NO180231C - Indolderivater for behandling av migrene - Google Patents

Indolderivater for behandling av migrene

Info

Publication number: NO180231C
Authority: NO; Norway
Prior art keywords: image; alkyl group; migraine; treatment; indole derivatives
Prior art date: 1992-07-28

Application number

NO941019A

Other languages

English (en)

Norwegian (no)

Other versions

NO941019L (no

NO180231B (no

NO941019D0 (no

Inventor

Dolors Fernandez Forner

Carles Puig Duran

Armando Vega Noverola

Jose Prieto Soto

Jacinto Moragues Mauri

Original Assignee

Almirall Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-28

Filing date

1994-03-22

Publication date

1997-03-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10719423&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO180231(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-03-22 Application filed by Almirall Lab filed Critical Almirall Lab

1994-03-22 Publication of NO941019L publication Critical patent/NO941019L/no

1994-03-22 Publication of NO941019D0 publication Critical patent/NO941019D0/no

1996-12-02 Publication of NO180231B publication Critical patent/NO180231B/no

1997-03-12 Publication of NO180231C publication Critical patent/NO180231C/no

Links

208000019695 Migraine disease Diseases 0.000 title abstract 2
206010027599 migraine Diseases 0.000 title abstract 2
229940054051 antipsychotic indole derivative Drugs 0.000 title 1
150000002475 indoles Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000006114 decarboxylation reaction Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
HCUARRIEZVDMPT-UHFFFAOYSA-N indolyl-2-carboxylic acid Natural products C1=CC=C2NC(C(=O)O)=CC2=C1 HCUARRIEZVDMPT-UHFFFAOYSA-N 0.000 abstract 1
-1 methoxy benzyl Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Processing Of Solid Wastes (AREA)
Fertilizers (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO941019A 1992-07-28 1994-03-22 Indolderivater for behandling av migrene NO180231C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929216009A GB9216009D0 (en)	1992-07-28	1992-07-28	New indol derivatives
PCT/EP1993/001901 WO1994002460A1 (fr)	1992-07-28	1993-07-19	Derives d'indole utilises dans le traitement de la migraine

Publications (4)

Publication Number	Publication Date
NO941019L NO941019L (no)	1994-03-22
NO941019D0 NO941019D0 (no)	1994-03-22
NO180231B NO180231B (no)	1996-12-02
NO180231C true NO180231C (no)	1997-03-12

Family

ID=10719423

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO941019A NO180231C (no)	1992-07-28	1994-03-22	Indolderivater for behandling av migrene

Country Status (32)

