NO20010046L - Dolastatin-15-derivater - Google Patents

Dolastatin-15-derivater

Info

Publication number
NO20010046L
NO20010046L NO20010046A NO20010046A NO20010046L NO 20010046 L NO20010046 L NO 20010046L NO 20010046 A NO20010046 A NO 20010046A NO 20010046 A NO20010046 A NO 20010046A NO 20010046 L NO20010046 L NO 20010046L
Authority
NO
Norway
Prior art keywords
dolastatin
derivatives
Prior art date
Application number
NO20010046A
Other languages
English (en)
Other versions
NO20010046D0 (no
Inventor
Kurt Ritter
Bernd Janssen
Andreas Haupt
Andreas Kling
Teresa Barlozzari
Wilhelm Amberg
Original Assignee
Basf Biores Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Biores Corp filed Critical Basf Biores Corp
Publication of NO20010046D0 publication Critical patent/NO20010046D0/no
Publication of NO20010046L publication Critical patent/NO20010046L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO20010046A 1998-07-08 2001-01-04 Dolastatin-15-derivater NO20010046L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/112,249 US5985837A (en) 1998-07-08 1998-07-08 Dolastatin 15 derivatives
PCT/US1999/014099 WO2000002906A1 (en) 1998-07-08 1999-06-23 Dolastatin 15 derivatives

Publications (2)

Publication Number Publication Date
NO20010046D0 NO20010046D0 (no) 2001-01-04
NO20010046L true NO20010046L (no) 2001-03-02

Family

ID=22342878

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20010046A NO20010046L (no) 1998-07-08 2001-01-04 Dolastatin-15-derivater

Country Status (14)

