ECSP930953A - Nuevos derivados de indol - Google Patents

Nuevos derivados de indol

Info

Publication number
ECSP930953A
ECSP930953A EC1993000953A ECSP930953A ECSP930953A EC SP930953 A ECSP930953 A EC SP930953A EC 1993000953 A EC1993000953 A EC 1993000953A EC SP930953 A ECSP930953 A EC SP930953A EC SP930953 A ECSP930953 A EC SP930953A
Authority
EC
Ecuador
Prior art keywords
alkyl group
formula
indol
new derivatives
group
Prior art date
Application number
EC1993000953A
Other languages
English (en)
Inventor
Noverola Armando Vega
Soto Jose Manuel Prieto
Mauri Jacinto Moragues
Forner Dolores Fernandez
Duran Carles Puig
Original Assignee
Laboratorios Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10719423&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP930953(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Laboratorios Almirall Sa filed Critical Laboratorios Almirall Sa
Publication of ECSP930953A publication Critical patent/ECSP930953A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Processing Of Solid Wastes (AREA)
  • Fertilizers (AREA)

Abstract

Un proceso para la preparación de un componente de fórmula I donde cada R1 y R2 representa un átomo hidrógeno o un grupo alquilo, Z representa un anillo seleccionado de: FORMULA en el cual n representa 4,5 ó 6; en el cual R3 representa hidrógeno o un grupo alquilo y R4 representa un alquilo metoxi, bencilo o R5NHCO siendo el grupo R5 un grupo alquilo; y, N-en el cual R6 representa un grupo alquilo y farmacéuticamente sales aceptables cuyo proceso comprende una descarboxilación o un ácido carboxílico de fórmula VI donde Z, R| y R2 están definidos anteriormente.
EC1993000953A 1992-07-28 1993-07-26 Nuevos derivados de indol ECSP930953A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929216009A GB9216009D0 (en) 1992-07-28 1992-07-28 New indol derivatives

Publications (1)

Publication Number Publication Date
ECSP930953A true ECSP930953A (es) 1994-08-15

Family

ID=10719423

Family Applications (1)

Application Number Title Priority Date Filing Date
EC1993000953A ECSP930953A (es) 1992-07-28 1993-07-26 Nuevos derivados de indol

Country Status (32)

Country Link
US (1) US5565447A (es)
EP (1) EP0605697B1 (es)
JP (1) JP2716585B2 (es)
KR (1) KR100191830B1 (es)
CN (1) CN1035179C (es)
AT (1) ATE177080T1 (es)
BR (2) BR9305589A (es)
CA (1) CA2120028C (es)
CZ (1) CZ282659B6 (es)
DE (2) DE69323712T2 (es)
DK (1) DK0605697T3 (es)
EC (1) ECSP930953A (es)
EG (1) EG20340A (es)
FI (1) FI109998B (es)
GB (1) GB9216009D0 (es)
GR (1) GR3029915T3 (es)
HU (2) HUT70518A (es)
IL (1) IL106387A (es)
LU (1) LU90758I2 (es)
MX (1) MX9304524A (es)
MY (1) MY113266A (es)
NL (1) NL300053I2 (es)
NO (1) NO180231C (es)
NZ (1) NZ254152A (es)
PL (1) PL174352B1 (es)
RU (1) RU2117667C1 (es)
SG (1) SG48708A1 (es)
TW (1) TW235297B (es)
UA (1) UA27818C2 (es)
UY (1) UY23624A1 (es)
WO (1) WO1994002460A1 (es)
ZA (1) ZA935316B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2712591B1 (fr) * 1993-11-19 1996-02-09 Pf Medicament Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.
FR2731224B1 (fr) * 1995-03-02 1997-05-30 Pf Medicament Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
GB9523462D0 (en) * 1995-11-16 1996-01-17 Merck Sharp & Dohme Therapeutic agents
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6310066B1 (en) 1998-04-29 2001-10-30 American Home Products Corp. Antipsychotic indolyl derivatives
US6204274B1 (en) 1998-04-29 2001-03-20 American Home Products Corporation Indolyl derivatives as serotonergic agents
US6066637A (en) * 1998-06-19 2000-05-23 American Home Products Corporation Indolyl derivatives as serotonergic agents
WO2004020434A1 (ja) * 2002-08-30 2004-03-11 Eisai Co., Ltd. 含窒素芳香環誘導体
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
RS20050901A (sr) * 2003-06-05 2007-12-31 Zentaris Gmbh., Derivati indola sa efektom na apoptozu
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
BRPI0511722A (pt) * 2004-06-01 2008-01-08 Hoffmann La Roche 3-amino-1-arilpropilindóis como inibidores da recaptação de monoamina
WO2006129190A1 (en) * 2005-06-03 2006-12-07 Glenmark Pharmaceuticals Limited Process for the preparation of almotriptan
US20070112055A1 (en) * 2005-09-30 2007-05-17 Glenmark Pharmaceuticals Limited Crystalline forms of almotriptan and processes for their preparation
DE102006027229A1 (de) * 2006-06-09 2007-12-20 Grünenthal GmbH 1,3-Disubstituierte 4-Methyl-1H-pyrrol-2-carbonsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln
BRPI0715579A2 (pt) 2006-10-19 2015-05-26 Auspex Pharmaceuticals Inc "composto, composição farmacêutica e uso de um composto"
TWI321616B (en) 2007-03-27 2010-03-11 Coretronic Corp Centrifugal blower
CZ302424B6 (cs) * 2007-06-13 2011-05-11 Zentiva, A. S. Zpusob prípravy almotriptanu o vysoké cistote
AU2008281594A1 (en) * 2007-08-02 2009-02-05 Generics [Uk] Limited Novel process
CN103724252A (zh) * 2012-10-12 2014-04-16 苏州四同医药科技有限公司 一种阿莫曲坦的制备方法
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2082175B (en) * 1980-08-12 1984-05-02 Glaxo Group Ltd Heterocyclic compounds
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
GB2162532B (en) * 1984-08-04 1988-08-03 Ritchie Swanson John Decontaminant wash composition
GB8431426D0 (en) * 1984-12-13 1985-01-23 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
KR100215627B1 (ko) * 1990-06-07 1999-08-16 레슬리 제인 에드워즈 치료용 헤테로사이클 화합물

