NO20021040L - Substituerte N-fenyl- 2-hydroksy-2-metyl-3,3,3-trifluorpropanamid-derivater som eleverer puruvatdehydrogenase-aktivitet - Google Patents

Substituerte N-fenyl- 2-hydroksy-2-metyl-3,3,3-trifluorpropanamid-derivater som eleverer puruvatdehydrogenase-aktivitet

Info

Publication number: NO20021040L
Authority: NO; Norway
Prior art keywords: puruvate; teach; hydroxy; phenyl; substituted
Prior art date: 1999-09-04

Application number

NO20021040A

Other languages

English (en)

Norwegian (no)

Other versions

NO20021040D0 (no

Inventor

Roger John Butlin

Thorsten Nowak

Jeremy Nicholas Burrows

Michael Howard Block

Elizabeth Janet Pease

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-04

Filing date

2002-03-01

Publication date

2002-05-02

1999-09-04 Priority claimed from GBGB9920814.2A external-priority patent/GB9920814D0/en

2000-03-21 Priority claimed from GB0006641A external-priority patent/GB0006641D0/en

2002-03-01 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2002-03-01 Publication of NO20021040D0 publication Critical patent/NO20021040D0/no

2002-05-02 Publication of NO20021040L publication Critical patent/NO20021040L/no

Links

JHSBXNFXGVSVQO-UHFFFAOYSA-N 3,3,3-trifluoro-2-hydroxy-2-methyl-n-phenylpropanamide Chemical class FC(F)(F)C(O)(C)C(=O)NC1=CC=CC=C1 JHSBXNFXGVSVQO-UHFFFAOYSA-N 0.000 title 1
101710088194 Dehydrogenase Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
- C07C317/42—Y being a hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Pyrrole Compounds (AREA)

NO20021040A 1999-09-04 2002-03-01 Substituerte N-fenyl- 2-hydroksy-2-metyl-3,3,3-trifluorpropanamid-derivater som eleverer puruvatdehydrogenase-aktivitet NO20021040L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9920814.2A GB9920814D0 (en)	1999-09-04	1999-09-04	Chemical compounds
GB0006641A GB0006641D0 (en)	2000-03-21	2000-03-21	Chemical compounds
PCT/GB2000/003314 WO2001017956A1 (en)	1999-09-04	2000-08-30	Substituted n-phenyl 2-hydroxy-2-methyl-3,3,3-trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity

Publications (2)

Publication Number	Publication Date
NO20021040D0 NO20021040D0 (no)	2002-03-01
NO20021040L true NO20021040L (no)	2002-05-02

Family

ID=26243905

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20021040A NO20021040L (no)	1999-09-04	2002-03-01	Substituerte N-fenyl- 2-hydroksy-2-metyl-3,3,3-trifluorpropanamid-derivater som eleverer puruvatdehydrogenase-aktivitet

Country Status (32)

Country	Link
US (1)	US6689909B1 (is)
EP (1)	EP1214296B1 (is)
JP (1)	JP2003508515A (is)
KR (1)	KR100692232B1 (is)
CN (1)	CN1235877C (is)
AR (1)	AR035163A1 (is)
AT (1)	ATE262507T1 (is)
AU (1)	AU760061B2 (is)
BG (1)	BG65099B1 (is)
BR (1)	BR0013694A (is)
CA (1)	CA2381581A1 (is)
CO (1)	CO5190690A1 (is)
CZ (1)	CZ2002773A3 (is)
DE (1)	DE60009319T2 (is)
DK (1)	DK1214296T3 (is)
EE (1)	EE05080B1 (is)
ES (1)	ES2216940T3 (is)
HK (1)	HK1045496B (is)
HU (1)	HUP0202725A3 (is)
IL (2)	IL148111A0 (is)
IS (1)	IS2069B (is)
MX (1)	MXPA02002319A (is)
MY (1)	MY127036A (is)
NO (1)	NO20021040L (is)
NZ (1)	NZ517147A (is)
PL (1)	PL353887A1 (is)
PT (1)	PT1214296E (is)
RU (1)	RU2255085C2 (is)
SK (1)	SK286774B6 (is)
TR (1)	TR200200550T2 (is)
TW (1)	TW577867B (is)
WO (1)	WO2001017956A1 (is)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003508509A (ja)	1999-09-04	2003-03-04	アストラゼネカアクチボラグ	ピルビン酸デヒドロゲナーゼの阻害剤としてのアミド
GB0012012D0 (en) *	2000-05-19	2000-07-05	Astrazeneca Ab	Chemical compound
GB0120471D0 (en) *	2001-08-23	2001-10-17	Astrazeneca Ab	Chemical compounds
US7399775B2 (en) *	2001-12-27	2008-07-15	Daiichi Pharmaceutical Co., Ltd.	β-amyloid protein production/secretion inhibitor
WO2012151448A1 (en) *	2011-05-03	2012-11-08	Agios Pharmaceuticals, Inc.	Pyruvate kinase activators for use in therapy
CA2890664A1 (en)	2012-11-08	2014-05-15	Agios Pharmaceuticals, Inc.	Therapeutic compounds and compositions and their use as pkm2 modulators
WO2014139144A1 (en)	2013-03-15	2014-09-18	Agios Pharmaceuticals, Inc.	Therapeutic compounds and compositions
CN111032045B (zh)	2017-08-15	2023-08-15	安吉奥斯医药品有限公司	用于治疗血液病症的丙酮酸激酶激活剂
CN109096186B (zh) *	2018-09-29	2020-08-04	中南大学	一种2-芳磺酰基喹啉衍生物的合成方法
JPWO2023032940A1 (is) *	2021-09-01	2023-03-09

