NO20005435L - Bifenylderivater - Google Patents

Bifenylderivater

Info

Publication number
NO20005435L
NO20005435L NO20005435A NO20005435A NO20005435L NO 20005435 L NO20005435 L NO 20005435L NO 20005435 A NO20005435 A NO 20005435A NO 20005435 A NO20005435 A NO 20005435A NO 20005435 L NO20005435 L NO 20005435L
Authority
NO
Norway
Prior art keywords
biphenyl
prophylaxis
inhibitors
therapy
formula
Prior art date
Application number
NO20005435A
Other languages
English (en)
Other versions
NO20005435D0 (no
Inventor
Dieter Dorsch
Horst Juraszyk
Werner Mederski
Hanns Wurziger
Hans-Peter Buchstaller
Sabine Bernotat-Danielowski
Guido Melzer
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO20005435D0 publication Critical patent/NO20005435D0/no
Publication of NO20005435L publication Critical patent/NO20005435L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Nye forbindelser med formel (T) hvor X, R1, R2, R3, R4 og R5 har de i patentkrav l angitte betydninger, er inhibitorer for koagulasjons- faktoren Xa og kan anvendes til profylakse og/eller terapi av tromboembolske sykdommer.
NO20005435A 1998-04-30 2000-10-27 Bifenylderivater NO20005435L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19819548A DE19819548A1 (de) 1998-04-30 1998-04-30 Biphenylderivate
PCT/EP1999/002457 WO1999057096A1 (de) 1998-04-30 1999-04-12 Biphenylderivate

Publications (2)

Publication Number Publication Date
NO20005435D0 NO20005435D0 (no) 2000-10-27
NO20005435L true NO20005435L (no) 2000-10-27

Family

ID=7866421

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005435A NO20005435L (no) 1998-04-30 2000-10-27 Bifenylderivater

Country Status (19)

Country Link
US (1) US6380430B1 (no)
EP (1) EP1076643A1 (no)
JP (1) JP2002513780A (no)
KR (1) KR20010052249A (no)
CN (1) CN1299343A (no)
AR (1) AR019264A1 (no)
AU (1) AU750472B2 (no)
BR (1) BR9910021A (no)
CA (1) CA2328732A1 (no)
DE (1) DE19819548A1 (no)
HU (1) HUP0102220A3 (no)
ID (1) ID27152A (no)
NO (1) NO20005435L (no)
PL (1) PL343598A1 (no)
RU (1) RU2219166C2 (no)
SK (1) SK15962000A3 (no)
UA (1) UA58593C2 (no)
WO (1) WO1999057096A1 (no)
ZA (1) ZA200007039B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1179344B1 (en) * 1999-01-28 2006-09-13 Teijin Limited Release-regulating preparations
DE19945302A1 (de) * 1999-09-22 2001-03-29 Merck Patent Gmbh Biphenylderivate als NHE-3-Inhibitoren
DE10027024A1 (de) * 2000-05-31 2001-12-06 Merck Patent Gmbh Carbaminsäureester
WO2002000647A1 (en) * 2000-06-23 2002-01-03 Bristol-Myers Squibb Pharma Company Heteroaryl-phenyl substituted factor xa inhibitors
DE10037146A1 (de) * 2000-07-29 2002-02-07 Merck Patent Gmbh Acetamidderivate
EP1569912B1 (en) 2002-12-03 2015-04-29 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
US7534894B2 (en) 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5922697B2 (ja) * 1976-01-13 1984-05-28 エーザイ株式会社 ビス−（メタ−アミジノフエノキシ）−化合物
US4086244A (en) * 1976-12-10 1978-04-25 E. R. Squibb & Sons, Inc. Amidines
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
DE4219158A1 (de) 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4430213A1 (de) * 1994-08-28 1996-02-29 Merck Patent Gmbh Arylbenzoylguanidine
PL316438A1 (en) 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
GB9600063D0 (en) * 1996-01-03 1996-03-06 Fujisawa Pharmaceutical Co Guaridine derivatives

Also Published As

Publication number Publication date
DE19819548A1 (de) 1999-11-04
US6380430B1 (en) 2002-04-30
JP2002513780A (ja) 2002-05-14
NO20005435D0 (no) 2000-10-27
ID27152A (id) 2001-03-08
HUP0102220A2 (hu) 2001-10-28
CN1299343A (zh) 2001-06-13
UA58593C2 (uk) 2003-08-15
AU3815499A (en) 1999-11-23
EP1076643A1 (de) 2001-02-21
PL343598A1 (en) 2001-08-27
RU2219166C2 (ru) 2003-12-20
ZA200007039B (en) 2002-02-28
SK15962000A3 (sk) 2001-05-10
AU750472B2 (en) 2002-07-18
AR019264A1 (es) 2002-02-13
BR9910021A (pt) 2000-12-26
HUP0102220A3 (en) 2002-11-28
WO1999057096A1 (de) 1999-11-11
KR20010052249A (ko) 2001-06-25
CA2328732A1 (en) 1999-11-11

Similar Documents

Publication Publication Date Title
NO20002958L (no) Benzamidinderivater som koagulasjonsfaktor Xa-hemmere
MXPA03006483A (es) Derivados de fenilo.
MY140031A (en) Carbonyl compounds
RU94031102A (ru) Сульфамиды в качестве антагонистов эндотелина и способ лечения соответствующих заболеваний
NO992821L (no) Ketobenzamider som calpain-inhibitorer
NO992770L (no) Nye heterocyklisk substituerte benzamider og deres anvendelse ved bekjempelse av sykdommer
NO20013384L (no) Imidazo[4,5-c]pyridin-4-on-derivater
GEP20063871B (en) Inhibitors of factor xa and other serine proteases involved in the coagulation cascade
TW200504012A (en) Ethynylproline derivatives
NO965412D0 (no) Nye trombin-inhibitorer, deres fremstilling og bruk
DK0726899T3 (da) Nye pyrazincarboxamidderivater, deres fremstilling og deres anvendelse i lægemidler
SE9602646D0 (sv) Pharmaceutically-useful compounds
ATE246184T1 (de) Chinoline und deren therapeutische verwendung
NO990662L (no) Trombin-inhibitorer
SE9602263D0 (sv) New amino acid derivatives
NO971625L (no) Nye peptider med immunomodulatoriske effekter
WO2004002477A8 (de) 2-(phenyl)-2h-pyrazol-3-carbonsäure-n-4-(thioxo-heterocyclyl)-phenyl-amid derivate und entsprechende imino-heterocyclyl derivate sowie verwandte verbindungen als inhibitoren der koagulationsfaktoren xa und/oder viia zur behandlung bon thrombosen
NO20002848L (no) Nye forbindelser
NZ332096A (en) Alpha-hydroxylic acid derivatives their production and use in treating conditions requiring endothelin inhibition
NO972559L (no) Nye dipeptid-p-amidinobenzylamider med N-terminale sulfonyl- eller aminosulfonylrester
UA85676C2 (en) Carbonyl compounds
IS5966A (is) Nýjar amídínóafleiður og notkun þeirra sem þrombínhemlar
MXPA03010205A (es) Derivados de acido oxalico.
MXPA04004307A (es) Derivados de fenoxi-n-`4-(1,1-dioxoisotiazolidin-2-il)fenil-valeramida y otros compuestos como inhibidores del factor de coagulacion xa para el tratamiento de enfermedades tromboembolicas y tumores.
NO991734L (no) Pyrazolinoner for behandling av potensforstyrrelser

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application