ES2185357T3 - Compuestos 2-sustituidos-1-piperidil bencimidazol como agonistas del receptor orl1. - Google Patents
Compuestos 2-sustituidos-1-piperidil bencimidazol como agonistas del receptor orl1.Info
- Publication number
- ES2185357T3 ES2185357T3 ES99926688T ES99926688T ES2185357T3 ES 2185357 T3 ES2185357 T3 ES 2185357T3 ES 99926688 T ES99926688 T ES 99926688T ES 99926688 T ES99926688 T ES 99926688T ES 2185357 T3 ES2185357 T3 ES 2185357T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- halo
- aromatic
- group
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un compuesto de la siguiente fórmula: o una sal del mismo, en la que R se selecciona entre el grupo formado por: cicloalquilo(C3-C11), bicicloalquilo(C6-C16), tricicloalquilo(C6-C16) y tetracicloalquilo(C8-C16) en los que dichos grupos son parcialmente saturados, totalmente saturados o totalmente insaturados y son opcionalmente sustituidos con hasta tres sustituyentes escogidos independientemente entre el grupo formado por: halo, hidroxi, alquilo(C1-C5) y cicloalquilo(C3-C7); A está unido al átomo de carbono de R con el que R se une al átomo de nitrógeno del anillo de piperidina, y se selecciona entre el grupo formado por: alquilo(C1-C7), mono-, di- o tri-halo alquilo(C1-C7), alquenilo(C2-C5), alquinilo(C2-C5), fenil-alquilo(C1-C5), arilo, y heterocíclicos aromáticos y no aromáticos que comprendan de cuatro a diez átomos en el anillo, en donde de uno a cuatro átomos del anillo se seleccionan independientemente entre heteroátomos, y siendo dicha fracción fenilo en fenil-alquilo(C1-C5), arilo, o heterocíclicos aromáticos o no aromáticos siendo opcionalmente sustituida con hasta tres sustituyentes escogidos independientemente entre el grupo formado por: halo, hidroxi, alquilo(C1-C4), halo- alquilo(C1-C4), alcoxi(C1-C4), halo-alcoxi(C1-C4), alquil(C1-C4)¿CO-, fenilo, bencilo, -CHO, ciano, alquil(C1- C4)¿CO-, NH2-CO-, NH2-CH2-, amino, alquil(C1-C4)¿NH-, di(alquil(C1-C4))-N-, alquil(C1-C4)¿CO-NH-, alquil(C1-C4)- NH¿CO-, hidracino, azido, ureido, amidino, guanidino, oxo y =N-OH; Y se selecciona entre el grupo formado por: hidrógeno, halo, amino, mercapto, alquil(C1-C12)¿M-, cicloalquil(C3-C7)¿M-, alquenilo(C2-C6)¿M-, arilo-M, heterocíclicos-M- aromáticos o no aromáticos, aril- alquil(C1-C5)-M-, heterocíclicos-alquil(C1-C5)-M- aromáticos o no aromáticos, comprendiendo dicha fracción heterocíclica aromática o no aromática de dichos grupos de cuatro adiez átomos en el anillo, en donde de uno a cuatro átomos del anillo se seleccionan independientemente entre heteroátomos (es decir, O, S y N), y M se selecciona entre el grupo formado por un enlace covalente, O, S, SO, SO2, CO (es decir, C(=O)), NQ (es decir, N(Q)), NQCO (es decir, N(Q)C(=O)), CONQ (es decir, C(=O)N(Q)), en donde Q se selecciona entre el grupo formado por hidrógeno y alquilo(C1-C6), siendo dicha fracción alquilo(C1-C12), cicloalquilo(C3-C7) o alquenilo(C2-C6) opcionalmente sustituida en dichos grupos con hasta tres (preferiblemente de cero a dos) sustituyentes escogidos independientemente entre el grupo formado por: halo, hidroxi, amino, alquilo(C1-C4), halo-alquil(C1-C4)-NH-, di- alquil(C1-C4)-N-, hidracino, azido, ureido, amidino, guanidino, alcoxi(C1-C4), alquil(C1-C4)-S-, alquil(C1-C4)- SO-, y alquil(C1-C4)-SO2-, y siendo dicha fracción arilo o heterocíclica