Family Cites Families (23)

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Publication number	Priority date	Publication date	Assignee	Title
DE2862100D1 (en)	1977-10-12	1983-01-05	Ici Plc	Acylanilides, process for their manufacture and pharmaceutical and veterinary compositions containing them
US4191775A (en)	1977-12-15	1980-03-04	Imperial Chemical Industries Limited	Amide derivatives
NZ197008A (en)	1980-05-22	1984-10-19	Ici Ltd	Acylanilide derivatives and pharmaceutical compositions
AU8961382A (en)	1981-11-06	1983-05-12	Imperial Chemical Industries Plc	Amide derivatives
US4537618A (en)	1982-05-26	1985-08-27	Ciba Geigy Corporation	N-phenylsulfonyl-N'-pyrimidinylureas
ATE28864T1 (de)	1982-07-23	1987-08-15	Ici Plc	Amide-derivate.
GB8617653D0 (en)	1986-07-18	1986-08-28	Ici Plc	Amide derivatives
GB8617652D0 (en)	1986-07-18	1986-08-28	Ici Plc	Acylanilide derivatives
GB9116069D0 (en) *	1991-07-25	1991-09-11	Ici Plc	Therapeutic amides
GB9214120D0 (en) *	1991-07-25	1992-08-12	Ici Plc	Therapeutic amides
EP0539329A1 (de)	1991-10-25	1993-04-28	Ciba-Geigy Ag	Acetylen-Verbindungen, verwendbar als Leukotrien-Antagonisten
SE9103397D0 (sv)	1991-11-18	1991-11-18	Kabi Pharmacia Ab	Nya substituerade salicylsyror
IL105558A (en)	1992-05-18	1998-04-05	Zeneca Ltd	Tertiary carbinols having potassium channel activity, process for their preparation and pharmaceutical compositions containing them
GB9305295D0 (en) *	1993-03-15	1993-05-05	Zeneca Ltd	Therapeutic compounds
GB9309716D0 (en)	1993-05-12	1993-06-23	Zeneca Ltd	Heterocyclic derivatives
GB9310095D0 (en)	1993-05-17	1993-06-30	Zeneca Ltd	Therapeutic compounds
GB9310069D0 (en)	1993-05-17	1993-06-30	Zeneca Ltd	Heterocyclic compounds
GB2278054A (en)	1993-05-18	1994-11-23	Zeneca Ltd	Compounds for the treatment of urinary incontinence
GB9505082D0 (en)	1995-03-14	1995-05-03	Zeneca Ltd	Medicament
GB9607458D0 (en)	1996-04-10	1996-06-12	Zeneca Ltd	Enzymatic process for stereoselective preparation of therapeutic amides
GB9804648D0 (en)	1998-03-06	1998-04-29	Zeneca Ltd	Chemical compounds
GB9805520D0 (en)	1998-03-17	1998-05-13	Zeneca Ltd	Chemical compounds
GB9811427D0 (en) *	1998-05-29	1998-07-22	Zeneca Ltd	Chemical compounds

