NO20001198L - Pyrrolopyrrolondervater som inhibitorer av nøytrofil elastase - Google Patents

Pyrrolopyrrolondervater som inhibitorer av nøytrofil elastase

Info

Publication number
NO20001198L
NO20001198L NO20001198A NO20001198A NO20001198L NO 20001198 L NO20001198 L NO 20001198L NO 20001198 A NO20001198 A NO 20001198A NO 20001198 A NO20001198 A NO 20001198A NO 20001198 L NO20001198 L NO 20001198L
Authority
NO
Norway
Prior art keywords
pyrrolopyrrole
subunits
inhibitors
neutrophil elastase
elastase
Prior art date
Application number
NO20001198A
Other languages
English (en)
Norwegian (no)
Other versions
NO20001198D0 (no
Inventor
Geoffrey Duke Edward Clarke
Michael Dennis Dowle
Harry Finch
Lee Andrew Harrison
Graham George Adam Inglis
Martin Redpath Johnson
Simon John Fawcett Macdonald
Pritom Shah
Robin Andrew Smith
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en
Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en
Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en
Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO20001198D0 publication Critical patent/NO20001198D0/no
Publication of NO20001198L publication Critical patent/NO20001198L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
NO20001198A 1997-09-09 2000-03-08 Pyrrolopyrrolondervater som inhibitorer av nøytrofil elastase NO20001198L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9719183.7A GB9719183D0 (en) 1997-09-09 1997-09-09 Compounds
GBGB9719189.4A GB9719189D0 (en) 1997-09-09 1997-09-09 New therapeutic method
GBGB9719290.0A GB9719290D0 (en) 1997-09-10 1997-09-10 Compounds
GBGB9803611.4A GB9803611D0 (en) 1998-02-21 1998-02-21 Compounds
PCT/EP1998/005609 WO1999012933A2 (en) 1997-09-09 1998-09-07 Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Publications (2)

Publication Number Publication Date
NO20001198D0 NO20001198D0 (no) 2000-03-08
NO20001198L true NO20001198L (no) 2000-05-08

Family

ID=27451698

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001198A NO20001198L (no) 1997-09-09 2000-03-08 Pyrrolopyrrolondervater som inhibitorer av nøytrofil elastase

Country Status (24)

Country Link
EP (1) EP1003748A2 (is)
JP (1) JP2001515904A (is)
KR (1) KR20010023766A (is)
CN (1) CN1278820A (is)
AP (1) AP2000001761A0 (is)
AR (1) AR017072A1 (is)
AU (1) AU9741298A (is)
BR (1) BR9812062A (is)
CA (1) CA2303176A1 (is)
CO (1) CO4970719A1 (is)
EA (1) EA200000204A1 (is)
EE (1) EE200000138A (is)
HU (1) HUP0004644A3 (is)
ID (1) ID24452A (is)
IL (1) IL134791A0 (is)
IS (1) IS5391A (is)
MA (1) MA26543A1 (is)
NO (1) NO20001198L (is)
NZ (1) NZ503130A (is)
PE (1) PE107899A1 (is)
PL (1) PL339176A1 (is)
SK (1) SK3192000A3 (is)
TR (1) TR200000907T2 (is)
WO (1) WO1999012933A2 (is)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9905418D0 (en) * 1999-03-09 1999-05-05 Glaxo Group Ltd Process
US7429659B2 (en) 2004-03-31 2008-09-30 Janssen Pharmaceutica N.V. Furan compounds as histamine H3 modulators
DE102004024772A1 (de) 2004-05-17 2005-12-22 Grünenthal GmbH Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide
JP4853759B2 (ja) * 2004-05-27 2012-01-11 日本農薬株式会社 置換ピラジンカルボン酸アニリド誘導体又はその塩類、その中間体及び農園芸用薬剤並びにその使用方法
TWI355380B (en) 2004-05-27 2012-01-01 Nihon Nohyaku Co Ltd Substituted pyrazinecarboxanilide derivatives or s
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
AU2005308575A1 (en) 2004-11-23 2006-06-01 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia
US8198288B2 (en) 2006-05-04 2012-06-12 Pulmagen Therapeutics (Inflammation) Limited Tetrahydropyrrolopyrimidinediones and their use in therapy
NZ572250A (en) 2006-05-04 2011-10-28 Pulmagen Therapeutics Inflammation Ltd Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors
GB2452696B (en) 2007-08-02 2009-09-23 Cambridge Entpr Ltd 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
US7662967B2 (en) 2007-08-02 2010-02-16 Cambridge Enterprise Limited Anti-inflammatory compounds and compositions
WO2009060206A1 (en) * 2007-11-07 2009-05-14 Argenta Discovery Limited 3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
US20110212181A1 (en) * 2010-02-26 2011-09-01 The University Of Hong Kong Compositions and methods for treating chronic respiratory inflammation
WO2021053058A1 (en) 2019-09-17 2021-03-25 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
LT4106757T (lt) 2020-04-16 2023-11-10 Mereo Biopharma 4 Limited Neutrofilų elastazės inhibitoriaus alvelestato panaudojimas kvėpavimo sistemos ligų, nulemtų alfa-1 antitripsino nepakankamumo, gydymui
JP2024540952A (ja) 2021-10-20 2024-11-06 メレオ バイオファーマ ４ リミテッド 線維化の治療における使用のための好中球エラスターゼ阻害剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211783D0 (en) * 1992-06-04 1992-07-15 Ici Plc Amide derivatives
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
EA001437B1 (ru) * 1996-03-28 2001-02-26 Глаксо Груп Лимитед Производные пирролопирролона в качестве ингибиторов нейтрофильной эластазы