aromática o no aromática de dichos grupos opcionalmente sustituida con hasta tres sustituyentes escogidos independientemente entre el grupo formado por: halo, hidroxi, alquilo(C1-C4), halo-alquilo(C1-C4), alcoxi(C1-C4), halo-alcoxi(C1-C4), alquil(C1-C4)¿CO-, fenilo, bencilo, -CHO, ciano, alquil(C1-C4)¿CO-, NH2-CO-, NH2-CH2-, amino, alquil(C1-C4)¿NH-, di-alquil(C1-C4)-N-, alquil(C1-C4)¿CO-NH-, alquil(C1-C4)-NH¿CO-, hidracino, azido, ureido, amidino, guanidino, oxo y =N-OH; y Z1, Z2, Z3 y Z4 se seleccionan independientemente entre el grupo formado por: hidrógeno, halo, alquilo(C1- C4), halo-alquilo(C1-C4), alcoxi(C1-C4), alquil(C1-C4)- sulfonilo, alquil(C1-C4)-CO-, carboxi, alquil(C1-C4)-COO-, amino, NH2CO-, alquil(C1-C4)-CO-NH-, alquil(C1-C4)-SO2-NH- , fenilo y naftilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IBPCT/IB98/01206 | 1998-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2185357T3 true ES2185357T3 (es) | 2003-04-16 |
Family
ID=11004738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99926688T Expired - Lifetime ES2185357T3 (es) | 1998-08-06 | 1999-07-05 | Compuestos 2-sustituidos-1-piperidil bencimidazol como agonistas del receptor orl1. |
Country Status (44)
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6340681B1 (en) * | 1999-07-16 | 2002-01-22 | Pfizer Inc | 2-benzimidazolylamine compounds as ORL-1-receptor agonists |
| SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
| SE9903544D0 (sv) | 1999-10-01 | 1999-10-01 | Astra Pharma Prod | Novel compounds |
| DE60023100T2 (de) | 2000-01-05 | 2006-07-06 | Pfizer Inc. | Benzimidazol-Verbindungen zur Verwendung als ORL1-Rezeptor-Antagonisten |
| GB2359078A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
| GB2359081A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active thiazolopyrimidines |
| GB2359551A (en) | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
| GB0005642D0 (en) | 2000-03-10 | 2000-05-03 | Astrazeneca Uk Ltd | Chemical compounds |
| SE0003828D0 (sv) | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Novel compounds |
| WO2002040019A1 (en) | 2000-11-15 | 2002-05-23 | Banyu Pharmaceutical Co.,Ltd. | Benzimidazole derivatives |
| GB0104050D0 (en) | 2001-02-19 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| GB0107228D0 (en) | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
| SE0101322D0 (sv) | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | Novel compounds |
| NZ551453A (en) * | 2001-04-18 | 2008-02-29 | Euro Celtique Sa | Nociceptin analogs for the treatment of pain |
| PT1385514E (pt) | 2001-04-18 | 2009-02-04 | Euro Celtique Sa | Compostos espiroindeno e espiroindano |
| KR100855204B1 (ko) | 2001-04-18 | 2008-09-01 | 유로-셀티크 소시에떼 아노뉨 | 노시셉틴 유사체 |
| US6872733B2 (en) | 2001-04-18 | 2005-03-29 | Euro-Celtique S.A. | Benzimidazolone compounds |
| KR100628292B1 (ko) | 2001-04-18 | 2006-09-27 | 유로-셀티크 소시에떼 아노뉨 | 스파이로파이라졸 화합물 |
| EP1406629A1 (en) * | 2001-07-02 | 2004-04-14 | Omeros Corporation | Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump |
| US20030040479A1 (en) * | 2001-07-02 | 2003-02-27 | Omeros Corporation | Rotational intrathecal analgesia method and device |
| SE0102716D0 (sv) * | 2001-08-14 | 2001-08-14 | Astrazeneca Ab | Novel compounds |
| SE0103818D0 (sv) * | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