Also Published As

Publication number Publication date
FI109998B (fi) 2002-11-15
HUT70518A (en) 1995-10-30
FI941413L (fi) 1994-03-25
JPH06511261A (ja) 1994-12-15
AU4570793A (en) 1994-02-14
NL300053I2 (nl) 2002-04-02
NL300053I1 (nl) 2001-11-01
HK1011680A1 (en) 1999-07-16
US5565447A (en) 1996-10-15
GB9216009D0 (en) 1992-09-09
EP0605697A1 (en) 1994-07-13
SG48708A1 (en) 1998-05-18
LU90758I2 (fr) 2001-06-11
UA27818C2 (uk) 2000-10-16
RU2117667C1 (ru) 1998-08-20
CZ66494A3 (en) 1994-12-15
EG20340A (en) 1998-10-31
IL106387A (en) 1997-04-15
ATE177080T1 (de) 1999-03-15
KR100191830B1 (ko) 1999-06-15
TW235297B (es) 1994-12-01
BR1100061A (pt) 2000-04-18
NO180231B (no) 1996-12-02
CN1087629A (zh) 1994-06-08
UY23624A1 (es) 1993-08-10
DE10199016I1 (de) 2001-05-23
DE69323712T2 (de) 1999-07-01
AU661190B2 (en) 1995-07-13
DE10199016I2 (de) 2006-04-06
BR9305589A (pt) 1996-01-02
NO180231C (no) 1997-03-12
PL174352B1 (pl) 1998-07-31
CA2120028A1 (en) 1994-02-03
PL302917A1 (en) 1994-09-05
HU9400869D0 (en) 1994-06-28
CN1035179C (zh) 1997-06-18
CZ282659B6 (cs) 1997-08-13
NO941019L (no) 1994-03-22
IL106387A0 (en) 1993-11-15
MX9304524A (es) 1994-04-29
DK0605697T3 (da) 1999-09-27
JP2716585B2 (ja) 1998-02-18
GR3029915T3 (en) 1999-07-30
NO941019D0 (no) 1994-03-22
CA2120028C (en) 1999-03-23
DE69323712D1 (de) 1999-04-08
EP0605697B1 (en) 1999-03-03
MY113266A (en) 2002-01-31
WO1994002460A1 (en) 1994-02-03
NZ254152A (en) 1996-12-20
HU211243A9 (en) 1995-11-28
FI941413A0 (fi) 1994-03-25
ZA935316B (en) 1994-02-14

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