Azabicyclo (3.2.0) hept-2-ene carboxylic acid derivatives
ES474289A1 (es)	1979-11-01	Un procedimiento para la preparacion de derivados del acido 6-(1'-hidroxietil)-7-oxi-1-aza-biciclo(3,2,0)hept-2-en -2- carboxilico-3-sustutuidos
NZ234216A (en)	1993-03-26	Vitamin d analogues, preparation and pharmaceutical compositions thereof
RU95113157A (ru)	1996-11-20	Новые аналоги витамина d, способ их получения, фармацевтическая композиция на их основе, способ лечения и профилактики патологических состояний
AU5782290A (en)	1991-01-03	4,5-dihydro-6h-imidazo(4,5,1-ij)quinolin-6-one-6-oxime-0- sulfonic acid derivatives
JPS5775988A (en)	1982-05-12	Novel cephem compound and its preparation