NO178894C - Rekombinant DNA-molekyl, ekspresjonsvektor, vertcelle, fusjonsprotein og fremgangsmåte for fremstilling av proteinet - Google Patents

Rekombinant DNA-molekyl, ekspresjonsvektor, vertcelle, fusjonsprotein og fremgangsmåte for fremstilling av proteinet

Info

Publication number: NO178894C
Authority: NO; Norway
Prior art keywords: protein; fusion protein; gst; recombinant dna; expression vector
Prior art date: 1987-05-28

Application number

NO890325A

Other languages

English (en)

Norwegian (no)

Other versions

NO890325D0 (no

NO178894B (no

NO890325L (no

Inventor

Donald Bruce Smith

Original Assignee

Amrad Corp Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-28

Filing date

1989-01-26

Publication date

1996-06-26

1989-01-26 Application filed by Amrad Corp Ltd filed Critical Amrad Corp Ltd

1989-01-26 Publication of NO890325D0 publication Critical patent/NO890325D0/no

1989-03-06 Publication of NO890325L publication Critical patent/NO890325L/no

1996-03-18 Publication of NO178894B publication Critical patent/NO178894B/no

1996-06-26 Publication of NO178894C publication Critical patent/NO178894C/no

Links

102000004169 proteins and genes Human genes 0.000 title abstract 4
108090000623 proteins and genes Proteins 0.000 title abstract 4
108020001507 fusion proteins Proteins 0.000 title abstract 3
102000037865 fusion proteins Human genes 0.000 title abstract 3
102000053602 DNA Human genes 0.000 title abstract 2
108020004511 Recombinant DNA Proteins 0.000 title abstract 2
239000013604 expression vector Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
108090000790 Enzymes Proteins 0.000 abstract 4
102000004190 Enzymes Human genes 0.000 abstract 4
229940088598 enzyme Drugs 0.000 abstract 4
239000002773 nucleotide Substances 0.000 abstract 3
125000003729 nucleotide group Chemical group 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 abstract 1
102100028255 Renin Human genes 0.000 abstract 1
108090000783 Renin Proteins 0.000 abstract 1
241000242677 Schistosoma japonicum Species 0.000 abstract 1
108090000190 Thrombin Proteins 0.000 abstract 1
230000037431 insertion Effects 0.000 abstract 1
238000003780 insertion Methods 0.000 abstract 1
108091008146 restriction endonucleases Proteins 0.000 abstract 1
229960004072 thrombin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
- C12N9/1088—Glutathione transferase (2.5.1.18)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
- C07K14/43559—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from trematodes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Microbiology (AREA)
Tropical Medicine & Parasitology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Plant Pathology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO890325A 1987-05-28 1989-01-26 Rekombinant DNA-molekyl, ekspresjonsvektor, vertcelle, fusjonsprotein og fremgangsmåte for fremstilling av proteinet NO178894C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPI219587		1987-05-28
PCT/AU1988/000164 WO1988009372A1 (en)	1987-05-28	1988-05-27	Novel fusion proteins containing glutathione-s-transferase

Publications (4)

Publication Number	Publication Date
NO890325D0 NO890325D0 (no)	1989-01-26
NO890325L NO890325L (no)	1989-03-06
NO178894B NO178894B (no)	1996-03-18
NO178894C true NO178894C (no)	1996-06-26

Family

ID=3772204

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO890325A NO178894C (no)	1987-05-28	1989-01-26	Rekombinant DNA-molekyl, ekspresjonsvektor, vertcelle, fusjonsprotein og fremgangsmåte for fremstilling av proteinet

Country Status (14)

