|
ATE395912T1
(de)
|
2001-03-27 |
2008-06-15 |
Merck & Co Inc |
Dipeptidylpeptidase-hemmer für die behandlung oder prävention von diabetes
|
|
ES2296979T3
(es)
*
|
2001-06-27 |
2008-05-01 |
Smithkline Beecham Corporation |
Fluoropirrolidinas como inhibidores de dipeptidil peptidasa.
|
|
JP4300108B2
(ja)
|
2001-06-27 |
2009-07-22 |
スミスクライン ビーチャム コーポレーション |
ジペプチジルペプチダーゼ阻害剤としてのピロリジン類
|
|
DE60221983T2
(de)
|
2001-06-27 |
2008-05-15 |
Smithkline Beecham Corp. |
Fluorpyrrolidine als dipeptidyl-peptidase inhibitoren
|
|
GB0125445D0
(en)
*
|
2001-10-23 |
2001-12-12 |
Ferring Bv |
Protease Inhibitors
|
|
AU2002360732A1
(en)
*
|
2001-12-26 |
2003-07-24 |
Guilford Pharmaceuticals |
Change inhibitors of dipeptidyl peptidase iv
|
|
DE60304911D1
(de)
|
2002-02-25 |
2006-06-08 |
Eisai Co Ltd |
Xanthin-Derivate als DPP-IV-Inhibitoren
|
|
HUP0200849A2
(hu)
*
|
2002-03-06 |
2004-08-30 |
Sanofi-Synthelabo |
N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
|
|
AU2003235913A1
(en)
*
|
2002-05-09 |
2003-11-11 |
Taisho Pharmaceutical Co., Ltd. |
Cyanopyrrolidine derivatives
|
|
JP2005533771A
(ja)
*
|
2002-06-04 |
2005-11-10 |
ファイザー・プロダクツ・インク |
ジペプチジルペプチダーゼiv阻害剤としてのフッ素化環式アミド
|
|
WO2004007446A1
(ja)
*
|
2002-07-10 |
2004-01-22 |
Yamanouchi Pharmaceutical Co., Ltd. |
新規なアゼチジン誘導体又はその塩
|
|
TW200401635A
(en)
*
|
2002-07-23 |
2004-02-01 |
Yamanouchi Pharma Co Ltd |
2-Cyano-4-fluoropyrrolidine derivative or salt thereof
|
|
ZA200501418B
(en)
*
|
2002-08-29 |
2006-10-25 |
Taisho Pharmaceutical Co Ltd |
Benzenesulfonate salts of 4-fluoro-2-cyanopyrrolidine derivatives
|
|
EP1565437A1
(en)
*
|
2002-11-18 |
2005-08-24 |
Pfizer Products Inc. |
Dipeptidyl peptidase iv inhibiting fluorinated cyclic amides
|
|
JP2005170792A
(ja)
*
|
2002-11-22 |
2005-06-30 |
Mitsubishi Pharma Corp |
L−プロリン誘導体およびその医薬としての用途。
|
|
DE10308351A1
(de)
|
2003-02-27 |
2004-11-25 |
Aventis Pharma Deutschland Gmbh |
1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
DE10308355A1
(de)
|
2003-02-27 |
2004-12-23 |
Aventis Pharma Deutschland Gmbh |
Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
|
|
DE10308352A1
(de)
|
2003-02-27 |
2004-09-09 |
Aventis Pharma Deutschland Gmbh |
Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
|
|
DE10308353A1
(de)
|
2003-02-27 |
2004-12-02 |
Aventis Pharma Deutschland Gmbh |
Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
US7148246B2
(en)
|
2003-02-27 |
2006-12-12 |
Sanofi-Aventis Deutschland Gmbh |
Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
|
|
US7550590B2
(en)
*
|
2003-03-25 |
2009-06-23 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
JP5690463B2
(ja)
|
2003-05-05 |
2015-03-25 |
プロビオドルグ エージー |
グルタミニル、及びグルタミン酸シクラーゼのエフェクターの使用
|
|
JP4806628B2
(ja)
|
2003-05-05 |
2011-11-02 |
プロビオドルグ エージー |
グルタミニルシクラーゼ阻害剤
|
|
KR20110059664A
(ko)
|
2003-05-05 |
2011-06-02 |
프로비오드룩 아게 |
