NO20005453L - N-(3-etynylfenylamino)-6,7-bis(2-metoksyetoksy)-4- quinazolinamin mesylat anhydrat og monohydrat - Google Patents

N-(3-etynylfenylamino)-6,7-bis(2-metoksyetoksy)-4- quinazolinamin mesylat anhydrat og monohydrat

Info

Publication number: NO20005453L
Authority: NO; Norway
Prior art keywords: ethynylphenylamino; methoxyethoxy; monohydrate; bis; quinazolinamine mesylate
Prior art date: 1998-04-29

Application number

NO20005453A

Other languages

English (en)

Other versions

NO20005453D0 (no

NO317301B1 (no

Inventor

Douglas John Meldrum Allen

Timothy Norris

Jeffrey William Raggon

Dinos Paul Santafianos

Ravi Mysore Shanker

Original Assignee

Osi Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-29

Filing date

2000-10-27

Publication date

2000-12-20

2000-10-27 Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc

2000-10-27 Publication of NO20005453D0 publication Critical patent/NO20005453D0/no

2000-12-20 Publication of NO20005453L publication Critical patent/NO20005453L/no

2004-10-04 Publication of NO317301B1 publication Critical patent/NO317301B1/no

Links

ZKHFAIQCKLXUHC-UHFFFAOYSA-N 1-[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]-2-(3-ethynylphenyl)hydrazine;methanesulfonic acid Chemical compound CS(O)(=O)=O.C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NNC1=CC=CC(C#C)=C1 ZKHFAIQCKLXUHC-UHFFFAOYSA-N 0.000 title 1
150000004682 monohydrates Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Engineering & Computer Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20005453A 1998-04-29 2000-10-27 N-(3-etynylfenylamino)-6,7-bis(2-metoksyetoksy)-4-quinazolinamin mesylat anhydrat og monohydrat NO317301B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8344198P	1998-04-29	1998-04-29
PCT/IB1999/000612 WO1999055683A1 (en)	1998-04-29	1999-04-08	N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate

Publications (3)

Publication Number	Publication Date
NO20005453D0 NO20005453D0 (no)	2000-10-27
NO20005453L true NO20005453L (no)	2000-12-20
NO317301B1 NO317301B1 (no)	2004-10-04

Family

ID=22178359

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20005453A NO317301B1 (no)	1998-04-29	2000-10-27	N-(3-etynylfenylamino)-6,7-bis(2-metoksyetoksy)-4-quinazolinamin mesylat anhydrat og monohydrat

Country Status (41)

