NO20023098D0 - Nye estere avledet fra (RR, SS)-3-(2-dimetylaminometyl-1- hydroksysykloheksyl)fenyl 2-hydroksybenzoat - Google Patents

Nye estere avledet fra (RR, SS)-3-(2-dimetylaminometyl-1- hydroksysykloheksyl)fenyl 2-hydroksybenzoat

Info

Publication number
NO20023098D0
NO20023098D0 NO20023098A NO20023098A NO20023098D0 NO 20023098 D0 NO20023098 D0 NO 20023098D0 NO 20023098 A NO20023098 A NO 20023098A NO 20023098 A NO20023098 A NO 20023098A NO 20023098 D0 NO20023098 D0 NO 20023098D0
Authority
NO
Norway
Prior art keywords
dimethylaminomethyl
hydroxybenzoate
cyclohexyl
hydroxy
phenyl
Prior art date
Application number
NO20023098A
Other languages
English (en)
Norwegian (no)
Other versions
NO20023098L (no
Inventor
Marisabel Mourelle Mancini
Elisabet De Ramon Amat
Juan Huguet Clotet
Original Assignee
Vita Invest Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Invest Sa filed Critical Vita Invest Sa
Publication of NO20023098L publication Critical patent/NO20023098L/no
Publication of NO20023098D0 publication Critical patent/NO20023098D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO20023098A 1999-12-30 2002-06-26 Nye estere avledet fra (RR, SS)-3-(2-dimetylaminometyl-1- hydroksysykloheksyl)fenyl 2-hydroksybenzoat NO20023098D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200000060A ES2160534B1 (es) 1999-12-30 1999-12-30 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
PCT/ES2000/000486 WO2001049650A1 (fr) 1999-12-30 2000-12-26 Nouveaux esters derives de (rr,ss)-2-hydroxybenzoate de 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyle

Publications (2)

Publication Number Publication Date
NO20023098L NO20023098L (no) 2002-06-26
NO20023098D0 true NO20023098D0 (no) 2002-06-26

Family

ID=8491916

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023098A NO20023098D0 (no) 1999-12-30 2002-06-26 Nye estere avledet fra (RR, SS)-3-(2-dimetylaminometyl-1- hydroksysykloheksyl)fenyl 2-hydroksybenzoat

Country Status (30)

Country Link
US (1) US6894076B2 (fr)
EP (1) EP1251120B1 (fr)
JP (1) JP2003519208A (fr)
KR (1) KR20020063281A (fr)
CN (1) CN1414946A (fr)
AP (1) AP1234A (fr)
AT (1) ATE284380T1 (fr)
AU (1) AU775918B2 (fr)
BG (1) BG106883A (fr)
BR (1) BR0016882A (fr)
CA (1) CA2395976A1 (fr)
CZ (1) CZ20022189A3 (fr)
DE (1) DE60016631D1 (fr)
EA (1) EA004770B1 (fr)
EE (1) EE200200365A (fr)
ES (1) ES2160534B1 (fr)
HR (1) HRP20020559A2 (fr)
HU (1) HUP0204147A3 (fr)
IL (1) IL150392A0 (fr)
IS (1) IS6440A (fr)
MA (1) MA26862A1 (fr)
MX (1) MXPA02006514A (fr)
NO (1) NO20023098D0 (fr)
NZ (1) NZ520263A (fr)
OA (1) OA12132A (fr)
PL (1) PL356056A1 (fr)
SK (1) SK9252002A3 (fr)
WO (1) WO2001049650A1 (fr)
YU (1) YU50902A (fr)
ZA (1) ZA200205193B (fr)