Country Link
US (2) US5985837A (no)
EP (1) EP1093460A1 (no)
JP (1) JP2002520335A (no)
KR (1) KR20010053428A (no)
CN (1) CN1312817A (no)
AU (1) AU4708199A (no)
BR (1) BR9911932A (no)
CA (1) CA2332641A1 (no)
HK (1) HK1041007A1 (no)
HU (1) HUP0103560A3 (no)
IL (1) IL140578A0 (no)
NO (1) NO20010046L (no)
WO (1) WO2000002906A1 (no)
ZA (1) ZA200100169B (no)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
WO2002090503A2 (en) * 2001-05-04 2002-11-14 The Scripps Research Institute Anti-microbial peptides and compositions
AU2002334192A1 (en) * 2001-10-17 2003-04-28 Instituto Biomar S.A. Cytotoxic compounds
BR0307178A (pt) * 2002-01-22 2004-12-07 Du Pont Composto, composição e método para controle de pragas invertebradas
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
DK1545613T3 (da) 2002-07-31 2011-11-14 Seattle Genetics Inc Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
AU2003302239A1 (en) * 2002-12-06 2004-06-30 Adaptive Therapeutics, Inc. Novel cyclic peptides comprising cis-3 aminocycloalkanecarboxylic acids
EP2478912B1 (en) 2003-11-06 2016-08-31 Seattle Genetics, Inc. Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy
GB0329572D0 (en) * 2003-12-20 2004-01-28 Astrazeneca Ab Amide derivatives
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
CN101535300B (zh) 2006-05-16 2014-05-28 埃格拉医疗公司 Iap bir域结合化合物
PE20090943A1 (es) 2007-07-16 2009-08-05 Genentech Inc Anticuerpos anti-cd79b e inmunoconjugados
EP2176295B1 (en) 2007-07-16 2014-11-19 Genentech, Inc. Humanized anti-cd79b antibodies and immunoconjugates and methods of use
KR101607346B1 (ko) 2008-01-31 2016-03-29 제넨테크, 인크. 항-ｃｄ７９ｂ 항체 및 면역접합체 및 사용 방법
KR20130009760A (ko) 2010-02-10 2013-01-23 이뮤노젠 아이엔씨 Ｃｄ２０ 항체 및 이의 용도
US9284350B2 (en) 2010-02-12 2016-03-15 Pharmascience Inc. IAP BIR domain binding compounds
CN102173999A (zh) * 2011-02-28 2011-09-07 盐城工学院 一种2-氨基-n,n-二甲基苯甲酰胺的合成方法
WO2012145112A2 (en) * 2011-04-18 2012-10-26 Immunogen, Inc. Novel maytansinoid derivatives with sulfoxide linker
CN104185477B (zh) 2011-11-17 2017-05-24 辉瑞公司 细胞毒性肽及其抗体‑药物缀合物
CA2890571A1 (en) 2012-11-07 2014-05-15 Kenneth G. Geles Anti-notch3 antibodies and antibody-drug conjugates
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
EP2972394A4 (en) 2013-03-15 2016-11-02 Sloan Kettering Inst Cancer HSP90-DESIGNING AND THERAPY
HUE049175T2 (hu) 2014-09-23 2020-09-28 Hoffmann La Roche Eljárás anti-CD79b immunkonjugátumok alkalmazására
WO2017058808A1 (en) * 2015-10-02 2017-04-06 Sirenas Llc Anti-cancer compounds and conjugates thereof
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
WO2022182415A1 (en) 2021-02-24 2022-09-01 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof
US20240209080A1 (en) 2021-04-10 2024-06-27 Profoundbio Us Co. Folr1 binding agents, conjugates thereof and methods of using the same
CA3216459A1 (en) 2021-04-23 2022-10-27 Profoundbio Us Co. Anti-cd70 antibodies, conjugates thereof and methods of using the same
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
CN118119409A (zh) 2021-09-03 2024-05-31 东丽株式会社 癌的治疗和/或预防用药物组合物
AR133955A1 (es) 2023-09-26 2025-11-19 Profoundbio Us Co Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos
WO2025149661A1 (en) 2024-01-10 2025-07-17 Genmab A/S Slitrk6 binding agents, conjugates thereof and methods of using the same
US20250381289A1 (en) 2024-02-29 2025-12-18 Genmab A/S Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US49818A (en) * 1865-09-05 Improvement in seeding-machines
US49617A (en) * 1865-08-29 Inkstand
US13071A (en) * 1855-06-12 Joshua turner
US29258A (en) * 1860-07-24 Improvement in capstans for ditching-plows
US55861A (en) * 1866-06-26 Improvement in machines for fine-cutting tobiacco
US5860A (en) * 1848-10-17 peters
US32091A (en) * 1861-04-16 Improvement in corn-planters
US52764A (en) * 1866-02-20 Improved machine for extracting essential oils
US35506A (en) * 1862-06-10 Improvement in parlor-stoves
US42772A (en) * 1864-05-17 Improvement in apparatus for distilling off gases, and vapors
US29177A (en) * 1860-07-17 Improvement in planishing copper vessels
US5857A (en) * 1848-10-17 Flood-fence
US69077A (en) * 1867-09-24 Josiah copley
US54115A (en) * 1866-04-24 Improved hair-curling fluid
US4346442A (en) * 1980-07-29 1982-08-24 Merrill Lynch, Pierce, Fenner & Smith Incorporated Securities brokerage-cash management system
US4648037A (en) * 1984-03-15 1987-03-03 Metropolitan Life Insurance Company Method and apparatus for benefit and financial communication
US4750121A (en) * 1985-10-03 1988-06-07 Halley Gustavo M Pension benefits system
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
US4969094A (en) * 1989-05-22 1990-11-06 Pension Benefits System Trust Self-implementing pension benefits system
US5091368A (en) * 1990-08-08 1992-02-25 Harbor Branch Oceanographic Institution, Inc. Biologically active compounds from blue-green algae
WO1993003054A1 (fr) * 1991-08-09 1993-02-18 Teikoku Hormone Mfg. Co., Ltd. Nouveau derive de tetrapeptide
US5136502A (en) * 1991-10-02 1992-08-04 Fred Van Remortel System for funding, analyzing and managing health care liabilities
CA2136339C (en) * 1992-05-20 2008-02-05 Andreas Haupt Derivatives of dolastatin
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
PL178766B1 (pl) * 1992-12-16 2000-06-30 Basf Ag Nowe peptydy
US5429506A (en) * 1993-04-05 1995-07-04 Westport Management Services, Inc. Method of computerized administration of a life insurance plan using computerized administration supervisory system
US5913198A (en) * 1997-09-09 1999-06-15 Sbp Services, Inc. System and method for designing and administering survivor benefit plans
US5590037A (en) * 1993-09-17 1996-12-31 The Evergreen Group Incorporated Digital computer system and methods for computing a financial projection and an illustration of a prefunding program for an employee benefit
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5554725A (en) * 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
US5966693A (en) * 1996-05-07 1999-10-12 Money Accumulation Programs, Inc. Method for combining loan with key employee life insurance
US5897620A (en) * 1997-07-08 1999-04-27 Priceline.Com Inc. Method and apparatus for the sale of airline-specified flight tickets
US6370571B1 (en) * 1997-03-05 2002-04-09 At Home Corporation System and method for delivering high-performance online multimedia services
US5970478A (en) * 1997-03-12 1999-10-19 Walker Asset Management Limited Partnership Method, apparatus, and program for customizing credit accounts
US6154732A (en) * 1997-07-25 2000-11-28 Guidedchoice.Com System for providing investment advice and management of pension assets
US5960411A (en) * 1997-09-12 1999-09-28 Amazon.Com, Inc. Method and system for placing a purchase order via a communications network
US6092047A (en) * 1997-10-07 2000-07-18 Benefits Technologies, Inc. Apparatus and method of composing a plan of flexible benefits
US6219694B1 (en) * 1998-05-29 2001-04-17 Research In Motion Limited System and method for pushing information from a host system to a mobile data communication device having a shared electronic address
US6322125B2 (en) * 1999-02-09 2001-11-27 Cordell Eric Bauer Truck bed extension
US6401079B1 (en) * 1999-10-01 2002-06-04 Inleague, Inc. System for web-based payroll and benefits administration

Also Published As

Publication number Publication date
US5985837A (en) 1999-11-16
HK1041007A1 (zh) 2002-06-28
EP1093460A1 (en) 2001-04-25
IL140578A0 (en) 2002-02-10
US20010018422A1 (en) 2001-08-30
ZA200100169B (en) 2002-01-08
HUP0103560A3 (en) 2002-05-28
CN1312817A (zh) 2001-09-12
CA2332641A1 (en) 2000-01-20
HUP0103560A2 (hu) 2002-02-28
KR20010053428A (ko) 2001-06-25
BR9911932A (pt) 2001-10-16
NO20010046D0 (no) 2001-01-04
JP2002520335A (ja) 2002-07-09
WO2000002906A1 (en) 2000-01-20
AU4708199A (en) 2000-02-01

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application
FC2A Withdrawal, rejection or dismissal of laid open patent application