Country	Link
EP (1)	EP0293249B1 (da)
JP (1)	JPH0681596B2 (da)
AT (1)	ATE79902T1 (da)
AU (1)	AU607511B2 (da)
CA (1)	CA1338903C (da)
DE (1)	DE3873989T2 (da)
DK (1)	DK169975B1 (da)
ES (1)	ES2045115T3 (da)
GR (1)	GR3006173T3 (da)
NO (1)	NO178894C (da)
NZ (1)	NZ224663A (da)
SG (1)	SG25093G (da)
WO (1)	WO1988009372A1 (da)
ZA (1)	ZA883681B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH04507235A (ja) *	1989-01-31	1992-12-17	ダラテック　ピーテーワイ　リミテッド	反芻動物における肝吸虫感染に対する予防治療のためのワクチン
USRE37919E1 (en)	1989-05-12	2002-12-03	The General Hospital Corporation	Recombinant DNA method for production of parathyroid hormone
US5171670A (en) *	1989-05-12	1992-12-15	The General Hospital Corporation	Recombinant dna method for production of parathyroid hormone
FR2657883A1 (da) *	1990-02-07	1991-08-09	Transgene Sa
US6077694A (en) *	1990-09-21	2000-06-20	The United States Of America As Represented By The Department Of Health And Human Services	Method for over-expression and rapid purification of biosynthetic proteins
WO1993003157A1 (en) *	1991-07-29	1993-02-18	Dana Farber Cancer Institute	Plasmids for the rapid preparation of modified proteins
US6372249B1 (en)	1991-12-16	2002-04-16	Baylor College Of Medicine	Senscent cell-derived inhibitors of DNA synthesis
US5596079A (en) *	1991-12-16	1997-01-21	Smith; James R.	Mimetics of senescent cell derived inhibitors of DNA synthesis
WO1993019091A1 (en) *	1992-03-18	1993-09-30	Amrad Corporation Limited	Tripartite fusion proteins of glutathione s-transferase
GB9210337D0 (en) *	1992-05-14	1992-07-01	Univ Court Of The University O	Feline leukaemia virus vaccine
AU6172194A (en) *	1993-02-08	1994-08-29	Paravax, Inc.	Defective sindbis virus vectors that express (toxoplasma gondii) p30 antigens
US5532142A (en) *	1993-02-12	1996-07-02	Board Of Regents, The University Of Texas System	Method of isolation and purification of fusion polypeptides
US5480864A (en) *	1993-08-06	1996-01-02	Shiseido Co., Ltd.	Modified maxadilan protein, its preparation and use, and DNA encoding the protein
EP0723402B1 (en) *	1993-08-30	2010-08-18	Baylor College Of Medicine	Senescent cell-derived inhibitors of dna synthesis
US6303369B1 (en)	1993-09-30	2001-10-16	Carl Spana	Protein expression system
GB9502489D0 (en) *	1995-02-09	1995-03-29	Animal Health Trust	Expression of the non-structural protein NS1 of influenza virus and detection of anti-NS1 antibody in serum
US5800811A (en) *	1995-06-06	1998-09-01	Hall; Frederick L.	Artificial skin prepared from coclagen matrix containing transforming growth factor-β having a collagen binding site
GB9513683D0 (en) *	1995-07-05	1995-09-06	Ciba Geigy Ag	Products
AU707191B2 (en)	1995-12-28	1999-07-08	Fujirebio Inc.	Fused DNA sequence, fused protein expressed from said fused DNA sequence and method for expressing said protein
DE19653498C1 (de) *	1996-12-20	1998-07-23	Wolf M Prof Dr Bertling	Klonierungsvektor-System mit Fusionssequenz
ATE491721T1 (de)	1997-08-01	2011-01-15	Max Planck Gesellschaft	Zusammensetzung und verfahren zum nachweis von krankheiten in zusammenhang mit der bildung von amyloid-ähnlichen fibrillen oder protein- aggregaten
US6428784B1 (en)	1997-10-31	2002-08-06	New Horizons Diagnostics Corp	Vaginal suppository for treating group B Streptococcus infection
US6277399B1 (en)	1997-10-31	2001-08-21	New Horizon Diagnostics Corporation	Composition incorporating bacterial phage associated lysing enzymes for treating dermatological infections
US6752988B1 (en)	2000-04-28	2004-06-22	New Horizons Diagnostic Corp	Method of treating upper resiratory illnesses
US6056954A (en)	1997-10-31	2000-05-02	New Horizons Diagnostics Corp	Use of bacterial phage associated lysing enzymers for the prophylactic and therapeutic treatment of various illnesses
US6432444B1 (en)	1997-10-31	2002-08-13	New Horizons Diagnostics Corp	Use of bacterial phage associated lysing enzymes for treating dermatological infections
US6406692B1 (en)	1997-10-31	2002-06-18	New Horizons Diagnostics Corp	Composition for treatment of an ocular bacterial infection
US7232576B2 (en)	1997-10-31	2007-06-19	New Horizons Diagnostics Corp	Throat lozenge for the treatment of Streptococcus Group A
US6423299B1 (en)	1997-10-31	2002-07-23	Vincent Fischetti	Composition for treatment of a bacterial infection of an upper respiratory tract
US6077689A (en) *	1997-12-24	2000-06-20	Amgen Inc.	Enhanced solubility of recombinant proteins
CA2331921A1 (en) *	1998-06-24	1999-12-29	Boyce Thompson Institute For Plant Research, Inc.	A novel invertebrate intestinal mucin cdna and related products and methods
US6187558B1 (en)	1998-06-24	2001-02-13	Boyce Thompson Institute For Plant Research, Inc.	Invertebrate intestinal mucin cDNA and related products and methods
US7595199B1 (en)	1998-07-31	2009-09-29	Max-Planck-Gesellschaft zur Förderung der Wissenchaften e.V.	Method of detecting amyloid-like fibrils or protein aggregates
GB9821821D0 (en) *	1998-10-07	1998-12-02	Univ Wales	Schistomiasis vaccine
US7063837B2 (en)	1999-09-14	2006-06-20	New Horizons Diagnostics Corp	Syrup composition containing phage associated lytic enzymes
US6632638B1 (en)	2000-11-17	2003-10-14	Amgen, Inc.	Enhanced solubility of recombinant proteins using Uracil DNA glycosylase inhibitor
US6962982B2 (en)	2001-06-22	2005-11-08	Roche Diagnostics Corporation	Soluble complexes of target proteins and peptidyl prolyl isomerase chaperones and methods of making and using them
US7094757B2 (en)	2001-06-22	2006-08-22	Roche Diagnostics Corporation	Complexes comprising a prion protein and a peptidyl prolyl isomerase chaperone, and method for producing and using them
DK2267452T3 (da)	2001-06-22	2012-10-29	Hoffmann La Roche	Opløseligt kompleks omfattende et retroviralt overfladeglycoprotein
ES2255347B1 (es) *	2003-05-21	2007-05-16	Universidad De Vigo	Proteina de fusion gst-fucosidasa con actividad enzimatica alfa-l-fucosidasica. proteina recombinante alfa-l-fucosidasa humana.
MY160430A (en) *	2008-12-12	2017-03-15	Univ Sains Malaysia	Recombinant antigen for detection of toxocariasis
GB0823550D0 (en)	2008-12-24	2009-01-28	Kinasource Ltd	Peptide tag and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU3036684A (en) *	1983-07-07	1985-01-10	Genex Corp.	Production of bovine calf chymosin
MA20977A1 (fr) *	1986-05-19	1987-12-31	Ciba Geigy Ag	Plantes tolerant les herbicides contenant le gene de gluthathione S-Transferase
AU613583B2 (en) *	1986-08-22	1991-08-08	Transgene S.A.	Proteins and the method for preparing them, DNA sequences, antibodies and their application, poxviruses, transformed or infected cells, pharmaceutical compositions which are useful in the prevention of schistosomiasis and application by way of an agent possessing glutathione s-transferase activity
CA1339736C (en) *	1986-10-14	1998-03-17	Shionogi & Co., Ltd.	Method for preparing fusion proteins