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US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
CA2713128C (fr) 2008-01-25 2016-04-05 Gruenenthal Gmbh Forme posologique pharmaceutique
BRPI0912014A2 (pt) 2008-05-09 2019-03-06 Grünenthal GmbH processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob uso de uma etapa de congelamento por atomização
US8058469B2 (en) * 2008-11-03 2011-11-15 Sabic Innovative Plastics Ip B.V. Method for making carbamates, ureas and isocyanates
RU2015138422A (ru) 2009-07-22 2018-12-25 Грюненталь Гмбх Стабильная при окислении, прочная на излом лекарственная форма
CN102573805A (zh) 2009-07-22 2012-07-11 格吕伦塔尔有限公司 热熔挤出的控制释放剂型
EP2383255A1 (fr) 2010-04-28 2011-11-02 Lacer, S.A. Nouveaux composés, synthèse et utilisation dans le traitement de la douleur
BR112013005234A2 (pt) 2010-09-02 2016-05-03 Gruenenthal Gmbh forma de dosagem resistente à violação compreendendo um polímero aniônico.
NZ607392A (en) 2010-09-02 2015-03-27 Gruenenthal Chemie Tamper resistant dosage form comprising inorganic salt
EP2530072A1 (fr) 2011-06-03 2012-12-05 Lacer, S.A. Nouveaux composés, synthèse et utilisation dans le traitement de la douleur
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
RS56527B1 (sr) 2011-07-29 2018-02-28 Gruenenthal Gmbh Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu
PE20141638A1 (es) 2011-07-29 2014-11-22 Gruenenthal Chemie Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato
MX356421B (es) 2012-02-28 2018-05-29 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico.
DK2838512T3 (en) 2012-04-18 2018-11-19 Gruenenthal Gmbh MANIPULATED AND DOSAGE DUMPED PHARMACEUTICAL DOSAGE FORM
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
AR096439A1 (es) 2013-05-29 2015-12-30 Gruenenthal Gmbh Forma de dosificación resistente al uso indebido que contiene una o más partículas
JP6445537B2 (ja) 2013-05-29 2018-12-26 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング １個または複数の粒子を含有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
US10624862B2 (en) 2013-07-12 2020-04-21 Grünenthal GmbH Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
AU2014356581C1 (en) 2013-11-26 2020-05-28 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of cryo-milling
MX2016014738A (es) 2014-05-12 2017-03-06 Gruenenthal Gmbh Formulacion en capsula de liberacion inmediata resistente a alteraciones que comprende tapentadol.
JP2018517676A (ja) 2015-04-24 2018-07-05 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 即時放出および溶媒抽出に対する耐性を有する改変防止製剤
AU2016319203A1 (en) 2015-09-10 2018-02-22 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
KR102703513B1 (ko) 2015-10-15 2024-09-06 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 옥사 스파이로 유도체, 이의 제조방법, 및 의약에서 이의 응용

Family Cites Families (8)

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DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
DE1518663A1 (de) 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3562589A (en) * 1968-09-09 1971-02-09 Ite Imperial Corp Electrically resetting undervoltage trip for circuit breakers
US5470885A (en) * 1993-09-29 1995-11-28 The Research Foundation Of The State University Of New York Fluorocarbons as anti-inflammatory agents
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
GB9924604D0 (en) * 1999-10-18 1999-12-22 European Molecular Biology Lab Embl Genetic switch

Also Published As

Publication number Publication date
EA004770B1 (ru) 2004-08-26
NZ520263A (en) 2004-07-30
IS6440A (is) 2002-06-25
AU2012601A (en) 2001-07-16
AP2002002571A0 (en) 2002-09-30
EA200200614A1 (ru) 2002-12-26
JP2003519208A (ja) 2003-06-17
YU50902A (sh) 2006-01-16
MA26862A1 (fr) 2004-12-20
US20030100598A1 (en) 2003-05-29
AP1234A (en) 2003-12-28
OA12132A (en) 2006-05-05
EP1251120A1 (fr) 2002-10-23
BR0016882A (pt) 2002-11-05
DE60016631D1 (de) 2005-01-13
ZA200205193B (en) 2003-06-27
EE200200365A (et) 2003-10-15
AU775918B2 (en) 2004-08-19
HUP0204147A2 (hu) 2003-04-28
WO2001049650A1 (fr) 2001-07-12
NO20023098L (no) 2002-06-26
ES2160534B1 (es) 2002-04-16
HUP0204147A3 (en) 2003-10-28
MXPA02006514A (es) 2004-07-30
ATE284380T1 (de) 2004-12-15
EP1251120B1 (fr) 2004-12-08
SK9252002A3 (en) 2003-04-01
KR20020063281A (ko) 2002-08-01
CA2395976A1 (fr) 2001-07-12
CZ20022189A3 (cs) 2003-03-12
IL150392A0 (en) 2002-12-01
ES2160534A1 (es) 2001-11-01
CN1414946A (zh) 2003-04-30
BG106883A (en) 2003-05-30
US6894076B2 (en) 2005-05-17
PL356056A1 (en) 2004-06-14
HRP20020559A2 (en) 2004-02-29

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Legal Events

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