NO20003514L - Hypolipidemiske benzothiazepin-forbindelser - Google Patents
Hypolipidemiske benzothiazepin-forbindelserInfo
- Publication number
- NO20003514L NO20003514L NO20003514A NO20003514A NO20003514L NO 20003514 L NO20003514 L NO 20003514L NO 20003514 A NO20003514 A NO 20003514A NO 20003514 A NO20003514 A NO 20003514A NO 20003514 L NO20003514 L NO 20003514L
- Authority
- NO
- Norway
- Prior art keywords
- benzothiazepine compounds
- hypolipidemic benzothiazepine
- compounds
- hypolipidemic
- solvates
- Prior art date
Links
- 230000000055 hyoplipidemic effect Effects 0.000 title abstract 2
- 150000007657 benzothiazepines Chemical class 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9800428.6A GB9800428D0 (en) | 1998-01-10 | 1998-01-10 | Chemical compounds |
| PCT/EP1999/000021 WO1999035135A1 (en) | 1998-01-10 | 1999-01-07 | Hypolipidemic benzothiazepine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20003514D0 NO20003514D0 (no) | 2000-07-07 |
| NO20003514L true NO20003514L (no) | 2000-09-07 |
Family
ID=10825042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20003514A NO20003514L (no) | 1998-01-10 | 2000-07-07 | Hypolipidemiske benzothiazepin-forbindelser |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6465451B1 (is) |
| EP (1) | EP1045840A1 (is) |
| JP (1) | JP2002500220A (is) |
| KR (1) | KR20010033988A (is) |
| CN (1) | CN1292785A (is) |
| AP (1) | AP2000001860A0 (is) |
| AR (1) | AR014261A1 (is) |
| AU (1) | AU2515599A (is) |
| BR (1) | BR9906799A (is) |
| CA (1) | CA2317651A1 (is) |
| CO (1) | CO4820391A1 (is) |
| EA (1) | EA200000623A1 (is) |
| GB (1) | GB9800428D0 (is) |
| HR (1) | HRP20000468A2 (is) |
| HU (1) | HUP0201343A3 (is) |
| ID (1) | ID25495A (is) |
| IL (1) | IL137040A0 (is) |
| IS (1) | IS5551A (is) |
| MA (1) | MA26595A1 (is) |
| NO (1) | NO20003514L (is) |
| NZ (1) | NZ505453A (is) |
| PE (1) | PE20000179A1 (is) |
| PL (1) | PL341672A1 (is) |
| SK (1) | SK10242000A3 (is) |
| TR (1) | TR200001816T2 (is) |
| WO (1) | WO1999035135A1 (is) |
| ZA (1) | ZA9981B (is) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| WO2000038721A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
| ATE240120T1 (de) * | 1998-12-23 | 2003-05-15 | Searle Llc | Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen |
| SE0000772D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| US20020061888A1 (en) * | 2000-03-10 | 2002-05-23 | Keller Bradley T. | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| US20020183307A1 (en) * | 2000-07-26 | 2002-12-05 | Tremont Samuel J. | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake |
| SE0003766D0 (sv) * | 2000-10-18 | 2000-10-18 | Astrazeneca Ab | Novel formulation |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| GB0121337D0 (en) * | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| MXPA04002179A (es) | 2001-09-08 | 2004-06-29 | Astrazeneca Ab | Derivados de benzotiazepina y benzotiadiazepina con actividad inhibidora de transporte del acido ileal biliar (ibat) para tratar hiperlipidemia. |
| BR0306643A (pt) | 2002-01-17 | 2004-10-19 | Pharmacia Corp | Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| FR2849024B1 (fr) * | 2002-12-20 | 2007-11-02 | Aventis Pharma Sa | Nouveaux composes chiraux derives d'esters de l'acide hexanoique, procede et intermediaires de preparation, utilisation a la synthese de l'acide 2-(bromomethyl)2-ethyl hexanoique chiral |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| EP2367554A4 (en) * | 2008-11-26 | 2020-03-25 | Satiogen Pharmaceuticals, Inc. | Bile acid reflux inhibitor for the treatment of obesity and diabetes |