글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도
|
|
US20040229848A1
(en)
*
|
2003-05-05 |
2004-11-18 |
Hans-Ulrich Demuth |
Glutaminyl based DP IV-inhibitors
|
|
WO2004103993A1
(en)
|
2003-05-14 |
2004-12-02 |
Syrrx, Inc. |
Dipeptidyl peptidase inhibitors
|
|
EP1627870A1
(en)
*
|
2003-05-15 |
2006-02-22 |
Taisho Pharmaceutical Co., Ltd |
Cyanofluoropyrrolidine derivative
|
|
US7678909B1
(en)
|
2003-08-13 |
2010-03-16 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
US7169926B1
(en)
|
2003-08-13 |
2007-01-30 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
KR20060041309A
(ko)
*
|
2003-08-13 |
2006-05-11 |
다케다 야쿠힌 고교 가부시키가이샤 |
4-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도
|
|
WO2005030751A2
(en)
*
|
2003-09-08 |
2005-04-07 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
US7790734B2
(en)
*
|
2003-09-08 |
2010-09-07 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
BRPI0415409A
(pt)
|
2003-10-15 |
2006-12-05 |
Probiodrug Ag |
uso de efetuadores de ciclases de glutaminila e glutamato
|
|
EP2338490A3
(en)
|
2003-11-03 |
2012-06-06 |
Probiodrug AG |
Combinations useful for the treatment of neuronal disorders
|
|
KR20120008093A
(ko)
|
2003-11-17 |
2012-01-25 |
노파르티스 아게 |
디펩티딜 펩티다제 ⅳ 억제제의 용도
|
|
DK1715893T3
(da)
|
2004-01-20 |
2009-11-09 |
Novartis Pharma Ag |
Direkte kompressionsformulering og fremgangsmåde
|
|
US7241787B2
(en)
|
2004-01-25 |
2007-07-10 |
Sanofi-Aventis Deutschland Gmbh |
Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments
|
|
WO2005073186A1
(ja)
*
|
2004-01-29 |
2005-08-11 |
Ono Pharmaceutical Co., Ltd. |
ピロリジン誘導体
|
|
US7230002B2
(en)
*
|
2004-02-03 |
2007-06-12 |
Glenmark Pharmaceuticals Ltd. |
Dipeptidyl peptidase IV inhibitors; processes for their preparation and compositions thereof
|
|
US7304086B2
(en)
|
2004-02-05 |
2007-12-04 |
Probiodrug Ag |
Inhibitors of glutaminyl cyclase
|
|
PL1712547T3
(pl)
*
|
2004-02-05 |
2012-04-30 |
Kyorin Seiyaku Kk |
Pochodna bicykloestrowa
|
|
WO2005077900A1
(ja)
*
|
2004-02-18 |
2005-08-25 |
Kyorin Pharmaceutical Co., Ltd. |
ビシクロアミド誘導体
|
|
CA2557275C
(en)
*
|
2004-02-27 |
2012-06-05 |
Kyorin Pharmaceutical Co., Ltd. |
Bicyclo derivative
|
|
EP1729774A4
(en)
*
|
2004-03-09 |
2009-05-06 |
Nat Health Research Institutes |
PYRROLIDINE CONNECTIONS
|
|
US7732446B1
(en)
|
2004-03-11 |
2010-06-08 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
CN102127057A
(zh)
|
2004-03-15 |
2011-07-20 |
武田药品工业株式会社 |
二肽基肽酶抑制剂
|
|
EP1586573B1
(en)
|
2004-04-01 |
2007-02-07 |
Sanofi-Aventis Deutschland GmbH |
Oxadiazolones, processes for their preparation and their use as pharmaceuticals
|
|
TW200604167A
(en)
*
|
2004-04-27 |
2006-02-01 |
Astellas Pharma Inc |
Pyrrolidine derivatives
|
|
KR100869616B1
(ko)
|
2004-05-12 |
2008-11-21 |
화이자 프로덕츠 인코포레이티드 |
프롤린 유도체 및 그의 다이펩티딜 펩티다제-iv저해제로서의 용도
|
|
JP2008501714A