Country	Link
US (1)	US5565447A (fr)
EP (1)	EP0605697B1 (fr)
JP (1)	JP2716585B2 (fr)
KR (1)	KR100191830B1 (fr)
CN (1)	CN1035179C (fr)
AT (1)	ATE177080T1 (fr)
BR (2)	BR9305589A (fr)
CA (1)	CA2120028C (fr)
CZ (1)	CZ282659B6 (fr)
DE (2)	DE10199016I2 (fr)
DK (1)	DK0605697T3 (fr)
EC (1)	ECSP930953A (fr)
EG (1)	EG20340A (fr)
FI (1)	FI109998B (fr)
GB (1)	GB9216009D0 (fr)
GR (1)	GR3029915T3 (fr)
HU (2)	HUT70518A (fr)
IL (1)	IL106387A (fr)
LU (1)	LU90758I2 (fr)
MX (1)	MX9304524A (fr)
MY (1)	MY113266A (fr)
NL (1)	NL300053I2 (fr)
NO (1)	NO180231C (fr)
NZ (1)	NZ254152A (fr)
PL (1)	PL174352B1 (fr)
RU (1)	RU2117667C1 (fr)
SG (1)	SG48708A1 (fr)
TW (1)	TW235297B (fr)
UA (1)	UA27818C2 (fr)
UY (1)	UY23624A1 (fr)
WO (1)	WO1994002460A1 (fr)
ZA (1)	ZA935316B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2712591B1 (fr) *	1993-11-19	1996-02-09	Pf Medicament	Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.
FR2731224B1 (fr) *	1995-03-02	1997-05-30	Pf Medicament	Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
GB9523462D0 (en) *	1995-11-16	1996-01-17	Merck Sharp & Dohme	Therapeutic agents
US8022095B2 (en)	1996-08-16	2011-09-20	Pozen, Inc.	Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US7189753B1 (en)	1997-11-06	2007-03-13	Cady Roger K	Preemptive prophylaxis of migraine
US6310066B1 (en)	1998-04-29	2001-10-30	American Home Products Corp.	Antipsychotic indolyl derivatives
US6204274B1 (en)	1998-04-29	2001-03-20	American Home Products Corporation	Indolyl derivatives as serotonergic agents
US6066637A (en) *	1998-06-19	2000-05-23	American Home Products Corporation	Indolyl derivatives as serotonergic agents
WO2004020434A1 (fr) *	2002-08-30	2004-03-11	Eisai Co., Ltd.	Derives d'azaarene
GB0302094D0 (en)	2003-01-29	2003-02-26	Pharmagene Lab Ltd	EP4 receptor antagonists
KR101132599B1 (ko) *	2003-06-05	2012-06-21	아에테르나 젠타리스 게엠베하	아폽토시스 유도 효과를 갖는 인돌 유도체
GB0324269D0 (en)	2003-10-16	2003-11-19	Pharmagene Lab Ltd	EP4 receptor antagonists
WO2005118539A1 (fr) *	2004-06-01	2005-12-15	F.Hoffmann-La Roche Ag	3-amino-1-arylpropyl indoles utiles comme inhibiteurs de la reabsorption de la monoamine
WO2006129190A1 (fr) *	2005-06-03	2006-12-07	Glenmark Pharmaceuticals Limited	Procede de preparation de l'almotriptan
US20070112055A1 (en) *	2005-09-30	2007-05-17	Glenmark Pharmaceuticals Limited	Crystalline forms of almotriptan and processes for their preparation
DE102006027229A1 (de) *	2006-06-09	2007-12-20	Grünenthal GmbH	1,3-Disubstituierte 4-Methyl-1H-pyrrol-2-carbonsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln
CA2666149A1 (fr) *	2006-10-19	2008-04-24	Auspex Pharmaceuticals, Inc.	Indoles substitues
TWI321616B (en)	2007-03-27	2010-03-11	Coretronic Corp	Centrifugal blower
CZ302424B6 (cs) *	2007-06-13	2011-05-11	Zentiva, A. S.	Zpusob prípravy almotriptanu o vysoké cistote
CN101842352A (zh) *	2007-08-02	2010-09-22	基因里克斯(英国)有限公司	新方法
CN103724252A (zh) *	2012-10-12	2014-04-16	苏州四同医药科技有限公司	一种阿莫曲坦的制备方法
EP3766483A1 (fr)	2019-07-19	2021-01-20	BioPharma Synergies, S. L.	Composition de poudre orodispersible comprenant un triptane

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2082175B (en) *	1980-08-12	1984-05-02	Glaxo Group Ltd	Heterocyclic compounds
GR79215B (fr) *	1982-06-07	1984-10-22	Glaxo Group Ltd
GB2162532B (en) *	1984-08-04	1988-08-03	Ritchie Swanson John	Decontaminant wash composition
GB8431426D0 (en) *	1984-12-13	1985-01-23	Glaxo Group Ltd	Chemical compounds
GB8719167D0 (en) *	1987-08-13	1987-09-23	Glaxo Group Ltd	Chemical compounds
SI9111010B (sl) *	1990-06-07	2005-02-28	Astrazeneca Ab	3,5-disubstituirani indolni derivati kot "5-HT1-podobni" receptorski agonisti