| EP4137137A1 (en) | 2010-05-26 | 2023-02-22 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| PL3400944T3 (pl) | 2010-11-04 | 2020-11-16 | Albireo Ab | Inhibitory ibat w leczeniu chorób wątroby |
| PT2637646T (pt) | 2010-11-08 | 2016-08-17 | Albireo Ab | Uma combinação farmacêutica que compreende um inibidor do ibat e um sequestrador de ácido biliar |
| US20140323412A1 (en) | 2011-10-28 | 2014-10-30 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
| SG10201909122QA (en) | 2011-10-28 | 2019-11-28 | Lumena Pharmaceuticals Inc | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| CA2907214A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| KR102560954B1 (ko) | 2014-06-25 | 2023-07-31 | 이에이 파마 가부시키가이샤 | 고형 제제 및 그의 착색 방지 또는 착색 감소 방법 |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| ES2874669T3 (es) | 2016-02-09 | 2021-11-05 | Albireo Ab | Formulación oral de colestiramina y uso de la misma |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CN108601745B (zh) | 2016-02-09 | 2021-12-07 | 阿尔比里奥公司 | 口服考来烯胺制剂及其用途 |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| WO2019032027A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | CHOLESTYRAMINE TABLETS, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE |
| EP3802504B1 (en) | 2018-06-05 | 2023-01-18 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| EP3810084A1 (en) | 2018-06-20 | 2021-04-28 | Albireo AB | Pharmaceutical formulation of odevixibat |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| DK3921028T3 (da) | 2019-02-06 | 2023-01-23 | Albireo Ab | Benzothiadiazepinforbindelser og anvendelse deraf som galdesyremodulatorer |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| CN118834175A (zh) | 2019-02-06 | 2024-10-25 | 阿尔比里奥公司 | 苯并硫氮杂环庚三烯化合物及其用作胆汁酸调节剂的用途 |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| JP7562546B2 (ja) | 2019-02-12 | 2024-10-07 | ミルム ファーマシューティカルズ インコーポレイテッド | 胆汁うっ滞性肝疾患を有する小児対象の成長を増加させる方法 |
| WO2021110884A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| ES2972045T3 (es) * | 2019-12-04 | 2024-06-10 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| CN114761018B (zh) | 2019-12-04 | 2025-12-02 | 阿尔比里奥公司 | 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| CA3158175A1 (en) * | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothiazepine compounds and their use as bile acid modulators |
| AR120674A1 (es) * | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiazepina y su uso como ácido biliar |
| DK4069360T3 (da) * | 2019-12-04 | 2024-02-26 | Albireo Ab | Benzothia(di)azepinforbindelser og anvendelse deraf som galdesyremodulatorer |
| PT4069360T (pt) | 2019-12-04 | 2024-03-06 | Albireo Ab | Compostos de benzotia(di)azepina e a sua utilização como moduladores de ácido biliar |
| WO2021110886A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| TWI877263B (zh) | 2019-12-04 | 2025-03-21 | 瑞典商艾爾比瑞歐公司 | 苯并噻二氮呯化合物及其作為膽酸調節劑之用途 |
| JP7696897B2 (ja) * | 2019-12-04 | 2025-06-23 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| CN116157389B (zh) | 2020-08-03 | 2026-02-10 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| JP2023549226A (ja) | 2020-11-12 | 2023-11-22 | アルビレオ エービー | 進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット |
| WO2022117778A1 (en) * | 2020-12-04 | 2022-06-09 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| AU2023285002A1 (en) | 2022-06-09 | 2024-12-05 | Albireo Ab | Treating hepatitis |
| WO2025146508A1 (en) | 2024-01-05 | 2025-07-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2025146507A1 (en) | 2024-01-05 | 2025-07-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0723449A1 (en) | 1993-08-06 | 1996-07-31 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| ZA956647B (en) | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
| GB9423172D0 (en) * | 1994-11-17 | 1995-01-04 | Wellcom Foundation The Limited | Hypolipidemic benzothiazepines |
-
1998
- 1998-01-10 GB GBGB9800428.6A patent/GB9800428D0/en not_active Ceased
-
1999
- 1999-01-06 ZA ZA9900081A patent/ZA9981B/xx unknown
- 1999-01-06 PE PE1999000007A patent/PE20000179A1/es not_active Application Discontinuation
- 1999-01-06 AR ARP990100035A patent/AR014261A1/es unknown
- 1999-01-07 AP APAP/P/2000/001860A patent/AP2000001860A0/en unknown
- 1999-01-07 MA MA25421A patent/MA26595A1/fr unknown
- 1999-01-07 SK SK1024-2000A patent/SK10242000A3/sk unknown
- 1999-01-07 AU AU25155/99A patent/AU2515599A/en not_active Abandoned
- 1999-01-07 NZ NZ505453A patent/NZ505453A/xx unknown
- 1999-01-07 HU HU0201343A patent/HUP0201343A3/hu unknown
- 1999-01-07 CA CA002317651A patent/CA2317651A1/en not_active Abandoned
- 1999-01-07 JP JP2000527536A patent/JP2002500220A/ja active Pending
- 1999-01-07 WO PCT/EP1999/000021 patent/WO1999035135A1/en not_active Ceased
- 1999-01-07 US US09/582,907 patent/US6465451B1/en not_active Expired - Fee Related
- 1999-01-07 EA EA200000623A patent/EA200000623A1/ru unknown
- 1999-01-07 CN CN998036447A patent/CN1292785A/zh active Pending
- 1999-01-07 KR KR1020007007581A patent/KR20010033988A/ko not_active Withdrawn
- 1999-01-07 EP EP99904742A patent/EP1045840A1/en not_active Withdrawn
- 1999-01-07 HR HR20000468A patent/HRP20000468A2/hr not_active Application Discontinuation
- 1999-01-07 ID IDW20001337A patent/ID25495A/id unknown
- 1999-01-07 TR TR2000/01816T patent/TR200001816T2/xx unknown
- 1999-01-07 PL PL99341672A patent/PL341672A1/xx not_active Application Discontinuation
- 1999-01-07 BR BR9906799-4A patent/BR9906799A/pt not_active IP Right Cessation
- 1999-01-07 IL IL13704099A patent/IL137040A0/xx unknown
- 1999-01-08 CO CO99001036A patent/CO4820391A1/es unknown
-
2000
- 2000-06-27 IS IS5551A patent/IS5551A/is unknown
- 2000-07-07 NO NO20003514A patent/NO20003514L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6465451B1 (en) | 2002-10-15 |
| NZ505453A (en) | 2002-11-26 |
| MA26595A1 (fr) | 2004-12-20 |
| ZA9981B (en) | 2000-07-06 |
| HRP20000468A2 (en) | 2000-10-31 |
| CO4820391A1 (es) | 1999-07-28 |
| IS5551A (is) | 2000-06-27 |
| CA2317651A1 (en) | 1999-07-15 |
| WO1999035135A1 (en) | 1999-07-15 |
| SK10242000A3 (sk) | 2001-02-12 |
| KR20010033988A (ko) | 2001-04-25 |
| PE20000179A1 (es) | 2000-03-16 |
| JP2002500220A (ja) | 2002-01-08 |
| EA200000623A1 (ru) | 2001-04-23 |
| AU2515599A (en) | 1999-07-26 |
| HUP0201343A2 (hu) | 2003-06-28 |
| CN1292785A (zh) | 2001-04-25 |
| GB9800428D0 (en) | 1998-03-04 |
| ID25495A (id) | 2000-10-05 |
| AP2000001860A0 (en) | 2000-09-30 |
| BR9906799A (pt) | 2000-10-10 |
| PL341672A1 (en) | 2001-04-23 |
| AR014261A1 (es) | 2001-02-07 |
| HUP0201343A3 (en) | 2003-08-28 |
| NO20003514D0 (no) | 2000-07-07 |
| EP1045840A1 (en) | 2000-10-25 |
| TR200001816T2 (tr) | 2000-11-21 |
| IL137040A0 (en) | 2001-06-14 |
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