NO20002600L - Mellomprodukter og fremgangsmÕter for anvendelse ved semisyntesen av paclitaxel og analoger - Google Patents

Mellomprodukter og fremgangsmÕter for anvendelse ved semisyntesen av paclitaxel og analoger

Info

Publication number: NO20002600L
Authority: NO; Norway
Prior art keywords: paclitaxel; analogs; intermediates; semisynthesis; methods
Prior art date: 1997-11-21

Application number

NO20002600A

Other languages

English (en)

Norwegian (no)

Other versions

NO20002600D0 (no

Inventor

Ezio Bombardelli

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-21

Filing date

2000-05-19

Publication date

2000-07-17

2000-05-19 Application filed by Indena Spa filed Critical Indena Spa

2000-05-19 Publication of NO20002600D0 publication Critical patent/NO20002600D0/no

2000-07-17 Publication of NO20002600L publication Critical patent/NO20002600L/no

Links

229930012538 Paclitaxel Natural products 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
229960001592 paclitaxel Drugs 0.000 title abstract 2
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 2
YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical class O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 1
125000005910 alkyl carbonate group Chemical group 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

NO20002600A 1997-11-21 2000-05-19 Mellomprodukter og fremgangsmÕter for anvendelse ved semisyntesen av paclitaxel og analoger NO20002600L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/975,804 US5917062A (en)	1997-11-21	1997-11-21	Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
PCT/IB1998/001912 WO1999026939A1 (en)	1997-11-21	1998-11-19	Intermediates and methods useful in the semisynthesis of paclitaxel and analogs

Publications (2)

Publication Number	Publication Date
NO20002600D0 NO20002600D0 (no)	2000-05-19
NO20002600L true NO20002600L (no)	2000-07-17

Family

ID=25523419

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20002600A NO20002600L (no)	1997-11-21	2000-05-19	Mellomprodukter og fremgangsmÕter for anvendelse ved semisyntesen av paclitaxel og analoger

Country Status (19)

Country	Link
US (2)	US5917062A (de)
EP (1)	EP1049686B9 (de)
JP (1)	JP3445973B2 (de)
KR (1)	KR100545436B1 (de)
CN (1)	CN1229364C (de)
AT (1)	ATE308533T1 (de)
AU (1)	AU746448C (de)
CA (1)	CA2310778C (de)
CZ (1)	CZ296350B6 (de)
DE (1)	DE69832202T2 (de)
DK (1)	DK1049686T3 (de)
ES (1)	ES2251106T3 (de)
HU (1)	HUP0100375A3 (de)
NO (1)	NO20002600L (de)
PL (1)	PL192422B1 (de)
RU (1)	RU2213739C2 (de)
SI (1)	SI1049686T1 (de)
SK (1)	SK285797B6 (de)
WO (1)	WO1999026939A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19925926A1 (de) *	1999-06-08	2000-12-14	Bayer Ag	Katalysatoren auf Basis Titan-haltiger, organisch-anorganischer Hybridmaterialien zur selektiven Oxidation von Kohlenwasserstoffen
JP4502338B2 (ja) *	1999-09-17	2010-07-14	株式会社横浜国際バイオ研究所	タキソイド化合物の製造法
HK1049787B (en)	1999-10-01	2014-07-25	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
IT1319682B1 (it)	2000-12-06	2003-10-23	Indena Spa	Procedimento di sintesi del paclitaxel.
ITMI20012185A1 (it) *	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20020782A1 (it) *	2002-04-12	2003-10-13	Indena Spa	Processo semisintetico per la preparazione di n-debenzoilpaclitaxel
ITMI20050614A1 (it) *	2005-04-12	2006-10-13	Indena Spa	Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
US7662980B2 (en) *	2006-10-20	2010-02-16	Scinopharm Singapore Pte Ltd.	Crystalline forms of docetaxel and process for preparation thereof
WO2010059916A2 (en) *	2008-11-20	2010-05-27	Dr. Reddy's Laboratories Ltd.	Preparation of docetaxel
PL388144A1 (pl)	2009-05-29	2010-12-06	Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością	Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US34277A (en) *		1862-01-28		Improvement in lamps
FR2601676B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
USRE34277E (en)	1988-04-06	1993-06-08	Centre National De La Recherche Scientifique	Process for preparing taxol
FR2629818B1 (fr) *	1988-04-06	1990-11-16	Centre Nat Rech Scient	Procede de preparation du taxol
MY110249A (en) *	1989-05-31	1998-03-31	Univ Florida State	Method for preparation of taxol using beta lactam
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
MX9102128A (es) *	1990-11-23	1992-07-08	Rhone Poulenc Rorer Sa	Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2678930B1 (fr) *	1991-07-10	1995-01-13	Rhone Poulenc Rorer Sa	Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
CA2071160A1 (en) *	1991-07-31	1993-02-01	Vittorio Farina	Asymmetric synthesis of taxol side chain
US5229526A (en) *	1991-09-23	1993-07-20	Florida State University	Metal alkoxides
US5470866A (en) *	1992-08-18	1995-11-28	Virginia Polytechnic Institute And State University	Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
FR2696460B1 (fr) *	1992-10-05	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.
US5703247A (en) *	1993-03-11	1997-12-30	Virginia Tech Intellectual Properties, Inc.	2-Debenzoyl-2-acyl taxol derivatives and methods for making same
CA2170661A1 (en) *	1995-03-22	1996-09-23	John K. Thottathil	Novel methods for the preparation of taxanes using oaxzolidine intermediates
IT1275435B (it) *	1995-05-19	1997-08-07	Indena Spa	Derivati della 10-desacetil-14beta-idrossibaccatina iii,loro metodo di preparazione e formulazioni che li contengono
KR100225535B1 (ko) *	1996-08-27	1999-10-15	정지석	파클리탁셀의 제조방법

