NO20010603L - 2-substituert-1-piperidylbenzimidazol forbindelser som ORL 1- reseptor agonister - Google Patents

2-substituert-1-piperidylbenzimidazol forbindelser som ORL 1- reseptor agonister

Info

Publication number: NO20010603L
Authority: NO; Norway
Prior art keywords: alkyl; orl; aromatic; unsubstituted; piperidylbenzimidazole
Prior art date: 1998-08-06

Application number

NO20010603A

Other languages

English (en)

Norwegian (no)

Other versions

NO20010603D0 (no

Inventor

Fumitaka Ito

Hirohide Noguchi

Hiroshi Kondo

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-06

Filing date

2001-02-05

Publication date

2001-04-05

2001-02-05 Application filed by Pfizer filed Critical Pfizer

2001-02-05 Publication of NO20010603D0 publication Critical patent/NO20010603D0/no

2001-04-05 Publication of NO20010603L publication Critical patent/NO20010603L/no

Links

108010020615 nociceptin receptor Proteins 0.000 title abstract 2
-1 2-substituted-1-piperidylbenzimidazole compounds Chemical class 0.000 title 1
239000000018 receptor agonist Substances 0.000 title 1
229940044601 receptor agonist Drugs 0.000 title 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
125000006729 (C2-C5) alkenyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
229940035676 analgesics Drugs 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical group [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Toxicology (AREA)
Psychology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20010603A 1998-08-06 2001-02-05 2-substituert-1-piperidylbenzimidazol forbindelser som ORL 1- reseptor agonister NO20010603L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IBPCT/IB98/01206		1998-08-06
PCT/IB1999/001239 WO2000008013A2 (fr)	1998-08-06	1999-07-05	Composés de 1-pipéridyl benzimidazole substitué en 2, agonistes du récepteur orl1

Publications (2)

Publication Number	Publication Date
NO20010603D0 NO20010603D0 (no)	2001-02-05
NO20010603L true NO20010603L (no)	2001-04-05

Family

ID=11004738

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20010603A NO20010603L (no)	1998-08-06	2001-02-05	2-substituert-1-piperidylbenzimidazol forbindelser som ORL 1- reseptor agonister

Country Status (44)

Country	Link
US (1)	US6172067B1 (fr)
EP (1)	EP1102762B1 (fr)
JP (1)	JP3367945B2 (fr)
CN (1)	CN1317968A (fr)
AP (1)	AP2001002063A0 (fr)
AR (1)	AR018686A1 (fr)
AT (1)	ATE227716T1 (fr)
AU (1)	AU749166B2 (fr)
BG (1)	BG105301A (fr)
BR (1)	BR9912778A (fr)
CA (1)	CA2339621C (fr)
CZ (1)	CZ2001397A3 (fr)
DE (1)	DE69903953T2 (fr)
DK (1)	DK1102762T3 (fr)
EA (1)	EA200100104A1 (fr)
EE (1)	EE200100075A (fr)
ES (1)	ES2185357T3 (fr)
GE (1)	GEP20033000B (fr)
GT (1)	GT199900125A (fr)
HK (1)	HK1040188A1 (fr)
HN (1)	HN1999000105A (fr)
HR (1)	HRP20010089B1 (fr)
HU (1)	HUP0103567A3 (fr)
ID (1)	ID27212A (fr)
IL (1)	IL141029A0 (fr)
IS (1)	IS5812A (fr)
MA (1)	MA26659A1 (fr)
NO (1)	NO20010603L (fr)
NZ (1)	NZ509299A (fr)
OA (1)	OA11590A (fr)
PA (1)	PA8477701A1 (fr)
PE (1)	PE20000868A1 (fr)
PL (1)	PL346211A1 (fr)
PT (1)	PT1102762E (fr)
SI (1)	SI1102762T1 (fr)
SK (1)	SK1602001A3 (fr)
SV (1)	SV1999000099A (fr)
TN (1)	TNSN99142A1 (fr)
TR (1)	TR200100403T2 (fr)
TW (1)	TW513424B (fr)
UY (1)	UY25659A1 (fr)
WO (1)	WO2000008013A2 (fr)
YU (1)	YU8201A (fr)
ZA (1)	ZA200100900B (fr)

