NO180334C - Analogifremgangsmåte for fremstilling av terapeutisk aktive difluorstatonanaloger - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive difluorstatonanaloger

Info

Publication number
NO180334C
NO180334C NO932377A NO932377A NO180334C NO 180334 C NO180334 C NO 180334C NO 932377 A NO932377 A NO 932377A NO 932377 A NO932377 A NO 932377A NO 180334 C NO180334 C NO 180334C
Authority
NO
Norway
Prior art keywords
preparation
analogs
difluorostatone
therapeutically active
analogous process
Prior art date
Application number
NO932377A
Other languages
English (en)
Norwegian (no)
Other versions
NO180334B (no
NO932377D0 (no
NO932377L (no
Inventor
Daniel Schirlin
Viviane Van Dorsselaer
Celine Tarnus
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO932377D0 publication Critical patent/NO932377D0/no
Publication of NO932377L publication Critical patent/NO932377L/no
Publication of NO180334B publication Critical patent/NO180334B/no
Publication of NO180334C publication Critical patent/NO180334C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
NO932377A 1991-01-02 1993-06-29 Analogifremgangsmåte for fremstilling av terapeutisk aktive difluorstatonanaloger NO180334C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP91400005 1991-01-02
PCT/US1991/009741 WO1992012123A1 (en) 1991-01-02 1991-12-20 Anti-viral compounds
US08/788,098 US5716973A (en) 1991-01-02 1997-01-23 Anti-viral compounds

Publications (4)

Publication Number Publication Date
NO932377D0 NO932377D0 (no) 1993-06-29
NO932377L NO932377L (no) 1993-06-29
NO180334B NO180334B (no) 1996-12-23
NO180334C true NO180334C (no) 1997-04-02

Family

ID=26129945

Family Applications (1)

Application Number Title Priority Date Filing Date
NO932377A NO180334C (no) 1991-01-02 1993-06-29 Analogifremgangsmåte for fremstilling av terapeutisk aktive difluorstatonanaloger

Country Status (19)

Country Link
US (1) US5716973A (de)
EP (1) EP0565631B1 (de)
JP (1) JP3198416B2 (de)
AT (1) ATE143025T1 (de)
AU (1) AU649766B2 (de)
CA (1) CA2098020C (de)
DE (1) DE69122266T2 (de)
DK (1) DK0565631T3 (de)
ES (1) ES2094344T3 (de)
FI (1) FI106466B (de)
GR (1) GR3021988T3 (de)
HU (1) HU210647B (de)
IE (1) IE75381B1 (de)
IL (1) IL100477A (de)
NO (1) NO180334C (de)
NZ (1) NZ241099A (de)
PT (1) PT99961B (de)
WO (1) WO1992012123A1 (de)
ZA (1) ZA9110141B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
JPH07504654A (ja) * 1992-03-11 1995-05-25 ナルヘックス リミテッド オキソ及びヒドロキシ置換炭化水素のアミン誘導体
DE69333270T2 (de) 1992-03-11 2004-08-05 Narhex Ltd. Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5939430A (en) * 1993-02-22 1999-08-17 Merrell Pharmaceuticals Inc. Combinations of retroviral inhibitors
GB9303518D0 (en) * 1993-02-22 1993-04-07 Merrell Dow Pharma Combinations of retroviral inhibitors
ATE196465T1 (de) * 1993-07-08 2000-10-15 Merrell Pharma Inc Analoge von difluoro-staton
HUT74569A (en) * 1993-09-09 1997-01-28 Merrell Pharma Inc Difluoro statone antiviral analogs, pharmaceutical compn. contg. them and process for preparing the said comds.
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
US5977074A (en) * 1993-10-01 1999-11-02 Merrell Pharmaceuticals, Inc. Inhibitors of β-amyloid protein production
EP0742791B1 (de) * 1994-02-04 2001-01-10 Merrell Pharmaceuticals Inc. Makrocyclische difluorostatonderivate als antivirale mittel
EP0773926A1 (de) * 1994-07-15 1997-05-21 Merrell Pharmaceuticals Inc. Difluorostatone als antivirale mittel
US6114380A (en) * 1995-12-18 2000-09-05 Merrell Pharmaceuticals Inc. Difluoro statone analogs
KR100965201B1 (ko) 2001-06-12 2010-06-24 웰스테트 테라퓨틱스 코포레이션 대사 질환의 치료용 화합물