| AU2002360561A1 (en) * | 2001-12-11 | 2003-06-23 | Sepracor, Inc. | 4-substituted piperidines, and methods of use thereof |
| JP4056977B2 (ja) | 2002-03-29 | 2008-03-05 | 田辺三菱製薬株式会社 | 睡眠障害治療薬 |
| GB0221828D0 (en) | 2002-09-20 | 2002-10-30 | Astrazeneca Ab | Novel compound |
| GB0221829D0 (en) * | 2002-09-20 | 2002-10-30 | Astrazeneca Ab | Novel compound |
| DE10252666A1 (de) * | 2002-11-11 | 2004-08-05 | Grünenthal GmbH | N-Piperidyl-cyclohexan-Derivate |
| DE10252665A1 (de) * | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
| SE0301369D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
| GB0315203D0 (en) * | 2003-06-28 | 2003-08-06 | Celltech R&D Ltd | Chemical compounds |
| SA04250305B1 (ar) | 2003-09-25 | 2008-06-02 | سولفاي فارماسوتيكالز بي . في | مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية |
| GB0328243D0 (en) | 2003-12-05 | 2004-01-07 | Astrazeneca Ab | Methods |
| US20050228023A1 (en) * | 2003-12-19 | 2005-10-13 | Sri International | Agonist and antagonist ligands of the nociceptin receptor |
| WO2006038738A1 (ja) * | 2004-10-08 | 2006-04-13 | Takeda Pharmaceutical Company Limited | 受容体機能調節剤 |
| US7842817B2 (en) | 2005-01-11 | 2010-11-30 | Neurosearch A/S | 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
| US20090239880A1 (en) * | 2006-07-03 | 2009-09-24 | Ulrik Svane Sorensen | Combinations of monoamine reuptake inhibitors and potassium channel activators |
| EP2280008B1 (en) | 2007-01-16 | 2013-05-29 | Purdue Pharma L.P. | Heterocyclic-substituted piperidines as orl-1 ligands |
| TW201322983A (zh) | 2007-08-31 | 2013-06-16 | Purdue Pharma Lp | 經取代之喹□啉型哌啶化合物及其用途 |
| US8119661B2 (en) * | 2007-09-11 | 2012-02-21 | Astrazeneca Ab | Piperidine derivatives and their use as muscarinic receptor modulators |
| CN102105465B (zh) | 2008-07-21 | 2015-03-11 | 普渡制药公司 | 取代的喹喔啉型桥连哌啶化合物及其用途 |
| CN103168032A (zh) | 2010-08-05 | 2013-06-19 | 安美基公司 | 抑制间变性淋巴瘤激酶的苯并咪唑和氮杂苯并咪唑化合物 |
| JP6007262B2 (ja) | 2012-01-06 | 2016-10-12 | ノーバス・インターナショナル・インコーポレイテッドＮｏｖｕｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ，Ｉｎｃ． | スルホキシドベース界面活性剤 |
| EP2812313A4 (en) | 2012-02-09 | 2015-09-30 | Novus Int Inc | FUNCTIONALIZED POLYMERIC COMPOSITIONS |
| JO3300B1 (ar) | 2012-06-06 | 2018-09-16 | Novartis Ag | مركبات وتركيبات لتعديل نشاط egfr |
| MX2015000395A (es) | 2012-07-12 | 2015-04-10 | Novus Int Inc | Composiciones de matriz y capa para proteccion de bioactivos. |
| US9085561B2 (en) * | 2012-07-30 | 2015-07-21 | Purdue Pharma L.P. | Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators |
| US9090618B2 (en) | 2012-12-27 | 2015-07-28 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
| WO2014153529A1 (en) | 2013-03-22 | 2014-09-25 | The Scripps Research Institute | Substituted benzimidazoles as nociceptin receptor modulators |
| KR102416358B1 (ko) * | 2014-03-20 | 2022-07-07 | 카펠라 테라퓨틱스, 인크. | 암 치료용의 ｅｒｂｂ 티로신 키나제 억제제로서의 벤즈이미다졸 유도체 |
| US10227551B2 (en) | 2015-11-12 | 2019-03-12 | Novus International, Inc. | Sulfur-containing compounds as solvents |
| US10584306B2 (en) | 2017-08-11 | 2020-03-10 | Board Of Regents Of The University Of Oklahoma | Surfactant microemulsions |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3318900A (en) * | 1964-05-06 | 1967-05-09 | Janssen Pharmaceutica Nv | Derivatives of benzimidazolinyl piperidine |