1988
- 1988-05-17 NZ NZ224663A patent/NZ224663A/en unknown
- 1988-05-24 ZA ZA883681A patent/ZA883681B/xx unknown
- 1988-05-25 CA CA000567639A patent/CA1338903C/en not_active Expired - Lifetime
- 1988-05-27 DE DE8888304868T patent/DE3873989T2/de not_active Expired - Lifetime
- 1988-05-27 AT AT88304868T patent/ATE79902T1/de not_active IP Right Cessation
- 1988-05-27 AU AU17932/88A patent/AU607511B2/en not_active Expired
- 1988-05-27 JP JP63504420A patent/JPH0681596B2/ja not_active Expired - Lifetime
- 1988-05-27 ES ES88304868T patent/ES2045115T3/es not_active Expired - Lifetime
- 1988-05-27 EP EP88304868A patent/EP0293249B1/en not_active Expired - Lifetime
- 1988-05-27 WO PCT/AU1988/000164 patent/WO1988009372A1/en not_active Ceased
1989
- 1989-01-26 NO NO890325A patent/NO178894C/no not_active IP Right Cessation
- 1989-01-27 DK DK038189A patent/DK169975B1/da not_active IP Right Cessation
1992
- 1992-11-05 GR GR920402494T patent/GR3006173T3/el unknown
1993
- 1993-03-06 SG SG250/93A patent/SG25093G/en unknown

