ATE265534T1 - Verfahren zur vermehrung der hemoproteinherstellung in filamentösen fungi - Google Patents

Verfahren zur vermehrung der hemoproteinherstellung in filamentösen fungi

Info

Publication number
ATE265534T1
ATE265534T1 AT97928925T AT97928925T ATE265534T1 AT E265534 T1 ATE265534 T1 AT E265534T1 AT 97928925 T AT97928925 T AT 97928925T AT 97928925 T AT97928925 T AT 97928925T AT E265534 T1 ATE265534 T1 AT E265534T1
Authority
AT
Austria
Prior art keywords
hemoprotein
fungal cell
filamentous fungal
nucleic acid
increase
Prior art date
Application number
AT97928925T
Other languages
English (en)
Inventor
Susan L Elrod
Joel R Cherry
Aubrey Jones
Original Assignee
Novozymes Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes Biotech Inc filed Critical Novozymes Biotech Inc
Application granted granted Critical
Publication of ATE265534T1 publication Critical patent/ATE265534T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT97928925T 1996-06-10 1997-06-09 Verfahren zur vermehrung der hemoproteinherstellung in filamentösen fungi ATE265534T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66275296A 1996-06-10 1996-06-10
US4115897P 1997-03-17 1997-03-17
PCT/US1997/010003 WO1997047746A1 (en) 1996-06-10 1997-06-09 A method for increasing hemoprotein production in filamentous fungi

Publications (1)

Publication Number Publication Date
ATE265534T1 true ATE265534T1 (de) 2004-05-15

Family

ID=26717857

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97928925T ATE265534T1 (de) 1996-06-10 1997-06-09 Verfahren zur vermehrung der hemoproteinherstellung in filamentösen fungi

Country Status (9)

Country Link
US (2) US6100057A (de)
EP (1) EP0910642B1 (de)
JP (1) JP3462218B2 (de)
CN (1) CN1267556C (de)
AT (1) ATE265534T1 (de)
AU (1) AU3307797A (de)
DE (1) DE69728878T2 (de)
DK (1) DK0910642T3 (de)
WO (1) WO1997047746A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100057A (en) * 1996-06-10 2000-08-08 Novo Nordisk Biotech, Inc. Method for increasing hemoprotein production in filamentous fungi
CN1221455A (zh) * 1996-06-10 1999-06-30 诺沃诺尔迪斯克生物技术有限公司 曲霉属胆色素原合酶和编码该酶的核酸
DK1032683T3 (da) * 1997-11-17 2005-06-06 Novozymes Inc Polypeptider med 5-aminolevulinsyre-syntase-aktivitet og nukleinsyrer, der koder for disse
AU1526699A (en) * 1997-11-17 1999-06-07 Novo Nordisk Biotech, Inc. Polypeptides having uroporphyrinogen decarboxylase activity and nucleic acids encoding same
US6033892A (en) * 1998-11-16 2000-03-07 Novo Nordis Biotech, Inc. Polypeptides having 5-aminolevulinic acid synthase activity and nucleic acids encoding same
AU1807899A (en) * 1997-12-08 1999-06-28 Novo Nordisk Biotech, Inc. Methods for increasing hemoprotein production in fungal mutants
EP2119773A1 (de) 2000-06-26 2009-11-18 Novozymes A/S Lipolytische Enzyme aus Fusarium und Acremonium Stämmen
WO2003089648A1 (en) 2002-04-22 2003-10-30 Novozymes Biotech, Inc. Methods for preparing variants of a dna sequence in filamentous fungi
US8148155B2 (en) 2002-04-22 2012-04-03 Novozymes, Inc. Methods for increasing homologous recombination of a nucleic acid sequence
US7183091B2 (en) * 2003-02-19 2007-02-27 Nugen Bioscience (Taiwan) Co., Ltd. Sulfite reductase, the process for producing the same and the use thereof
US20050089972A1 (en) * 2003-08-01 2005-04-28 Claudia Schmidt-Dannert Production of porphyrins
SI2943072T1 (en) † 2013-01-11 2018-07-31 Impossible Foods Inc. Methods and compositions for affecting the flavor and aroma profile of consumables
JP6759103B2 (ja) 2014-03-31 2020-09-23 インポッシブル フーズ インコーポレイテッド ひき肉レプリカ
CN107614516A (zh) 2015-05-11 2018-01-19 非凡食品有限公司 用于基因工程改造甲基营养型酵母的表达构建体和方法
JP6615525B2 (ja) * 2015-07-30 2019-12-04 シスメックス株式会社 ヘムタンパク質の生産方法
CN105483147B (zh) * 2016-01-22 2019-05-03 吉林大学 一种与致病力相关的灰霉病菌基因BcUdc1及其应用
CN108251441A (zh) * 2017-12-28 2018-07-06 广州天宝颂原生物科技开发有限公司 一种链亲和素融合光敏色素的荧光标记物的制备方法
WO2020215017A1 (en) 2019-04-17 2020-10-22 Impossible Foods Inc. Materials and methods for protein production
KR20220004090A (ko) 2019-04-25 2022-01-11 임파서블 푸즈 인크. 헴-함유 단백질의 생산을 위한 균주 및 방법
WO2023039012A1 (en) * 2021-09-07 2023-03-16 The Regents Of The University Of California Expression of heme biosynthesis and heme proteins in edible filamentous fungi
US20230340077A1 (en) * 2021-12-01 2023-10-26 Luyef Biotechnologies Inc. Production of myoglobin from trichoderma using a feeding media

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902620A (en) 1985-04-25 1990-02-20 Eli Lilly And Company Novel DNA for expression of delta-aminolevulinic acid synthetase and related method
IL88095A0 (en) * 1987-10-23 1989-06-30 California Inst Of Techn Dna sequences,proteins and gene preparations
NZ242074A (en) * 1991-03-22 1993-08-26 Novo Nordisk As Extracellular production of a heterologous heme protein in a filamentous fungus; dna construct therefor
WO1993025697A1 (en) * 1992-06-15 1993-12-23 California Institute Of Technology Enhancement of cell growth by expression of cloned oxygen-binding proteins
US5824511A (en) * 1995-08-01 1998-10-20 University Technology Corporation Method for enhancing the production of hemoproteins
US6100057A (en) * 1996-06-10 2000-08-08 Novo Nordisk Biotech, Inc. Method for increasing hemoprotein production in filamentous fungi

Also Published As

Publication number Publication date
DE69728878D1 (de) 2004-06-03
US6261827B1 (en) 2001-07-17
EP0910642A1 (de) 1999-04-28
CN1221453A (zh) 1999-06-30
DE69728878T2 (de) 2005-04-07
EP0910642B1 (de) 2004-04-28
CN1267556C (zh) 2006-08-02
WO1997047746A1 (en) 1997-12-18
US6100057A (en) 2000-08-08
AU3307797A (en) 1998-01-07
JP3462218B2 (ja) 2003-11-05
DK0910642T3 (da) 2004-08-09
JP2000512151A (ja) 2000-09-19

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