Country	Link
EP (1)	EP1076652B1 (no)
JP (1)	JP4652569B2 (no)
KR (1)	KR100668412B1 (no)
CN (2)	CN1298396A (no)
AP (1)	AP1252A (no)
AR (1)	AR018201A1 (no)
AT (1)	ATE295839T1 (no)
AU (1)	AU759691C (no)
BR (1)	BR9910025A (no)
CA (1)	CA2330447C (no)
CO (1)	CO5060467A1 (no)
CZ (1)	CZ298230B6 (no)
DE (1)	DE69925366T2 (no)
DZ (1)	DZ2777A1 (no)
EA (1)	EA002836B1 (no)
EG (1)	EG24000A (no)
ES (1)	ES2238825T3 (no)
GT (1)	GT199900063A (no)
HN (1)	HN1999000057A (no)
HU (1)	HU227569B1 (no)
ID (1)	ID27198A (no)
IL (1)	IL139172A0 (no)
MA (1)	MA26624A1 (no)
ME (1)	MEP42008A (no)
MX (1)	MXPA00010610A (no)
MY (1)	MY136033A (no)
NO (1)	NO317301B1 (no)
NZ (1)	NZ508154A (no)
OA (1)	OA11769A (no)
PA (1)	PA8471001A1 (no)
PE (1)	PE20000441A1 (no)
PL (1)	PL196940B1 (no)
RS (1)	RS50081B (no)
SA (1)	SA99200216B1 (no)
TN (1)	TNSN99079A1 (no)
TR (1)	TR200003166T2 (no)
TW (1)	TWI248437B (no)
UA (1)	UA60363C2 (no)
UY (1)	UY26099A1 (no)
WO (1)	WO1999055683A1 (no)
ZA (1)	ZA992972B (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6706721B1 (en)	1998-04-29	2004-03-16	Osi Pharmaceuticals, Inc.	N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
RS49836B (sr)	1999-03-31	2008-08-07	Pfizer Products Inc.,	Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja
UA74803C2 (uk) *	1999-11-11	2006-02-15	Осі Фармасьютікалз, Інк.	Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7087613B2 (en)	1999-11-11	2006-08-08	Osi Pharmaceuticals, Inc.	Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
UA73993C2 (uk) *	2000-06-06	2005-10-17	Астразенека Аб	Хіназолінові похідні для лікування пухлин та фармацевтична композиція
WO2003000188A2 (en)	2001-06-21	2003-01-03	Ariad Pharmaceuticals, Inc.	Novel quinazolines and uses thereof
US7078409B2 (en)	2002-03-28	2006-07-18	Beta Pharma, Inc.	Fused quinazoline derivatives useful as tyrosine kinase inhibitors
GB0223854D0 (en) *	2002-10-12	2002-11-20	Astrazeneca Ab	Therapeutic treatment
US7148231B2 (en) *	2003-02-17	2006-12-12	Hoffmann-La Roche Inc.	[6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph
AU2004291709C1 (en)	2003-05-30	2010-03-11	Astrazeneca Uk Limited	Process
EP1680426B1 (en)	2003-06-10	2007-09-19	F. Hoffmann-La Roche Ag	1.3.4-triaza-phenalene and 1,3,4,6-tetraazaphenalene derivatives
GB0403744D0 (en)	2004-02-20	2004-03-24	Astrazeneca Ab	Chemical process
BRPI0510717B8 (pt)	2004-05-06	2021-05-25	Bioresponse Llc	uso de 3,3' diindolilmetano (dim) ou 2-(indol-3-ilmetil)-3,3´-diindolilmetano (ltr)
WO2006083458A2 (en)	2004-12-30	2006-08-10	Bioresponse Llc	Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions
CA2659307A1 (en)	2006-07-28	2008-01-31	Synthon B.V.	Crystalline erlotinib
BRPI0717753B1 (pt)	2006-10-27	2022-04-12	Bioresponse, Llc	Uso de uma composição compreendendo 50-250 mg de um ou mais indóis relacionados com dim e um ou mais agentes anti-protozoários, e, composição
WO2008122776A2 (en) *	2007-04-04	2008-10-16	Cipla Limited	Process for preparation of erlotinib and its pharmaceutically acceptable salts
WO2009007984A2 (en)	2007-07-11	2009-01-15	Hetero Drugs Limited	An improved process for erlotinib hydrochloride
WO2009024989A2 (en)	2007-08-17	2009-02-26	Hetero Drugs Limited	A novel hydrated form of erlotinib free base and a process for preparation of erlotinib hydrochloride polymorph form a substantially free of polymorph form b
KR101132937B1 (ko) *	2008-10-01	2012-04-06	주식회사종근당	Ｎ-(3-에티닐페닐)-6,7-비스(2-메톡시에톡시)-4-퀴나졸린아민 납실레이트 염
EP2411373B1 (en)	2009-03-26	2015-10-21	Ranbaxy Laboratories Limited	Process for the preparation of erlotinib or its pharmaceutically acceptable salts thereof
WO2011068404A2 (en)	2009-12-02	2011-06-09	Ultimorphix Technologies B.V.	Administration of n-(3-ethynylphenylamino)-6,7-bis(2- methoxyethoxy)-4-quinazolinamine mesylate salt by inhalation
DE202010006543U1 (de)	2010-05-07	2010-09-09	Ratiopharm Gmbh	Erlotinibresinat
HU230483B1 (hu)	2011-10-10	2016-07-28	Egis Gyógyszergyár Nyrt.	Erlotinib sók
US9593083B2 (en)	2012-09-04	2017-03-14	Shilpa Medicare Limited	Crystalline erlotinib hydrochloride process

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ243082A (en) *	1991-06-28	1995-02-24	Ici Plc	4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
JP2994165B2 (ja) *	1992-06-26	1999-12-27	ゼネカ・リミテッド	キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤
GB9323290D0 (en) *	1992-12-10	1994-01-05	Zeneca Ltd	Quinazoline derivatives
DE69536015D1 (de) *	1995-03-30	2009-12-10	Pfizer Prod Inc	Chinazolinone Derivate
US5747498A (en) *	1996-05-28	1998-05-05	Pfizer Inc.	Alkynyl and azido-substituted 4-anilinoquinazolines

