NO20022932L - Nye bisamidatfosfonat-prodrugs - Google Patents

Nye bisamidatfosfonat-prodrugs

Info

Publication number
NO20022932L
NO20022932L NO20022932A NO20022932A NO20022932L NO 20022932 L NO20022932 L NO 20022932L NO 20022932 A NO20022932 A NO 20022932A NO 20022932 A NO20022932 A NO 20022932A NO 20022932 L NO20022932 L NO 20022932L
Authority
NO
Norway
Prior art keywords
new
phosphonate prodrugs
bisamidate phosphonate
bisamidate
prodrugs
Prior art date
Application number
NO20022932A
Other languages
English (en)
Other versions
NO20022932D0 (no
Inventor
Srinivas Rao Kasibhatla
Raja K Reddy
Tao Jiang
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Publication of NO20022932D0 publication Critical patent/NO20022932D0/no
Publication of NO20022932L publication Critical patent/NO20022932L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C07F9/4461—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4465—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20022932A 1999-12-22 2002-06-18 Nye bisamidatfosfonat-prodrugs NO20022932L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17186299P 1999-12-22 1999-12-22
PCT/IB2000/002071 WO2001047935A2 (en) 1999-12-22 2000-12-22 Novel bisamidate phosphonate prodrugs

Publications (2)

Publication Number Publication Date
NO20022932D0 NO20022932D0 (no) 2002-06-18
NO20022932L true NO20022932L (no) 2002-08-22

Family

ID=22625436

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20022932A NO20022932L (no) 1999-12-22 2002-06-18 Nye bisamidatfosfonat-prodrugs

Country Status (20)

Country Link
US (3) US6965033B2 (no)
EP (1) EP1240174A2 (no)
JP (1) JP2003519154A (no)
KR (1) KR100875335B1 (no)
CN (2) CN1740182A (no)
AU (1) AU784370B2 (no)
BR (1) BR0017048A (no)
CA (1) CA2396713A1 (no)
CZ (1) CZ301401B6 (no)
HK (1) HK1049841A1 (no)
HU (1) HUP0204092A3 (no)
IL (1) IL149887A0 (no)
MX (1) MXPA02006156A (no)
NO (1) NO20022932L (no)
NZ (1) NZ519219A (no)
PL (1) PL356525A1 (no)
RU (2) RU2273642C2 (no)
SK (1) SK8892002A3 (no)
WO (1) WO2001047935A2 (no)
ZA (1) ZA200204399B (no)

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WO2001047935A3 (en) 2002-03-21
US20020173490A1 (en) 2002-11-21
US20090192121A1 (en) 2009-07-30
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CA2396713A1 (en) 2001-07-05
CN1740182A (zh) 2006-03-01
WO2001047935A2 (en) 2001-07-05
RU2273642C2 (ru) 2006-04-10
HK1049841A1 (zh) 2003-05-30
NZ519219A (en) 2004-03-26
CZ20022172A3 (cs) 2003-01-15
PL356525A1 (en) 2004-06-28
CN100595204C (zh) 2010-03-24
MXPA02006156A (es) 2003-09-22
RU2002119708A (ru) 2004-03-20
AU5244701A (en) 2001-07-09
US20050004077A1 (en) 2005-01-06
BR0017048A (pt) 2002-11-05
IL149887A0 (en) 2002-11-10
JP2003519154A (ja) 2003-06-17
US6965033B2 (en) 2005-11-15
NO20022932D0 (no) 2002-06-18
HUP0204092A3 (en) 2005-02-28
CN1434828A (zh) 2003-08-06
RU2005138719A (ru) 2007-06-20
KR100875335B1 (ko) 2008-12-22
ZA200204399B (en) 2003-11-26
CZ301401B6 (cs) 2010-02-17
EP1240174A2 (en) 2002-09-18
KR20020063248A (ko) 2002-08-01
HUP0204092A2 (hu) 2003-03-28
AU784370B2 (en) 2006-03-23

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