Also Published As

Publication number Publication date
WO1999012933A2 (en) 1999-03-18
HUP0004644A2 (hu) 2001-09-28
AR017072A1 (es) 2001-08-22
CA2303176A1 (en) 1999-03-18
PL339176A1 (en) 2000-12-04
CN1278820A (zh) 2001-01-03
AP2000001761A0 (en) 2000-03-31
ID24452A (id) 2000-07-20
PE107899A1 (es) 1999-11-17
CO4970719A1 (es) 2000-11-07
EP1003748A2 (en) 2000-05-31
HUP0004644A3 (en) 2002-01-28
EA200000204A1 (ru) 2000-10-30
BR9812062A (pt) 2000-09-26
SK3192000A3 (en) 2001-03-12
WO1999012933A3 (en) 1999-05-27
NZ503130A (en) 2001-08-31
EE200000138A (et) 2001-02-15
TR200000907T2 (tr) 2000-11-21
MA26543A1 (fr) 2004-12-20
JP2001515904A (ja) 2001-09-25
KR20010023766A (ko) 2001-03-26
IL134791A0 (en) 2001-04-30
NO20001198D0 (no) 2000-03-08
IS5391A (is) 2000-02-29
AU9741298A (en) 1999-03-29

Similar Documents

Publication Publication Date Title
YU11997A (sh) Laktamski derivati i njihove farmaceutske kompozicije
DK1392666T3 (da) Biologisk aktive methylenblåt-derivater
PT618190E (pt) 9-¬glicil substituido)amido|-6-(substituido)-5-hidroxi-6-desoxitetraciclinas
DK0778277T3 (da) Substituerede heterocycliske derivater som CRF antagonister
DK0876359T3 (da) (-)-cis-6(S)-phenyl-5(R)- [4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol-D-tartrat
TR200100432T2 (tr) Hepatit C inhibitörü tri-peptidler
ES2189968T3 (es) Amidinofenil-pirrolidinas,-pirrolinas,e -isoxazolidinas y derivadOS DE LOS MISMOS.
DK0931788T3 (da) Metalloproteasehæmmere
TR200800474T2 (tr) Florfenikole aracı maddelerin hazırlanmasına ilişkin işlem.
NO20020725D0 (no) Celleadhesjonsinhibitorer
SE0004245D0 (sv) Novel compounds and their use
AU9281198A (en) Benzofuran derivatives
DE69505470D1 (de) Pyrrolocarbazol
TR200201128T2 (tr) PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
NO20001198D0 (no) Pyrrolopyrrolondervater som inhibitorer av neutrofil elastase
NO981393L (no) Guanidinoproteasehemmere
ATE213241T1 (de) Amidin- und isothioharnstoffderivate als inhibitoren der stickstoffoxid-synthase
BR0210746A (pt) Derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina tendo atividade antiviral
DK0490816T3 (da) Fluorforbindelser som aromatase-inhibitorer.
NO20001200L (no) Pyrrolopyrrolonderivater som inhibitorer av nøyrofil elastase
TR200100133T2 (tr) FKBP İnhibitörleri
NO20002588L (no) Bifenylamidinderivater
ATE149159T1 (de) Heteroarylmethylbenzole-aromatasehemmer
UA26459C2 (uk) Іhгібітор впливу амілоїдhих білків
AR027349A1 (es) Derivados de amidas heterociclicas

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application