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1171103A (en) * 1966-03-24 1969-11-19 Gas Council Hydrogenation of Hydrocarbons.
US5066643A (en) * 1985-02-19 1991-11-19 Sandoz Ltd. Fluorine and chlorine statine or statone containing peptides and method of use
CH672792A5 (de) * 1985-02-19 1989-12-29 Sandoz Ag
DE3674131D1 (de) * 1985-04-19 1990-10-18 Upjohn Co Substituierte dihalo-statin-reninhemmungsmittel.
GB8619182D0 (en) * 1986-08-06 1986-09-17 Sandoz Ltd Peptides & derivatives
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity
FR2614533A1 (fr) * 1987-04-23 1988-11-04 Sandoz Sa Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments
GB2212158A (en) * 1987-12-15 1989-07-19 Sandoz Ltd Trialkylsilymethyl-substituted peptides; renin inhibitors
IL90872A0 (en) * 1988-07-08 1990-02-09 Smithkline Beckman Corp Retroviral protease binding peptides
FI910084A0 (fi) * 1988-07-08 1991-01-07 Smithkline Beckman Corp Retrovirala proteaser bindande peptider.
CA2010531A1 (en) * 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
US5151438A (en) * 1989-05-23 1992-09-29 Abbott Laboratories Retroviral protease inhibiting compounds
KR100220876B1 (ko) * 1991-01-02 1999-10-01 슈테펜엘.네스비트 항 바이러스 화합물
EP0632808A1 (de) * 1992-03-25 1995-01-11 Pfizer Limited Antivirale peptide
JPH07508020A (ja) * 1992-05-21 1995-09-07 ジー.ディー.サール アンド カンパニー レトロウイルスプロテアーゼインヒビター

Also Published As

Publication number Publication date
PT99961B (pt) 1999-06-30
IE75381B1 (en) 1997-09-10
US5716973A (en) 1998-02-10
JP3198416B2 (ja) 2001-08-13
NO180334B (no) 1996-12-23
IL100477A (en) 1996-07-23
PT99961A (pt) 1993-01-29
AU9179091A (en) 1992-08-17
HU9301918D0 (en) 1993-12-28
HUT65739A (en) 1994-07-28
WO1992012123A1 (en) 1992-07-23
JPH07502255A (ja) 1995-03-09
NZ241099A (en) 1994-08-26
DK0565631T3 (da) 1996-10-07
ZA9110141B (en) 1992-10-28
NO932377D0 (no) 1993-06-29
GR3021988T3 (en) 1997-03-31
AU649766B2 (en) 1994-06-02
NO932377L (no) 1993-06-29
ATE143025T1 (de) 1996-10-15
CA2098020A1 (en) 1992-07-03
DE69122266T2 (de) 1997-03-27
EP0565631B1 (de) 1996-09-18
DE69122266D1 (de) 1996-10-24
FI932997A0 (fi) 1993-06-29
ES2094344T3 (es) 1997-01-16
IE914580A1 (en) 1992-07-15
EP0565631A1 (de) 1993-10-20
HU210647B (en) 1995-06-28
FI106466B (fi) 2001-02-15
FI932997L (fi) 1993-06-29
CA2098020C (en) 2003-10-21

Similar Documents

Publication Publication Date Title
NO854833L (no) Fremgangsmaate for fremstilling av terapeutisk aktive tricykloforbindelser.
NZ208529A (en) 2-pyrimidinyl-1-piperazine derivatives and pharmaceutical compositions
NO20000762L (no) Anvendelse av substituerte adeninderivater til behandling av multippel sklerose
MX9604378A (es) Amidas de acido quinolin-2-carboxilico sustituidas, su preparacion y su empleo como medicamentos, asi como productos intermedios.
DK0565631T3 (da) Antivirale forbindelser
FI903571A0 (fi) Menetelmä farmaseuttisesti aktiivisten peptidien valmistamiseksi
NO179209C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte silylalkylenaminer
FR2355846A1 (fr) Esters de penicillines utilisables comme medicaments
MY103593A (en) Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
ES2066605T3 (es) Nuevas ureas y tioureas, su preparacion y su aplicacion en terapeutica.
FR2392020A1 (fr) Nouvelles amidines, leur procede de preparation et leur utilisation comme anti-inflammatoires
DE69418050D1 (de) Antivirale analoge von difluorostaton
ATE196465T1 (de) Analoge von difluoro-staton
CA2249786A1 (en) Difluoro statone analogs
JPS52142087A (en) Purification of alpha-amino-epsilon-caprolactam
IT1263913B (it) Composti terapeuticamente attivi, utili per il trattamento di malattieconnesse con alterata funzionalita' del sistema immunitario, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
MX9710257A (es) Azepanes novedosos y sus homologos de anillo para terapia y profilaxis de enfermedades mediadas por proteina cinasa.

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN JUNE 2001