NO20001465L - Syreaddisjonssalt av morfin-alkaloider og deres anvendelse - Google Patents

Syreaddisjonssalt av morfin-alkaloider og deres anvendelse

Info

Publication number: NO20001465L
Authority: NO; Norway
Prior art keywords: acids; substituted; addition salt; acid addition; hydroxy
Prior art date: 1997-09-25

Application number

NO20001465A

Other languages

English (en)

Norwegian (no)

Other versions

NO20001465D0 (no

Inventor

Rainer Hoffmann

Rudolf Matusch

Bodo Asmussen

Andreas Koch

Thomas Hille

Bernd Adam

Original Assignee

Lohmann Therapie Syst Lts

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-25

Filing date

2000-03-21

Publication date

2000-03-21

1998-07-29 Priority claimed from DE19834005A external-priority patent/DE19834005A1/de

2000-03-21 Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts

2000-03-21 Publication of NO20001465D0 publication Critical patent/NO20001465D0/no

2000-03-21 Publication of NO20001465L publication Critical patent/NO20001465L/no

Links

239000002253 acid Substances 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2
229930013053 morphinan alkaloid Natural products 0.000 title 1
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
-1 amino-substituted benzoic acids Chemical class 0.000 abstract 2
235000010233 benzoic acid Nutrition 0.000 abstract 2
150000001559 benzoic acids Chemical class 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
150000007524 organic acids Chemical class 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
150000001298 alcohols Chemical class 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
229930013930 alkaloid Natural products 0.000 abstract 1
150000003797 alkaloid derivatives Chemical class 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
150000003460 sulfonic acids Chemical class 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C07D489/04—Salts; Organic complexes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Addiction (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)

NO20001465A 1997-09-25 2000-03-21 Syreaddisjonssalt av morfin-alkaloider og deres anvendelse NO20001465L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19742296		1997-09-25
DE19834005A DE19834005A1 (de)	1997-09-25	1998-07-29	Säureadditionssalze von Morphin-Alkaloiden und deren Verwendung
PCT/EP1998/005652 WO1999015528A1 (fr)	1997-09-25	1998-09-05	Sels d'addition d'acide d'alcaloides de la morphine et leur utilisation

Publications (2)

Publication Number	Publication Date
NO20001465D0 NO20001465D0 (no)	2000-03-21
NO20001465L true NO20001465L (no)	2000-03-21

Family

ID=26040297

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20001465A NO20001465L (no)	1997-09-25	2000-03-21	Syreaddisjonssalt av morfin-alkaloider og deres anvendelse

Country Status (20)

Country	Link
EP (1)	EP1017696B1 (fr)
JP (1)	JP2001517669A (fr)
AT (1)	ATE214702T1 (fr)
AU (1)	AU741434B2 (fr)
CA (1)	CA2304722C (fr)
CZ (1)	CZ300532B6 (fr)
DK (1)	DK1017696T3 (fr)
ES (1)	ES2174490T3 (fr)
HU (1)	HUP0003686A3 (fr)
ID (1)	ID26296A (fr)
IL (1)	IL134787A (fr)
MX (1)	MXPA00002658A (fr)
NO (1)	NO20001465L (fr)
NZ (1)	NZ503459A (fr)
PL (1)	PL193321B1 (fr)
PT (1)	PT1017696E (fr)
SK (1)	SK4322000A3 (fr)
TR (1)	TR200000653T2 (fr)
TW (1)	TW576836B (fr)
WO (1)	WO1999015528A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9924797D0 (en)	1999-10-20	1999-12-22	West Pharm Serv Drug Res Ltd	Compound
GB0218811D0 (en) *	2002-08-14	2002-09-18	Cenes Ltd	Salts of morphine-6-glucuronide
DE102006054732B4 (de)	2006-11-21	2010-12-30	Lts Lohmann Therapie-Systeme Ag	Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren
WO2010016219A1 (fr) *	2008-08-05	2010-02-11	株式会社メドレックス	Préparation externe comprenant un sel d'acide gras ou un sel d'acide benzoïque d'un composant basique pharmacologiquement actif, et procédé de production de celui-ci
WO2013019825A1 (fr) *	2011-08-02	2013-02-07	Mallinckrodt Llc	Procédé par étapes pour obtention de sels d'alcaloïdes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE524639C (de) *	1929-05-25	1931-05-09	Chem Fab Vorm Sandoz	Verfahren zur Darstellung von leichtloeslichen Salzen des Benzylmorphons
DE728804C (de) *	1935-04-02	1942-12-03	Jean Lucien Regnier	Verfahren zur Herstellung von Salzen des Morphins mit Aralkylcarbonsaeuren
DE1172267B (de) *	1961-09-19	1964-06-18	Dausse S A Lab	Verfahren zur Herstellung des bis-guajakol-sulfonsauren Salzes des Morphin-ª‰-morpholyl-aethylaethers
FR6598M (fr) *	1967-07-28	1969-01-06
US4626539A (en) *	1984-08-10	1986-12-02	E. I. Dupont De Nemours And Company	Trandermal delivery of opioids
US4908389A (en) *	1986-08-27	1990-03-13	Warner-Lambert Company	Penetration enhancement system
US4879297A (en) *	1987-06-01	1989-11-07	Warner-Lambert Company	Fatty acids and their small chain esters as penetration enhancers in aqueous systems
US5374645A (en) *	1990-01-22	1994-12-20	Ciba-Geigy Corporation	Transdermal administation of ionic pharmaceutically active agents via aqueous isopropanol
TW225536B (fr) *	1990-08-23	1994-06-21	Ciba Geigy Ag
FR2708611B1 (fr) *	1993-07-29	1995-10-27	Meram Lab	Sel de codéine de l'acide 2-(3-benzoylphényl)propionique, procédé d'obtention et compositions pharmaceutiques le contenant.
DE19607395C2 (de) *	1996-02-28	2002-11-21	Lohmann Therapie Syst Lts	Salze aus einem kationischen narkotischen Analgetikum mit einem anionischen nichtnarkotischen Analgetikum, Verfahren zu deren Herstellung und die diese Salze enthaltenden pharmazeutischen Präparate