(ja)
*
|
2004-06-04 |
2008-01-24 |
武田薬品工業株式会社 |
ジペプチジルペプチダーゼインヒビター
|
|
WO2006019965A2
(en)
|
2004-07-16 |
2006-02-23 |
Takeda San Diego, Inc. |
Dipeptidyl peptidase inhibitors
|
|
ATE553077T1
(de)
|
2004-07-23 |
2012-04-15 |
Nuada Llc |
Peptidaseinhibitoren
|
|
BRPI0516340A
(pt)
|
2004-10-12 |
2008-09-16 |
Glenmark Pharmaceuticals Sa |
composto, composição farmacêutica, método para tratar uma condição que é regulada ou normalizada via inibição de dpp-iv, método para tratar um distúrbio metabólico, método para tratar diabete tipo ii, método para diminuir glicose no sangue, método para tratamento e profilaxia de uma doença, método para tratar toleráncia não prejudicada a glicose insulino-resistente, método para a manufatura de uma composição farmacêutica e processo para a preparação de compostos
|
|
JP2008019168A
(ja)
*
|
2004-10-22 |
2008-01-31 |
Astellas Pharma Inc |
2−シアノ−4−フルオロピロリジン誘導体の製造法
|
|
WO2006068978A2
(en)
*
|
2004-12-21 |
2006-06-29 |
Takeda Pharmaceutial Company Limited |
Dipeptidyl peptidase inhibitors
|
|
DOP2006000008A
(es)
*
|
2005-01-10 |
2006-08-31 |
Arena Pharm Inc |
Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
|
|
JP2008024592A
(ja)
*
|
2005-01-28 |
2008-02-07 |
Taisho Pharmaceut Co Ltd |
シアノピロリジン誘導体含有固形製剤用組成物、それを含有する固形製剤及びその製造方法
|
|
WO2006090244A1
(en)
*
|
2005-02-22 |
2006-08-31 |
Glenmark Pharmaceuticals S.A. |
New adamantane derivatives as dipeptidyl, peptidase iv inhibitors, processes for their preparation, and pharmaceutical compositions containing them
|
|
JP2008115080A
(ja)
*
|
2005-04-22 |
2008-05-22 |
Taisho Pharmaceutical Co Ltd |
併用医薬
|
|
AU2006239929B2
(en)
*
|
2005-04-22 |
2011-11-03 |
Alantos Pharmaceuticals Holding, Inc. |
Dipeptidyl peptidase-IV inhibitors
|
|
EP1888101B1
(en)
|
2005-06-06 |
2012-03-21 |
Georgetown University |
Compositions and methods for lipo modeling
|
|
DE102005026762A1
(de)
|
2005-06-09 |
2006-12-21 |
Sanofi-Aventis Deutschland Gmbh |
Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
|
|
MY152185A
(en)
|
2005-06-10 |
2014-08-29 |
Novartis Ag |
Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation
|
|
PL1931350T5
(pl)
*
|
2005-09-14 |
2021-11-15 |
Takeda Pharmaceutical Company Limited |
Podanie inhibitorów dipeptydylo-peptydazy
|
|
GEP20135838B
(en)
|
2005-09-14 |
2013-06-10 |
Takeda Pharmaceutical |
Dipeptidyl peptidase inhibitors usage at diabetes treatment
|
|
TW200745080A
(en)
*
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
|
|
TW200745079A
(en)
*
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
|
|
CN101360723A
(zh)
|
2005-09-16 |
2009-02-04 |
武田药品工业株式会社 |
制备嘧啶二酮衍生物的方法
|
|
WO2007100374A2
(en)
|
2005-12-19 |
2007-09-07 |
Trustees Of Tufts College |
Soft protease inhibitors and pro-soft forms thereof
|
|
GB0526291D0
(en)
|
2005-12-23 |
2006-02-01 |
Prosidion Ltd |
Therapeutic method
