NO20004075D0 - Substituerte pyrimidin-2-yloksy-karboksylsyrederivater, fremstilling av disse og deres anvendelse som endotelin- antagonister - Google Patents
Substituerte pyrimidin-2-yloksy-karboksylsyrederivater, fremstilling av disse og deres anvendelse som endotelin- antagonisterInfo
- Publication number
- NO20004075D0 NO20004075D0 NO20004075A NO20004075A NO20004075D0 NO 20004075 D0 NO20004075 D0 NO 20004075D0 NO 20004075 A NO20004075 A NO 20004075A NO 20004075 A NO20004075 A NO 20004075A NO 20004075 D0 NO20004075 D0 NO 20004075D0
- Authority
- NO
- Norway
- Prior art keywords
- yloxy
- preparation
- carboxylic acid
- acid derivatives
- endothelin antagonists
- Prior art date
Links
- 102000002045 Endothelin Human genes 0.000 title 1
- 108050009340 Endothelin Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
- IUBKMGVNAYWGSL-UHFFFAOYSA-N pyrimidin-2-yl hydrogen carbonate Chemical class OC(=O)OC1=NC=CC=N1 IUBKMGVNAYWGSL-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19806438A DE19806438A1 (de) | 1998-02-17 | 1998-02-17 | Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung |
| PCT/EP1999/000776 WO1999042453A1 (de) | 1998-02-17 | 1999-02-05 | 5-substituierte pyrimidin-2-yloxy-carbonsäurederivate, deren herstellung und deren verwendung als endothelin-antagonisten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20004075L NO20004075L (no) | 2000-08-15 |
| NO20004075D0 true NO20004075D0 (no) | 2000-08-15 |
Family
ID=7857948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004075A NO20004075D0 (no) | 1998-02-17 | 2000-08-15 | Substituerte pyrimidin-2-yloksy-karboksylsyrederivater, fremstilling av disse og deres anvendelse som endotelin- antagonister |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1066268A1 (no) |
| JP (1) | JP2002503726A (no) |
| KR (1) | KR20010086247A (no) |
| CN (1) | CN1291190A (no) |
| AR (1) | AR014960A1 (no) |
| AU (1) | AU3027199A (no) |
| BG (1) | BG104577A (no) |
| BR (1) | BR9907911A (no) |
| CA (1) | CA2321182A1 (no) |
| DE (1) | DE19806438A1 (no) |
| HR (1) | HRP20000602A2 (no) |
| HU (1) | HUP0100957A3 (no) |
| IL (1) | IL137038A0 (no) |
| NO (1) | NO20004075D0 (no) |
| PL (1) | PL342311A1 (no) |
| SK (1) | SK11512000A3 (no) |
| TR (1) | TR200002376T2 (no) |
| TW (1) | TW579376B (no) |
| WO (1) | WO1999042453A1 (no) |
| ZA (1) | ZA991214B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19924892A1 (de) * | 1999-06-01 | 2000-12-07 | Basf Ag | Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten |
| US8168616B1 (en) * | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
| AU2008282773B8 (en) * | 2007-07-31 | 2013-03-07 | Gilead Sciences, Inc. | Metabolites and derivatives of ambrisentan |
| PT2562166E (pt) * | 2008-01-22 | 2015-10-28 | Dow Agrosciences Llc | Derivados de 5-fluoro-pirimidina como fungicidas |
| CN102215691B (zh) * | 2008-08-01 | 2015-02-04 | 陶氏益农公司 | 5-氟胞嘧啶作为杀真菌剂的用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4411225A1 (de) * | 1994-03-31 | 1995-10-05 | Basf Ag | Verwendung von Carbonsäurederivaten als Arzneimittel |
| DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| DE19614533A1 (de) * | 1996-04-12 | 1997-10-16 | Basf Ag | Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung |
| DE19614534A1 (de) * | 1996-04-12 | 1997-10-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| ID26234A (id) * | 1996-12-18 | 2000-12-07 | Basf Ag | Turunan-turunan asam karboksilat heterosiklik, pembuatan dan penggunaannya sebagai antagonis-antagonis reseptor endotelen |
| DE19726146A1 (de) * | 1997-06-19 | 1998-12-24 | Basf Ag | Neue ß-Amino und ß-Azidopcarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
| AU2266199A (en) * | 1997-10-31 | 1999-05-24 | Basf Aktiengesellschaft | New carboxylic acid derivatives, carrying amido side-chains; production and use as endothelin receptor antagonists |
-
1998
- 1998-02-17 DE DE19806438A patent/DE19806438A1/de not_active Withdrawn
-
1999
- 1999-02-05 EP EP99911657A patent/EP1066268A1/de not_active Withdrawn
- 1999-02-05 WO PCT/EP1999/000776 patent/WO1999042453A1/de not_active Ceased
- 1999-02-05 PL PL99342311A patent/PL342311A1/xx unknown
- 1999-02-05 JP JP2000532405A patent/JP2002503726A/ja active Pending
- 1999-02-05 HR HR20000602A patent/HRP20000602A2/hr not_active Application Discontinuation
- 1999-02-05 SK SK1151-2000A patent/SK11512000A3/sk unknown
- 1999-02-05 CA CA002321182A patent/CA2321182A1/en not_active Abandoned
- 1999-02-05 CN CN99803037A patent/CN1291190A/zh active Pending
- 1999-02-05 TR TR2000/02376T patent/TR200002376T2/xx unknown
- 1999-02-05 KR KR1020007008925A patent/KR20010086247A/ko not_active Withdrawn
- 1999-02-05 AU AU30271/99A patent/AU3027199A/en not_active Abandoned
- 1999-02-05 HU HU0100957A patent/HUP0100957A3/hu unknown
- 1999-02-05 IL IL13703899A patent/IL137038A0/xx unknown
- 1999-02-05 BR BR9907911-9A patent/BR9907911A/pt not_active IP Right Cessation
- 1999-02-10 TW TW088102031A patent/TW579376B/zh active
- 1999-02-16 ZA ZA9901214A patent/ZA991214B/xx unknown
- 1999-02-16 AR ARP990100634A patent/AR014960A1/es not_active Application Discontinuation
-
2000
- 2000-07-04 BG BG104577A patent/BG104577A/bg unknown
- 2000-08-15 NO NO20004075A patent/NO20004075D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW579376B (en) | 2004-03-11 |
| BG104577A (bg) | 2001-03-30 |
| KR20010086247A (ko) | 2001-09-10 |
| CA2321182A1 (en) | 1999-08-26 |
| IL137038A0 (en) | 2001-06-14 |
| HUP0100957A2 (hu) | 2002-02-28 |
| BR9907911A (pt) | 2000-10-24 |
| WO1999042453A1 (de) | 1999-08-26 |
| DE19806438A1 (de) | 1999-08-19 |
| HUP0100957A3 (en) | 2002-03-28 |
| CN1291190A (zh) | 2001-04-11 |
| AR014960A1 (es) | 2001-04-11 |
| NO20004075L (no) | 2000-08-15 |
| EP1066268A1 (de) | 2001-01-10 |
| ZA991214B (en) | 2000-08-16 |
| TR200002376T2 (tr) | 2000-12-21 |
| PL342311A1 (en) | 2001-06-04 |
| JP2002503726A (ja) | 2002-02-05 |
| HRP20000602A2 (en) | 2001-06-30 |
| SK11512000A3 (sk) | 2001-04-09 |
| AU3027199A (en) | 1999-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |