NO20005312L - Stabile sammensetninger som omfatter levosimendan og alginsyre - Google Patents

Stabile sammensetninger som omfatter levosimendan og alginsyre

Info

Publication number: NO20005312L
Authority: NO; Norway
Prior art keywords: levosimendan; alginic acid; stable compositions; compositions; stable
Prior art date: 1998-04-23

Application number

NO20005312A

Other languages

English (en)

Other versions

NO318575B1 (no

NO20005312D0 (no

Inventor

Ilkka Larma

Maarit Baeckman

Original Assignee

Orion Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-23

Filing date

2000-10-20

Publication date

2000-11-21

2000-10-20 Application filed by Orion Corp filed Critical Orion Corp

2000-10-20 Publication of NO20005312D0 publication Critical patent/NO20005312D0/no

2000-11-21 Publication of NO20005312L publication Critical patent/NO20005312L/no

2005-04-11 Publication of NO318575B1 publication Critical patent/NO318575B1/no

Links

WHXMKTBCFHIYNQ-SECBINFHSA-N levosimendan Chemical compound C[C@@H]1CC(=O)NN=C1C1=CC=C(NN=C(C#N)C#N)C=C1 WHXMKTBCFHIYNQ-SECBINFHSA-N 0.000 title abstract 4
229960000692 levosimendan Drugs 0.000 title abstract 4
229960001126 alginic acid Drugs 0.000 title abstract 2
235000010443 alginic acid Nutrition 0.000 title abstract 2
229920000615 alginic acid Polymers 0.000 title abstract 2
239000000783 alginic acid Substances 0.000 title abstract 2
150000004781 alginic acids Chemical class 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Jellies, Jams, And Syrups (AREA)
Detergent Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

NO20005312A 1998-04-23 2000-10-20 Stabile sammensetninger som omfatter levosimendan og alginsyre NO318575B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI980902A FI980902A7 (fi)	1998-04-23	1998-04-23	Levosimendaanin stabiileja koostumuksia
PCT/FI1999/000331 WO1999055337A1 (en)	1998-04-23	1999-04-23	Stabile compositions comprising levosimendan and alginic acid

Publications (3)

Publication Number	Publication Date
NO20005312D0 NO20005312D0 (no)	2000-10-20
NO20005312L true NO20005312L (no)	2000-11-21
NO318575B1 NO318575B1 (no)	2005-04-11

Family

ID=8551576

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20005312A NO318575B1 (no)	1998-04-23	2000-10-20	Stabile sammensetninger som omfatter levosimendan og alginsyre

Country Status (32)

Country	Link
US (1)	US6531458B1 (no)
EP (1)	EP1079834B1 (no)
JP (1)	JP4475809B2 (no)
KR (1)	KR100590622B1 (no)
CN (1)	CN1165309C (no)
AT (1)	ATE231395T1 (no)
AU (1)	AU756338B2 (no)
BG (1)	BG64766B1 (no)
BR (1)	BR9909867A (no)
CA (1)	CA2329232C (no)
CZ (1)	CZ290911B6 (no)
DE (1)	DE69905034T2 (no)
DK (1)	DK1079834T3 (no)
EA (1)	EA002428B1 (no)
EE (1)	EE04143B1 (no)
ES (1)	ES2191426T3 (no)
FI (1)	FI980902A7 (no)
GE (1)	GEP20032942B (no)
HR (1)	HRP20000703B1 (no)
HU (1)	HUP0105446A3 (no)
ID (1)	ID26650A (no)
IL (2)	IL138950A0 (no)
MX (1)	MXPA00010368A (no)
NO (1)	NO318575B1 (no)
NZ (1)	NZ507455A (no)
PL (1)	PL192274B1 (no)
PT (1)	PT1079834E (no)
RS (1)	RS49955B (no)
SK (1)	SK284600B6 (no)
TR (1)	TR200003101T2 (no)
WO (1)	WO1999055337A1 (no)
ZA (1)	ZA200005630B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI980901A7 (fi) *	1998-04-23	1999-10-24	Orion Yhtymae Oyj	Levosimendaania säädellysti vapauttavia oraalisia koostumuksia
FI109659B (fi) *	1999-09-10	2002-09-30	Orion Yhtymae Oyj	Levosimendaanin farmaseuttisia liuoksia
FI20010233A0 (fi) *	2001-02-08	2001-02-08	Orion Corp	Menetelmä sydämen vajaatoiminnan hoitoon
EP1366761A4 (en) *	2001-02-13	2004-04-21	Taisho Pharmaceutical Co Ltd	GEL PREPARATIONS FOR INTERNAL USE
JP2008533109A (ja) *	2005-03-14	2008-08-21	オリオンコーポレーション	利尿を促進するための複合治療
AU2016349408B2 (en) *	2015-11-06	2021-06-03	Carinopharm Gmbh	Improved formulations of Levosimendan for intravenous administration as infusion or injection and of infusion concentrate
EP4076398B1 (en)	2019-12-16	2026-02-18	Tenax Therapeutics, Inc.	Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (ph-hf-pef)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1509866A (en)	1975-06-10	1978-05-04	Johnson & Johnson	Enteric coated digestive enzyme compositions
PT76448B (en) *	1982-04-05	1986-03-20	Merck Sharp & Dohme	Process for preparing stabilization of unstable drugs or food supplements containing antibiotics mainly ephrotomycin
EP0123291A2 (en)	1983-04-20	1984-10-31	Kyowa Hakko Kogyo Co., Ltd.	Method for stabilizing interferon
US4906630A (en) *	1985-11-22	1990-03-06	Rorer Pharmaceutical Corporation	Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds
US4716042A (en)	1986-06-16	1987-12-29	American Home Products Corporation	Stabilized coated aspirin tablets
GB8903130D0 (en)	1989-02-11	1989-03-30	Orion Yhtymae Oy	Substituted pyridazinones
GB2251615B (en) *	1991-01-03	1995-02-08	Orion Yhtymae Oy	(-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en)	1992-05-06	1993-11-17	Orion Yhtymae Oy	Compounds for use as anti-ischemic medicaments
GB9614098D0 (en)	1996-07-05	1996-09-04	Orion Yhtymae Oy	Transdermal delivery of levosimendan
FI973804A7 (fi) *	1997-09-26	1999-03-27	Orion Yhtymae Oy	Levosimendaanin oraalisia koostumuksia

1998
- 1998-04-23 FI FI980902A patent/FI980902A7/fi unknown
1999
- 1999-04-23 RS YUP-640/00A patent/RS49955B/sr unknown
- 1999-04-23 HR HR20000703A patent/HRP20000703B1/xx not_active IP Right Cessation
- 1999-04-23 BR BR9909867-9A patent/BR9909867A/pt not_active Application Discontinuation
- 1999-04-23 DE DE69905034T patent/DE69905034T2/de not_active Expired - Lifetime
- 1999-04-23 PL PL343722A patent/PL192274B1/pl not_active IP Right Cessation
- 1999-04-23 JP JP2000545535A patent/JP4475809B2/ja not_active Expired - Lifetime
- 1999-04-23 EP EP99916943A patent/EP1079834B1/en not_active Expired - Lifetime
- 1999-04-23 ID IDW20002368A patent/ID26650A/id unknown
- 1999-04-23 US US09/673,793 patent/US6531458B1/en not_active Expired - Fee Related
- 1999-04-23 EE EEP200000616A patent/EE04143B1/xx not_active IP Right Cessation
- 1999-04-23 IL IL13895099A patent/IL138950A0/xx active IP Right Grant
- 1999-04-23 HU HU0105446A patent/HUP0105446A3/hu unknown
- 1999-04-23 PT PT99916943T patent/PT1079834E/pt unknown
- 1999-04-23 AT AT99916943T patent/ATE231395T1/de not_active IP Right Cessation
- 1999-04-23 GE GEAP19995638A patent/GEP20032942B/en unknown
- 1999-04-23 EA EA200001097A patent/EA002428B1/ru not_active IP Right Cessation
- 1999-04-23 KR KR1020007011789A patent/KR100590622B1/ko not_active Expired - Fee Related
- 1999-04-23 DK DK99916943T patent/DK1079834T3/da active
- 1999-04-23 ES ES99916943T patent/ES2191426T3/es not_active Expired - Lifetime
- 1999-04-23 WO PCT/FI1999/000331 patent/WO1999055337A1/en not_active Ceased
- 1999-04-23 CZ CZ20003779A patent/CZ290911B6/cs not_active IP Right Cessation
- 1999-04-23 MX MXPA00010368A patent/MXPA00010368A/es active IP Right Grant
- 1999-04-23 AU AU35248/99A patent/AU756338B2/en not_active Ceased
- 1999-04-23 SK SK1555-2000A patent/SK284600B6/sk not_active IP Right Cessation
- 1999-04-23 NZ NZ507455A patent/NZ507455A/en unknown
- 1999-04-23 CA CA002329232A patent/CA2329232C/en not_active Expired - Fee Related
- 1999-04-23 TR TR2000/03101T patent/TR200003101T2/xx unknown
- 1999-04-23 CN CNB998053805A patent/CN1165309C/zh not_active Expired - Fee Related
2000
- 2000-10-11 IL IL138950A patent/IL138950A/en not_active IP Right Cessation
- 2000-10-12 ZA ZA200005630A patent/ZA200005630B/en unknown
- 2000-10-20 NO NO20005312A patent/NO318575B1/no not_active IP Right Cessation
- 2000-11-17 BG BG104958A patent/BG64766B1/bg unknown