Also Published As

Publication number	Publication date
EP0293249A1 (en)	1988-11-30
JPH0681596B2 (ja)	1994-10-19
CA1338903C (en)	1997-02-11
DE3873989D1 (de)	1992-10-01
DE3873989T2 (de)	1993-02-04
EP0293249B1 (en)	1992-08-26
ATE79902T1 (de)	1992-09-15
NO890325D0 (no)	1989-01-26
GR3006173T3 (da)	1993-06-21
WO1988009372A1 (en)	1988-12-01
AU1793288A (en)	1988-12-21
AU607511B2 (en)	1991-03-07
ES2045115T3 (es)	1994-01-16
NZ224663A (en)	1990-11-27
JPH01503441A (ja)	1989-11-22
DK169975B1 (da)	1995-04-18
SG25093G (en)	1993-06-11
NO178894B (no)	1996-03-18
DK38189D0 (da)	1989-01-27
NO890325L (no)	1989-03-06
ZA883681B (en)	1989-07-26
DK38189A (da)	1989-01-27

Legal Events

Date	Code	Title	Description
2008-06-23	MK1K	Patent expired

Publication	Publication Date	Title
ATE79902T1 (de)	1992-09-15	Fusionsprotein.
NO922237L (no)	1992-08-06	Proteiner og nukleinsyrer
WO2000011033A3 (en)	2000-06-22	Expression and export of angiostatin and endostatin as immunofusins
IL94128A (en)	2005-11-20	Nucleic acids encoding vascular endothelial cell growth factors, expression vectors and host cells comprising such nucleic acids and methods of producing such vascular endothelial growth factors
ATE113985T1 (de)	1994-11-15	Verfahren zur reinigung von rekombinanten polypeptiden.
DK0724642T4 (da)	2010-10-25	Nucleinsyrevektor, sammensætning indeholdende en sådan vektor og vaccine til immunisering mod hepatitis
WO1995028486A3 (fr)	1996-01-11	Proteines recombinantes de l'hemagglutinine filamenteuse de bordetella, notamment bordetella pertussis, procede pour leur production et leurs applications a la production de proteines etrangeres ou de principes actifs vaccinants
ATE108205T1 (de)	1994-07-15	Rekombinantverfahren zur herstellung von serinproteaseinhibitoren, sowie dns-sequenzen dazu.
AU1283288A (en)	1988-09-08	Production and purification of a protein fused to a binding protein
DE3686399D1 (de)	1992-09-17	Herstellung von thrombin-inhibitoren.
AU8110487A (en)	1988-05-12	DNA molecules coding for proteins targeted to plant cell walls
ATE265534T1 (de)	2004-05-15	Verfahren zur vermehrung der hemoproteinherstellung in filamentösen fungi
CN113025659A (zh)	2021-06-25	一种治疗a型血友病的基因编辑系统及其应用
DE59108128D1 (de)	1996-10-10	Verfahren zur Herstellung von Fremdproteinen in Streptomyceten
ATE34584T1 (de)	1988-06-15	T4-dns-fragment als stabilisator fuer proteine exprimiert durch kloniertes dns.
Maffrand	1992	Direct thrombin inhibitors
NO307384B1 (no)	2000-03-27	Fremgangsmåte for spalting av proteiner og anvendelse av denne
Iemura et al.	1999	Properties of TCA-insoluble peptides in kimoto (traditional seed mash for sake brewing) and conditions for liberation of the peptides from rice protein
PT81052B (pt)	1988-01-22	Processo de preparacao de saccharomyces recombinantes
CN1037345A (zh)	1989-11-22	地龙溶栓酶的制备及其鉴定方法
Yamada et al.	1980	Nucleotide sequence of non-initiator methionine tRNA from Bacillus subtilis
NO971359L (no)	1997-05-21	Humant galaktokinase-gen