1999
- 1999-04-08 IL IL13917299A patent/IL139172A0/xx not_active IP Right Cessation
- 1999-04-08 MX MXPA00010610A patent/MXPA00010610A/es active IP Right Grant
- 1999-04-08 JP JP2000545843A patent/JP4652569B2/ja not_active Expired - Lifetime
- 1999-04-08 PL PL343766A patent/PL196940B1/pl not_active IP Right Cessation
- 1999-04-08 EA EA200001112A patent/EA002836B1/ru not_active IP Right Cessation
- 1999-04-08 CA CA002330447A patent/CA2330447C/en not_active Expired - Lifetime
- 1999-04-08 OA OA1200000300A patent/OA11769A/en unknown
- 1999-04-08 ID IDW20002186A patent/ID27198A/id unknown
- 1999-04-08 TR TR2000/03166T patent/TR200003166T2/xx unknown
- 1999-04-08 HU HU0101818A patent/HU227569B1/hu unknown
- 1999-04-08 AU AU28509/99A patent/AU759691C/en not_active Expired
- 1999-04-08 CZ CZ20003974A patent/CZ298230B6/cs not_active IP Right Cessation
- 1999-04-08 AT AT99909165T patent/ATE295839T1/de not_active IP Right Cessation
- 1999-04-08 ME MEP-420/08A patent/MEP42008A/xx unknown
- 1999-04-08 KR KR1020007011998A patent/KR100668412B1/ko not_active Expired - Lifetime
- 1999-04-08 RS YUP-661/00A patent/RS50081B/sr unknown
- 1999-04-08 CN CN99805497A patent/CN1298396A/zh active Pending
- 1999-04-08 WO PCT/IB1999/000612 patent/WO1999055683A1/en not_active Ceased
- 1999-04-08 ES ES99909165T patent/ES2238825T3/es not_active Expired - Lifetime
- 1999-04-08 CN CNA2008100051101A patent/CN101219999A/zh active Pending
- 1999-04-08 BR BR9910025-8A patent/BR9910025A/pt not_active Application Discontinuation
- 1999-04-08 NZ NZ508154A patent/NZ508154A/en not_active IP Right Cessation
- 1999-04-08 EP EP99909165A patent/EP1076652B1/en not_active Expired - Lifetime
- 1999-04-08 DE DE69925366T patent/DE69925366T2/de not_active Expired - Lifetime
- 1999-04-23 TW TW088106555A patent/TWI248437B/zh not_active IP Right Cessation
- 1999-04-26 HN HN1999000057A patent/HN1999000057A/es unknown
- 1999-04-27 PA PA19998471001A patent/PA8471001A1/es unknown
- 1999-04-27 AR ARP990101942A patent/AR018201A1/es active IP Right Grant
- 1999-04-27 MY MYPI99001636A patent/MY136033A/en unknown
- 1999-04-28 DZ DZ990077A patent/DZ2777A1/xx active
- 1999-04-28 ZA ZA9902972A patent/ZA992972B/xx unknown
- 1999-04-28 MA MA25557A patent/MA26624A1/fr unknown
- 1999-04-28 TN TNTNSN99079A patent/TNSN99079A1/fr unknown
- 1999-04-29 EG EG48299A patent/EG24000A/xx active
- 1999-04-29 CO CO99026003A patent/CO5060467A1/es unknown
- 1999-04-29 GT GT199900063A patent/GT199900063A/es unknown
- 1999-04-29 PE PE1999000356A patent/PE20000441A1/es not_active Application Discontinuation
- 1999-04-29 AP APAP/P/1999/001523A patent/AP1252A/en active
- 1999-06-02 SA SA99200216A patent/SA99200216B1/ar unknown
- 1999-08-04 UA UA2000116681A patent/UA60363C2/uk unknown
2000
- 2000-04-05 UY UY26099A patent/UY26099A1/es not_active Application Discontinuation
- 2000-10-27 NO NO20005453A patent/NO317301B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
HN1999000057A (es)	1999-09-29
CA2330447A1 (en)	1999-11-04
TR200003166T2 (tr)	2001-02-21
AP1252A (en)	2004-02-25
ES2238825T3 (es)	2005-09-01
DE69925366T2 (de)	2006-03-09
DZ2777A1 (fr)	2003-12-01
TNSN99079A1 (fr)	2005-11-10
WO1999055683A1 (en)	1999-11-04
NZ508154A (en)	2003-07-25
RS50081B (sr)	2009-01-22
CN101219999A (zh)	2008-07-16
HUP0101818A1 (hu)	2002-03-28
UA60363C2 (uk)	2003-10-15
ZA992972B (en)	2000-10-30
TWI248437B (en)	2006-02-01
OA11769A (en)	2005-07-25
JP2002513009A (ja)	2002-05-08
PL196940B1 (pl)	2008-02-29
KR100668412B1 (ko)	2007-01-12
DE69925366D1 (de)	2005-06-23
ATE295839T1 (de)	2005-06-15
CA2330447C (en)	2009-06-30
MEP42008A (en)	2011-02-10
BR9910025A (pt)	2000-12-26
PL343766A1 (en)	2001-09-10
MY136033A (en)	2008-07-31
MXPA00010610A (es)	2002-07-02
PE20000441A1 (es)	2000-05-23
IL139172A0 (en)	2001-11-25
NO20005453D0 (no)	2000-10-27
CZ298230B6 (cs)	2007-08-01
AU759691C (en)	2004-04-29
JP4652569B2 (ja)	2011-03-16
EA200001112A1 (ru)	2001-04-23
AU759691B2 (en)	2003-04-17
NO317301B1 (no)	2004-10-04
EG24000A (en)	2008-03-19
CO5060467A1 (es)	2001-07-30
CZ20003974A3 (en)	2001-05-16
HU227569B1 (en)	2011-08-29
GT199900063A (es)	2000-10-20
PA8471001A1 (es)	2000-09-29
AU2850999A (en)	1999-11-16
UY26099A1 (es)	2001-12-28
YU66100A (sh)	2003-07-07
KR20010078710A (ko)	2001-08-21
AP9901523A0 (en)	1999-06-30
MA26624A1 (fr)	2004-12-20
EA002836B1 (ru)	2002-10-31
ID27198A (id)	2001-03-08
HK1037180A1 (en)	2002-02-01
EP1076652A1 (en)	2001-02-21
CN1298396A (zh)	2001-06-06
SA99200216B1 (ar)	2006-06-04
AR018201A1 (es)	2001-10-31
EP1076652B1 (en)	2005-05-18
HUP0101818A3 (en)	2002-05-28

