NO20010603L - 2-substituert-1-piperidylbenzimidazol forbindelser som ORL 1- reseptor agonister - Google Patents

2-substituert-1-piperidylbenzimidazol forbindelser som ORL 1- reseptor agonister

Info

Publication number: NO20010603L
Authority: NO; Norway
Prior art keywords: alkyl; orl; aromatic; unsubstituted; piperidylbenzimidazole
Prior art date: 1998-08-06

Application number

NO20010603A

Other languages

English (en)

Norwegian (no)

Other versions

NO20010603D0 (no

Inventor

Fumitaka Ito

Hirohide Noguchi

Hiroshi Kondo

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-06

Filing date

2001-02-05

Publication date

2001-04-05

2001-02-05 Application filed by Pfizer filed Critical Pfizer

2001-02-05 Publication of NO20010603D0 publication Critical patent/NO20010603D0/no

2001-04-05 Publication of NO20010603L publication Critical patent/NO20010603L/no

Links

108010020615 nociceptin receptor Proteins 0.000 title abstract 2
-1 2-substituted-1-piperidylbenzimidazole compounds Chemical class 0.000 title 1
239000000018 receptor agonist Substances 0.000 title 1
229940044601 receptor agonist Drugs 0.000 title 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
125000006729 (C2-C5) alkenyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
229940035676 analgesics Drugs 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical group [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Diabetes (AREA)
Addiction (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Obesity (AREA)
Rheumatology (AREA)
Toxicology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20010603A 1998-08-06 2001-02-05 2-substituert-1-piperidylbenzimidazol forbindelser som ORL 1- reseptor agonister NO20010603L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IBPCT/IB98/01206		1998-08-06
PCT/IB1999/001239 WO2000008013A2 (en)	1998-08-06	1999-07-05	2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Publications (2)

Publication Number	Publication Date
NO20010603D0 NO20010603D0 (no)	2001-02-05
NO20010603L true NO20010603L (no)	2001-04-05

Family

ID=11004738

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20010603A NO20010603L (no)	1998-08-06	2001-02-05	2-substituert-1-piperidylbenzimidazol forbindelser som ORL 1- reseptor agonister

Country Status (44)

