NO20023098L - Nye estere avledet fra (RR, SS)-3-(2-dimetylaminometyl-1- hydroksysykloheksyl)fenyl 2-hydroksybenzoat - Google Patents

Nye estere avledet fra (RR, SS)-3-(2-dimetylaminometyl-1- hydroksysykloheksyl)fenyl 2-hydroksybenzoat

Info

Publication number
NO20023098L
NO20023098L NO20023098A NO20023098A NO20023098L NO 20023098 L NO20023098 L NO 20023098L NO 20023098 A NO20023098 A NO 20023098A NO 20023098 A NO20023098 A NO 20023098A NO 20023098 L NO20023098 L NO 20023098L
Authority
NO
Norway
Prior art keywords
dimethylaminomethyl
hydroxybenzoate
cyclohexyl
hydroxy
phenyl
Prior art date
Application number
NO20023098A
Other languages
English (en)
Norwegian (no)
Other versions
NO20023098D0 (no
Inventor
Marisabel Mourelle Mancini
Elisabet De Ramon Amat
Juan Huguet Clotet
Original Assignee
Vita Invest Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Invest Sa filed Critical Vita Invest Sa
Publication of NO20023098D0 publication Critical patent/NO20023098D0/no
Publication of NO20023098L publication Critical patent/NO20023098L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO20023098A 1999-12-30 2002-06-26 Nye estere avledet fra (RR, SS)-3-(2-dimetylaminometyl-1- hydroksysykloheksyl)fenyl 2-hydroksybenzoat NO20023098L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200000060A ES2160534B1 (es) 1999-12-30 1999-12-30 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
PCT/ES2000/000486 WO2001049650A1 (es) 1999-12-30 2000-12-26 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil)fenilo

Publications (2)

Publication Number Publication Date
NO20023098D0 NO20023098D0 (no) 2002-06-26
NO20023098L true NO20023098L (no) 2002-06-26

Family

ID=8491916

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023098A NO20023098L (no) 1999-12-30 2002-06-26 Nye estere avledet fra (RR, SS)-3-(2-dimetylaminometyl-1- hydroksysykloheksyl)fenyl 2-hydroksybenzoat

Country Status (30)

Country Link
US (1) US6894076B2 (is)
EP (1) EP1251120B1 (is)
JP (1) JP2003519208A (is)
KR (1) KR20020063281A (is)
CN (1) CN1414946A (is)
AP (1) AP1234A (is)
AT (1) ATE284380T1 (is)
AU (1) AU775918B2 (is)
BG (1) BG106883A (is)
BR (1) BR0016882A (is)
CA (1) CA2395976A1 (is)
CZ (1) CZ20022189A3 (is)
DE (1) DE60016631D1 (is)
EA (1) EA004770B1 (is)
EE (1) EE200200365A (is)
ES (1) ES2160534B1 (is)
HR (1) HRP20020559A2 (is)
HU (1) HUP0204147A3 (is)
IL (1) IL150392A0 (is)
IS (1) IS6440A (is)
MA (1) MA26862A1 (is)
MX (1) MXPA02006514A (is)
NO (1) NO20023098L (is)
NZ (1) NZ520263A (is)
OA (1) OA12132A (is)
PL (1) PL356056A1 (is)
SK (1) SK9252002A3 (is)
WO (1) WO2001049650A1 (is)
YU (1) YU50902A (is)
ZA (1) ZA200205193B (is)