1992
- 1992-07-28 GB GB929216009A patent/GB9216009D0/en active Pending
1993
- 1993-07-19 BR BR9305589A patent/BR9305589A/pt not_active Application Discontinuation
- 1993-07-19 CZ CZ94664A patent/CZ282659B6/cs not_active IP Right Cessation
- 1993-07-19 KR KR1019940700865A patent/KR100191830B1/ko not_active Expired - Lifetime
- 1993-07-19 AT AT93915953T patent/ATE177080T1/de active
- 1993-07-19 NZ NZ254152A patent/NZ254152A/en not_active IP Right Cessation
- 1993-07-19 IL IL106387A patent/IL106387A/xx not_active IP Right Cessation
- 1993-07-19 UA UA94005336A patent/UA27818C2/uk unknown
- 1993-07-19 DE DE2001199016 patent/DE10199016I2/de active Active
- 1993-07-19 WO PCT/EP1993/001901 patent/WO1994002460A1/fr not_active Ceased
- 1993-07-19 RU RU94020400A patent/RU2117667C1/ru active
- 1993-07-19 HU HU9400869A patent/HUT70518A/hu unknown
- 1993-07-19 DE DE69323712T patent/DE69323712T2/de not_active Expired - Lifetime
- 1993-07-19 EP EP93915953A patent/EP0605697B1/fr not_active Expired - Lifetime
- 1993-07-19 DK DK93915953T patent/DK0605697T3/da active
- 1993-07-19 JP JP6504146A patent/JP2716585B2/ja not_active Expired - Lifetime
- 1993-07-19 PL PL93302917A patent/PL174352B1/pl unknown
- 1993-07-19 CA CA002120028A patent/CA2120028C/fr not_active Expired - Lifetime
- 1993-07-19 SG SG1996000062A patent/SG48708A1/en unknown
- 1993-07-21 TW TW082105804A patent/TW235297B/zh not_active IP Right Cessation
- 1993-07-22 ZA ZA935316A patent/ZA935316B/xx unknown
- 1993-07-26 EC EC1993000953A patent/ECSP930953A/es unknown
- 1993-07-27 MX MX9304524A patent/MX9304524A/es active IP Right Grant
- 1993-07-28 EG EG47893A patent/EG20340A/xx active
- 1993-07-28 CN CN93109364A patent/CN1035179C/zh not_active Expired - Lifetime
- 1993-07-28 MY MYPI93001483A patent/MY113266A/en unknown
- 1993-07-28 UY UY23624A patent/UY23624A1/es not_active IP Right Cessation
1994
- 1994-03-22 NO NO941019A patent/NO180231C/no not_active IP Right Cessation
- 1994-03-25 FI FI941413A patent/FI109998B/fi not_active IP Right Cessation
1995
- 1995-05-09 US US08/437,682 patent/US5565447A/en not_active Expired - Lifetime
- 1995-06-30 HU HU95P/P00696P patent/HU211243A9/hu unknown
1996
- 1996-10-10 BR BR1100061-9A patent/BR1100061A/pt active IP Right Grant
1999
- 1999-04-07 GR GR990401006T patent/GR3029915T3/el unknown
2001
- 2001-04-11 LU LU90758C patent/LU90758I2/fr unknown
- 2001-08-21 NL NL300053C patent/NL300053I2/nl unknown