Country	Link
US (1)	US6172067B1 (de)
EP (1)	EP1102762B1 (de)
JP (1)	JP3367945B2 (de)
CN (1)	CN1317968A (de)
AP (1)	AP2001002063A0 (de)
AR (1)	AR018686A1 (de)
AT (1)	ATE227716T1 (de)
AU (1)	AU749166B2 (de)
BG (1)	BG105301A (de)
BR (1)	BR9912778A (de)
CA (1)	CA2339621C (de)
CZ (1)	CZ2001397A3 (de)
DE (1)	DE69903953T2 (de)
DK (1)	DK1102762T3 (de)
EA (1)	EA200100104A1 (de)
EE (1)	EE200100075A (de)
ES (1)	ES2185357T3 (de)
GE (1)	GEP20033000B (de)
GT (1)	GT199900125A (de)
HK (1)	HK1040188A1 (de)
HN (1)	HN1999000105A (de)
HR (1)	HRP20010089B1 (de)
HU (1)	HUP0103567A3 (de)
ID (1)	ID27212A (de)
IL (1)	IL141029A0 (de)
IS (1)	IS5812A (de)
MA (1)	MA26659A1 (de)
NO (1)	NO20010603L (de)
NZ (1)	NZ509299A (de)
OA (1)	OA11590A (de)
PA (1)	PA8477701A1 (de)
PE (1)	PE20000868A1 (de)
PL (1)	PL346211A1 (de)
PT (1)	PT1102762E (de)
SI (1)	SI1102762T1 (de)
SK (1)	SK1602001A3 (de)
SV (1)	SV1999000099A (de)
TN (1)	TNSN99142A1 (de)
TR (1)	TR200100403T2 (de)
TW (1)	TW513424B (de)
UY (1)	UY25659A1 (de)
WO (1)	WO2000008013A2 (de)
YU (1)	YU8201A (de)
ZA (1)	ZA200100900B (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6340681B1 (en) *	1999-07-16	2002-01-22	Pfizer Inc	2-benzimidazolylamine compounds as ORL-1-receptor agonists
SE9902987D0 (sv)	1999-08-24	1999-08-24	Astra Pharma Prod	Novel compounds
SE9903544D0 (sv)	1999-10-01	1999-10-01	Astra Pharma Prod	Novel compounds
EP1122257B1 (de) *	2000-01-05	2005-10-12	Pfizer Inc.	Benzimidazol-Verbindungen zur Verwendung als ORL1-Rezeptor-Antagonisten
GB2359078A (en) *	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB2359081A (en)	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active thiazolopyrimidines
GB2359551A (en)	2000-02-23	2001-08-29	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en)	2000-03-10	2000-05-03	Astrazeneca Uk Ltd	Chemical compounds
SE0003828D0 (sv)	2000-10-20	2000-10-20	Astrazeneca Ab	Novel compounds
AU2403802A (en) *	2000-11-15	2002-05-27	Banyu Pharma Co Ltd	Benzimidazole derivatives
GB0104050D0 (en)	2001-02-19	2001-04-04	Astrazeneca Ab	Chemical compounds
GB0107228D0 (en)	2001-03-22	2001-05-16	Astrazeneca Ab	Chemical compounds
SE0101322D0 (sv)	2001-04-12	2001-04-12	Astrazeneca Ab	Novel compounds
EP1385518B1 (de) *	2001-04-18	2008-08-06	Euro-Celtique S.A.	Benzimidazolon-verbindungen
JP4489354B2 (ja)	2001-04-18	2010-06-23	ユーロ−セルティークエス．エイ．	スピロインデンおよびスピロインダン化合物類
RU2268883C2 (ru)	2001-04-18	2006-01-27	Эро-Селтик, С.А.	Аналоги ноницептина и фармацевтическая композиция на их основе
IL158484A0 (en)	2001-04-18	2004-05-12	Euro Celtique Sa	Nociceptin analogs
KR100628292B1 (ko)	2001-04-18	2006-09-27	유로-셀티크 소시에떼 아노뉨	스파이로파이라졸 화합물
JP2005502619A (ja) *	2001-07-02	2005-01-27	オメロスコーポレイション	オピオイドレセプター様レセプター１アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法
US20030040479A1 (en) *	2001-07-02	2003-02-27	Omeros Corporation	Rotational intrathecal analgesia method and device
SE0102716D0 (sv) *	2001-08-14	2001-08-14	Astrazeneca Ab	Novel compounds
SE0103818D0 (sv) *	2001-11-15	2001-11-15	Astrazeneca Ab	Chemical compounds
AU2002360561A1 (en) *	2001-12-11	2003-06-23	Sepracor, Inc.	4-substituted piperidines, and methods of use thereof
JP4056977B2 (ja)	2002-03-29	2008-03-05	田辺三菱製薬株式会社	睡眠障害治療薬
GB0221829D0 (en) *	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
GB0221828D0 (en)	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
DE10252666A1 (de) *	2002-11-11	2004-08-05	Grünenthal GmbH	N-Piperidyl-cyclohexan-Derivate
DE10252665A1 (de)	2002-11-11	2004-06-03	Grünenthal GmbH	4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
SE0301369D0 (sv)	2003-05-09	2003-05-09	Astrazeneca Ab	Chemical compounds
GB0315203D0 (en) *	2003-06-28	2003-08-06	Celltech R&D Ltd	Chemical compounds
AR045939A1 (es)	2003-09-25	2005-11-16	Solvay Pharm Bv	Derivados de bencimidazolona y quinazolinona como agonistas de los receptores orl 1 humanos
