NO20006195L - Gener for biosyntesen av epothiloner - Google Patents

Gener for biosyntesen av epothiloner

Info

Publication number
NO20006195L
NO20006195L NO20006195A NO20006195A NO20006195L NO 20006195 L NO20006195 L NO 20006195L NO 20006195 A NO20006195 A NO 20006195A NO 20006195 A NO20006195 A NO 20006195A NO 20006195 L NO20006195 L NO 20006195L
Authority
NO
Norway
Prior art keywords
epothilones
biosynthesis
genes
Prior art date
Application number
NO20006195A
Other languages
English (en)
Norwegian (no)
Other versions
NO20006195D0 (no
Inventor
Thomas Schupp
James Madison Ligon
Istvan Molnar
Ross Zirkle
Joern Goerlach
Devon Cyr
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20006195D0 publication Critical patent/NO20006195D0/no
Publication of NO20006195L publication Critical patent/NO20006195L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
NO20006195A 1998-06-18 2000-12-06 Gener for biosyntesen av epothiloner NO20006195L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9950498A 1998-06-18 1998-06-18
US10163198P 1998-09-24 1998-09-24
US11890699P 1999-02-05 1999-02-05
PCT/EP1999/004171 WO1999066028A2 (en) 1998-06-18 1999-06-16 Genes for the biosynthesis of epothilones

Publications (2)

Publication Number Publication Date
NO20006195D0 NO20006195D0 (no) 2000-12-06
NO20006195L true NO20006195L (no) 2001-02-16

Family

ID=27378840

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20006195A NO20006195L (no) 1998-06-18 2000-12-06 Gener for biosyntesen av epothiloner
NO20091055A NO20091055L (no) 1998-06-18 2009-03-09 Gener for biosyntesen av epotiloner

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20091055A NO20091055L (no) 1998-06-18 2009-03-09 Gener for biosyntesen av epotiloner

Country Status (16)

Country Link
EP (1) EP1088078A2 (id)
JP (3) JP2002518004A (id)
KR (1) KR100511233B1 (id)
CN (1) CN100374565C (id)
AU (1) AU753567B2 (id)
BR (1) BR9911349A (id)
CA (1) CA2329774A1 (id)
HU (1) HUP0102186A3 (id)
ID (1) ID29128A (id)
IL (3) IL139735A0 (id)
NO (2) NO20006195L (id)
NZ (1) NZ508326A (id)
PL (1) PL200157B1 (id)
SK (1) SK19242000A3 (id)
TR (1) TR200003759T2 (id)
WO (1) WO1999066028A2 (id)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
FR2775187B1 (fr) 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
DE19846493A1 (de) * 1998-10-09 2000-04-13 Biotechnolog Forschung Gmbh DNA-Sequenzen für die enzymatische Synthese von Polyketid- oder Heteropolyketidverbindungen
US6303342B1 (en) * 1998-11-20 2001-10-16 Kason Biosciences, Inc. Recombinant methods and materials for producing epothilones C and D
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
US20030113715A1 (en) * 2000-01-21 2003-06-19 Daniel Santi Method for cloning polyketide synthase genes
US6998256B2 (en) 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
AU2001295195B2 (en) * 2000-04-28 2007-02-01 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
JP2005500974A (ja) 2000-10-13 2005-01-13 ザ ユニバーシテイ オブ ミシシッピー エポシロン類及び関連類似体の合成
US7257562B2 (en) 2000-10-13 2007-08-14 Thallion Pharmaceuticals Inc. High throughput method for discovery of gene clusters
SI1483251T1 (sl) 2002-03-12 2010-03-31 Bristol Myers Squibb Co C cian epotilonski derivati
CN101310022B (zh) * 2005-01-31 2013-01-16 默沙东公司 大规模生产质粒dna的上游和下游纯化方法
AU2012211052A1 (en) 2011-01-28 2013-09-05 Amyris, Inc. Gel-encapsulated microcolony screening
US20140057314A1 (en) 2011-05-13 2014-02-27 Amyris, Inc. Methods and compositions for detecting microbial production of water-immiscible compounds
BR112015002724B1 (pt) 2012-08-07 2022-02-01 Total Marketing Services Método para produzir um composto não catabólico heterólogo, e, composição de fermentação
BR112015023089A2 (pt) 2013-03-15 2017-11-21 Amyris Inc célula hospedeira, método para produzir um isoprenoide, e método para aumentar a produção de acetil-coa ou um composto derivado de acetil-coa
US10563229B2 (en) 2013-08-07 2020-02-18 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
CN108474009B (zh) 2015-06-25 2022-10-04 阿迈瑞斯公司 麦芽糖依赖性降解决定子、麦芽糖响应型启动子、稳定化构建体及其在生成非分解代谢化合物中的用途
CN106916834B (zh) * 2015-12-24 2022-08-05 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
CN111138444B (zh) * 2020-01-08 2022-05-03 山东大学 一组埃博霉素b葡萄糖苷类化合物及其酶法制备与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2312695T3 (es) * 1996-11-18 2009-03-01 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) Epotilones e y f.

Also Published As

Publication number Publication date
CN100374565C (zh) 2008-03-12
JP2002518004A (ja) 2002-06-25
BR9911349A (pt) 2001-03-13
IL139735A0 (en) 2002-02-10
SK19242000A3 (sk) 2001-07-10
CA2329774A1 (en) 1999-12-23
NO20091055L (no) 2001-02-16
NZ508326A (en) 2003-10-31
AU4611699A (en) 2000-01-05
CN1305530A (zh) 2001-07-25
WO1999066028A3 (en) 2000-06-29
TR200003759T2 (tr) 2001-06-21
HUP0102186A2 (hu) 2001-10-28
ID29128A (id) 2001-08-02
PL345579A1 (en) 2001-12-17
WO1999066028A2 (en) 1999-12-23
EP1088078A2 (en) 2001-04-04
NO20006195D0 (no) 2000-12-06
JP2008092958A (ja) 2008-04-24
JP2006061166A (ja) 2006-03-09
IL190391A0 (en) 2008-11-03
IL139735A (en) 2009-06-15
AU753567B2 (en) 2002-10-24
PL200157B1 (pl) 2008-12-31
HUP0102186A3 (en) 2005-10-28
KR100511233B1 (ko) 2005-08-31
KR20010052962A (ko) 2001-06-25

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