2000
- 2000-08-30 WO PCT/GB2000/003314 patent/WO2001017956A1/en not_active Ceased
- 2000-08-30 EE EEP200200113A patent/EE05080B1/xx not_active IP Right Cessation
- 2000-08-30 DE DE60009319T patent/DE60009319T2/de not_active Expired - Fee Related
- 2000-08-30 SK SK300-2002A patent/SK286774B6/sk not_active IP Right Cessation
- 2000-08-30 EP EP00956672A patent/EP1214296B1/en not_active Expired - Lifetime
- 2000-08-30 TR TR2002/00550T patent/TR200200550T2/xx unknown
- 2000-08-30 US US10/069,994 patent/US6689909B1/en not_active Expired - Fee Related
- 2000-08-30 RU RU2002108508/04A patent/RU2255085C2/ru not_active IP Right Cessation
- 2000-08-30 MY MYPI20004037 patent/MY127036A/en unknown
- 2000-08-30 KR KR1020027002841A patent/KR100692232B1/ko not_active Expired - Fee Related
- 2000-08-30 CN CNB008152446A patent/CN1235877C/zh not_active Expired - Fee Related
- 2000-08-30 PT PT00956672T patent/PT1214296E/pt unknown
- 2000-08-30 BR BR0013694-8A patent/BR0013694A/pt not_active Application Discontinuation
- 2000-08-30 ES ES00956672T patent/ES2216940T3/es not_active Expired - Lifetime
- 2000-08-30 PL PL00353887A patent/PL353887A1/xx not_active Application Discontinuation
- 2000-08-30 IL IL14811100A patent/IL148111A0/xx active IP Right Grant
- 2000-08-30 JP JP2001521703A patent/JP2003508515A/ja active Pending
- 2000-08-30 AU AU68543/00A patent/AU760061B2/en not_active Ceased
- 2000-08-30 HU HU0202725A patent/HUP0202725A3/hu unknown
- 2000-08-30 MX MXPA02002319A patent/MXPA02002319A/es active IP Right Grant
- 2000-08-30 NZ NZ517147A patent/NZ517147A/en unknown
- 2000-08-30 CA CA002381581A patent/CA2381581A1/en not_active Abandoned
- 2000-08-30 HK HK02107004.7A patent/HK1045496B/en not_active IP Right Cessation
- 2000-08-30 DK DK00956672T patent/DK1214296T3/da active
- 2000-08-30 CZ CZ2002773A patent/CZ2002773A3/cs unknown
- 2000-08-30 AT AT00956672T patent/ATE262507T1/de not_active IP Right Cessation
- 2000-09-01 CO CO00065992A patent/CO5190690A1/es not_active Application Discontinuation
- 2000-09-04 TW TW089118053A patent/TW577867B/zh not_active IP Right Cessation
- 2000-09-04 AR ARP000104623A patent/AR035163A1/es unknown
2002
- 2002-02-11 IL IL148111A patent/IL148111A/en not_active IP Right Cessation
- 2002-02-26 IS IS6285A patent/IS2069B/is unknown
- 2002-03-01 NO NO20021040A patent/NO20021040L/no not_active Application Discontinuation
- 2002-03-14 BG BG106520A patent/BG65099B1/bg unknown

Also Published As

Publication number	Publication date
RU2002108508A (ru)	2004-01-20
CN1235877C (zh)	2006-01-11
NO20021040D0 (no)	2002-03-01
HUP0202725A3 (en)	2005-04-28
MY127036A (en)	2006-11-30
TW577867B (en)	2004-03-01
IL148111A0 (en)	2002-09-12
KR100692232B1 (ko)	2007-03-09
SK3002002A3 (en)	2002-07-02
CZ2002773A3 (cs)	2002-06-12
IS6285A (is)	2002-02-26
ES2216940T3 (es)	2004-11-01
RU2255085C2 (ru)	2005-06-27
CA2381581A1 (en)	2001-03-15
HK1045496A1 (en)	2002-11-29
HK1045496B (en)	2004-10-21
KR20020067498A (ko)	2002-08-22
IS2069B (is)	2005-11-15
BR0013694A (pt)	2002-05-21
DK1214296T3 (da)	2004-07-05
ATE262507T1 (de)	2004-04-15
BG106520A (en)	2003-03-31
IL148111A (en)	2007-05-15
DE60009319T2 (de)	2005-03-31
HUP0202725A2 (hu)	2003-01-28
DE60009319D1 (de)	2004-04-29
BG65099B1 (bg)	2007-02-28
SK286774B6 (sk)	2009-05-07
PL353887A1 (en)	2003-12-15
AU760061B2 (en)	2003-05-08
AU6854300A (en)	2001-04-10
TR200200550T2 (tr)	2002-06-21
US6689909B1 (en)	2004-02-10
WO2001017956A1 (en)	2001-03-15
CO5190690A1 (es)	2002-08-29
MXPA02002319A (es)	2002-07-30
CN1387509A (zh)	2002-12-25
EE05080B1 (et)	2008-10-15
EE200200113A (et)	2003-06-16
JP2003508515A (ja)	2003-03-04
EP1214296B1 (en)	2004-03-24
AR035163A1 (es)	2004-05-05
NZ517147A (en)	2003-11-28
EP1214296A1 (en)	2002-06-19
PT1214296E (pt)	2004-08-31

Legal Events

Date	Code	Title	Description
2009-12-14	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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