Legal Events

Date	Code	Title	Description
2013-12-02	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO20005453D0 (no)	2000-10-27	N-(3-etynylfenylamino)-6,7-bis(2-metoksyetoksy)-4- quinazolinaminmesylatanhydrat og monohydrat
IS6359A (is)	2002-04-24	Stöðugur fjölgervingur N-(3-etynýlfenýlamínó)-6,7-bis(2-metoxýetoxý)-4-qínazólínamín hýdróklíríðs, aðferð við framleiðslu hans og lyfjanotkun
ATE417847T1 (de)	2009-01-15	Chinazolin- und pyridopyrimidinderivate
NO20000487D0 (no)	2000-01-31	Substituerte quinazolinderivater og anvendelse derav som tyrosin kinase inhibitorer
EE200300071A (et)	2004-12-15	Kinasoliini derivaadid
DE60103974D1 (de)	2004-07-29	Gyrase-inhibitoren und ihre verwendung
ATE448238T1 (de)	2009-11-15	3-beta-d-ribofuranosylthiazolo(4,5- delta)pyridimin-nucleoside und ihre verwendung
EP1164733A4 (en)	2009-03-11	Channel constructing method and base station using the method
DE60117907D1 (de)	2006-05-11	Funkhandgerät und Ortungssystem
DK1676845T3 (da)	2008-09-15	Nye quinazolinderivater
NO20031268D0 (no)	2003-03-19	4-aminokinazoliner
IS2165B (is)	2006-11-15	Týrósín kínasa latar
NO20012473D0 (no)	2001-05-18	Kinolin-4-karboksamidderivater som NK-3 og NK-2 reseptor antagonister
DE60122160D1 (de)	2006-09-21	Antennenstruktur und zugehöriges verfahren
ATE227724T1 (de)	2002-11-15	Muscarinagonisten und antagonisten
ATE309225T1 (de)	2005-11-15	Substituierte chinazoline derivate
NO20035573D0 (no)	2003-12-12	Kinazolinderivater
NO20031267L (no)	2003-05-19	4-aminokinazoliner
DE10195304D2 (de)	2003-10-23	Chinolin-Derivative und ihre Verwendung
NO20021475D0 (no)	2002-03-25	Vasopressinantagonist, formulering og fremgangsmåte
DK1122253T3 (da)	2005-09-26	Quinazolinonderivater
KR980000611U (ko)	1998-03-30	야광, 축광 버티칼 및 롤 스크린