GB0328243D0 (en)	2003-12-05	2004-01-07	Astrazeneca Ab	Methods
US20050228023A1 (en) *	2003-12-19	2005-10-13	Sri International	Agonist and antagonist ligands of the nociceptin receptor
US20080021069A1 (en) *	2004-10-08	2008-01-24	Takeda Pharmaceutical Company Limited	Receptor Function Regulating Agent
EP1838306B1 (de)	2005-01-11	2010-11-17	NeuroSearch A/S	Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit
JP2009541454A (ja) *	2006-07-03	2009-11-26	ノイロサーチアクティーゼルスカブ	モノアミン再摂取阻害剤及びカリウムチャネル活性剤の併用
EP2397477B1 (de) *	2007-01-16	2014-03-05	Purdue Pharma LP	Heterocyclisch-substituierte Piperidinverbindungen und Verwendungen davon
MY150602A (en) *	2007-08-31	2014-01-30	Purdue Pharma Lp	Subtituted-quinoxaline-type piperidine compounds and the uses thereof
US8119661B2 (en) *	2007-09-11	2012-02-21	Astrazeneca Ab	Piperidine derivatives and their use as muscarinic receptor modulators
KR101333660B1 (ko)	2008-07-21	2013-11-27	시오노기세이야쿠가부시키가이샤	치환-퀴녹살린-형 가교-피페리딘 화합물 및 그의 용도
SG10201505997TA (en)	2010-08-05	2015-09-29	Amgen Inc	Benzimidazole And Azabenzimidazole Compounds That Inhibit Anaplastic Lymphoma Kinase
MX346043B (es)	2012-01-06	2017-03-03	Novus Int Inc	Tensioactivos basados en sulfoxido.
US9284294B2 (en)	2012-02-09	2016-03-15	Novus International, Inc.	Functionalized polymer compositions
JO3300B1 (ar)	2012-06-06	2018-09-16	Novartis Ag	مركبات وتركيبات لتعديل نشاط egfr
PL2871973T3 (pl)	2012-07-12	2019-02-28	Novus International Inc.	Kompozycje matrycy i warstwy do ochrony środków bioaktywnych
US9085561B2 (en) *	2012-07-30	2015-07-21	Purdue Pharma L.P.	Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
WO2014102594A2 (en) *	2012-12-27	2014-07-03	Purdue Pharma L.P.	Substituted benzimidazole-type piperidine compounds and uses thereof
WO2014153529A1 (en)	2013-03-22	2014-09-25	The Scripps Research Institute	Substituted benzimidazoles as nociceptin receptor modulators
CA2943220C (en) *	2014-03-20	2024-01-16	Capella Therapeutics, Inc.	Benzimidazole derivatives as erbb tyrosine kinase inhibitors for the treatment of cancer
HK1255204A1 (zh)	2015-11-12	2019-08-09	Novus International Inc.	含硫化合物溶剂
US10584306B2 (en)	2017-08-11	2020-03-10	Board Of Regents Of The University Of Oklahoma	Surfactant microemulsions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3318900A (en) *	1964-05-06	1967-05-09	Janssen Pharmaceutica Nv	Derivatives of benzimidazolinyl piperidine
JPS5297978A (en) *	1976-06-02	1977-08-17	Yoshitomi Pharmaceut Ind Ltd	Preparation of alicyclic derivatives
US5821219A (en)	1995-08-11	1998-10-13	Oregon Health Sciences University	Opioid antagonists and methods of their use
CA2229202C (en)	1995-08-15	2008-05-20	Universite Libre De Bruxells	Methods for identifying antagonist or agonist to human opioid receptor-like 1 "orl1"
US5866346A (en)	1995-09-27	1999-02-02	Indiana Unversity Foundation	Methods of using dynorphins as ligands for XOR1 receptor
US6180649B1 (en) *	1996-04-19	2001-01-30	Nerosearch A/S	1-(4-piperidyl)-benzimidazoles having neurotrophic activity
EP0813065A3 (de)	1996-06-13	1998-07-22	F. Hoffmann-La Roche Ag	Regulierung von LC-132(Opioid-ähnlich)-Rezeptor-Funktion
EP0829481A1 (de) *	1996-09-16	1998-03-18	Pfizer Inc.	Morphinan-Hydroxamsäure-Derivate
US5718912A (en) *	1996-10-28	1998-02-17	Merck & Co., Inc.	Muscarine agonists
ES2226129T3 (es)	1997-05-30	2005-03-16	Banyu Pharmaceutical Co., Ltd.	Derivados de 2-0x0imidazol.
WO1999003880A1 (en)	1997-07-15	1999-01-28	Novo Nordisk A/S	Nociceptin analogues
US5929035A (en)	1998-04-14	1999-07-27	Regents Of The University Of Michigan	Methods of treating intestinal disorders
ID29137A (id)	1998-07-27	2001-08-02	Schering Corp	Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1

