NO20005671D0 - Metabolitter av ecteinascidin 743 - Google Patents

Metabolitter av ecteinascidin 743

Info

Publication number
NO20005671D0
NO20005671D0 NO20005671A NO20005671A NO20005671D0 NO 20005671 D0 NO20005671 D0 NO 20005671D0 NO 20005671 A NO20005671 A NO 20005671A NO 20005671 A NO20005671 A NO 20005671A NO 20005671 D0 NO20005671 D0 NO 20005671D0
Authority
NO
Norway
Prior art keywords
etm
ecteinascidin
metabolites
compounds
abbreviated
Prior art date
Application number
NO20005671A
Other languages
English (en)
Other versions
NO20005671L (no
NO318081B1 (no
Inventor
Kenneth Lloyd Rinehart
Jose J Morales
Joel Reid
Isabel Reymundo
Pablo Floriano
Lola Garcia Gravalos
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of NO20005671D0 publication Critical patent/NO20005671D0/no
Publication of NO20005671L publication Critical patent/NO20005671L/no
Publication of NO318081B1 publication Critical patent/NO318081B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO20005671A 1998-05-11 2000-11-10 Metabolitter av ecteinascidin 743, farmasoytiske preparater inneholdende dem, samt metode for bestemmelse av matabolitter derav NO318081B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8502498P 1998-05-11 1998-05-11
PCT/US1999/010233 WO1999058125A1 (en) 1998-05-11 1999-05-11 Metabolites of ecteinascidin 743

Publications (3)

Publication Number Publication Date
NO20005671D0 true NO20005671D0 (no) 2000-11-10
NO20005671L NO20005671L (no) 2001-01-10
NO318081B1 NO318081B1 (no) 2005-01-31

Family

ID=22188976

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005671A NO318081B1 (no) 1998-05-11 2000-11-10 Metabolitter av ecteinascidin 743, farmasoytiske preparater inneholdende dem, samt metode for bestemmelse av matabolitter derav

Country Status (22)

Country Link
US (3) US6316214B1 (no)
EP (1) EP1077698B1 (no)
JP (2) JP4583598B2 (no)
KR (1) KR100643092B1 (no)
CN (3) CN1195514C (no)
AT (1) ATE289810T1 (no)
AU (1) AU759281B2 (no)
BG (1) BG65235B1 (no)
BR (1) BR9910419A (no)
CA (1) CA2331593C (no)
CZ (1) CZ302168B6 (no)
DE (1) DE69923965T2 (no)
ES (1) ES2239442T3 (no)
HU (1) HUP0101960A3 (no)
IL (2) IL139607A0 (no)
NO (1) NO318081B1 (no)
NZ (1) NZ508585A (no)
PL (1) PL192409B1 (no)
RU (1) RU2225864C2 (no)
SK (1) SK285069B6 (no)
TR (1) TR200003470T2 (no)
WO (1) WO1999058125A1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100643092B1 (ko) 1998-05-11 2006-11-10 파르마 마르, 에스.에이. 엑테인아시딘 743의 대사산물
RU2266734C2 (ru) * 1999-05-13 2005-12-27 Фарма Мар, С.А. Композиции и применение ет743 для лечения злокачественных опухолей
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
US7919493B2 (en) 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
JP5219323B2 (ja) * 2000-04-12 2013-06-26 ファルマ・マール・ソシエダード・アノニマ 抗腫瘍性エクチナサイジン誘導体
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
CA2447553A1 (en) 2000-11-03 2002-05-23 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
EA005564B1 (ru) * 2000-11-06 2005-04-28 Фарма Мар, С.А. Эффективные противоопухолевые лекарственные средства
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
US7407327B2 (en) * 2003-03-21 2008-08-05 Seagate Technology Llc Method and system for withstanding shock in a spindle motor bearing
SI1689404T1 (sl) 2003-11-13 2009-02-28 Pharma Mar Sau Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka
KR101188691B1 (ko) 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
RU2270536C9 (ru) * 2004-12-01 2006-06-10 Ооо "Твинн" Свч плазмохимический реактор
US20090325971A1 (en) * 2005-03-02 2009-12-31 The Trustees Of Columbia University In The City Of New York Pentacyclic Alkaloid Compounds and Methods of Use Thereof
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
US20090012157A1 (en) * 2006-02-06 2009-01-08 Sears Barry D Sesamol Derivatives as Novel Inhibitors of Arachidonic Acid Formation
DK2786753T3 (en) 2010-11-12 2019-04-15 Pharma Mar Sa Combination therapy with an antitumor antibiotic
US11332480B2 (en) 2017-04-27 2022-05-17 Pharma Mar, S.A. Antitumoral compounds
WO2021098992A1 (en) 2019-11-21 2021-05-27 Pharma Mar, S.A. Methods of treating small cell lung cancer with lurbinectedin formulations