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GB2359078A (en) *	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
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GB2359551A (en)	2000-02-23	2001-08-29	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en)	2000-03-10	2000-05-03	Astrazeneca Uk Ltd	Chemical compounds
SE0003828D0 (sv)	2000-10-20	2000-10-20	Astrazeneca Ab	Novel compounds
US6969712B2 (en)	2000-11-15	2005-11-29	Banyu Pharmaceutical Co., Ltd.	Benzimidazole derivatives
GB0104050D0 (en)	2001-02-19	2001-04-04	Astrazeneca Ab	Chemical compounds
GB0107228D0 (en)	2001-03-22	2001-05-16	Astrazeneca Ab	Chemical compounds
SE0101322D0 (sv)	2001-04-12	2001-04-12	Astrazeneca Ab	Novel compounds
ATE410165T1 (de)	2001-04-18	2008-10-15	Euro Celtique Sa	Nociceptin-analoga
EP2033644A1 (fr)	2001-04-18	2009-03-11	Euro-Celtique S.A.	Composés spiro-indene et spiro-indane
ATE403431T1 (de) *	2001-04-18	2008-08-15	Euro Celtique Sa	Benzimidazolon-verbindungen
RU2268883C2 (ru) *	2001-04-18	2006-01-27	Эро-Селтик, С.А.	Аналоги ноницептина и фармацевтическая композиция на их основе
CN1516584A (zh)	2001-04-18	2004-07-28	ŷ��ǹɷ��޹�˾	螺吡唑化合物
US20030040479A1 (en) *	2001-07-02	2003-02-27	Omeros Corporation	Rotational intrathecal analgesia method and device
WO2003004034A1 (fr) *	2001-07-02	2003-01-16	Omeros Corporation	Procede visant a induire une analgesie, qui comprend l'administration alternee d'un agoniste de recepteur d'opioides et d'un agoniste de recepteur 1 du type recepteur d'opioides, et pompe a perfusion implantable
SE0102716D0 (sv) *	2001-08-14	2001-08-14	Astrazeneca Ab	Novel compounds
SE0103818D0 (sv)	2001-11-15	2001-11-15	Astrazeneca Ab	Chemical compounds
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US7566728B2 (en)	2002-03-29	2009-07-28	Mitsubishi Tanabe Pharma Corporation	Remedy for sleep disturbance
GB0221829D0 (en) *	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
GB0221828D0 (en)	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
DE10252666A1 (de) *	2002-11-11	2004-08-05	Grünenthal GmbH	N-Piperidyl-cyclohexan-Derivate
DE10252665A1 (de) *	2002-11-11	2004-06-03	Grünenthal GmbH	4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
SE0301369D0 (sv)	2003-05-09	2003-05-09	Astrazeneca Ab	Chemical compounds
GB0315203D0 (en) *	2003-06-28	2003-08-06	Celltech R&D Ltd	Chemical compounds
SA04250305B1 (ar)	2003-09-25	2008-06-02	سولفاي فارماسوتيكالز بي . في	مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية
GB0328243D0 (en)	2003-12-05	2004-01-07	Astrazeneca Ab	Methods
WO2005060947A2 (fr) *	2003-12-19	2005-07-07	Sri International	Ligands agonistes et antagonistes du recepteur de la nociceptine
JPWO2006038738A1 (ja) *	2004-10-08	2008-05-15	武田薬品工業株式会社	受容体機能調節剤
EP2319512A1 (fr)	2005-01-11	2011-05-11	NeuroSearch AS	Dérivés de 2-amino benzimidazole et leur utilisation comme modulateurs des canaux potassiques calcium-dépendants de faible conductance
JP2009541454A (ja) *	2006-07-03	2009-11-26	ノイロサーチアクティーゼルスカブ	モノアミン再摂取阻害剤及びカリウムチャネル活性剤の併用
EP2397477B1 (fr)	2007-01-16	2014-03-05	Purdue Pharma LP	Composés de pipéridine hétérocycliques substitués et leurs utilisations
WO2009027820A2 (fr)	2007-08-31	2009-03-05	Purdue Pharma L.P.	Composés de pipéridine de type quinoxaline substituée et leurs utilisations
US8119661B2 (en) *	2007-09-11	2012-02-21	Astrazeneca Ab	Piperidine derivatives and their use as muscarinic receptor modulators
RS52590B2 (sr)	2008-07-21	2018-05-31	Purdue Pharma Lp	Jedinjenja tipa supstituisanog hinoksalina sa premošćenim piperidinom i njihova upotreba
SG10201505997TA (en)	2010-08-05	2015-09-29	Amgen Inc	Benzimidazole And Azabenzimidazole Compounds That Inhibit Anaplastic Lymphoma Kinase
MX346043B (es)	2012-01-06	2017-03-03	Novus Int Inc	Tensioactivos basados en sulfoxido.
HRP20181671T1 (hr)	2012-02-09	2018-12-14	Novus International, Inc.	Heteroatom koji sadrži cikličke dimere
JO3300B1 (ar)	2012-06-06	2018-09-16	Novartis Ag	مركبات وتركيبات لتعديل نشاط egfr
PL2871973T3 (pl)	2012-07-12	2019-02-28	Novus International Inc.	Kompozycje matrycy i warstwy do ochrony środków bioaktywnych
US9085561B2 (en) *	2012-07-30	2015-07-21	Purdue Pharma L.P.	Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
US9090618B2 (en)	2012-12-27	2015-07-28	Purdue Pharma L.P.	Substituted benzimidazole-type piperidine compounds and uses thereof
EP2976077A4 (fr)	2013-03-22	2016-11-30	Scripps Research Inst	Benzimidazoles substitués en tant que modulateurs d'un récepteur de nociceptine
IL291000B2 (en) *	2014-03-20	2024-04-01	Capella Therapeutics Inc	Benzimidazole derivatives as erbb tyrosine kinase inhibitors for the treatment of cancer
CN112707851A (zh)	2015-11-12	2021-04-27	诺华丝国际股份有限公司	作为溶剂的含硫化合物
US10584306B2 (en)	2017-08-11	2020-03-10	Board Of Regents Of The University Of Oklahoma	Surfactant microemulsions