|
|
EP1995237A4
(en)
*
|
2006-03-08 |
2011-07-06 |
Kyorin Seiyaku Kk |
PROCESS FOR PREPARING AN AMINOACETYLPYRROLIDINCARBONITRILE DERIVATIVE AND PRODUCTION PRODUCT THEREOF
|
|
EP1999108A1
(en)
*
|
2006-03-28 |
2008-12-10 |
Takeda Pharmaceutical Company Limited |
Preparation of (r)-3-aminopiperidine dihydrochloride
|
|
WO2007112347A1
(en)
|
2006-03-28 |
2007-10-04 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
WO2007113634A1
(en)
*
|
2006-04-03 |
2007-10-11 |
Matrix Laboratories Ltd. |
Novel dipeptidyl peptidase iv inhibitors and processes for their preparation and pharmaceutical compositions containing them
|
|
PE20071221A1
(es)
|
2006-04-11 |
2007-12-14 |
Arena Pharm Inc |
Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
|
|
SG10201404220TA
(en)
|
2006-04-11 |
2014-10-30 |
Arena Pharm Inc |
Methods of using gpr119 receptor to identify compounds useful for increasing bone mass in an individual
|
|
AU2007235876A1
(en)
|
2006-04-12 |
2007-10-18 |
Probiodrug Ag |
Enzyme inhibitors
|
|
RU2434862C2
(ru)
|
2006-06-29 |
2011-11-27 |
Тайсо Фармасьютикал Ко., Лтд. |
С-фенил-1-тиоглюцитолы
|
|
US8324383B2
(en)
|
2006-09-13 |
2012-12-04 |
Takeda Pharmaceutical Company Limited |
Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
|
|
EP2089383B1
(en)
|
2006-11-09 |
2015-09-16 |
Probiodrug AG |
3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
|
|
TW200838536A
(en)
*
|
2006-11-29 |
2008-10-01 |
Takeda Pharmaceutical |
Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
|
|
US9126987B2
(en)
|
2006-11-30 |
2015-09-08 |
Probiodrug Ag |
Inhibitors of glutaminyl cyclase
|
|
AU2007332476A1
(en)
|
2006-12-14 |
2008-06-19 |
Taisho Pharmaceutical Co., Ltd. |
1-phenyl 1-thio-D-glucitol derivative
|
|
US8093236B2
(en)
|
2007-03-13 |
2012-01-10 |
Takeda Pharmaceuticals Company Limited |
Weekly administration of dipeptidyl peptidase inhibitors
|
|
US8143427B2
(en)
*
|
2007-03-22 |
2012-03-27 |
Kyorin Pharmaceutical Co., Ltd. |
Method for producing aminoacetylpyrrolidinecarbonitrile derivative
|
|
JP5667440B2
(ja)
|
2007-04-18 |
2015-02-12 |
プロビオドルグ エージー |
グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
|
|
US8338450B2
(en)
*
|
2007-09-21 |
2012-12-25 |
Lupin Limited |
Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors
|
|
BRPI0906094B8
(pt)
|
2008-03-05 |
2021-05-25 |
National Health Res Inst |
composto
|
|
EP2108960A1
(en)
|
2008-04-07 |
2009-10-14 |
Arena Pharmaceuticals, Inc. |
Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
|
|
CA2732984A1
(en)
*
|
2008-08-07 |
2010-02-11 |
Kyorin Pharmaceutical Co., Ltd. |
Process for production of bicyclo[2.2.2]octylamine derivative
|
|
CN102186474A
(zh)
*
|
2008-08-14 |
2011-09-14 |
杏林制药株式会社 |
稳定的医药组合物
|
|
MX2011002825A
(es)
*
|
2008-09-18 |
2011-04-05 |
Astellas Pharma Inc |
Compuestos heterociclicos de carboxamida.