1997
- 1997-11-21 US US08/975,804 patent/US5917062A/en not_active Expired - Fee Related
1998
- 1998-09-30 US US09/163,249 patent/US5907042A/en not_active Expired - Fee Related
- 1998-11-19 SI SI9830811T patent/SI1049686T1/sl unknown
- 1998-11-19 CA CA002310778A patent/CA2310778C/en not_active Expired - Fee Related
- 1998-11-19 DK DK98954684T patent/DK1049686T3/da active
- 1998-11-19 CN CNB988114143A patent/CN1229364C/zh not_active Expired - Fee Related
- 1998-11-19 ES ES98954684T patent/ES2251106T3/es not_active Expired - Lifetime
- 1998-11-19 WO PCT/IB1998/001912 patent/WO1999026939A1/en not_active Ceased
- 1998-11-19 JP JP2000522097A patent/JP3445973B2/ja not_active Expired - Fee Related
- 1998-11-19 AU AU11705/99A patent/AU746448C/en not_active Ceased
- 1998-11-19 CZ CZ20001869A patent/CZ296350B6/cs not_active IP Right Cessation
- 1998-11-19 HU HU0100375A patent/HUP0100375A3/hu unknown
- 1998-11-19 PL PL340553A patent/PL192422B1/pl unknown
- 1998-11-19 RU RU2000115955/04A patent/RU2213739C2/ru not_active IP Right Cessation
- 1998-11-19 EP EP98954684A patent/EP1049686B9/de not_active Expired - Lifetime
- 1998-11-19 DE DE69832202T patent/DE69832202T2/de not_active Expired - Fee Related
- 1998-11-19 KR KR1020007005257A patent/KR100545436B1/ko not_active Expired - Fee Related
- 1998-11-19 SK SK732-2000A patent/SK285797B6/sk unknown
- 1998-11-19 AT AT98954684T patent/ATE308533T1/de not_active IP Right Cessation
2000
- 2000-05-19 NO NO20002600A patent/NO20002600L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2001524476A (ja)	2001-12-04
KR20010024619A (ko)	2001-03-26
SK7322000A3 (en)	2000-11-07
EP1049686B9 (de)	2005-12-28
KR100545436B1 (ko)	2006-01-24
JP3445973B2 (ja)	2003-09-16
CN1279677A (zh)	2001-01-10
CZ296350B6 (cs)	2006-02-15
SI1049686T1 (sl)	2006-02-28
ES2251106T3 (es)	2006-04-16
SK285797B6 (sk)	2007-08-02
AU746448C (en)	2002-12-05
CA2310778A1 (en)	1999-06-03
EP1049686A1 (de)	2000-11-08
US5907042A (en)	1999-05-25
DE69832202D1 (de)	2005-12-08
CZ20001869A3 (cs)	2000-11-15
HK1028046A1 (en)	2001-02-02
AU1170599A (en)	1999-06-15
WO1999026939A1 (en)	1999-06-03
CN1229364C (zh)	2005-11-30
ATE308533T1 (de)	2005-11-15
PL192422B1 (pl)	2006-10-31
PL340553A1 (en)	2001-02-12
US5917062A (en)	1999-06-29
NO20002600D0 (no)	2000-05-19
DK1049686T3 (da)	2006-01-16
DE69832202T2 (de)	2006-07-13
CA2310778C (en)	2005-02-22
EP1049686B1 (de)	2005-11-02
HUP0100375A2 (hu)	2001-12-28
AU746448B2 (en)	2002-05-02
RU2213739C2 (ru)	2003-10-10
HUP0100375A3 (en)	2002-04-29

