NO20004697L - Benzoksazinoner/benzotiazinoner som serin protease inhibitorer - Google Patents
Benzoksazinoner/benzotiazinoner som serin protease inhibitorerInfo
- Publication number
- NO20004697L NO20004697L NO20004697A NO20004697A NO20004697L NO 20004697 L NO20004697 L NO 20004697L NO 20004697 A NO20004697 A NO 20004697A NO 20004697 A NO20004697 A NO 20004697A NO 20004697 L NO20004697 L NO 20004697L
- Authority
- NO
- Norway
- Prior art keywords
- benzothiazinones
- benzoxazinones
- protease inhibitors
- serine protease
- serine
- Prior art date
Links
- MJNPHLBKHKJDEF-UHFFFAOYSA-N 2h-1$l^{4},2-benzothiazine 1-oxide Chemical class C1=CC=C2S(=O)NC=CC2=C1 MJNPHLBKHKJDEF-UHFFFAOYSA-N 0.000 title 1
- HQQTZCPKNZVLFF-UHFFFAOYSA-N 4h-1,2-benzoxazin-3-one Chemical class C1=CC=C2ONC(=O)CC2=C1 HQQTZCPKNZVLFF-UHFFFAOYSA-N 0.000 title 1
- 239000003001 serine protease inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8004298P | 1998-03-31 | 1998-03-31 | |
| PCT/US1998/026704 WO1999050254A1 (en) | 1998-03-31 | 1998-12-15 | Quinoxalinones as serine protease inhibitors such as factor xa and thrombin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20004697L true NO20004697L (no) | 2000-09-20 |
| NO20004697D0 NO20004697D0 (no) | 2000-09-20 |
Family
ID=22154891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004697A NO20004697D0 (no) | 1998-03-31 | 2000-09-20 | Benzoksazinoner/benzotiazinoner som serin protease inhibitorer |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6410536B1 (no) |
| EP (1) | EP1068190A1 (no) |
| JP (1) | JP2002509923A (no) |
| KR (1) | KR20010042298A (no) |
| AU (1) | AU1917999A (no) |
| BR (1) | BR9815785A (no) |
| CA (1) | CA2319554C (no) |
| HU (1) | HUP0101470A3 (no) |
| IL (1) | IL137655A0 (no) |
| IS (1) | IS5589A (no) |
| NO (1) | NO20004697D0 (no) |
| PL (1) | PL343321A1 (no) |
| WO (1) | WO1999050254A1 (no) |
| ZA (1) | ZA992447B (no) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
| AU3127900A (en) * | 1998-12-23 | 2000-07-31 | Du Pont Pharmaceuticals Company | Thrombin or factor xa inhibitors |
| SK11422001A3 (sk) * | 1999-02-09 | 2002-04-04 | 3-Dimensional Pharmaceuticals Inc. | Heteroarylamidíny, metylamidíny a guanidíny ako inhibítory proteázy |
| SE9902202D0 (sv) * | 1999-06-10 | 1999-06-10 | Astra Ab | Production of aggregates |
| US6777413B2 (en) | 2000-02-01 | 2004-08-17 | Millennium Pharmaceuticals, Inc. | 2-[1H]-quinolone and 2-[1H]-quinoxalone inhibitors of factor Xa |
| EP1569912B1 (en) | 2002-12-03 | 2015-04-29 | Pharmacyclics, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
| TWI289141B (en) | 2003-03-11 | 2007-11-01 | Hoffmann La Roche F. Ag. | Quinolinone derivatives and uses thereof |
| DK1633340T3 (da) * | 2003-04-15 | 2011-02-07 | Wellstat Therapeutics Corp | Forbindelser til behandling af stofskifteforstyrrelser |
| CA2525713A1 (en) * | 2003-05-20 | 2004-12-29 | Genentech, Inc. | Benzofuran inhibitors of factor viia |
| AU2004249670A1 (en) * | 2003-05-20 | 2004-12-29 | Genentech, Inc. | Acylsulfamide inhibitors of factor VIIa |
| EP1742636B1 (de) * | 2004-05-05 | 2013-04-10 | Immunopharm Aktiengesellschaft | Präparat zur Behandlung von Krebs |
| DE102004023332A1 (de) * | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
| CA2576258A1 (en) * | 2004-08-09 | 2006-02-16 | Warner-Lambert Company Llc | Novel quinoxalinone norepinephrine reuptake inhibitors for the treatment of central nervous system disorders |