1999
- 1999-06-25 MA MA25646A patent/MA26659A1/fr unknown
- 1999-06-28 TW TW088110899A patent/TW513424B/zh not_active IP Right Cessation
- 1999-07-05 JP JP2000563646A patent/JP3367945B2/ja not_active Expired - Fee Related
- 1999-07-05 EE EEP200100075A patent/EE200100075A/xx unknown
- 1999-07-05 BR BR9912778-4A patent/BR9912778A/pt not_active Application Discontinuation
- 1999-07-05 GE GEAP19995740A patent/GEP20033000B/en unknown
- 1999-07-05 CZ CZ2001397A patent/CZ2001397A3/cs unknown
- 1999-07-05 CA CA002339621A patent/CA2339621C/en not_active Expired - Fee Related
- 1999-07-05 SK SK160-2001A patent/SK1602001A3/sk unknown
- 1999-07-05 AT AT99926688T patent/ATE227716T1/de not_active IP Right Cessation
- 1999-07-05 HN HN1999000105A patent/HN1999000105A/es unknown
- 1999-07-05 EP EP99926688A patent/EP1102762B1/de not_active Expired - Lifetime
- 1999-07-05 DK DK99926688T patent/DK1102762T3/da active
- 1999-07-05 CN CN99810857A patent/CN1317968A/zh active Pending
- 1999-07-05 PL PL99346211A patent/PL346211A1/xx not_active Application Discontinuation
- 1999-07-05 AU AU43859/99A patent/AU749166B2/en not_active Ceased
- 1999-07-05 HU HU0103567A patent/HUP0103567A3/hu unknown
- 1999-07-05 OA OA1200100031A patent/OA11590A/en unknown
- 1999-07-05 PT PT99926688T patent/PT1102762E/pt unknown
- 1999-07-05 TR TR2001/00403T patent/TR200100403T2/xx unknown
- 1999-07-05 HR HR970081A patent/HRP20010089B1/xx not_active IP Right Cessation
- 1999-07-05 SI SI9930151T patent/SI1102762T1/xx unknown
- 1999-07-05 NZ NZ509299A patent/NZ509299A/en not_active Application Discontinuation
- 1999-07-05 EA EA200100104A patent/EA200100104A1/ru unknown
- 1999-07-05 WO PCT/IB1999/001239 patent/WO2000008013A2/en not_active Ceased
- 1999-07-05 TN TNTNSN99142A patent/TNSN99142A1/fr unknown
- 1999-07-05 ES ES99926688T patent/ES2185357T3/es not_active Expired - Lifetime
- 1999-07-05 HK HK02101444.8A patent/HK1040188A1/zh unknown
- 1999-07-05 ID IDW20010284D patent/ID27212A/id unknown
- 1999-07-05 AP APAP/P/2001/002063A patent/AP2001002063A0/en unknown
- 1999-07-05 DE DE69903953T patent/DE69903953T2/de not_active Expired - Fee Related
- 1999-07-05 YU YU8201A patent/YU8201A/sh unknown
- 1999-07-05 IL IL14102999A patent/IL141029A0/xx unknown
- 1999-07-06 AR ARP990103264A patent/AR018686A1/es active IP Right Grant
- 1999-07-15 PE PE1999000717A patent/PE20000868A1/es not_active Application Discontinuation
- 1999-07-16 PA PA19998477701A patent/PA8477701A1/es unknown
- 1999-07-16 SV SV1999000099A patent/SV1999000099A/es not_active Application Discontinuation
- 1999-08-05 US US09/369,208 patent/US6172067B1/en not_active Expired - Fee Related
- 1999-08-06 GT GT199900125A patent/GT199900125A/es unknown
- 1999-08-13 UY UY25659A patent/UY25659A1/es not_active Application Discontinuation
2001
- 2001-01-16 IS IS5812A patent/IS5812A/is unknown
- 2001-02-01 ZA ZA200100900A patent/ZA200100900B/xx unknown
- 2001-02-05 NO NO20010603A patent/NO20010603L/no not_active Application Discontinuation
- 2001-03-01 BG BG105301A patent/BG105301A/xx unknown