Legal Events

Date	Code	Title	Description
2009-06-29	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20054195D0 (no)	2005-09-09	Isoksazolforbindelser som inhibitorer for varmesjokkproteiner
DK0863887T3 (da)	2002-04-22	Mellemprodukter til hemisyntese af taxaner og fremgangsmåder til deres fremstilling
DK1001036T3 (da)	2004-11-29	Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fremstillingen af taxaner
DK1474406T3 (da)	2007-07-23	Disubstituerede thiazolylcarboxanilider samt deres anvendelse som mikrobicider
AR040546A1 (es)	2005-04-13	Derivados de la 1-h- pirrolidin -2,4- diona espirociclicos, cis- alcoxisubstituidos
MX9305767A (es)	1994-05-31	Procedimiento para la preparacion de derivados de taxano y los derivados de taxano asi obtenidos.
NO20003111D0 (no)	2000-06-16	Ortho-anthranilamidderivater som antikoagulanter
ES2139959T3 (es)	2000-02-16	Derivados de estilbeno utiles como inhibidores de la ciclooxigenasa-2.
ES2098127T3 (es)	1997-04-16	Procedimiento para la purificacion de taxoides.
NO20002600L (no)	2000-07-17	Mellomprodukter og fremgangsmÕter for anvendelse ved semisyntesen av paclitaxel og analoger
NO20071835L (no)	2007-05-07	Semisynteseprosess for fremstillingen av 10-deacetyl-N-debenzoyl-paklitaxel.
EA200100347A1 (ru)	2001-10-22	Метод и композиция для лечения и профилактики туберкулеза
ECSP034531A (es)	2003-05-26	Derivados sustituidos de c-ciclohexilmetilamina
NO20016151L (no)	2001-12-17	Fremstilling av substituerte piperidin-4-oner
NO20020017D0 (no)	2002-01-03	Taxanderivater og fremgangsmåter ved fremstilling derav
PE20050120A1 (es)	2005-03-04	Camptotecinas con un anillo de lactona modificada
DK0889885T3 (da)	2002-09-16	Fremgangsmåde til selektiv beskyttelse af baccatinderivater og anvendelse deraf ved syntese af taxaner
BR0110490B1 (pt)	2012-07-24	agentes de tingimento contendo derivados de n-heteroarilmetil-m-fenilenodiamina para fibras de queratina bem como novos derivados de n-heteroarilmetil-m-fenilenodiamina.
DK1307436T3 (da)	2005-01-31	Fremgangsmåde til fremstilling af baccatin III-derivater
EA200600608A1 (ru)	2006-10-27	Производные имидазопиридина как ингибиторы индуцируемой no-синтазы
DK0703907T3 (da)	1998-03-23	Fremgangsmåde til fremstilling af terapeutisk aktive taxoider
DE69703115D1 (de)	2000-10-19	Zwischenprodukte um 2-imidazolin-5onederivate herzustellen.
ATE401325T1 (de)	2008-08-15	C10-carbamoyloxysubstituierte taxane als antitumormittel
DE50303586D1 (de)	2006-07-06	Methylthiophencarboxanilide
ATE392422T1 (de)	2008-05-15	C7-carbamoyloxysubstituierte taxane als antitumormittel