Also Published As

Publication number	Publication date
HUP0105446A3 (en)	2002-09-30
EA200001097A1 (ru)	2001-04-23
ID26650A (id)	2001-01-25
HK1031998A1 (en)	2001-07-06
HUP0105446A2 (hu)	2002-07-29
CN1165309C (zh)	2004-09-08
NO318575B1 (no)	2005-04-11
YU64000A (sh)	2002-12-10
ES2191426T3 (es)	2003-09-01
JP4475809B2 (ja)	2010-06-09
EE200000616A (et)	2002-06-17
CN1298303A (zh)	2001-06-06
TR200003101T2 (tr)	2001-01-22
SK284600B6 (sk)	2005-07-01
EE04143B1 (et)	2003-10-15
BG64766B1 (bg)	2006-03-31
EA002428B1 (ru)	2002-04-25
WO1999055337A1 (en)	1999-11-04
PT1079834E (pt)	2003-04-30
CA2329232C (en)	2007-10-30
ATE231395T1 (de)	2003-02-15
CZ290911B6 (cs)	2002-11-13
CZ20003779A3 (en)	2001-05-16
KR20010072577A (ko)	2001-07-31
MXPA00010368A (es)	2002-07-02
FI980902A0 (fi)	1998-04-23
RS49955B (sr)	2008-09-29
US6531458B1 (en)	2003-03-11
HRP20000703B1 (hr)	2009-11-30
DE69905034D1 (de)	2003-02-27
AU3524899A (en)	1999-11-16
CA2329232A1 (en)	1999-11-04
DE69905034T2 (de)	2003-09-04
NZ507455A (en)	2002-02-01
PL192274B1 (pl)	2006-09-29
NO20005312D0 (no)	2000-10-20
DK1079834T3 (da)	2003-04-07
BG104958A (bg)	2001-07-31
GEP20032942B (en)	2003-04-25
IL138950A (en)	2006-08-20
AU756338B2 (en)	2003-01-09
ZA200005630B (en)	2002-01-14
IL138950A0 (en)	2001-11-25
HRP20000703A2 (en)	2001-04-30
FI980902A7 (fi)	1999-10-24
EP1079834A1 (en)	2001-03-07
JP2002512964A (ja)	2002-05-08
SK15552000A3 (sk)	2001-05-10
EP1079834B1 (en)	2003-01-22
BR9909867A (pt)	2000-12-19
KR100590622B1 (ko)	2006-06-19
PL343722A1 (en)	2001-09-10

Legal Events

Date	Code	Title	Description
2011-11-28	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
ATE289332T1 (de)	2005-03-15	Silikongel enthaltend salizylsäure
NO970051L (no)	1997-01-07	Vandige risperidon formuleringer
ATE508735T1 (de)	2011-05-15	Pulmonale verabreichung von aminoglykosiden
EE9900217A (et)	1999-12-15	Sulfiinhappe derivaadid, nende valmistamine ja kasutamine
EA200300906A1 (ru)	2004-02-26	Новые спиротрициклические производные и их применение в качестве ингибиторов фосфодиэстеразы-7
DE60013098D1 (de)	2004-09-23	Zusammensetzung zur hautdesinfizierung
ATE376835T1 (de)	2007-11-15	Verwendung von fucanen in der behandlung von adhäsion, arthritis und psoriasis
BR9713338A (pt)	2000-05-09	Benzonaftiridinas como terapêuticos brÈnquicos.
DK0760848T3 (da)	1998-09-23	Lactobacillusstammer af menneskelig oprindelse, deres sammensætninger og anvendelse deraf
BR9811099A (pt)	2002-05-14	Inibidores de urocinase
DE60143906D1 (de)	2011-03-03	Verwendung von derivaten der 2-oxothiazolidin-4-corbonsäure als prä-abschuppungsmittel
DK1097173T3 (da)	2008-09-01	Anvendelse af peptider af IL-2 og derivater deraf som terapeutiske midler
DE60111362D1 (de)	2005-07-14	Stabilisierte ascorbinsäure-lösungen
NO20022201L (no)	2002-05-08	Lösninger inneholdende Epinastin
DE69525740D1 (de)	2002-04-11	Spezielle halofantrinhaltige Zusammensetzungen
NO20005312D0 (no)	2000-10-20	Stabile sammensetninger som omfatter levosimendan og alginsyre
NO20003758L (no)	2000-07-21	Trekonserveringsmidler
NO20061138L (no)	2006-05-10	Gjaercellevegger for behandling eller forebygging av hyperglukemi eller for a stabilisere glukemi
DK0921806T3 (da)	2003-12-08	Mannose-6-phosphat-præparat og anvendelse deraf til behandling af fibrøse lidelser
TR200200278T2 (tr)	2002-06-21	Kalsilitik bileşimler
DE60219940D1 (de)	2007-06-14	Verwendung von irbesartan zur vorbeugung oder behandlung pulmonaler hypertonie
DE60034770D1 (de)	2007-06-21	Stabile fumagillin-formulierung
ATE238791T1 (de)	2003-05-15	Verwendung von 2-methyl-thiazolidin-2,4- dicarbonsäure als mukolytikum
DE60137506D1 (de)	2009-03-12	Verwendung von polysulfatierten cyclodextrinen zur behandlung von arthrose
ATE184155T1 (de)	1999-09-15	Verwendung der jodwasserstoffsäure als aphrodisiakum