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4273773A (en) 1979-09-24 1981-06-16 American Home Products Corporation Antihypertensive tricyclic isoindole derivatives
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
AU589282B2 (en) 1986-06-09 1989-10-05 University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5149804A (en) 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
TW221441B (no) * 1991-01-25 1994-03-01 Taiho Pharmaceutical Co Ltd
DK0574857T3 (da) * 1992-06-19 1998-05-04 Hoechst Ag Polycycliske 31668P- og 31668U-forbindelser, fremgangsmåder til deres fremstilling samt deres anvendelse som antibiotiske eller antitumorale lægemidler
US5426108A (en) 1993-11-10 1995-06-20 American Cyanamid Company Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5809563A (en) * 1996-11-12 1998-09-15 Institute For The Development Of Emerging Architectures, Llc Method and apparatus utilizing a region based page table walk bit
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
CZ301083B6 (cs) * 1998-04-06 2009-11-04 The Board Of Trustees Of The University Of Illinois Ekteinascidinová sloucenina, farmaceutický prostredek ji obsahující a její použití
KR100643092B1 (ko) 1998-05-11 2006-11-10 파르마 마르, 에스.에이. 엑테인아시딘 743의 대사산물
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
JP2003520801A (ja) 2000-01-19 2003-07-08 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成
JP5219323B2 (ja) 2000-04-12 2013-06-26 ファルマ・マール・ソシエダード・アノニマ 抗腫瘍性エクチナサイジン誘導体
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.

Also Published As

Publication number Publication date
CN1896064A (zh) 2007-01-17
BG65235B1 (bg) 2007-09-28
US6316214B1 (en) 2001-11-13
US20020032326A1 (en) 2002-03-14
EP1077698A1 (en) 2001-02-28
CZ20004183A3 (en) 2001-06-13
CN100548988C (zh) 2009-10-14
US7115743B2 (en) 2006-10-03
HUP0101960A2 (hu) 2001-11-28
SK17152000A3 (sk) 2001-07-10
TR200003470T2 (tr) 2001-06-21
IL139607A0 (en) 2002-02-10
KR20010071237A (ko) 2001-07-28
CN1371279A (zh) 2002-09-25
NO20005671L (no) 2001-01-10
NZ508585A (en) 2002-11-26
JP2010215656A (ja) 2010-09-30
CN1195514C (zh) 2005-04-06
IL139607A (en) 2006-12-10
CZ302168B6 (cs) 2010-11-24
AU759281B2 (en) 2003-04-10
CN1683299A (zh) 2005-10-19
ATE289810T1 (de) 2005-03-15
RU2225864C2 (ru) 2004-03-20
HUP0101960A3 (en) 2003-03-28
BG105023A (en) 2001-08-31
BR9910419A (pt) 2001-01-09
EP1077698A4 (en) 2002-05-08
KR100643092B1 (ko) 2006-11-10
ES2239442T3 (es) 2005-09-16
DE69923965T2 (de) 2006-04-06
CA2331593C (en) 2008-08-05
PL344183A1 (en) 2001-10-08
SK285069B6 (sk) 2006-05-04
US6867334B2 (en) 2005-03-15
WO1999058125A1 (en) 1999-11-18
PL192409B1 (pl) 2006-10-31
JP4583598B2 (ja) 2010-11-17
JP2002514597A (ja) 2002-05-21
DE69923965D1 (de) 2005-04-07
EP1077698B1 (en) 2005-03-02
AU4073799A (en) 1999-11-29
CN100339375C (zh) 2007-09-26
NO318081B1 (no) 2005-01-31
CA2331593A1 (en) 1999-11-18
US20050261326A1 (en) 2005-11-24

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Legal Events

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MM1K Lapsed by not paying the annual fees