Also Published As

Publication number	Publication date
BR1100061A (pt)	2000-04-18
CN1087629A (zh)	1994-06-08
NL300053I1 (nl)	2001-11-01
DK0605697T3 (da)	1999-09-27
EG20340A (en)	1998-10-31
IL106387A (en)	1997-04-15
TW235297B (fr)	1994-12-01
MY113266A (en)	2002-01-31
ZA935316B (en)	1994-02-14
WO1994002460A1 (fr)	1994-02-03
HK1011680A1 (en)	1999-07-16
ECSP930953A (es)	1994-08-15
RU2117667C1 (ru)	1998-08-20
GR3029915T3 (en)	1999-07-30
NO941019L (no)	1994-03-22
ATE177080T1 (de)	1999-03-15
DE69323712T2 (de)	1999-07-01
PL302917A1 (en)	1994-09-05
DE69323712D1 (de)	1999-04-08
GB9216009D0 (en)	1992-09-09
HU9400869D0 (en)	1994-06-28
FI941413A0 (fi)	1994-03-25
HU211243A9 (en)	1995-11-28
IL106387A0 (en)	1993-11-15
NZ254152A (en)	1996-12-20
UY23624A1 (es)	1993-08-10
DE10199016I2 (de)	2006-04-06
AU661190B2 (en)	1995-07-13
CZ66494A3 (en)	1994-12-15
SG48708A1 (en)	1998-05-18
BR9305589A (pt)	1996-01-02
JPH06511261A (ja)	1994-12-15
JP2716585B2 (ja)	1998-02-18
UA27818C2 (uk)	2000-10-16
FI109998B (fi)	2002-11-15
AU4570793A (en)	1994-02-14
US5565447A (en)	1996-10-15
EP0605697A1 (fr)	1994-07-13
CZ282659B6 (cs)	1997-08-13
CA2120028C (fr)	1999-03-23
DE10199016I1 (de)	2001-05-23
HUT70518A (en)	1995-10-30
PL174352B1 (pl)	1998-07-31
KR100191830B1 (ko)	1999-06-15
CN1035179C (zh)	1997-06-18
LU90758I2 (fr)	2001-06-11
NL300053I2 (nl)	2002-04-02
NO180231B (no)	1996-12-02
EP0605697B1 (fr)	1999-03-03
CA2120028A1 (fr)	1994-02-03
MX9304524A (es)	1994-04-29
FI941413L (fi)	1994-03-25
NO941019D0 (no)	1994-03-22

Legal Events

Date	Code	Title	Description
2013-08-19	MK1K	Patent expired

Publication	Publication Date	Title
NO941019D0 (no)	1994-03-22	Indolderivater for behandling av migrene
HUP0100615A2 (hu)	2001-10-28	Szubsztituált 2-(2,6-dioxo-3-fluoro-piperidin-3-il)-izoindolinok és ezek alkalmazása TNFalfa-szint csökkentésére
RU94020400A (ru)	1995-11-10	Производные индола, способ их получения, фармацевтическая композиция, способ лечения головной боли
FI891548A0 (fi)	1989-03-31	Administrering av monoaminakridiner i kolinergiska bristtillstaond av nervceller.
TR200100439T2 (tr)	2001-05-21	1H-İmidazopiridin türevleri
ES2091615T3 (es)	1996-11-01	Derivados de indol fungicidas.
IE811831L (en)	1982-02-12	Indoles.
DE69332945D1 (de)	2003-06-12	Indol-derivat, verfahren zu dessen herstellung und dessen medizinische anwendung
AP9801321A0 (en)	2000-02-14	2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-h-indole derivatives.
NO924166D0 (no)	1992-10-29	Nye ftalaziner som i 1-stilling inneholder en eter- ellertioetergruppe og fremgangsmaate for fremstilling derav
MD1744F2 (ro)	2001-09-30	Săruri ale acidului clavulanic şi procedeu de obţinere a lor
TW336232B (en)	1998-07-11	Indol-3-yl propenoic acid derivatives for antagonizing NMDA(N-methyl-D-aspartate) and pharmaceutical compositions thereof
ES2056025A1 (es)	1994-09-16	Nuevos derivados de indol.
EP0782988A4 (fr)	1999-04-21	Derives d'indole
EA200000922A1 (ru)	2001-04-23	Производные аминоантрациклинона и их применение в лечении амилоидоза
TW349092B (en)	1999-01-01	Substituted indole derivatives
NO974759L (no)	1998-04-23	Cefalosporinpyridiniumderivater