|
|
NZ593361A
(en)
|
2009-01-09 |
2012-12-21 |
Orchid Res Lab Ltd |
Dipeptidyl peptidase iv inhibitors
|
|
US8748457B2
(en)
|
2009-06-18 |
2014-06-10 |
Lupin Limited |
2-amino-2- [8-(dimethyl carbamoyl)- 8-aza- bicyclo [3.2.1] oct-3-yl]-exo- ethanoyl derivatives as potent DPP-IV inhibitors
|
|
AR077642A1
(es)
|
2009-07-09 |
2011-09-14 |
Arena Pharm Inc |
Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
|
|
JP5934645B2
(ja)
|
2009-09-11 |
2016-06-15 |
プロビオドルグ エージー |
グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
|
|
WO2011107530A2
(en)
|
2010-03-03 |
2011-09-09 |
Probiodrug Ag |
Novel inhibitors
|
|
JP5688745B2
(ja)
|
2010-03-10 |
2015-03-25 |
プロビオドルグ エージー |
グルタミニルシクラーゼ(qc、ec2.3.2.5)の複素環阻害剤
|
|
AU2011237775A1
(en)
|
2010-04-06 |
2012-11-22 |
Arena Pharmaceuticals, Inc. |
Modulators of the GPR119 receptor and the treatment of disorders related thereto
|
|
WO2011131748A2
(en)
|
2010-04-21 |
2011-10-27 |
Probiodrug Ag |
Novel inhibitors
|
|
PH12013500547A1
(en)
|
2010-09-22 |
2013-06-10 |
Arena Pharm Inc |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
EP2686313B1
(en)
|
2011-03-16 |
2016-02-03 |
Probiodrug AG |
Benzimidazole derivatives as inhibitors of glutaminyl cyclase
|
|
US20140018371A1
(en)
|
2011-04-01 |
2014-01-16 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
|
US20140066369A1
(en)
|
2011-04-19 |
2014-03-06 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
|
WO2012145604A1
(en)
|
2011-04-22 |
2012-10-26 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
US20140038889A1
(en)
|
2011-04-22 |
2014-02-06 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
|
WO2012170702A1
(en)
|
2011-06-08 |
2012-12-13 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
WO2013055910A1
(en)
|
2011-10-12 |
2013-04-18 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
TWI500613B
(zh)
|
2012-10-17 |
2015-09-21 |
Cadila Healthcare Ltd |
新穎之雜環化合物
|
|
WO2014074668A1
(en)
|
2012-11-08 |
2014-05-15 |
Arena Pharmaceuticals, Inc. |
Modulators of gpr119 and the treatment of disorders related thereto
|
|
CN103922986B
(zh)
*
|
2013-01-16 |
2017-02-15 |
上海彩迩文生化科技有限公司 |
维大列汀及其类似物、中间体及其制备方法和应用
|
|
EA201791982A1
(ru)
|
2015-03-09 |
2020-02-17 |
Интекрин Терапьютикс, Инк. |
Способы лечения неалкогольной жировой болезни печени и/или липодистрофии
|
|
WO2018162722A1
(en)
|
2017-03-09 |
2018-09-13 |
Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke |
Dpp-4 inhibitors for use in treating bone fractures
|
|
AU2018249822A1
(en)
|
2017-04-03 |
2019-10-31 |
Coherus Biosciences Inc. |
PPArgamma agonist for treatment of progressive supranuclear palsy
|
|
ES2812698T3
(es)
|
2017-09-29 |
2021-03-18 |
Probiodrug Ag |
Inhibidores de glutaminil ciclasa
|
|
WO2021165927A1
(en)
*
|
2020-02-21 |
2021-08-26 |
Wockhardt Bio Ag |
2-cyanopyrroldines, -piperidines or -dazepines as hyperglycemic agents
|