| JPS5297978A (en) * | 1976-06-02 | 1977-08-17 | Yoshitomi Pharmaceut Ind Ltd | Preparation of alicyclic derivatives |
| US5821219A (en) | 1995-08-11 | 1998-10-13 | Oregon Health Sciences University | Opioid antagonists and methods of their use |
| WO1997007208A1 (en) | 1995-08-15 | 1997-02-27 | Universite Libre De Bruxelles | Nucleic acid molecules encoding peptides having pronociceptive properties |
| US5866346A (en) | 1995-09-27 | 1999-02-02 | Indiana Unversity Foundation | Methods of using dynorphins as ligands for XOR1 receptor |
| WO1997040035A1 (en) * | 1996-04-19 | 1997-10-30 | Neurosearch A/S | 1-(4-piperidyl)-benzimidazoles having neurotrophic activity |
| EP0813065A3 (en) | 1996-06-13 | 1998-07-22 | F. Hoffmann-La Roche Ag | Modulation of LC132 (opioid-like) receptor function |
| EP0829481A1 (en) * | 1996-09-16 | 1998-03-18 | Pfizer Inc. | Morphinan hydroxamic acid compounds |
| US5718912A (en) * | 1996-10-28 | 1998-02-17 | Merck & Co., Inc. | Muscarine agonists |
| WO1998054168A1 (en) | 1997-05-30 | 1998-12-03 | Banyu Pharmaceutical Co., Ltd. | 2-oxoimidazole derivatives |
| WO1999003880A1 (en) | 1997-07-15 | 1999-01-28 | Novo Nordisk A/S | Nociceptin analogues |
| US5929035A (en) | 1998-04-14 | 1999-07-27 | Regents Of The University Of Michigan | Methods of treating intestinal disorders |
| ID29137A (id) | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
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1999
- 1999-06-25 MA MA25646A patent/MA26659A1/fr unknown
- 1999-06-28 TW TW088110899A patent/TW513424B/zh not_active IP Right Cessation
- 1999-07-05 EE EEP200100075A patent/EE200100075A/xx unknown
- 1999-07-05 AT AT99926688T patent/ATE227716T1/de not_active IP Right Cessation
- 1999-07-05 SI SI9930151T patent/SI1102762T1/xx unknown
- 1999-07-05 TN TNTNSN99142A patent/TNSN99142A1/fr unknown
- 1999-07-05 SK SK160-2001A patent/SK1602001A3/sk unknown
- 1999-07-05 JP JP2000563646A patent/JP3367945B2/ja not_active Expired - Fee Related
- 1999-07-05 HU HU0103567A patent/HUP0103567A3/hu unknown
- 1999-07-05 GE GEAP19995740A patent/GEP20033000B/en unknown
- 1999-07-05 YU YU8201A patent/YU8201A/sh unknown
- 1999-07-05 PL PL99346211A patent/PL346211A1/xx not_active Application Discontinuation
- 1999-07-05 DE DE69903953T patent/DE69903953T2/de not_active Expired - Fee Related
- 1999-07-05 ID IDW20010284D patent/ID27212A/id unknown
- 1999-07-05 WO PCT/IB1999/001239 patent/WO2000008013A2/en not_active Ceased
- 1999-07-05 EA EA200100104A patent/EA200100104A1/ru unknown
- 1999-07-05 BR BR9912778-4A patent/BR9912778A/pt not_active Application Discontinuation
- 1999-07-05 AP APAP/P/2001/002063A patent/AP2001002063A0/en unknown
- 1999-07-05 HR HR970081A patent/HRP20010089B1/xx not_active IP Right Cessation
- 1999-07-05 CZ CZ2001397A patent/CZ2001397A3/cs unknown
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- 1999-07-05 EP EP99926688A patent/EP1102762B1/en not_active Expired - Lifetime
- 1999-07-05 ES ES99926688T patent/ES2185357T3/es not_active Expired - Lifetime
- 1999-07-05 HK HK02101444.8A patent/HK1040188A1/zh unknown
- 1999-07-05 CN CN99810857A patent/CN1317968A/zh active Pending
- 1999-07-05 CA CA002339621A patent/CA2339621C/en not_active Expired - Fee Related
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- 1999-07-05 DK DK99926688T patent/DK1102762T3/da active
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