NO20000016L - Sykliske azapeptider med angiogen virkning - Google Patents

Sykliske azapeptider med angiogen virkning

Info

Publication number
NO20000016L
NO20000016L NO20000016A NO20000016A NO20000016L NO 20000016 L NO20000016 L NO 20000016L NO 20000016 A NO20000016 A NO 20000016A NO 20000016 A NO20000016 A NO 20000016A NO 20000016 L NO20000016 L NO 20000016L
Authority
NO
Norway
Prior art keywords
angiogenic activity
aarg
aasp
agly
azapeptides
Prior art date
Application number
NO20000016A
Other languages
English (en)
Other versions
NO20000016D0 (no
Inventor
Alfred Jonczyk
Simon Goodman
Horst Kessler
Jochen Wermuth
Joerg Schmitt
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO20000016L publication Critical patent/NO20000016L/no
Publication of NO20000016D0 publication Critical patent/NO20000016D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Forbindelser med formel (I) syklo-(aArg-aGly-aAsp-aX-aY), hvor aArg, aGly, aAsp, aX og aY har de i krav l angitte betydninger, samt deres salter, kan anvendes som integrininhi- bitorer, særlig til profylakse og be- handling av sykdommer i blodomløpet, ved trombose, hjerteinfarkt, koronare hjertesykdommer, arteriosklerose, ved patologiske tilstander som underholdes og propageres av angiogenese, og i tumorterapi.
NO20000016A 1997-07-04 2000-01-03 Sykliske azapeptider med angiogen virkning NO20000016D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19728524A DE19728524A1 (de) 1997-07-04 1997-07-04 Cyclische Azapeptide
PCT/EP1998/003955 WO1999001472A1 (de) 1997-07-04 1998-06-29 Cyclische azapeptide mit angiogener wirkung

Publications (2)

Publication Number Publication Date
NO20000016L true NO20000016L (no) 2000-01-03
NO20000016D0 NO20000016D0 (no) 2000-01-03

Family

ID=7834596

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20000016A NO20000016D0 (no) 1997-07-04 2000-01-03 Sykliske azapeptider med angiogen virkning

Country Status (20)

Country Link
US (1) US6534478B1 (no)
EP (1) EP1001979B1 (no)
JP (1) JP2002511872A (no)
KR (1) KR20010014267A (no)
CN (1) CN1261895A (no)
AR (1) AR010924A1 (no)
AT (1) ATE297947T1 (no)
AU (1) AU733831B2 (no)
BR (1) BR9810394A (no)
CA (1) CA2297181A1 (no)
DE (2) DE19728524A1 (no)
HU (1) HUP0003357A3 (no)
ID (1) ID23415A (no)
NO (1) NO20000016D0 (no)
PL (1) PL337616A1 (no)
RU (1) RU2188205C2 (no)
SK (1) SK173599A3 (no)
TW (1) TW482768B (no)
WO (1) WO1999001472A1 (no)
ZA (1) ZA985896B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA71608C2 (en) * 1999-03-11 2004-12-15 Merck Patent Gmbh A method for producing the cyclic pentapeptide
ATE325114T1 (de) * 1999-06-22 2006-06-15 Takeda Pharmaceutical Acylhydrazinderivate, verfahren zu ihrer herstellung und ihre verwendung
GB0217017D0 (en) * 2002-07-23 2002-08-28 Bioacta Ltd Peptide 2
WO2008033557A2 (en) * 2006-09-15 2008-03-20 Siemens Medical Solutions Usa, Inc. Click chemistry-derived cyclic peptidomimetics as integrin markers
EP2182974B1 (en) 2007-07-27 2015-08-26 Siemens Medical Solutions USA, Inc. Cyclic azapeptides as integrin markers
WO2009134382A2 (en) 2008-04-30 2009-11-05 Siemens Medical Solutions Usa, Inc. Cyclopeptides containing rgd mimetics as imaging markers for integrins
JP5681102B2 (ja) 2008-05-30 2015-03-04 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッドＳｉｅｍｅｎｓ Ｍｅｄｉｃａｌ Ｓｏｌｕｔｉｏｎｓ ＵＳＡ，Ｉｎｃ． 分子イメージング手法のための化合物
CA2665302A1 (en) * 2009-05-01 2010-11-01 Universite De Montreal Cd36 modulation and uses thereof
CN101906144B (zh) * 2009-06-03 2013-06-19 首都医科大学 一根Arg-Gly-Asp-Val链通过Asp与两根脂肪醇链的偶联物、它们的合成及在医学中的应用
KR101335203B1 (ko) * 2010-03-26 2013-11-29 숙명여자대학교산학협력단 혈관신생촉진용 펩타이드 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL98506A (en) * 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them
ES2121088T3 (es) * 1992-06-04 1998-11-16 Merrell Pharma Inc Analogos de peptidos limitados conformacionalmente como agentes antiplaquetarios.
UA43823C2 (uk) * 1992-07-06 2002-01-15 Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН
AU1975695A (en) * 1994-03-04 1995-09-18 Du Pont Merck Pharmaceutical Company, The Novel carbocyclic compounds which inhibit platelet aggregation by interaction with the gpiib/iiia receptor complex
US5858972A (en) * 1996-01-11 1999-01-12 La Jolla Cancer Research Foundation Antithrombotic agents and methods of use
ZA978758B (en) * 1996-10-02 1999-03-30 Du Pont Merck Pharma Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents
DE19653036A1 (de) * 1996-12-19 1998-06-25 Merck Patent Gmbh Cyclopeptidderivate

Also Published As

Publication number Publication date
WO1999001472A1 (de) 1999-01-14
SK173599A3 (en) 2000-06-12
HUP0003357A3 (en) 2001-12-28
EP1001979A1 (de) 2000-05-24
HUP0003357A2 (hu) 2001-02-28
KR20010014267A (ko) 2001-02-26
NO20000016D0 (no) 2000-01-03
DE59812870D1 (de) 2005-07-21
AR010924A1 (es) 2000-07-12
US6534478B1 (en) 2003-03-18
ATE297947T1 (de) 2005-07-15
CN1261895A (zh) 2000-08-02
EP1001979B1 (de) 2005-06-15
ZA985896B (en) 1999-06-14
AU733831B2 (en) 2001-05-24
TW482768B (en) 2002-04-11
RU2188205C2 (ru) 2002-08-27
CA2297181A1 (en) 1999-01-14
AU8541198A (en) 1999-01-25
ID23415A (id) 2000-04-20
DE19728524A1 (de) 1999-01-07
JP2002511872A (ja) 2002-04-16
BR9810394A (pt) 2000-09-05
PL337616A1 (en) 2000-08-28

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