| WO2006016450A1 (ja) | 2004-08-11 | 2006-02-16 | Kowa Company, Ltd. | 脳梗塞の予防・治療方法 |
| AP2007003973A0 (en) * | 2004-10-12 | 2007-07-30 | Glenmark Pharmaceuticals Sa | Novel dideptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and proces for their preparation |
| US7893066B2 (en) | 2006-10-05 | 2011-02-22 | Gilead Palo Alto, Inc. | Pyridol[2,3-B]pyrazinones for use as stearoyl CoA desaturase inhibitors |
| KR20090057416A (ko) * | 2006-10-05 | 2009-06-05 | 씨브이 쎄러퓨틱스, 인코포레이티드 | 스테아로일 ＣｏＡ 탈포화효소 억제제로서 사용하기 위한, 바이시클릭 질소 함유 헤테로시클릭 화합물 |
| EP2131844A1 (en) | 2007-04-09 | 2009-12-16 | CV Therapeutics Inc. | PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS |
| KR20100017766A (ko) * | 2007-05-10 | 2010-02-16 | 에이엠알 테크놀로지, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤조-1,4-디아제핀 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 이의 용도 |
| JP5554709B2 (ja) | 2007-08-31 | 2014-07-23 | パーデュー、ファーマ、リミテッド、パートナーシップ | 置換キノキサリンタイプピペリジン化合物とその使用 |
| US8415352B2 (en) | 2008-03-05 | 2013-04-09 | MERCK Patent Gesellschaft mit beschränkter Haftung | Quinoxalinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
| MX2010010504A (es) * | 2008-03-26 | 2010-12-15 | Daiichi Sankyo Co Ltd | Derivado de hidroxi-quinoxalin-carboxamida. |
| EP2276748A1 (en) * | 2008-04-10 | 2011-01-26 | Gilead Sciences, Inc. | Bicyclic nitrogen containing heterocyclic compounds for use as stearoyl coa desaturase inhibitors |
| ES2393849T7 (es) | 2008-07-21 | 2015-01-28 | Purdue Pharma Lp | Compuestos de piperidina puenteada, de tipo quinoxalina sustituida, y usos de los mismos |
| EP2654751B1 (en) | 2010-12-22 | 2016-11-23 | Purdue Pharma L.P. | Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof |
| WO2013071217A1 (en) | 2011-11-10 | 2013-05-16 | OSI Pharmaceuticals, LLC | Dihydropteridinones |
| US9290488B2 (en) | 2011-12-01 | 2016-03-22 | Purdue Pharma L.P. | Azetidine-substituted quinoxalines as opioid receptor like-1 modulators |
| US9085561B2 (en) | 2012-07-30 | 2015-07-21 | Purdue Pharma L.P. | Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators |
| US9951038B2 (en) | 2012-12-27 | 2018-04-24 | Purdue Pharma L.P. | Quinazolin-4(3H)-one-type piperidine compounds and uses thereof |
| WO2014102588A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
| WO2014102592A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Oxime/substituted quinoxaline-type piperidine compounds and uses thereof |
| WO2014102594A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
| WO2017019828A1 (en) * | 2015-07-30 | 2017-02-02 | Bristol-Myers Squibb Company | Aryl substituted bicyclic heteroaryl compounds |
| PT3394040T (pt) | 2015-12-24 | 2022-03-24 | Univ California | Reguladores de cftr e seus métodos de uso |
| US11084795B2 (en) | 2015-12-24 | 2021-08-10 | The Regents Of The University Of California | CFTR regulators and methods of use thereof |
| PT3394083T (pt) | 2015-12-24 | 2021-12-07 | Univ California | Derivados de n-[5-[(3,4-dimetoxifenil)metil]-1,3,4-tiadiazol-2-il]-2-metoxi-benzenoacetamida e compostos relacionados como ativadores de cftr para tratar a obstipação ou colestase |
| DE102017005089A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substitulerte 3,4-Dihydrochinoxalin-2(1H)-one |
| DE102017005091A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substituierte 3,4-Dihydropyrido[2,3-b]pyrazin-2(1H)-one |