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US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
CA2713128C (en) 2008-01-25 2016-04-05 Gruenenthal Gmbh Pharmaceutical dosage form
AU2009243681B2 (en) 2008-05-09 2013-12-19 Grunenthal Gmbh Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
US8058469B2 (en) * 2008-11-03 2011-11-15 Sabic Innovative Plastics Ip B.V. Method for making carbamates, ureas and isocyanates
CN102639118B (zh) 2009-07-22 2015-07-29 格吕伦塔尔有限公司 氧化稳定的抗干扰剂型
KR101738369B1 (ko) 2009-07-22 2017-05-22 그뤼넨탈 게엠베하 핫 멜트 압출된 제어 방출 투여형
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
TWI516286B (zh) 2010-09-02 2016-01-11 歌林達股份有限公司 含陰離子聚合物之抗破碎劑型
BR112013005194A2 (pt) 2010-09-02 2016-05-03 Gruenenthal Gmbh forma de dosagem resistente à violação compreendendo sal inorgânico
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
BR112014001091A2 (pt) 2011-07-29 2017-02-14 Gruenenthal Gmbh comprimido resistente à adulteração que fornece liberação imediata do fármaco
EA201400172A1 (ru) 2011-07-29 2014-06-30 Грюненталь Гмбх Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства
MX356421B (es) 2012-02-28 2018-05-29 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico.
EP2838512B1 (en) 2012-04-18 2018-08-22 Grünenthal GmbH Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
US9737490B2 (en) 2013-05-29 2017-08-22 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
EP3003279A1 (en) 2013-05-29 2016-04-13 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
BR112016000194A8 (pt) 2013-07-12 2019-12-31 Gruenenthal Gmbh forma de dosagem resistente à violação contendo o polímero de acetato de etileno-vinila
EP3073994A1 (en) 2013-11-26 2016-10-05 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of cryo-milling
WO2015173195A1 (en) 2014-05-12 2015-11-19 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
WO2016170097A1 (en) 2015-04-24 2016-10-27 Grünenthal GmbH Tamper-resistant dosage form with immediate release and resistance against solvent extraction
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
WO2017063509A1 (zh) 2015-10-15 2017-04-20 江苏恒瑞医药股份有限公司 氧杂螺环类衍生物、其制备方法及其在医药上的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
DE1518663A1 (de) 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3562589A (en) * 1968-09-09 1971-02-09 Ite Imperial Corp Electrically resetting undervoltage trip for circuit breakers
US5470885A (en) * 1993-09-29 1995-11-28 The Research Foundation Of The State University Of New York Fluorocarbons as anti-inflammatory agents
DE19525137C2 (de) 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
GB9924604D0 (en) * 1999-10-18 1999-12-22 European Molecular Biology Lab Embl Genetic switch

Also Published As

Publication number Publication date
US20030100598A1 (en) 2003-05-29
KR20020063281A (ko) 2002-08-01
EE200200365A (et) 2003-10-15
ES2160534B1 (es) 2002-04-16
YU50902A (sh) 2006-01-16
EP1251120A1 (en) 2002-10-23
MXPA02006514A (es) 2004-07-30
EP1251120B1 (en) 2004-12-08
CA2395976A1 (en) 2001-07-12
AP1234A (en) 2003-12-28
BG106883A (en) 2003-05-30
AU2012601A (en) 2001-07-16
CZ20022189A3 (cs) 2003-03-12
IS6440A (is) 2002-06-25
HUP0204147A3 (en) 2003-10-28
EA004770B1 (ru) 2004-08-26
WO2001049650A1 (es) 2001-07-12
AU775918B2 (en) 2004-08-19
AP2002002571A0 (en) 2002-09-30
SK9252002A3 (en) 2003-04-01
HRP20020559A2 (en) 2004-02-29
NO20023098D0 (no) 2002-06-26
MA26862A1 (fr) 2004-12-20
PL356056A1 (en) 2004-06-14
DE60016631D1 (de) 2005-01-13
HUP0204147A2 (hu) 2003-04-28
ES2160534A1 (es) 2001-11-01
IL150392A0 (en) 2002-12-01
US6894076B2 (en) 2005-05-17
NZ520263A (en) 2004-07-30
BR0016882A (pt) 2002-11-05
ZA200205193B (en) 2003-06-27
CN1414946A (zh) 2003-04-30
JP2003519208A (ja) 2003-06-17
ATE284380T1 (de) 2004-12-15
OA12132A (en) 2006-05-05
EA200200614A1 (ru) 2002-12-26

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