Also Published As

Publication number	Publication date
SV1999000099A (es)	2000-09-05
OA11590A (en)	2004-08-18
TR200100403T2 (tr)	2001-07-23
ID27212A (id)	2001-03-08
AR018686A1 (es)	2001-11-28
JP2002522431A (ja)	2002-07-23
DE69903953T2 (de)	2003-03-27
DK1102762T3 (da)	2002-12-16
ES2185357T3 (es)	2003-04-16
US6172067B1 (en)	2001-01-09
IL141029A0 (en)	2002-02-10
AP2001002063A0 (en)	2001-03-31
HUP0103567A3 (en)	2003-01-28
NO20010603D0 (no)	2001-02-05
WO2000008013A2 (en)	2000-02-17
TNSN99142A1 (fr)	2005-11-10
PE20000868A1 (es)	2000-08-31
PA8477701A1 (es)	2000-09-29
GT199900125A (es)	2001-01-27
EP1102762B1 (de)	2002-11-13
HRP20010089B1 (en)	2003-04-30
DE69903953D1 (de)	2002-12-19
HN1999000105A (es)	2000-11-11
HK1040188A1 (zh)	2002-05-31
CA2339621C (en)	2005-04-05
AU4385999A (en)	2000-02-28
CZ2001397A3 (cs)	2002-05-15
AU749166B2 (en)	2002-06-20
BG105301A (en)	2001-12-29
NZ509299A (en)	2003-05-30
ZA200100900B (en)	2002-08-28
PL346211A1 (en)	2002-01-28
ATE227716T1 (de)	2002-11-15
EE200100075A (et)	2002-06-17
HUP0103567A2 (hu)	2002-02-28
JP3367945B2 (ja)	2003-01-20
MA26659A1 (fr)	2004-12-20
SK1602001A3 (en)	2002-09-10
CA2339621A1 (en)	2000-02-17
SI1102762T1 (en)	2003-04-30
HRP20010089A2 (en)	2002-02-28
PT1102762E (pt)	2003-02-28
YU8201A (sh)	2003-07-07
CN1317968A (zh)	2001-10-17
UY25659A1 (es)	2000-02-23
IS5812A (is)	2001-01-16
EP1102762A2 (de)	2001-05-30
WO2000008013A3 (en)	2000-03-23
BR9912778A (pt)	2001-09-25
EA200100104A1 (ru)	2001-08-27
TW513424B (en)	2002-12-11
GEP20033000B (en)	2003-06-25

Legal Events

Date	Code	Title	Description
2003-09-15	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20010603L (no)	2001-04-05	2-substituert-1-piperidylbenzimidazol forbindelser som ORL 1- reseptor agonister
CA2290992A1 (en)	1998-12-10	(imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation
DE60039508D1 (de)	2008-08-28	Methoden zur behandlung der essstörungen
DK0977741T3 (da)	2003-12-01	Substituerede phenylderivater, deres fremstilling og anvendelse
TR200100137T2 (tr)	2001-05-21	Obesitenin ve başka bozuklukların tedavisinde yararlı nöropeptit Y Y5 reseptörü için ligandlar olarak N-ikameli aminotetralinler.
HUP0300602A2 (hu)	2003-06-28	A központi idegrendszerre ható diazabiciklusos hatóanyagok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0101672A2 (hu)	2002-04-29	Szubsztituált indolalkánkarbonsav-származékok
WO2001002400A8 (en)	2001-04-05	Fused imidazole compounds and remedies for diabetes mellitus
HUP0201659A2 (hu)	2002-11-28	Kristályos benzimidazol-vegyület
DK0406623T3 (da)	1995-03-13	Polyasparaginsyrederivater som overtræksmiddel til lægemiddelformer og levnedsmidler
MY146532A (en)	2012-08-15	Thiazole derivative
BR0014651A (pt)	2002-06-18	Inibidores de adesão de célula mediada por "alfa" l beta2
BR0007589A (pt)	2002-10-15	Inibidores da proliferação de células
TR200103683T2 (tr)	2003-01-21	Indol türevleri ve bu türevlerin diğer uygulamaların yanısıra osteoporoz tedavisinde kullanımı
TW200642689A (en)	2006-12-16	Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient
WO2001062705A8 (en)	2001-09-27	Aminoalcohol derivatives
NO20050666L (no)	2005-03-11	2,7-substituerte indoler og deres anvendelse som 5-HT6 modulatorer
NO20001934L (no)	2000-04-13	3-Substituerte tetrahydropyridopyrimidinon-derivater, deres fremstilling og anvendelse
DK719388A (da)	1989-06-26	Propoxybenzenderivater og fremgangsmaade til fremstilling deraf
TR200001121T2 (tr)	2000-09-21	Antiromatizmal madde.
ATE238274T1 (de)	2003-05-15	Naphthalin derivate
NO20031841L (no)	2003-06-19	Triazolderivater og farmasöytiske preparater inneholdende disse
SE9802538D0 (sv)	1998-07-13	New pharmaceutically active compounds
AP9901637A0 (en)	1999-09-30	Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid.
TR199903249T2 (xx)	2000-09-21	�l-5 inhibit�rleri olarak 6-Azaurasil t�revleri.