| CN111629730A (zh) | 2017-08-24 | 2020-09-04 | 加利福尼亚大学董事会 | 眼部药物组合物 |
| WO2023278222A1 (en) * | 2021-06-28 | 2023-01-05 | Merck Sharp & Dohme Llc | Il4i1 inhibitors and methods of use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4082736A (en) | 1976-04-26 | 1978-04-04 | Syntex (U.S.A.) Inc. | Novel immunological adjuvant compounds and methods of preparation thereof |
| US4082735A (en) | 1976-04-26 | 1978-04-04 | Syntex (U.S.A.) Inc. | Novel immunological adjuvant compounds and methods of preparation thereof |
| JPS63145272A (ja) | 1986-12-09 | 1988-06-17 | Morishita Seiyaku Kk | ４，５−ジヒドロ−６−（４−置換フエニル）−３（２ｈ）−ピリダジノン誘導体 |
| JPS63301874A (ja) * | 1987-03-27 | 1988-12-08 | Fujisawa Pharmaceut Co Ltd | キノキサリン誘導体およびその製造法 |
| JPH0276860A (ja) * | 1987-10-05 | 1990-03-16 | Toyo Jozo Co Ltd | ６−置換アルコキシ−２−オキソ−１，２−ジヒドロキノキサリン誘導体 |
| JPH01254348A (ja) | 1988-04-01 | 1989-10-11 | Matsushita Electric Ind Co Ltd | 成形用型 |
| HUT76640A (en) | 1995-08-17 | 1997-10-28 | Chinoin Gyogyszer Es Vegyeszet | Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use |
| WO1997048706A1 (en) * | 1996-06-18 | 1997-12-24 | Warner-Lambert Company | Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors |
| CA2259573A1 (en) * | 1996-07-08 | 1998-01-15 | Ruth Richmond Wexler | Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of factor xa and of thrombin |
| TW472045B (en) * | 1996-09-25 | 2002-01-11 | Astra Ab | Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation |
| GB2324729B (en) | 1997-04-30 | 2002-01-02 | Bradford Hospitals Nhs Trust | Lung treatment device |
-
1998
- 1998-12-15 JP JP2000541158A patent/JP2002509923A/ja active Pending
- 1998-12-15 AU AU19179/99A patent/AU1917999A/en not_active Abandoned
- 1998-12-15 CA CA002319554A patent/CA2319554C/en not_active Expired - Fee Related
- 1998-12-15 HU HU0101470A patent/HUP0101470A3/hu unknown
- 1998-12-15 PL PL98343321A patent/PL343321A1/xx not_active Application Discontinuation
- 1998-12-15 BR BR9815785-0A patent/BR9815785A/pt not_active Application Discontinuation
- 1998-12-15 KR KR1020007010842A patent/KR20010042298A/ko not_active Withdrawn
- 1998-12-15 IL IL13765598A patent/IL137655A0/xx unknown
- 1998-12-15 EP EP98963961A patent/EP1068190A1/en not_active Withdrawn
- 1998-12-15 WO PCT/US1998/026704 patent/WO1999050254A1/en not_active Ceased
-
1999
- 1999-03-30 ZA ZA9902447A patent/ZA992447B/xx unknown
-
2000
- 2000-08-03 US US09/601,606 patent/US6410536B1/en not_active Expired - Fee Related
- 2000-08-18 IS IS5589A patent/IS5589A/is unknown
- 2000-09-20 NO NO20004697A patent/NO20004697D0/no unknown
-
2002
- 2002-01-04 US US10/038,006 patent/US6916805B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL343321A1 (en) | 2001-08-13 |
| IS5589A (is) | 2000-08-18 |
| BR9815785A (pt) | 2000-12-05 |
| CA2319554A1 (en) | 1999-10-07 |
| KR20010042298A (ko) | 2001-05-25 |
| CA2319554C (en) | 2005-06-28 |
| HUP0101470A3 (en) | 2002-09-30 |
| NO20004697D0 (no) | 2000-09-20 |
| IL137655A0 (en) | 2001-10-31 |
| WO1999050254A1 (en) | 1999-10-07 |
| US6916805B2 (en) | 2005-07-12 |
| ZA992447B (en) | 2000-10-10 |
| HUP0101470A2 (hu) | 2001-10-28 |
| EP1068190A1 (en) | 2001-01-17 |
| JP2002509923A (ja) | 2002-04-02 |
| US6410536B1 (en) | 2002-06-25 |
| US20020086866A1 (en) | 2002-07-04 |
| AU1917999A (en) | 1999-10-18 |
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