1998
- 1998-09-05 PT PT98945312T patent/PT1017696E/pt unknown
- 1998-09-05 HU HU0003686A patent/HUP0003686A3/hu unknown
- 1998-09-05 PL PL339516A patent/PL193321B1/pl not_active IP Right Cessation
- 1998-09-05 ID IDW20000549A patent/ID26296A/id unknown
- 1998-09-05 JP JP2000512833A patent/JP2001517669A/ja active Pending
- 1998-09-05 WO PCT/EP1998/005652 patent/WO1999015528A1/fr not_active Ceased
- 1998-09-05 SK SK432-2000A patent/SK4322000A3/sk unknown
- 1998-09-05 ES ES98945312T patent/ES2174490T3/es not_active Expired - Lifetime
- 1998-09-05 MX MXPA00002658A patent/MXPA00002658A/es active IP Right Grant
- 1998-09-05 TR TR2000/00653T patent/TR200000653T2/xx unknown
- 1998-09-05 CA CA002304722A patent/CA2304722C/fr not_active Expired - Fee Related
- 1998-09-05 CZ CZ20001048A patent/CZ300532B6/cs not_active IP Right Cessation
- 1998-09-05 IL IL134787A patent/IL134787A/en not_active IP Right Cessation
- 1998-09-05 NZ NZ503459A patent/NZ503459A/en not_active IP Right Cessation
- 1998-09-05 AT AT98945312T patent/ATE214702T1/de active
- 1998-09-05 EP EP98945312A patent/EP1017696B1/fr not_active Expired - Lifetime
- 1998-09-05 DK DK98945312T patent/DK1017696T3/da active
- 1998-09-05 AU AU92666/98A patent/AU741434B2/en not_active Ceased
- 1998-09-23 TW TW087115805A patent/TW576836B/zh not_active IP Right Cessation
2000
- 2000-03-21 NO NO20001465A patent/NO20001465L/no unknown

Also Published As

Publication number	Publication date
AU9266698A (en)	1999-04-12
PT1017696E (pt)	2002-09-30
IL134787A0 (en)	2001-04-30
CZ300532B6 (cs)	2009-06-10
IL134787A (en)	2007-05-15
EP1017696B1 (fr)	2002-03-20
AU741434B2 (en)	2001-11-29
TW576836B (en)	2004-02-21
MXPA00002658A (es)	2004-03-10
HUP0003686A2 (hu)	2001-09-28
CA2304722A1 (fr)	1999-04-01
DK1017696T3 (da)	2002-07-08
TR200000653T2 (tr)	2000-07-21
NO20001465D0 (no)	2000-03-21
ID26296A (id)	2000-12-14
ATE214702T1 (de)	2002-04-15
ES2174490T3 (es)	2002-11-01
WO1999015528A1 (fr)	1999-04-01
HUP0003686A3 (en)	2003-04-28
CZ20001048A3 (cs)	2000-08-16
PL193321B1 (pl)	2007-01-31
CA2304722C (fr)	2005-11-22
PL339516A1 (en)	2000-12-18
SK4322000A3 (en)	2000-10-09
JP2001517669A (ja)	2001-10-09
EP1017696A1 (fr)	2000-07-12
NZ503459A (en)	2001-12-21

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