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JPS5297978A (en) *	1976-06-02	1977-08-17	Yoshitomi Pharmaceut Ind Ltd	Preparation of alicyclic derivatives
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CA2229202C (fr)	1995-08-15	2008-05-20	Universite Libre De Bruxells	Methodes pour l'identification d'antagonistes ou d'agonistes du recepteur orl-1 humain
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EP0813065A3 (fr)	1996-06-13	1998-07-22	F. Hoffmann-La Roche Ag	Modulation de la fonction d'un récepteur LC-132(analogue à opioide)
EP0829481A1 (fr) *	1996-09-16	1998-03-18	Pfizer Inc.	Dérivés de l'acide morphinane hydroxamique
US5718912A (en) *	1996-10-28	1998-02-17	Merck & Co., Inc.	Muscarine agonists
CA2291094C (fr)	1997-05-30	2008-02-26	Banyu Pharmaceutical Co., Ltd.	Derive de 2-0xoimidazole
WO1999003880A1 (fr)	1997-07-15	1999-01-28	Novo Nordisk A/S	Analogues de nociceptine
US5929035A (en)	1998-04-14	1999-07-27	Regents Of The University Of Michigan	Methods of treating intestinal disorders
ID29137A (id)	1998-07-27	2001-08-02	Schering Corp	Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1

1999
- 1999-06-25 MA MA25646A patent/MA26659A1/fr unknown
- 1999-06-28 TW TW088110899A patent/TW513424B/zh not_active IP Right Cessation
- 1999-07-05 CZ CZ2001397A patent/CZ2001397A3/cs unknown
- 1999-07-05 HU HU0103567A patent/HUP0103567A3/hu unknown
- 1999-07-05 WO PCT/IB1999/001239 patent/WO2000008013A2/fr not_active Ceased
- 1999-07-05 TN TNTNSN99142A patent/TNSN99142A1/fr unknown
- 1999-07-05 JP JP2000563646A patent/JP3367945B2/ja not_active Expired - Fee Related
- 1999-07-05 AU AU43859/99A patent/AU749166B2/en not_active Ceased
- 1999-07-05 ID IDW20010284D patent/ID27212A/id unknown
- 1999-07-05 YU YU8201A patent/YU8201A/sh unknown
- 1999-07-05 HR HR970081A patent/HRP20010089B1/xx not_active IP Right Cessation
- 1999-07-05 AT AT99926688T patent/ATE227716T1/de not_active IP Right Cessation
- 1999-07-05 OA OA1200100031A patent/OA11590A/en unknown
- 1999-07-05 ES ES99926688T patent/ES2185357T3/es not_active Expired - Lifetime
- 1999-07-05 EE EEP200100075A patent/EE200100075A/xx unknown
- 1999-07-05 EP EP99926688A patent/EP1102762B1/fr not_active Expired - Lifetime
- 1999-07-05 GE GEAP19995740A patent/GEP20033000B/en unknown
- 1999-07-05 TR TR2001/00403T patent/TR200100403T2/xx unknown
- 1999-07-05 BR BR9912778-4A patent/BR9912778A/pt not_active Application Discontinuation
- 1999-07-05 SK SK160-2001A patent/SK1602001A3/sk unknown
- 1999-07-05 CA CA002339621A patent/CA2339621C/fr not_active Expired - Fee Related
- 1999-07-05 DK DK99926688T patent/DK1102762T3/da active
- 1999-07-05 PL PL99346211A patent/PL346211A1/xx not_active Application Discontinuation
- 1999-07-05 AP APAP/P/2001/002063A patent/AP2001002063A0/en unknown
- 1999-07-05 HN HN1999000105A patent/HN1999000105A/es unknown
- 1999-07-05 NZ NZ509299A patent/NZ509299A/en not_active Application Discontinuation
- 1999-07-05 DE DE69903953T patent/DE69903953T2/de not_active Expired - Fee Related
- 1999-07-05 HK HK02101444.8A patent/HK1040188A1/zh unknown
- 1999-07-05 EA EA200100104A patent/EA200100104A1/ru unknown
- 1999-07-05 SI SI9930151T patent/SI1102762T1/xx unknown
- 1999-07-05 PT PT99926688T patent/PT1102762E/pt unknown
- 1999-07-05 CN CN99810857A patent/CN1317968A/zh active Pending
- 1999-07-05 IL IL14102999A patent/IL141029A0/xx unknown
- 1999-07-06 AR ARP990103264A patent/AR018686A1/es active IP Right Grant
- 1999-07-15 PE PE1999000717A patent/PE20000868A1/es not_active Application Discontinuation
- 1999-07-16 SV SV1999000099A patent/SV1999000099A/es not_active Application Discontinuation
- 1999-07-16 PA PA19998477701A patent/PA8477701A1/es unknown
- 1999-08-05 US US09/369,208 patent/US6172067B1/en not_active Expired - Fee Related
- 1999-08-06 GT GT199900125A patent/GT199900125A/es unknown
- 1999-08-13 UY UY25659A patent/UY25659A1/es not_active Application Discontinuation
2001
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- 2001-02-01 ZA ZA200100900A patent/ZA200100900B/xx unknown
- 2001-02-05 NO NO20010603A patent/NO20010603L/no not_active Application Discontinuation
- 2001-03-01 BG BG105301A patent/BG105301A/xx unknown

Also Published As

Publication number	Publication date
TW513424B (en)	2002-12-11
DK1102762T3 (da)	2002-12-16
EP1102762A2 (fr)	2001-05-30
SV1999000099A (es)	2000-09-05
AP2001002063A0 (en)	2001-03-31
HN1999000105A (es)	2000-11-11
IS5812A (is)	2001-01-16
ES2185357T3 (es)	2003-04-16
SI1102762T1 (en)	2003-04-30
HK1040188A1 (zh)	2002-05-31
AU4385999A (en)	2000-02-28
IL141029A0 (en)	2002-02-10
CZ2001397A3 (cs)	2002-05-15
HUP0103567A2 (hu)	2002-02-28
PE20000868A1 (es)	2000-08-31
NO20010603D0 (no)	2001-02-05
JP3367945B2 (ja)	2003-01-20
WO2000008013A2 (fr)	2000-02-17
HRP20010089A2 (en)	2002-02-28
CA2339621C (fr)	2005-04-05
ID27212A (id)	2001-03-08
BR9912778A (pt)	2001-09-25
CA2339621A1 (fr)	2000-02-17
HRP20010089B1 (en)	2003-04-30
EE200100075A (et)	2002-06-17
BG105301A (en)	2001-12-29
ZA200100900B (en)	2002-08-28
UY25659A1 (es)	2000-02-23
NZ509299A (en)	2003-05-30
EA200100104A1 (ru)	2001-08-27
WO2000008013A3 (fr)	2000-03-23
PA8477701A1 (es)	2000-09-29
MA26659A1 (fr)	2004-12-20
AU749166B2 (en)	2002-06-20
OA11590A (en)	2004-08-18
PT1102762E (pt)	2003-02-28
CN1317968A (zh)	2001-10-17
ATE227716T1 (de)	2002-11-15
TR200100403T2 (tr)	2001-07-23
GT199900125A (es)	2001-01-27
EP1102762B1 (fr)	2002-11-13
PL346211A1 (en)	2002-01-28
HUP0103567A3 (en)	2003-01-28
DE69903953T2 (de)	2003-03-27
US6172067B1 (en)	2001-01-09
JP2002522431A (ja)	2002-07-23
AR018686A1 (es)	2001-11-28
GEP20033000B (en)	2003-06-25
SK1602001A3 (en)	2002-09-10
DE69903953D1 (de)	2002-12-19
TNSN99142A1 (fr)	2005-11-10
YU8201A (sh)	2003-07-07

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Date	Code	Title	Description
2003-09-15	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
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TW200642689A (en)	2006-12-16	Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient
WO2001062705A8 (fr)	2001-09-27	Derive d'aminoalcool
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